Industrial biotechnology is an innovative field that applies biological systems and processes to produce sustainable products. Companies in this sector address modern challenges by offering solutions like alternative fuels, bio-based chemicals, and improved agricultural practices. As global demand for eco-friendly products rises, industrial biotechnologists are increasingly leveraging advanced techniques, such as synthetic biology and fermentation technologies, to reshape manufacturing approaches. Recent trends indicate a booming market driven by the need to reduce carbon footprints and develop renewable resources, positioning industrial biotechnology as a pivotal player in the transition to a greener economy.

The following companies represent a mix of sizes and specializations within the industrial biotechnology sector in the U.S. Founded between 1988 and 2020, these firms, mainly operating in California and North Carolina, typically focus on biomanufacturing, enzyme development, and sustainable chemical production. Categories range from private and venture-capital backed firms to larger corporate entities. Each company brings its unique innovations, searching for efficiencies and sustainability that cater to a variety of industries.

Read on for insights into the top industrial biotechnology companies in the U.S.

Top 24 Industrial Biotechnology Companies in the US

1. Zymergen, Inc.

• Website: zymergen.com
• Ownership type: Corporate
• Headquarters: Emeryville, California, United States (USA)
• Latest funding: $300.0M, July 2022
• Founded year: 2013
• Headcount: 501-1000
• LinkedIn: zymergen-inc-

Zymergen, Inc., founded in 2013 and based in Emeryville, California, is a biotechnology firm that specializes in leveraging genomics and machine learning to develop chemical-producing genetically modified organisms. The company aims to provide innovative solutions primarily for businesses in sectors such as defense and large-scale manufacturing. Zymergen's approach combines biological engineering with advanced data analytics to optimize production processes and create new chemical products. In July 2022, the company secured $300 million in funding, underscoring its potential and relevance in the biotechnology industry. Zymergen's work is pivotal in transforming how chemicals are produced, making it a notable player in the industrial biotechnology space.

2. Manus

• Website: manusbio.com
• Ownership type: Venture Capital
• Headquarters: Boston, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 98%, Peru 2%
• Latest funding: Other (Grant), $2.0M, August 2022
• Founded year: 2011
• Headcount: 51-200
• LinkedIn: manus

Manus Bio Inc., founded in 2011 and based in Boston, Massachusetts, is a biotechnology company that specializes in synthetic biology and the production of bioalternatives. The company aims to provide sustainable solutions for businesses seeking to replace traditional ingredients and materials with environmentally friendly alternatives. Manus Bio operates through a collaborative model, offering tailored programs and services that cater to the specific needs of its clients across various industries. Their expertise lies in biomanufacturing and cell factory engineering, which allows them to produce complex molecules efficiently and sustainably. Manus Bio has successfully commercialized products such as BioStevia and BioNootkatone, showcasing their ability to bridge the gap between laboratory research and market-ready solutions. The company has received funding, including a grant of $2 million in August 2022, which underscores its potential for growth and innovation in the biotechnology sector.

3. Phyton Biotech

• Website: phytonbiotech.com
• Ownership type: Private
• Headquarters: Fort Worth, Texas, United States (USA)
• Employee distribution: Germany 54%, Canada 43%, Mexico 2%
• Founded year: 2009
• Headcount: 51-200
• LinkedIn: phyton-biotech

Phyton Biotech, founded in 2009 and based in Fort Worth, Texas, is a private biotechnology company that specializes in the production of active pharmaceutical ingredients (APIs) through its proprietary plant cell fermentation technology. The company is recognized as the world's largest producer of paclitaxel and docetaxel, two critical compounds used in cancer treatment. Phyton serves various sectors, including pharmaceuticals, cosmetics, agriculture, and food ingredients, providing sustainable solutions that meet the needs of its clients. With a workforce of around 120 employees, Phyton operates significant facilities in Germany and Canada, which are certified for good manufacturing practices (GMP). This enables them to maintain high standards of quality and consistency in their products. Their commitment to environmentally responsible practices and innovative technology positions them as a key player in the industrial biotechnology field.

4. Geno

• Website: genomatica.com
• Ownership type: Venture Capital
• Headquarters: San Diego, California, United States (USA)
• Employee distribution: United States (USA) 96%, Germany 2%, Canada 2%
• Latest funding: August 2021
• Founded year: 2000
• Headcount: 51-200
• LinkedIn: genomatica

Geno, or Genomatica, is a biotechnology firm based in San Diego, California, founded in 2000. The company specializes in developing and licensing sustainable manufacturing processes for chemicals, focusing on eco-friendly alternatives to conventional materials. Their flagship products include plant-based nylon and butylene glycol, which cater to significant markets such as personal care and textiles. Geno's technology aims to replace fossil fuel sources with plant-derived materials, significantly reducing carbon emissions in the manufacturing process. The company has established partnerships with major brands, including lululemon, to facilitate the transition to sustainable materials. With a robust portfolio of over 1,800 patents and applications, Geno is actively contributing to the transformation of supply chains towards more responsible sourcing and transparency. Their commitment to sustainability and innovation positions them as a notable player in the industrial biotechnology sector.

5. Zymtronix

• Website: zymtronix.com
• Ownership type: Venture Capital
• Headquarters: Durham, North Carolina, United States (USA)
• Latest funding: Other (Debt), $2.0M, December 2021
• Founded year: 2013
• Headcount: 11-50
• LinkedIn: zymtronix-catalytic-systems

Zymtronix, founded in 2013 and based in Durham, North Carolina, specializes in enzyme technology and bioconversion processes. The company aims to make rare molecules economically accessible by utilizing multiple enzymes to produce target molecules that traditional methods struggle to achieve. Their technology not only maximizes substrate conversions but also addresses challenges related to product concentration and purification costs. Zymtronix serves a variety of industries, including pharmaceuticals, agriculture, and cosmetics, helping businesses enhance their product offerings through advanced enzyme applications. The company has secured funding, with a notable amount of $2 million in December 2021, indicating investor confidence in their innovative solutions and potential for growth. Zymtronix's focus on sustainability and efficiency aligns with current industry trends, making them a relevant player in the biotechnology sector.

6. Conagen

• Website: conagen.com
• Ownership type: Private
• Headquarters: Bedford, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $30.0M, April 2020
• Founded year: 2010
• Headcount: 51-200
• LinkedIn: conagen-inc.

Conagen, Inc. is a biotechnology firm based in Bedford, Massachusetts, founded in 2010. The company specializes in synthetic biology and biological manufacturing, focusing on the development and production of natural ingredients through advanced fermentation processes. Conagen serves a variety of industries, including food, pharmaceuticals, cosmetics, and nutraceuticals, by providing sustainable and high-quality natural products. Their capabilities include strain and organism development, biological process development, and microbial fermentation scale-up. Conagen has developed a range of products, such as amino acids, lipids, and terpenoids, showcasing their expertise in creating bio-based solutions. In April 2020, the company received $30 million in funding, reflecting its growth potential and the confidence investors have in its innovative approach to biotechnology.

7. Locus Fermentation Solutions

• Website: locusfs.com
• Ownership type: Private
• Headquarters: Solon, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Debt), $30.0M, March 2024
• Founded year: 2013
• Headcount: 51-200
• LinkedIn: locusfs

Locus Fermentation Solutions, based in Solon, Ohio, is a biotechnology company founded in 2013. The firm specializes in creating innovative, bio-based ingredients and solutions that cater to multiple industries, including agriculture, oil and gas, and consumer products. Their patented fermentation technology enables the scalable production of effective alternatives to traditional chemicals, which not only enhances productivity but also minimizes environmental impact. Locus FS has developed a range of products that improve food production, reduce greenhouse gas emissions, and enhance oil recovery processes. The company has received significant funding, with a recent amount of $30 million reported in March 2024, reflecting strong investor confidence in their approach and technology. With over 1,400 patents filed, Locus FS is positioned as a key player in the industrial biotechnology space, focusing on sustainable solutions that address pressing global challenges.

8. Solar Biotech

• Website: solarbiotech.com
• Ownership type: Corporate
• Headquarters: Norton, Virginia, United States (USA)
• Employee distribution: United States (USA) 86%, Canada 14%
• Latest funding: September 2024
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: solar-bioprocessing-llc

Solar Biotech, founded in 2019 and based in Norton, Virginia, is a biotechnology firm that specializes in sustainable biomanufacturing solutions tailored for synthetic biology products. The company is pioneering the use of proprietary SynBio Hyperintegration Algorithms to create customized modular plant architectures, known as BioNodes. These BioNodes are designed to produce a variety of synthetic biology products, including biodesigned cosmetics and functional food ingredients, with a focus on scalability and low operating costs. Solar Biotech operates with a strong commitment to environmental sustainability, utilizing solar energy, recycled water, and bio-capturing CO2 in its processes. This approach not only aims to meet the growing demand for synthetic biology products but also ensures that their production is both carbon-neutral and water-neutral, reflecting a modern ethos in the biotechnology industry.

9. Capra Biosciences

• Website: caprabiosciences.com
• Ownership type: Venture Capital
• Headquarters: Manassas, Virginia, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Convertible note, November 2024
• Founded year: 2020
• Headcount: 1-10
• LinkedIn: capra-biosciences

Capra Biosciences, founded in 2020 and based in Manassas, Virginia, is a biotechnology firm dedicated to sustainable chemical production. The company specializes in utilizing advanced bioreactor technology and biofilm processes to manufacture renewable chemicals, including retinol, which is widely used in the pharmaceutical and cosmetic industries. Capra's innovative approach focuses on converting waste materials into valuable products, positioning them as a player in the environmentally conscious segment of chemical manufacturing. Recently, they received a $7.5 million project agreement to demonstrate their platform for rapidly scaling the production of bio-derived small-molecule active pharmaceutical ingredients (APIs). This project highlights their commitment to addressing supply chain challenges in the pharmaceutical sector while promoting greener manufacturing methods.

10. Bota Biosciences

• Website: bota.bio
• Ownership type: Private Equity
• Headquarters: Lafayette, California, United States (USA)
• Employee distribution: China 88%, United States (USA) 12%
• Latest funding: Series B, $100.0M, July 2021
• Founded year: 2019
• Headcount: 51-200
• LinkedIn: botabio

Bota Biosciences, founded in 2019 and based in Lafayette, California, is a private equity-backed biotechnology firm. The company specializes in bio-manufacturing and enzyme engineering, providing innovative solutions for industrial strain modification and enzyme applications. Bota serves various sectors, including food, personal care, and pharmaceuticals, focusing on sustainable practices and efficient production processes. Their technology platform supports end-to-end solutions, from biological design to industrial production. Bota has received substantial funding, with a Series B round totaling $100 million in July 2021, which underscores its growth potential and relevance in the biotechnology industry.

11. AgBiome

• Website: agbiome.com
• Ownership type: Venture Capital
• Headquarters: Durham, North Carolina, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series D, $116.0M, September 2021
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: agbiome

AgBiome is an agricultural biotechnology company based in Durham, North Carolina, founded in 2012. The company specializes in developing microbial products aimed at crop protection, focusing on sustainable solutions to help farmers manage crop diseases. AgBiome's innovative products, such as Howler and Theia fungicides, utilize naturally occurring microbes to provide effective alternatives to traditional synthetic chemicals. Their proprietary GENESIS platform allows for the identification and development of these microbial solutions, enhancing agricultural productivity while minimizing environmental impact. AgBiome has attracted significant investment, securing $116 million in Series D funding in September 2021, which underscores its potential in the biotechnology sector. The company is also recognized for its commitment to sustainability, having achieved B Corporation certification, reflecting its dedication to social and environmental performance.

12. BioConsortia, Inc.

• Website: bioconsortia.com
• Ownership type: Venture Capital
• Headquarters: Davis, California, United States (USA)
• Employee distribution: United States (USA) 96%, New Zealand 4%
• Latest funding: Series E-K, $15.0M, April 2024
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: bioconsortia-inc-

BioConsortia, Inc., founded in 2014 and based in Davis, California, specializes in agricultural technology with a focus on microbial products designed to improve crop yields and sustainability. The company utilizes advanced microbial selection techniques to develop solutions for nitrogen fixation, pest control, and biostimulants. Their products aim to replace traditional chemical inputs, thereby minimizing ecological impact while enhancing agricultural productivity. BioConsortia operates a robust research and development platform, which includes a significant collection of over 60,000 pre-screened microorganisms. This extensive library supports their innovative product development pipeline. The company has successfully raised over $50 million in funding, with the latest round bringing in $15 million in April 2024, reflecting strong investor interest in their sustainable agricultural solutions.

13. Pow.Bio

• Website: pow.bio
• Ownership type: Venture Capital
• Headquarters: Alameda, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series A, $9.5M, October 2023
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: powbio

Pow.Bio, founded in 2019 and based in Alameda, California, specializes in biomanufacturing solutions through its innovative high efficiency fermentation platform. The company aims to transform the biomanufacturing sector by addressing key challenges such as contamination and genetic drift, which can hinder production efficiency. Pow.Bio's technology allows for the production of organic acids, food proteins, and biomass, significantly improving productivity rates. For instance, they report productivity gains of up to 6x in biomass production. Recently, Pow.Bio secured $9.5 million in Series A funding, which underscores their growth trajectory and commitment to advancing biomanufacturing processes. Their mission is to provide competitive cost solutions for biomanufacturing, enabling faster market entry and reduced production costs for their clients.

14. Arzeda

• Website: arzeda.com
• Ownership type: Venture Capital
• Headquarters: Seattle, Washington, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series C, $38.0M, September 2024
• Founded year: 2009
• Headcount: 51-200
• LinkedIn: arzeda-corp

Arzeda is a biotechnology firm based in Seattle, Washington, founded in 2009. The company specializes in protein design and enzyme development, creating innovative solutions for industries such as food, personal care, and materials science. Arzeda partners with major brands to enhance product sustainability and performance through its proprietary technology, which combines computational design and artificial intelligence. Their work includes optimizing existing proteins and developing new ones that address real-world challenges, such as improving the efficiency of food production and reducing the environmental impact of household products. Recently, Arzeda secured $38 million in a Series C funding round to advance its protein design commercialization efforts, further solidifying its position in the biotechnology sector.

15. Algenol

• Website: algenol.com
• Ownership type: Private
• Headquarters: Fort Myers, Florida, United States (USA)
• Employee distribution: United States (USA) 68%, Germany 32%
• Latest funding: Other (Grant), $25.0M, December 2007
• Founded year: 2006
• Headcount: 51-200
• LinkedIn: algenol-biofuels-inc-

Algenol is a biotechnology company based in Fort Myers, Florida, founded in 2006. The company specializes in the development and manufacturing of algae-based products, focusing on sustainability and innovation. Algenol's offerings include personal care ingredients, biofuels, and other industrial products, all derived from their extensive experience in algae cultivation. They utilize a proprietary closed system for algae growth, which allows for high purity and consistent product quality. Algenol's facility supports product development from research to commercial scale, ensuring they meet the needs of various industries. The company has received funding, including a notable grant of $25 million in 2007, which has likely supported their research and development efforts. Algenol's commitment to sustainable practices and their advanced technology in algae processing make them a significant player in the biotechnology sector.

16. Recombia Biosciences

• Website: recombia.com
• Ownership type: Corporate
• Headquarters: Brisbane, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: September 2022
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: recombiabio

Recombia Biosciences, founded in 2019 as a spinout from the Stanford Genome Technology Center, is based in Brisbane, California. The company focuses on synthetic biology and genome editing, specifically aimed at improving industrial yeast strains used in fermentation processes. Their technology platform allows for precise genetic modifications, enhancing the efficiency and yield of fermentation, which is crucial for applications in the biotechnology and food industries. In September 2022, Recombia was acquired by Lesaffre, a prominent global player in fermentation, which has further strengthened its capabilities and market presence. With a team of around 25 employees, Recombia is actively engaged in developing high-value microbial strains and optimizing production processes, contributing to advancements in sustainable manufacturing practices.

17. BIO-CAT Enzymes & Microbials

• Website: bio-cat.com
• Ownership type: Private
• Headquarters: Troy, Virginia, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1988
• Headcount: 51-200
• LinkedIn: bio-cat

BIO-CAT Enzymes & Microbials, founded in 1988 and based in Troy, Virginia, is a private biotechnology firm that specializes in the development and manufacturing of enzymes, probiotics, and microbials. The company provides innovative solutions tailored for dietary supplements, food and beverage production, and animal nutrition. Their clientele includes life science companies and agricultural businesses, all seeking to enhance health and efficiency through high-quality products. BIO-CAT emphasizes custom formulation and product development, offering services that include custom blending and R&D support. Their focus on non-genetically engineered products and adherence to quality standards, such as Kosher and Halal certifications, further solidifies their position in the biotechnology industry. With a dedicated team and a history of innovation, BIO-CAT continues to contribute to advancements in health and nutrition.

18. Oerth Bio

• Website: oerthbio.com
• Ownership type: Venture Capital
• Headquarters: Durham, North Carolina, United States (USA)
• Employee distribution: United States (USA) 93%, United Kingdom (UK) 7%
• Latest funding: $55.0M, February 2020
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: oerth-bio

Oerth Bio, founded in 2019 and based in Durham, North Carolina, is an agricultural biotechnology company that specializes in creating innovative solutions for crop protection, plant resilience, and health and nutrition. The company leverages PROTAC technology to enhance agricultural practices, focusing on sustainable methods that meet the needs of farmers and agricultural businesses. Oerth Bio's research and development efforts are aimed at addressing pressing agricultural challenges, such as climate change and pest resistance, by improving crop yield and quality. With a team of experts from agricultural chemistry, biotechnology, and pharmaceuticals, Oerth Bio is positioned to make significant contributions to the agricultural sector. The company has successfully raised $55 million in funding, reflecting strong investor interest in their mission to revolutionize agriculture through advanced biotechnology.

19. Prolific Machines

• Website: prolific-machines.com
• Ownership type: Venture Capital
• Headquarters: Emeryville, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series B, $55.0M, June 2024
• Founded year: 2020
• Headcount: 11-50
• LinkedIn: gaia-labs-inc

Prolific Machines, founded in 2020 and based in Emeryville, California, is a biotechnology company that specializes in photomolecular biology. This innovative approach leverages light to control cellular processes, offering a more efficient alternative to traditional biomanufacturing methods that often rely on chemicals and indirect control. Prolific Machines aims to revolutionize various applications, including therapeutic protein production, cultured meat, and tissue engineering. Their platform allows for precise control over cellular functions, enabling the production of complex proteins and tissues with improved yield and quality. The company has recently raised $55 million in Series B funding, highlighting its potential and relevance in the biotechnology and pharmaceutical sectors.

20. Antheia, Inc.

• Website: antheia.bio
• Ownership type: Venture Capital
• Headquarters: Menlo Park, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $12.0M, December 2024
• Founded year: 2015
• Headcount: 11-50
• LinkedIn: antheiabio

Antheia, Inc., founded in 2015 and based in Menlo Park, California, is a biotechnology company that specializes in pharmaceutical manufacturing through synthetic biology. The company focuses on producing biosynthetic Key Starting Materials (KSMs) and Active Pharmaceutical Ingredients (APIs) to tackle drug shortages and enhance supply chain efficiency for pharmaceutical companies and healthcare providers. Antheia's innovative platform allows for the rapid and sustainable production of essential medicines, addressing the challenges posed by traditional agricultural sourcing methods. With a workforce of around 57 employees, the company has garnered attention for its potential to transform pharmaceutical supply chains. Recently, Antheia secured $12 million in funding, indicating strong investor interest in their mission to create a more resilient and equitable pharmaceutical manufacturing landscape.

21. Microbial Discovery Group

• Website: mdgbio.com
• Ownership type: Private
• Headquarters: Oak Creek, Wisconsin, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2007
• Headcount: 51-200
• LinkedIn: microbial-discovery-group

Microbial Discovery Group (MDG), founded in 2007 and based in Oak Creek, Wisconsin, is a private research and development company that specializes in microbial solutions tailored for various industries. With a workforce of approximately 89 employees, MDG focuses on innovative biological solutions that enhance sustainability and operational efficiency. Their product offerings span several markets, including wastewater treatment, bioremediation, and plant health, catering to clients in agriculture and industrial sectors. MDG prides itself on its R&D capabilities, particularly in Bacillus fermentation, which allows them to develop and commercialize effective microbial products. Their commitment to real science, trusted processes, and proven success underscores their dedication to addressing global challenges such as environmental cleanup and food security. MDG's facilities support a comprehensive approach, from strain isolation to manufacturing, ensuring they meet the unique needs of their partners.

22. Fermworx

• Website: fermworx.com
• Ownership type: Private
• Headquarters: Columbus, Georgia, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2013
• Headcount: 51-200
• LinkedIn: fermworx

Fermworx, LLC, based in Columbus, Georgia, is a fermentation company that specializes in high-quality biopolymers and bio-based fermentation products. Founded in 2013, the company serves a variety of sectors, including biotechnology, pharmaceuticals, nutraceuticals, food, chemicals, and oil fields. Fermworx aims to simplify manufacturing complexities for its partners, allowing them to focus on their core operations. The company is currently enhancing its production capabilities by adding 2,000,000 liters of capacity, which will enable them to support both their projects and those of select strategic partners. This growth reflects their commitment to quality and customer satisfaction, as well as their ambition to establish a significant presence in the fermentation industry.

23. Early Charm

• Website: earlycharm.com
• Ownership type: Private
• Headquarters: Baltimore, Maryland, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $160,000, February 2025
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: early-charm-ventures-llc

Early Charm Ventures, founded in 2012 and based in Baltimore, Maryland, is a private venture studio dedicated to converting scientific discoveries into viable commercial ventures. The company specializes in building sustainable businesses across various industries, including energy, security, industrials, and life sciences. Early Charm collaborates closely with researchers and scientists to bring innovative solutions to market, particularly in drug design and advanced materials. They actively manage their portfolio companies, ensuring that each venture is well-supported and strategically aligned with their overall mission. Recently, Early Charm received a grant of $160,200 to develop a biomanufacturing incubator, showcasing their commitment to fostering growth in the biotechnology sector. Their approach emphasizes long-term sustainability over quick financial exits, positioning them as a significant player in the industrial biotechnology space.

24. Perfect Day

• Website: perfectday.com
• Ownership type: Private
• Headquarters: Berkeley, California, United States (USA)
• Latest funding: $90.0M, January 2024
• Founded year: 2014
• Headcount: 51-200
• LinkedIn: perfect-day-inc

Perfect Day is a food technology company based in Berkeley, California, founded in 2014. The company focuses on creating sustainable, animal-free dairy and protein products through precision fermentation. This innovative process allows them to replicate the proteins found in traditional dairy without the need for animals, thus addressing ethical and environmental concerns associated with conventional dairy farming. Perfect Day's flagship product, ProFerm, is already being utilized in various sustainable dairy applications, showcasing their commitment to transforming the food industry. The company has attracted significant investment, including a recent funding round of $90 million in January 2024, which underscores its growth potential and relevance in the biotechnology sector. Perfect Day also operates an enterprise biology platform called nth Bio, which collaborates with partners across multiple industries, including food, agriculture, and pharmaceuticals, to develop sustainable production methods. This positions Perfect Day as a key player in the industrial biotechnology landscape, particularly in the food technology niche.

Industrial Biotechnology Insights: Key Companies in the US

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