The healthcare software industry in Colorado is at the intersection of technology and patient care. This sector is characterized by companies that develop solutions for clinical documentation, patient management, and operational efficiencies. The interactive software focuses on improving healthcare delivery and ensuring compliance with regulations. As telehealth and data analytics gain traction, Colorado's firms are innovating to meet these needs. Most notably, AI integration is transforming data management and enhancing patient engagement, paving the way for a future focused on precision and real-time solutions.

This listing features 24 healthcare software companies based in Colorado, including startups and established firms. These companies vary in size, employing between 11 to 5000 people. Many were founded in the past two decades, reflecting a fertile ground for innovation. Headquartered throughout Colorado, they specialize in areas like patient engagement, clinical workflows, and data analytics, driving advancements in the healthcare sector.

Continue reading to learn more about top healthcare software companies in Colorado.

Top 24 Healthcare Software Companies in Colorado

1. Connexall

• Website: connexall.com
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: Canada 55%, United States (USA) 23%, Portugal 22%
• Founded year: 1992
• Headcount: 201-500
• LinkedIn: connexallgss

Connexall is a healthcare technology company based in Boulder, Colorado, founded in 1992. The company specializes in digital transformation solutions aimed at enhancing patient safety and streamlining clinical workflows. Connexall's product suite includes patient alarm management, risk management, and business analytics, which are designed to improve communication and operational efficiency within healthcare facilities. With a workforce of approximately 159 employees, Connexall serves a broad range of healthcare providers, including hospitals and clinics, and has a notable presence in both the U.S. and Canadian markets. Their solutions are implemented in over 60% of the top hospitals in North America, showcasing their impact on the healthcare sector. Connexall emphasizes collaboration with healthcare professionals to tailor their offerings to meet the unique needs of each facility, ensuring that their technology aligns with the evolving demands of patient care.

2. Blue Marble Smartware Private Limited

• Website: bmsmartware.com
• Ownership type: Private
• Headquarters: Englewood, Colorado, United States (USA)
• Employee distribution: India 93%, United States (USA) 7%
• Founded year: 2013
• Headcount: 51-200
• LinkedIn: bmsmartware

Blue Marble Smartware Private Limited, founded in 2013 and based in Englewood, Colorado, is an IT solutions company that specializes in healthcare technology. With a workforce of around 68 employees, the company focuses on providing innovative software solutions aimed at improving operational efficiency for healthcare providers. Their product lineup includes Electronic Health Records, Practice Management software, and Health Analytics, which are designed to enhance patient care and streamline healthcare processes. Blue Marble Smartware serves a variety of clients, primarily hospitals and healthcare organizations, demonstrating their commitment to the healthcare industry. The company also offers cloud solutions and analytics services, further supporting healthcare providers in their operational needs. Despite not having reported any funding, their sustained activity and relevance in the healthcare technology sector position them as a significant player in the industry.

3. MedKeeper

• Website: medkeeper.com
• Ownership type: Corporate
• Headquarters: Lakewood, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: July 2022
• Founded year: 2001
• Headcount: 51-200
• LinkedIn: medkeeper

MedKeeper, based in Lakewood, Colorado, is a healthcare technology company that specializes in providing cloud-based software solutions tailored for pharmacies. Founded in 2001, the company has developed its flagship product, PharmacyKeeper, which aims to enhance pharmacy operations through improved communication, compliance, and productivity. MedKeeper's offerings include tools for medication verification, tracking, environmental documentation, and staff training management. The company serves hundreds of hospitals and medical centers, ensuring that pharmacy teams can efficiently manage their workflows while adhering to regulatory standards. MedKeeper has been recognized in the industry, notably as a KLAS Category Leader for IV Workflow Management for seven consecutive years, underscoring its commitment to quality and reliability in pharmacy technology.

4. Cured by Innovaccer

• Website: cured.health
• Ownership type: Corporate
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 86%, India 14%
• Latest funding: January 2024
• Founded year: 2018
• Headcount: 11-50
• LinkedIn: curedhealth

Cured by Innovaccer, founded in 2018 and based in Boulder, Colorado, is a healthcare technology company dedicated to improving the healthcare experience. The company specializes in providing innovative solutions that enhance patient engagement and operational efficiency for healthcare organizations. Their product suite includes a consumer data platform, customer relationship management (CRM) tools, and AI-powered contact centers. Cured's platform aims to put consumers at the center of healthcare interactions, driving better outcomes and revenue growth for their clients. With a team that has extensive experience in health tech and marketing automation, Cured is positioned to tackle the challenges faced by healthcare marketers and organizations. They have not reported any funding, indicating a self-sustained growth model as they continue to expand their influence in the healthcare software market.

5. DocBuddy

• Website: docbuddy.com
• Ownership type: Venture Capital
• Headquarters: Greenwood, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $1.8M, June 2023
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: docbuddy

DocBuddy is a healthcare technology firm based in Greenwood, Colorado, founded in 2014. The company specializes in providing innovative solutions aimed at streamlining documentation and enhancing workflow efficiency for healthcare providers. Their product suite includes AI-driven note-taking capabilities, mobile applications that integrate with electronic health records (EHR), and tools designed to improve patient care. Primarily serving healthcare professionals in clinics and hospitals, DocBuddy helps reduce administrative burdens, allowing providers to focus more on patient interactions. Recently, the company raised $1.84 million in seed funding in June 2023, reflecting its active engagement in the healthcare technology space and its commitment to addressing the challenges faced by healthcare providers.

6. cliexa

• Website: cliexa.com
• Ownership type: Venture Capital
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $2.7M, February 2025
• Founded year: 2016
• Headcount: 11-50
• LinkedIn: cliexa

cliexa is a healthcare technology firm based in Denver, Colorado, established in 2016. The company specializes in AI-powered digital health solutions aimed at improving patient engagement, clinical decision-making, and operational efficiency for healthcare providers. Their platforms facilitate real-time data integration and advanced analytics, which are essential for enhancing patient care and optimizing clinical workflows. cliexa has developed several key offerings, including personalized patient engagement tools, a clinical rules engine, and a centralized population health command center. The company has also secured funding, with a recent seed round of $2.74 million in February 2025, reflecting its growth potential and the interest of investors in its innovative approach to healthcare technology.

7. Credo

• Website: credohealth.com
• Ownership type: Venture Capital
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $5.2M, January 2024
• Founded year: 2021
• Headcount: 11-50
• LinkedIn: credo-health

Credo Health, based in Denver, Colorado, is a healthcare technology company founded in 2021. With a team of approximately 33 employees, Credo focuses on innovative solutions for medical record management and risk adjustment. Their flagship product, the PreDx platform, utilizes artificial intelligence to streamline the retrieval and analysis of patient medical histories. This technology aids healthcare providers in making informed clinical decisions and enhances patient care. Credo addresses the inefficiencies associated with traditional record management systems, which often rely on outdated methods like faxing. The company has also formed strategic partnerships, such as with HealthMark Group, to further enhance their offerings in digital medical record solutions. In January 2024, Credo secured $5.25 million in seed funding, reflecting strong investor interest in their approach to transforming healthcare processes.

8. Ghx

• Website: ghx.com
• Ownership type: Private Equity
• Headquarters: Louisville, Colorado, United States (USA)
• Employee distribution: United States (USA) 62%, India 33%, Other 5%
• Latest funding: $500.0M, June 2021
• Founded year: 2000
• Headcount: 1001-5000
• LinkedIn: ghx

GHX, founded in 2000 and based in Louisville, Colorado, is a healthcare supply chain management company that specializes in providing solutions aimed at improving operational efficiency for healthcare providers and suppliers. The company offers a range of services, including inventory management, order automation, and vendor credentialing. GHX leverages technology and data management to enhance visibility across the supply chain, helping clients reduce costs and streamline processes. With a workforce of approximately 1,966 employees, GHX operates primarily in the United States and India, reflecting a global approach to healthcare supply chain challenges. The company has also secured significant funding, with a reported amount of $500 million in June 2021, indicating strong investor confidence in its business model and growth potential. GHX's solutions are particularly valuable in a healthcare environment that increasingly demands efficiency and cost-effectiveness, making them a key player in the healthcare software sector.

9. Helix Technologies

• Website: helixtechnologies.com
• Ownership type: Private
• Headquarters: Greenwood, Colorado, United States (USA)
• Latest funding: $1.9M, May 2017
• Founded year: 2015
• Headcount: 51-200
• LinkedIn: helixtechnologiesinc

Helix Technologies, now known as Forian, is a healthcare technology firm based in Greenwood, Colorado. Founded in 2015, the company specializes in providing innovative software solutions, proprietary data, and predictive analytics tailored for healthcare providers and payers. Their offerings include advanced analytics, consulting services, and data management solutions designed to optimize operational, clinical, and financial performance. Forian has developed a significant repository of healthcare data, focusing on real-world evidence to generate actionable insights. They have received funding amounting to $1,875,000 in 2017, which supports their growth and development in the healthcare technology space. With a team of around 59 employees, Forian is dedicated to addressing the complexities of the healthcare industry through sophisticated technology and data governance.

10. VerityStream by HealthStream

• Website: veritystream.com
• Ownership type: Private
• Headquarters: Louisville, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1985
• Headcount: 501-1000
• LinkedIn: verity-a-healthstream-company

VerityStream by HealthStream is a healthcare solutions provider based in Louisville, Colorado. Founded in 1985, the company focuses on delivering software solutions that streamline the credentialing, enrollment, and evaluation processes for healthcare organizations. Their offerings include the CredentialStream platform and CredentialMyDoc, which are designed to enhance efficiency and ensure the competency of healthcare providers. VerityStream serves a wide range of clients, including health systems, medical groups, and various specialized care facilities. The company operates primarily through a Software as a Service (SaaS) model, which allows for scalable and flexible solutions that meet the evolving needs of the healthcare industry. With a commitment to improving the quality of healthcare, VerityStream plays a vital role in managing the critical data associated with healthcare providers.

11. ZOLL Data Systems

• Website: zolldata.com
• Ownership type: Private
• Headquarters: Broomfield, Colorado, United States (USA)
• Employee distribution: United States (USA) 97%, Other 3%
• Founded year: 1993
• Headcount: 201-500
• LinkedIn: zolldata

ZOLL Data Systems, founded in 1993 and based in Broomfield, Colorado, is a private software company that provides cloud-based solutions specifically for the EMS, fire, and healthcare sectors. With a workforce of approximately 240 employees, ZOLL Data Systems focuses on enhancing operational efficiency and improving patient outcomes through its innovative software offerings. Their product suite includes tools for patient care reporting, billing, and revenue cycle management, which are essential for organizations in emergency services and healthcare. The company emphasizes interoperability and data availability, allowing for seamless integration across various platforms. ZOLL Data Systems is dedicated to empowering healthcare providers with the technology needed to optimize their operations and deliver better care to patients.

12. Gaia Software, LLC

• Website: gaiasoftware.com
• Ownership type: Private
• Headquarters: Littleton, Colorado, United States (USA)
• Founded year: 1998
• Headcount: 11-50
• LinkedIn: gaia-healthcare

Gaia Software, LLC, based in Littleton, Colorado, has been a dedicated player in the healthcare software industry since its founding in 1998. The company specializes in providing dialysis management solutions, which are crucial for both independent and hospital-based dialysis facilities. Their product suite includes a Clinical Electronic Health Record (EHR) system, billing services, and consulting tailored to the unique needs of dialysis providers. Gaia Software operates on a Software as a Service (SaaS) model, ensuring that clients receive ongoing support and training to enhance their operational efficiency. The company prides itself on its expertise in dialysis billing and financial consulting, helping facilities navigate the complexities of reimbursement and compliance. With a focus on improving patient care and maximizing revenue for dialysis organizations, Gaia Software has established itself as a trusted partner in the healthcare software space.

13. Empowered Margins, Inc.

• Website: empoweredmargins.com
• Ownership type: Private
• Headquarters: Colorado Springs, Colorado, United States (USA)
• Employee distribution: India 78%, United States (USA) 22%
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: empowered-margins

Empowered Margins, Inc., founded in 2014 and based in Colorado Springs, Colorado, is a private technology solutions provider specializing in data management and product development for the healthcare and insurance sectors. With a team of 11-50 employees, the company focuses on helping organizations streamline operations and enhance service delivery through a range of services, including data integration, analytics, and custom software solutions. Empowered Margins serves a variety of clients, including healthcare providers and insurance companies, and has developed specific products aimed at improving care management and compliance with regulations. Their solutions address critical issues such as Medicaid billing and Electronic Visit Verification (EVV), showcasing their commitment to the healthcare industry. The company operates with a significant portion of its workforce based in India, which may contribute to its operational efficiency and cost-effectiveness.

14. Agathos

• Website: agathos.health
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 50%, Nigeria 34%, Netherlands 16%
• Founded year: 2015
• Headcount: 11-50
• LinkedIn: agathos

Agathos, founded in 2015 and based in Boulder, Colorado, is a private healthcare technology company that specializes in data analytics and physician engagement solutions. The company offers three main products: Agathos Engage, Agathos Enterprise, and Agathos Continuity. These solutions are designed to help hospitals and healthcare organizations improve patient outcomes by organizing health data and generating actionable insights. Agathos Engage focuses on delivering trusted data to physicians, allowing them to compare their practice patterns with peers. Agathos Enterprise enhances this by providing a comprehensive clinical data pipeline and metrics to scale impact across organizations. Agathos Continuity addresses the challenges faced during electronic health record (EHR) downtimes, ensuring that critical clinical operations can continue seamlessly. The company has established partnerships with various healthcare systems, demonstrating its commitment to reducing clinical variation and enhancing care quality. With a workforce of around 68 employees, Agathos is actively contributing to the healthcare technology sector, making strides in improving physician engagement and patient care.

15. AxisPoint Health

• Website: axispointhealth.com
• Ownership type: Corporate
• Headquarters: Westminster, Colorado, United States (USA)
• Latest funding: $14.0M, March 2018
• Founded year: 2015
• Headcount: 501-1000
• LinkedIn: axispoint-health

AxisPoint Health, now known as Sagility, is a healthcare solutions provider based in Westminster, Colorado. Founded in 2015, the company specializes in technology-enabled services tailored for payers and providers in the healthcare sector. Sagility's core services include claims management, revenue cycle management, patient engagement, and clinical services. They process millions of transactions annually, working closely with health plans and healthcare providers to enhance operational efficiency and improve patient outcomes. The company has processed over 60 million claims, recovering more than $5 billion for its clients. With a workforce of around 500 to 1,000 employees, Sagility is recognized for its innovative approach, utilizing advanced analytics and automation to address complex healthcare challenges. In 2018, they secured $14 million in funding, which underscores their growth potential and commitment to transforming healthcare operations.

16. CereHealth Corp.

• Website: illumeai.com
• Ownership type: Private
• Headquarters: Littleton, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2008
• Headcount: 11-50
• LinkedIn: cerescan-inc-

CereHealth Corp., based in Littleton, Colorado, is a private healthcare technology firm founded in 2008. The company focuses on developing clinical decision support systems and analytics that leverage artificial intelligence to enhance patient care. Their flagship product, iLLUME Ai, is designed to collect and structure patient data from various sources, enabling healthcare professionals to make informed decisions. CereHealth collaborates with healthcare providers, insurance companies, and research institutions to improve clinical workflows and patient outcomes. The company has also received patents for its innovative medical imaging and data analytics technologies, underscoring its commitment to advancing healthcare solutions. With a small team of dedicated professionals, CereHealth continues to push the boundaries of healthcare analytics, aiming to integrate AI into everyday medical practices.

17. Intelliguard

• Website: intelliguardhealth.com
• Ownership type: Private
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 95%, Canada 5%
• Founded year: 2006
• Headcount: 51-200
• LinkedIn: intelliguardrfid

Intelliguard, based in Denver, Colorado, is a healthcare technology company founded in 2006. The firm specializes in medication management solutions, primarily targeting healthcare providers and pharmacies. Their flagship product, the Mira Ecosystem, utilizes RFID technology to enhance safety and efficiency in hospitals. Intelliguard's offerings include various solutions such as Mira Intelligence, Mira Prep, Mira Care, and Mira Supply, all aimed at improving medication tracking and inventory management. The company has established itself as a key player in the healthcare technology space, focusing on creating safer environments for medication decisions and ensuring compliance with regulatory standards. Intelliguard's innovative approach to medication management has garnered positive feedback from industry professionals, highlighting its impact on operational efficiency and patient safety.

18. Welltok

• Website: welltok.com
• Ownership type: Corporate
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: October 2021
• Founded year: 2009
• Headcount: 201-500
• LinkedIn: welltok-inc-

Welltok is a healthcare technology firm based in Denver, Colorado, founded in 2009. The company specializes in a consumer activation platform that connects individuals with tailored health improvement resources. Their primary clientele includes health plans, employers, and healthcare providers, all of whom utilize Welltok's solutions to boost consumer engagement and optimize health outcomes. Welltok's platform is designed to make it easier for consumers to take actionable steps towards better health, thereby enhancing overall wellbeing. The company has been recognized for its contributions to the healthcare sector, including awards for cybersecurity excellence, which underscores its commitment to protecting consumer data. Welltok has also expanded its capabilities through partnerships and acquisitions, further solidifying its position in the healthcare technology space.

19. Md-it

• Website: md-it.com
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2000
• Headcount: 501-1000
• LinkedIn: md-it

Md-it, also known as Command Health, is a healthcare technology provider based in Boulder, Colorado. Founded in 2000, the company specializes in clinical documentation and patient engagement solutions. They cater to healthcare providers and organizations by offering tools that facilitate mobile access to clinical data, actionable analytics, and secure messaging services. Command Health aims to simplify healthcare delivery and enhance patient outcomes through innovative technology. Their solutions include a mobile app for clinical data access, intelligent analytics for real-time data analysis, and a focus on improving clinical documentation processes. The company operates entirely within the United States and has a workforce of around 62 employees, indicating a solid presence in the healthcare technology sector.

20. MCN Healthcare

• Website: mcnhealthcare.com
• Ownership type: Private
• Headquarters: Denver, Colorado, United States (USA)
• Founded year: 1987
• Headcount: 11-50
• LinkedIn: mcn-healthcare

MCN Healthcare, based in Denver, Colorado, has been a significant player in the healthcare software industry since its founding in 1987. The company specializes in providing policy management and compliance solutions specifically designed for healthcare organizations. Their product suite includes a robust document management system, a comprehensive policy and procedure library, and a regulatory notification service known as StayAlert!. These tools help healthcare facilities manage their policies effectively and stay updated on regulatory changes. MCN Healthcare also offers a web-based learning management system, which supports training and compliance education for healthcare staff. With a focus on customer service and adaptability, MCN Healthcare has garnered positive feedback from clients who appreciate the user-friendly nature of their software and the support they receive. The company has reached a milestone of one million end users, indicating a strong presence in the market.

21. Amplifire eLearning

• Website: amplifire.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 98%, Argentina 2%
• Latest funding: July 2022
• Founded year: 2001
• Headcount: 51-200
• LinkedIn: amplifire-learn

Amplifire eLearning, founded in 2001 and based in Boulder, Colorado, specializes in adaptive eLearning solutions specifically designed for the healthcare sector and professional services. The company’s platform is built on principles of cognitive science, aiming to improve training efficiency and workforce competency through personalized learning experiences. Amplifire's services are particularly relevant for hospitals and healthcare systems, as they provide essential training for Electronic Health Records (EHR) and clinical operations. Their approach not only reduces training time but also enhances clinician proficiency and satisfaction. Amplifire has established partnerships with various healthcare organizations, demonstrating its commitment to improving clinician training and operational outcomes. The company has not reported any recent funding, indicating a stable operational status since its inception.

22. nVoq Incorporated

• Website: nvoq.com
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2000
• Headcount: 51-200
• LinkedIn: nvoq-inc-

nVoq Incorporated, based in Boulder, Colorado, is a healthcare technology company founded in 2000. The firm specializes in AI-enabled speech recognition solutions specifically designed for in-home healthcare and hospice services. Their offerings aim to enhance clinician workflows, improve patient care, and streamline operations for healthcare organizations. By providing tools that allow for faster and more accurate documentation, nVoq enables healthcare professionals to focus on patient care rather than administrative burdens. The company’s solutions are cloud-based and integrate seamlessly with various electronic health records (EHR) systems, making them accessible and easy to implement. nVoq's commitment to HIPAA compliance ensures that their technology meets the stringent security requirements of the healthcare industry. Their focus on the in-home healthcare market positions them uniquely to address the specific challenges faced by clinicians in this sector, ultimately aiming to improve both clinician satisfaction and patient outcomes.

23. CirrusMD

• Website: cirrusmd.com
• Ownership type: Venture Capital
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Convertible note, June 2024
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: cirrusmd-inc-

CirrusMD, founded in 2012 and based in Denver, Colorado, is a healthcare provider that specializes in virtual primary care services. The company offers a chat-based platform that allows patients to connect with physicians in under 60 seconds, providing immediate access to care. CirrusMD's services include behavioral health navigation and chronic condition management, leveraging artificial intelligence to enhance patient outcomes. The company primarily serves employers and health plans, aiming to improve healthcare access for their employees. CirrusMD has also been involved in significant partnerships, such as with The Black Car Fund, to provide no-cost healthcare access to thousands of drivers in New York. Their commitment to security and compliance is evident through their NCQA accreditation and HIPAA compliance, ensuring that patient data is handled with the utmost care. With a workforce of around 71 employees, CirrusMD continues to expand its impact in the healthcare software industry.

24. Exer AI

• Website: exer.ai
• Ownership type: Venture Capital
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $6.5M, November 2022
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: exerai

Exer AI, officially known as Exer Labs, Inc., is a healthcare technology company based in Denver, Colorado. Founded in 2019, the company specializes in creating innovative software solutions aimed at enhancing physical therapy and fall prevention. Their flagship products, Exer Health and Exer Scan, are designed to assist healthcare providers in monitoring patient progress and ensuring adherence to treatment plans. Exer Health engages patients at home with AI-based monitoring and real-time guidance, while Exer Scan allows for screening and monitoring of musculoskeletal (MSK) issues without the need for additional hardware. The company primarily serves physical therapists and clinics, focusing on improving patient outcomes through technology-driven solutions. Exer AI has attracted significant venture capital funding, with a recent seed round raising $6.5 million in November 2022, underscoring its growth potential and relevance in the healthcare technology industry.

Healthcare Software Insights: Key Companies in Colorado

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