Minnesota is home to a robust pharmaceuticals industry, characterized by innovative companies engaged in developing, manufacturing, and distributing various health solutions. The sector includes large corporations, startups, and specialized firms focusing on generics, biotechnology, and unique health technologies. Trends show an increasing emphasis on personalized medicine, microbiome-based therapies, and automated healthcare solutions, prompting growth and investment. The state's strong research background, notably partnerships with academic institutions, enhances the development of breakthrough treatments, harkening to Minnesota’s vital role in both domestic and global healthcare markets.

This list highlights 21 pharmaceuticals companies based in Minnesota, varying in size from a handful of employees to over 1,000. Founded between 1948 and 2020, the companies operate out of cities like Minneapolis, St. Cloud, and Rochester. Each specializes in unique pharmaceutical solutions such as drug delivery systems, veterinary medications, and microbiome therapies. This diversity underscores the state's growing influence in the pharmaceuticals industry, catering to various sectors from human health to veterinary care.

Read on to discover the top pharmaceuticals companies in Minnesota.

Top 21 Pharmaceuticals Companies in Minnesota

1. Upsher-Smith

• Website: upsher-smith.com
• Ownership type: Corporate
• Headquarters: Maple Grove, Minnesota, United States (USA)
• Employee distribution: United States (USA) 99%
• Latest funding: January 2024
• Founded year: 1919
• Headcount: 501-1000
• LinkedIn: upsher-smith-laboratories

Upsher-Smith Laboratories, LLC is a pharmaceutical company based in Maple Grove, Minnesota, with a history that spans over a century. Founded in 1919, the company initially focused on refining digitalis, a cardiac drug, and has since evolved to manufacture a wide range of brand and generic medications. Upsher-Smith is particularly known for its products aimed at treating migraine headaches and seizure disorders. The company prides itself on its commitment to quality and patient care, ensuring a reliable supply of pharmaceuticals to healthcare providers and patients alike. Recently, Upsher-Smith has expanded its product line, including the launch of TORPENZ™ (everolimus) tablets, which reflects its ongoing innovation in the pharmaceutical sector. The company operates a state-of-the-art manufacturing facility, Plant C, which enhances its production capabilities and supports its growth strategy. Upsher-Smith's focus on strategic partnerships and collaborations further positions it as a significant player in the pharmaceutical industry.

2. Rebiotix Inc (a Ferring Company)

• Website: rebiotix.com
• Ownership type: Corporate
• Headquarters: Roseville, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: April 2018
• Founded year: 2011
• Headcount: 11-50
• LinkedIn: rebiotix

Rebiotix Inc. is a biotechnology firm based in Roseville, Minnesota, that specializes in developing microbiome-based therapeutics. Founded in 2011, the company has carved out a niche in the treatment of recurrent Clostridioides difficile infections, a significant health concern in the United States. Rebiotix's primary therapeutic approach involves fecal transplant therapies, which aim to restore gut health and prevent the recurrence of infections. The company operates under the umbrella of Ferring Pharmaceuticals, which enhances its operational capabilities and market reach. Rebiotix is committed to advancing the understanding of the human microbiome and its implications for health, positioning itself at the forefront of a rapidly evolving area in the pharmaceutical industry. The company has not reported any recent funding, indicating a stable operational phase since its integration into Ferring.

3. Humanetics Corporation

• Website: humaneticscorp.com
• Ownership type: Private
• Headquarters: Minneapolis, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $5.0M, December 2024
• Founded year: 1988
• Headcount: 11-50
• LinkedIn: humanetics-corporation

Humanetics Corporation, based in Minneapolis, Minnesota, is a private pharmaceutical company founded in 1988. The firm is dedicated to developing and commercializing innovative treatments aimed at enhancing human health, particularly in the areas of oncology and radiation exposure. Their flagship product, BIO 300, is designed to improve outcomes for cancer patients undergoing radiation therapy and to act as a medical countermeasure against radiation injuries. Humanetics has established a strong partnership with the Armed Forces Radiobiology Research Institute, which has been instrumental in the development of BIO 300. The company has received over $60 million in non-dilutive funding from various federal agencies, including the Department of Defense and the National Cancer Institute, to support its research and development efforts. With a focus on clinical trials and a robust pipeline, Humanetics is actively working to address urgent health needs, including the treatment of inflammatory lung diseases and the effects of radiation exposure.

4. Laboratoire XO

• Website: laboratoirexo.com
• Ownership type: Private Equity
• Headquarters: St. Cloud, Minnesota, United States (USA)
• Latest funding: October 2022
• Founded year: 2015
• Headcount: 11-50
• LinkedIn: laboratoire-x.o

Laboratoire XO, also known as LXO Group, is a pharmaceutical and medical device manufacturer based in St. Cloud, Minnesota. Founded in 2015, the company specializes in essential medications and medical devices, focusing on therapeutic areas such as cardiology, central nervous system disorders, and internal medicine. LXO has made significant strides in the industry, achieving over 90 million euros in revenue and completing 20 acquisitions since its inception. The company operates in more than 80 countries, ensuring access to high-quality treatments for healthcare providers and patients alike. LXO is committed to maintaining a strong ethical framework and prioritizes human-centered growth. Their recent acquisition of Nimotop®, a medication used for treating cerebral vasospasms, further solidifies their position in the market and showcases their strategy of enhancing their product portfolio. With a workforce of around 43 employees and a focus on sustainable practices, Laboratoire XO is positioned as a dynamic player in the pharmaceutical sector.

5. LXO Group (Laboratoire X.O)

• Website: lxogroup.com
• Ownership type: Private
• Headquarters: St. Cloud, Minnesota, United States (USA)
• Employee distribution: France 93%, United States (USA) 7%
• Founded year: 2015
• Headcount: 11-50
• LinkedIn: laboratoire-x.o

LXO Group (Laboratoire X.O) is a private pharmaceutical company based in St. Cloud, Minnesota, founded in 2015. The company specializes in the development and distribution of essential medications and medical devices, aiming to improve patient care and ensure the availability of quality healthcare products. LXO Group operates primarily in the healthcare sector, focusing on therapeutic areas such as cardiology, the central nervous system, and internal medicine. With a workforce of around 60 employees, the company has made significant progress in a relatively short time, achieving over 90 million euros in revenue and expanding its product offerings to include 18 brands and 26 products. LXO Group has established a presence in more than 80 countries, reflecting its commitment to international growth. The company emphasizes ethical practices, transparency, and a human-centered approach in its operations, which are crucial in the pharmaceutical industry. Their recent acquisition of Nimotop® from Bayer marks a strategic move to enhance their portfolio and strengthen their market position.

6. Veterinary Pharmaceutical Solutions

• Website: veterinarypharmaceuticalsolutions.com
• Ownership type: Private
• Headquarters: Saint Peter, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1995
• Headcount: 11-50
• LinkedIn: veterinary-pharmaceutical-solutions

Veterinary Pharmaceutical Solutions (VPS), based in Saint Peter, Minnesota, is a private veterinary pharmaceutical company founded in 1995. With a workforce of 11 to 50 employees, VPS specializes in compounded medications specifically designed for livestock. The company has developed a range of products that address various health needs in the livestock sector, including antibiotics, anti-inflammatories, and other essential medications. VPS operates with a strong focus on quality and innovation, collaborating closely with veterinarians and livestock producers to create effective pharmaceutical solutions. Their commitment to research and development is evident in their continuous efforts to introduce new products and improve existing formulations. VPS has established itself as a trusted partner in livestock care, having treated over 2 billion pigs, which underscores their significant impact in the veterinary pharmaceutical market.

7. Tapemark

• Website: tapemark.com
• Ownership type: Corporate
• Headquarters: West Saint Paul, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: August 2022
• Founded year: 1952
• Headcount: 51-200
• LinkedIn: tapemark

Tapemark, founded in 1952 and based in West Saint Paul, Minnesota, is a pharmaceutical company that specializes in drug delivery systems. The company offers a range of services including transdermal patch drug delivery, oral film drug delivery, and unit dose semi-solid drug delivery. Tapemark collaborates primarily with pharmaceutical companies, providing innovative solutions for drug administration. Their proprietary platforms, such as IontoPatch™, MacroPerm™, and MicroDerm™, showcase their commitment to advancing drug delivery technologies. As a full-service CDMO, Tapemark also provides formulation, analytical services, blending, coating, converting, packaging, serialization, and shipment. Their expertise in these areas allows them to support clients throughout the drug development process, from initial formulation to final product delivery.

8. Kindeva Drug Delivery

• Website: kindevadd.com
• Ownership type: Corporate
• Headquarters: Woodbury, Minnesota, United States (USA)
• Employee distribution: United States (USA) 66%, United Kingdom (UK) 34%
• Latest funding: Other (Grant), $42.0M, August 2023
• Founded year: 2020
• Headcount: 1001-5000
• LinkedIn: kindeva

Kindeva Drug Delivery, founded in 2020 and based in Woodbury, Minnesota, operates as a contract development and manufacturing organization (CDMO) with a focus on drug-device combination products. The company offers a wide range of services, including aseptic injectable fill-finish, analytical support, and regulatory compliance assistance. Kindeva has a notable history of innovation, having pioneered several drug delivery technologies since its inception, including the first pressurized metered-dose inhaler and the emergency use autoinjector. With approximately 1,283 employees and facilities in both the United States and the United Kingdom, Kindeva is well-positioned to support pharmaceutical and biotechnology companies in accelerating product development. The company recently secured funding of over $41 million, which underscores its commitment to growth and sustainability initiatives in drug delivery. Kindeva's focus on quality and compliance, along with its extensive experience in the industry, makes it a valuable partner for companies looking to navigate the complexities of drug development and manufacturing.

9. Aurora Pharmaceutical Inc

• Website: aurorapharmaceutical.com
• Ownership type: Private
• Headquarters: Northfield, Minnesota, United States (USA)
• Employee distribution: United States (USA) 98%, Canada 2%
• Latest funding: $2.4M, May 2015
• Founded year: 2009
• Headcount: 11-50
• LinkedIn: aurora-pharmaceutical

Aurora Pharmaceutical Inc, founded in 2009 and based in Northfield, Minnesota, is a private company dedicated to veterinary pharmaceuticals. With a workforce of approximately 80 employees, the company focuses on manufacturing a wide array of products aimed at improving the health and well-being of livestock and pets. Their product line includes medications for pain management, wound care, and overall health management, catering specifically to veterinarians and animal health professionals. Aurora operates with a strong commitment to quality and innovation, utilizing state-of-the-art technologies and adhering to stringent manufacturing standards. The company has also engaged in funding activities, securing $2,412,000 in funding as of May 2015, which supports their ongoing research and development efforts in the veterinary pharmaceutical space.

10. Nanocopoeia

• Website: nanocopoeia.com
• Ownership type: Private
• Headquarters: Saint Paul, Minnesota, United States (USA)
• Latest funding: Other (Grant), $500,000, September 2006
• Founded year: 2001
• Headcount: 11-50
• LinkedIn: nanocopoeia

Nanocopoeia is a privately held specialty research company based in St. Paul, Minnesota, founded in 2001. The company emerged from a technology license with the University of Minnesota, initially focusing on medical devices and advanced nano-scale coating processes. Over the years, Nanocopoeia has shifted its focus to pharmaceutical development, specifically addressing high-value challenges related to drug solubility and bioavailability. They offer innovative drug formulation services that enhance the performance of low solubility drugs, thereby improving patient safety and compliance. With a small team of around 20 employees, Nanocopoeia has demonstrated a commitment to building a technically skilled workforce and has made strides in developing a pipeline of drug products. Their proprietary atomization technology, known as ElectronanoSpray, allows for the creation of homogeneous, macro-scale drug formulation particles, which are crucial for effective drug delivery. The company has also received funding, including a grant of $500,000 in 2006, which has supported their research and development efforts.

11. Cytotheryx, Inc.

• Website: cytotheryx.com
• Ownership type: Private
• Headquarters: Rochester, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: cytotheryx

Cytotheryx, Inc., founded in 2019 and based in Rochester, Minnesota, is a biotechnology firm dedicated to the development of primary human hepatocytes for the treatment and research of liver diseases. The company specializes in creating innovative solutions such as bioartificial livers and hepatocyte transplantation therapies. These advancements aim to meet the urgent need for high-quality liver cells in medical applications. Cytotheryx's platform technology allows for the scalable production of pure primary hepatocytes, which can significantly enhance research and therapeutic options for liver diseases. Their work is particularly relevant as liver diseases affect millions, and the company collaborates with notable institutions like the Mayo Clinic to further their mission. By focusing on cell therapy and regenerative medicine, Cytotheryx is positioned to make a meaningful impact in the pharmaceutical industry, particularly in addressing the challenges associated with liver health.

12. OneOme

• Website: oneome.com
• Ownership type: Private
• Headquarters: Minneapolis, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Debt), $100,000, June 2017
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: oneome

OneOme, founded in 2014 and based in Minneapolis, Minnesota, is a healthcare technology company that specializes in pharmacogenomics. Co-founded by the Mayo Clinic, OneOme aims to enhance patient care through its RightMed Test, which provides genetic insights to inform medication decisions. This test helps healthcare providers understand how a patient's DNA may affect their response to various medications, thereby enabling more personalized treatment plans. OneOme collaborates with healthcare systems, payers, and providers to implement pharmacogenomic programs that can lead to better patient outcomes and reduced healthcare costs. The company has received funding, with its last reported amount being $100,000 in June 2017, indicating ongoing support for its innovative approach in the healthcare sector.

13. Bloomington Drug

• Website: bloomingtondrug.com
• Ownership type: Family Owned
• Headquarters: Bloomington, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1948
• Headcount: 11-50
• LinkedIn: bloomington-drug

Bloomington Drug, established in 1948, is a family-owned retail pharmacy located in Bloomington, Minnesota. The company specializes in a variety of health services, including prescription medications, compounding, medication packaging, and long-term care solutions. With a dedicated team of professionals, Bloomington Drug aims to enhance patient health through personalized service and quality products. They cater to both individual consumers and organizations, such as assisted living facilities, ensuring that medication management is efficient and tailored to the needs of their clients. The pharmacy is recognized for its commitment to community health, offering services like local delivery, online prescription refills, and a mobile app for easy access to medication management. Bloomington Drug has built a reputation as a trusted partner for patients and healthcare providers in the Twin Cities area, emphasizing the importance of patient care and adherence to medication regimens.

14. Engage Health, Inc.

• Website: engagehealth.com
• Ownership type: Private
• Headquarters: Eagan, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2001
• Headcount: 11-50
• LinkedIn: engage-health

Engage Health, Inc., based in Eagan, Minnesota, is a health research firm established in 2001. The company specializes in market development for rare diseases, providing a range of services that support pharmaceutical companies and researchers. Their expertise includes clinical trial support, consulting, and the use of their proprietary database, EnCompass®, which connects patients and researchers to enhance therapy development. Engage Health has accumulated over 25 years of experience in the rare disease space, working across more than 100 rare disease areas. They play a vital role in the pharmaceutical ecosystem by helping to advance therapies and improve access to treatments for patients with rare conditions. Their commitment to this niche market positions them as a significant contributor to the pharmaceutical industry, particularly in the context of rare disease research and development.

15. Trumm Drug

• Website: trummdrug.com
• Ownership type: Family Owned
• Headquarters: Alexandria, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1951
• Headcount: 51-200
• LinkedIn: trumm-drug

Trumm Drug is a family-owned pharmacy and medical supply provider based in Alexandria, Minnesota. Founded in 1951, the company has built a reputation for delivering personalized healthcare services to individuals and families in the local community. Their service offerings include prescription refills, medication management, immunizations, and a range of home medical equipment. Trumm Drug emphasizes improving health outcomes through accessible pharmacy services, including medication synchronization and adherence programs. They also provide wellness classes on various health topics, further demonstrating their commitment to community health. With multiple locations in the Alexandria area, Trumm Drug has established itself as a trusted healthcare partner for its patients, focusing on quality service and community engagement.

16. Venipharm

• Website: venipharm.com
• Ownership type: Private
• Headquarters: St. Cloud, Minnesota, United States (USA)
• Employee distribution: France 78%, Germany 22%
• Founded year: 1999
• Headcount: 1-10
• LinkedIn: venipharm

Venipharm, founded in 1999 and based in St. Cloud, Minnesota, is a private pharmaceutical company that specializes in generics. The company develops and licenses its own generic dossiers, providing essential regulatory services to help manufacturing partners navigate the pharmaceutical market in France and the EU. With a team of chemists, pharmacists, and engineers, Venipharm has established a solid reputation for its expertise in product development and regulatory affairs. They have over 300 marketing authorizations granted for various molecules and are actively involved in lifecycle management, ensuring that their clients can maintain competitiveness in the generics market. Venipharm's operations are primarily focused in France and Germany, reflecting their commitment to the European pharmaceutical landscape.

17. Astrup Companies

• Website: astrupcompanies.com
• Ownership type: Family Owned
• Headquarters: Austin, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1952
• Headcount: 201-500
• LinkedIn: astrup-companies%20

Astrup Companies, founded in 1952 and based in Austin, Minnesota, is a family-owned business dedicated to enhancing the operations of independent pharmacies and long-term care facilities. With a workforce of 201-500 employees, the company has expanded from a single pharmacy to a network of seven companies, each focused on different aspects of pharmacy care. Their services include specialty medication access, pharmacy care, and buying group services, all aimed at helping pharmacies navigate the complexities of the healthcare landscape. Astrup Companies emphasizes the importance of personal relationships and community engagement, striving to empower pharmacies to provide high-quality patient care. Their innovative spirit is evident in their various initiatives designed to improve health outcomes for patients, making them a significant contributor to the pharmaceutical services sector.

18. Geritom Medical, Inc.

• Website: geritommedical.com
• Ownership type: Family Owned
• Headquarters: Bloomington, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1991
• Headcount: 51-200
• LinkedIn: geritom-medical

Geritom Medical, Inc., founded in 1991 and based in Bloomington, Minnesota, is a family-owned healthcare company that specializes in long-term care pharmacy, clinical pharmacy services, and medical supply. The company has built a strong reputation for providing tailored medication management and a wide range of medical supplies to individuals with complex health conditions and long-term care facilities. With over 12,000 customers and 1,600 facilities served in the greater Twin Cities area, Geritom Medical focuses on creating personalized programs that enhance health outcomes. Their services include custom medication packaging, flexible delivery schedules, and pharmacist-based clinical services. Geritom has achieved accreditations in URAC Drug Therapy Management and ACHC Long Term Care Pharmacy, underscoring their commitment to quality and compliance in the healthcare sector.

19. DaVita Clinical Research

• Website: davitaclinicalresearch.com
• Ownership type: Corporate
• Headquarters: Edina, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: November 2012
• Founded year: 2000
• Headcount: 51-200
• LinkedIn: davita-clinical-research

DaVita Clinical Research, founded in 2000 and based in Edina, Minnesota, operates as a clinical research organization with a strong emphasis on renal research. The company offers a comprehensive suite of services, including late-phase clinical trials, health economics, and outcomes research. Their primary clientele consists of pharmaceutical and biotech companies, as well as healthcare providers, who depend on DaVita's specialized knowledge to enhance drug development processes and improve patient care. With a history rooted in nephrology, DaVita Clinical Research has expanded its capabilities to include various specialty populations and primary care, making it a vital resource for advancing treatments in chronic kidney disease and other related areas. The organization has successfully supported over 500 clients in their development projects, showcasing its operational expertise and commitment to improving healthcare outcomes.

20. Be The Match BioTherapies

• Website: www2.bethematchbiotherapies.com
• Ownership type: Private
• Headquarters: Minneapolis, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2016
• Headcount: 1001-5000
• LinkedIn: be-the-match-biotherapies

Be The Match BioTherapies, founded in 2016 and based in Minneapolis, Minnesota, operates as a private consulting company within the biopharmaceutical and biotechnology sectors. The firm specializes in offering educational webinars and consulting services aimed at helping biopharma companies, transplant centers, and regulatory bodies navigate the complexities associated with cell therapies. Their expertise is particularly valuable in improving patient outcomes and ensuring compliance with regulatory standards. By focusing on the intricacies of cell and gene therapies, Be The Match BioTherapies plays a pivotal role in advancing the understanding and application of these innovative treatments in the healthcare landscape.

21. InstyMeds

• Website: instymeds.com
• Ownership type: Private
• Headquarters: Eden Prairie, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2001
• Headcount: 51-200
• LinkedIn: instymeds

InstyMeds is a healthcare technology company based in Eden Prairie, Minnesota, founded in 2001. The company specializes in automated medication dispensing systems designed to improve patient care by providing immediate access to prescriptions at the point of care. This innovation addresses a critical issue in healthcare: the challenge of medication adherence. InstyMeds' systems allow patients to fill prescriptions right after receiving treatment, significantly increasing the likelihood that they will start their medication promptly. With over 4 million prescriptions dispensed across three continents, InstyMeds has established itself as a trusted partner for healthcare providers, including hospitals and outpatient clinics. The company aims to streamline the medication dispensing process, reduce wait times, and enhance patient satisfaction, ultimately contributing to better health outcomes. InstyMeds operates without reported funding, indicating a self-sustaining business model focused on delivering value to its clients and their patients.

Pharmaceuticals Insights: Key Companies in Minnesota

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