Colorado’s biotechnology industry is vibrant and rapidly growing, focused on innovation in healthcare and environments. Companies range from pharmaceuticals and diagnostics to bioengineering and synthetic biology. This sector is at the forefront of disease research, vaccine development, and therapeutic solutions. The state's research institutions complement corporate efforts, contributing to a robust pipeline of products aimed at improving health outcomes. With increasing investment in biotech startups and advancements in technologies like CRISPR, Colorado is positioned to play a pivotal role in the evolution of biotechnology in the coming years, propelling breakthroughs to address critical medical needs.

The list features 21 biotechnology companies across Colorado, primarily headquartered in Boulder and Denver. These companies vary in size from small ventures to larger enterprises, focusing on specialties like vaccine development, cancer diagnostics, and antibody therapies. Founded between 1996 and 2024, these firms are backed by both venture capital and private funding sources, highlighting the state’s economic dynamism and innovative spirit.

Continue reading to learn more about top biotechnology companies in Colorado.

Top 21 Biotechnology Companies in Colorado

1. Think Bioscience

• Website: thinkbioscience.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $6.0M, May 2024
• Founded year: 2019
• Headcount: 1-10
• LinkedIn: think-bioscience

Think Bioscience, founded in 2019 and based in Boulder, Colorado, is a biotechnology company dedicated to the development of small-molecule therapeutics. The company leverages synthetic biology to tackle the complexities of drug discovery, particularly for diseases that have few or no effective treatments available. Their innovative platform combines applied microbiology, enzymology, and data science to create new medicines. Think Bioscience has attracted significant funding, including a recent $6 million seed round in May 2024, which underscores their potential for growth and impact in the biotechnology field. Their clientele includes pharmaceutical companies and research institutions, highlighting their role in advancing drug development solutions. With a focus on undruggable targets, Think Bioscience is positioned to make meaningful contributions to the healthcare landscape.

2. BioLoomics

• Website: bioloomics.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $8.7M, September 2023
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: bioloomics-llc

BioLoomics, founded in 2019 and based in Boulder, Colorado, is a biotechnology firm dedicated to revolutionizing cancer therapies. The company specializes in developing advanced antibody-drug conjugates (ADCs) that aim to improve treatment efficacy and safety for patients. By leveraging cutting-edge techniques in synthetic biology and artificial intelligence, BioLoomics is working to create a robust pipeline of anti-cancer therapies. Their unique process involves directed evolution to enhance antibody internalization and trafficking, which is crucial for effective treatment delivery. Recently, BioLoomics secured $8.7 million in seed funding, reflecting strong investor interest in their innovative approach to tackling significant challenges in cancer care. The team comprises experienced scientists and industry professionals, all driven by a shared mission to transform cancer treatment and improve patient outcomes.

3. Greffex, Inc.

• Website: greffex.com
• Ownership type: Private
• Headquarters: Aurora, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: greffex-inc-

Greffex, Inc. is a biotechnology firm based in Aurora, Colorado, founded in 1999. The company specializes in genetic engineering and vaccine development, utilizing its proprietary GreVac technology to create innovative vaccines aimed at infectious diseases, including COVID-19 and avian flu. Greffex has established partnerships with public health organizations, focusing on the rapid production and distribution of vaccines to meet urgent health needs. The company has made strides in its research, recently completing a COVID-19 vaccine and preparing for animal testing. Greffex's technology is designed to be efficient and cost-effective, with the potential to produce vaccines quickly and at scale. They hold several patents related to their vaccine technology and are actively advancing multiple vaccine candidates through clinical trials, including a universal flu vaccine and an H5N1 avian flu vaccine.

4. Millipore Corporation

• Website: emdmillipore.com
• Ownership type: Corporate
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $7.2B, March 2010
• Founded year: 1954
• Headcount: 51-200
• LinkedIn: millipore-corporation

Millipore Corporation, also known as Merck Millipore, is a life science supplier based in Boulder, Colorado. Founded in 1954, the company specializes in providing a wide array of products and services tailored for the biotechnology and pharmaceutical sectors. Their portfolio includes analytical tools, biopharmaceutical manufacturing solutions, and advanced water purification systems. These offerings are designed to meet the rigorous demands of research and production environments, ensuring that clients have access to high-quality materials necessary for drug therapies. Millipore's focus on compliance with industry standards and their commitment to innovation make them a key partner for organizations in the life sciences. With a workforce of around 222 employees, the company operates entirely within the United States, emphasizing its role in the domestic biotechnology landscape.

5. miRagen Therapeutics, Inc.

• Website: miragen.com
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Founded year: 2007
• Headcount: 11-50
• LinkedIn: miragen-therapuetics

miRagen Therapeutics, Inc. is a biopharmaceutical company based in Boulder, Colorado, founded in 2007. The company is dedicated to developing innovative medicines aimed at treating autoimmune and rare diseases. With a focus on antibody discovery, miRagen is working on optimized therapeutic candidates, particularly for conditions like Thyroid Eye Disease (TED). Their pipeline includes several investigational therapies that are currently undergoing clinical trials to assess their efficacy and safety. The company emphasizes improving patient care and treatment outcomes through its research and development efforts. miRagen's commitment to addressing high unmet medical needs is evident in their strategic allocation of resources towards developing therapies that offer improved safety and tolerability for patients.

6. Mosaic Biosciences

• Website: mosaicbio.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $11.4M, June 2022
• Founded year: 2009
• Headcount: 11-50
• LinkedIn: mosaic-biosciences

Mosaic Biosciences, founded in 2009 and based in Boulder, Colorado, is a biopharmaceutical company that specializes in drug discovery and development. The firm focuses on antibody and protein therapeutics, offering comprehensive services that assist partners in navigating the complexities of bringing therapeutic candidates from initial concept through to preclinical stages. With a team of experienced scientists, Mosaic Biosciences emphasizes a collaborative approach, working closely with clients to understand their research goals and deliver tailored solutions. The company has successfully advanced multiple compounds into clinical trials, showcasing its capability in transforming innovative ideas into viable drug candidates. In June 2022, Mosaic secured $11.4 million in funding, which underscores its growth potential and the confidence investors have in its business model. Their partnerships span various sectors, including startups, biopharmaceutical companies, and academic groups, reflecting their adaptability and commitment to advancing therapeutic programs.

7. Reven Pharmaceuticals

• Website: reven.com
• Ownership type: Venture Capital
• Headquarters: Golden, Colorado, United States (USA)
• Latest funding: Series D, $23.0M, January 2019
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: reven-pharmaceuticals

Reven Pharmaceuticals, founded in 1999 and based in Golden, Colorado, is a pharmaceutical company dedicated to innovative drug development and therapeutic solutions. The company specializes in addressing unmet medical needs through its proprietary RJX technology, which targets various health conditions, including cancer and cardiovascular diseases. Reven engages in clinical trials and collaborates with research organizations to enhance its offerings. With a workforce of 11-50 employees, the company has made strides in the biotechnology sector, particularly with its RJX platform, which aims to restore immune system balance and improve patient outcomes. Reven has also received significant funding, with a reported $23 million in its last funding round in 2019, reflecting investor interest in its potential to impact healthcare positively.

8. Infinome Biosciences

• Website: infinomebio.com
• Ownership type: Corporate
• Headquarters: Boulder, Colorado, United States (USA)
• Latest funding: January 2023
• Founded year: 2020
• Headcount: 11-50
• LinkedIn: infinome-biosciences

Infinome Biosciences is a biotechnology company based in Boulder, Colorado, founded in 2020. The company specializes in genome engineering and synthetic biology, providing innovative solutions aimed at improving the efficiency of strain engineering and biomanufacturing processes. Their key offerings include the GenoScaler™ Platform, which accelerates the development of optimized strains, and the MAD7® Nuclease, a CRISPR-based tool that democratizes access to genome editing technologies. Infinome's primary clientele consists of businesses in the biotechnology and pharmaceutical sectors, which seek advanced tools for genetic modification and product development. In January 2023, Infinome was acquired by Inscripta, further enhancing its capabilities and positioning within the biotechnology industry.

9. VitriVax

• Website: vitrivaxbio.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $3.6M, December 2024
• Founded year: 2017
• Headcount: 11-50
• LinkedIn: vitrivax

VitriVax, founded in 2017 and based in Boulder, Colorado, is a biotechnology firm dedicated to enhancing global vaccination efforts through innovative vaccine development. The company specializes in formulation technology, particularly focusing on creating thermostable and single-dose vaccines. Their proprietary ALTA™ technology addresses two major challenges in vaccine distribution: maintaining stability during transport and storage, and reducing the need for multiple doses. This technology allows vaccines to remain effective at higher temperatures and enables a single-shot administration, which is crucial for reaching remote areas and improving vaccination rates. VitriVax collaborates with healthcare organizations and vaccine manufacturers, aiming to improve public health outcomes. The company has secured funding, including a $3.6 million grant in December 2024, to support its research and development initiatives, further solidifying its role in the biotechnology industry.

10. Novus Biologicals, a Bio-Techne brand

• Website: novusbio.com
• Ownership type: Corporate
• Headquarters: Centennial, Colorado, United States (USA)
• Employee distribution: United States (USA) 95%, Canada 5%
• Latest funding: $60.0M, July 2014
• Founded year: 1996
• Headcount: 51-200
• LinkedIn: novus-biologicals-llc

Novus Biologicals, a Bio-Techne brand, is a biotechnology company based in Centennial, Colorado, founded in 1996. The company specializes in the production and distribution of high-quality antibodies, proteins, and research reagents that are vital for scientific research. Their products cater primarily to researchers and laboratories in the life sciences sector, who depend on these tools for various experimental applications. Novus Biologicals operates through an online platform, allowing customers to easily order products and access a wealth of scientific resources. The company has a strong commitment to supporting research initiatives, including the provision of COVID-19 research tools, and offers a range of products that facilitate advanced research techniques such as flow cytometry and Western blotting. With a workforce of around 44 employees, Novus Biologicals continues to play a significant role in the biotechnology field, contributing to the advancement of scientific knowledge and innovation.

11. Aleksia Therapeutics

• Website: aleksiatx.com
• Ownership type: Private
• Headquarters: Golden, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2022
• Headcount: 11-50
• LinkedIn: aleksia-therapeutics

Aleksia Therapeutics, based in Golden, Colorado, is a biotechnology firm established in 2022. The company is dedicated to developing innovative therapeutic options specifically for cancer patients whose conditions are driven by genetic alterations that conventional therapies cannot effectively address. With a team of experienced scientists and experts, Aleksia employs a scientific approach that combines known biology with innovative chemistry to create better therapeutic options. Their work focuses on the irreversible modification of proteins, a method that has shown promise in enhancing drug selectivity and efficacy. Although Aleksia has not reported any funding, their foundation by Cormorant Asset Management, a firm known for investing in life sciences, indicates a strategic backing that could support their growth and development in the competitive biotech landscape.

12. Foresight Diagnostics

• Website: foresight-dx.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 98%, Other 2%
• Latest funding: Series B, $33.0M, July 2024
• Founded year: 2020
• Headcount: 51-200
• LinkedIn: foresight-diagnostics-inc

Foresight Diagnostics, founded in 2020 and based in Boulder, Colorado, is a biotechnology company focused on developing ultra-sensitive cancer diagnostic tests. The firm specializes in minimal residual disease (MRD) detection, which is vital for improving clinical outcomes in cancer treatment. Their flagship product, the Foresight CLARITY™ platform, utilizes PhasED-Seq™ technology to detect circulating tumor DNA (ctDNA) with unprecedented sensitivity. This capability allows for earlier and more accurate detection of cancer recurrence compared to traditional methods. Foresight Diagnostics collaborates with biopharma companies and academic researchers, providing diagnostic testing, clinical trial support, and regulatory expertise. The company has garnered significant attention in the industry, evidenced by its recent Series B funding round, which raised $33 million in July 2024, further solidifying its position in the biotechnology sector.

13. InDevR, Inc.

• Website: indevr.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series B, $9.0M, January 2023
• Founded year: 2003
• Headcount: 11-50
• LinkedIn: indevr-inc-

InDevR, Inc., based in Boulder, Colorado, is a biotechnology firm founded in 2003. The company specializes in advanced analytical technologies aimed at improving vaccine development and manufacturing processes. InDevR offers a range of products, including the VaxArray Portfolio and the CypherOne System, which are designed to enhance testing efficiency and data quality for vaccine manufacturers. Their clientele primarily consists of biopharmaceutical companies looking to streamline their vaccine testing processes. InDevR's commitment to innovation is underscored by their recent Series B funding round, which raised $9 million in January 2023. This funding supports their ongoing efforts to provide expert services and custom solutions tailored to the unique challenges faced in vaccine development.

14. Pharmatech

• Website: pharmatech.com
• Ownership type: Corporate
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 16%, Egypt 16%, India 16%, Other 53%
• Latest funding: May 2019
• Founded year: 1987
• Headcount: 11-50
• LinkedIn: pharmatech

Pharmatech, known as Caris Life Sciences, is a healthcare technology company based in Denver, Colorado. Founded in 1987, the company specializes in precision medicine and cancer care. Caris Life Sciences offers advanced molecular profiling services that help oncologists and patients make informed treatment decisions. Their portfolio includes blood and tissue profiling, utilizing cutting-edge technologies to analyze DNA, RNA, and proteins. This comprehensive approach aids in identifying the most effective therapies for various cancer types. Additionally, Caris provides clinical trial solutions, enhancing patient access to innovative treatments. They also support biopharmaceutical companies by offering insights that drive research and development efforts. With a global employee distribution and a commitment to improving patient outcomes, Caris Life Sciences plays a vital role in the biotechnology sector.

15. GT Molecular

• Website: gtmolecular.com
• Ownership type: Private
• Headquarters: Fort Collins, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2018
• Headcount: 11-50
• LinkedIn: gt-molecular

GT Molecular, founded in 2018 and based in Fort Collins, Colorado, is a biotechnology firm dedicated to advancing molecular detection technologies. The company specializes in developing high-performance PCR kits and comprehensive wastewater testing services aimed at enhancing public health monitoring and scientific research. Their product offerings include a variety of PCR assay kits for cancer research, such as the GT-Plex™ and GT-Digital panels, as well as pathogen detection kits for infectious diseases. GT Molecular has also gained recognition for its role in wastewater surveillance, particularly during the COVID-19 pandemic, where they provided critical data to help communities track virus progression. Their clientele includes hospitals, research laboratories, and municipalities, reflecting their commitment to improving health outcomes through innovative biotechnology solutions.

16. Flagship Biosciences, Inc.

• Website: flagshipbio.com
• Ownership type: Venture Capital
• Headquarters: Broomfield, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $5.0M, April 2024
• Founded year: 2009
• Headcount: 51-200
• LinkedIn: flagship-biosciences

Flagship Biosciences, Inc., based in Broomfield, Colorado, is a biotechnology company that specializes in spatial biology and biomarker analysis. Founded in 2009, the company offers a comprehensive suite of services that includes anatomical pathology, genomics, and data science, primarily aimed at supporting pharmaceutical and biotechnology clients. Flagship is known for its innovative approach to drug development, utilizing advanced technologies to provide precise data that informs clinical trials. Their proprietary TissueInsight® diagnostic service and extensive library of validated assays demonstrate their capability in biomarker development. The company is also recognized for its commitment to quality, being both CLIA-certified and CAP-accredited. Recently, Flagship secured $5 million in funding, reflecting investor confidence in their business model and growth potential. With a team of experts in pathology and data science, Flagship Biosciences is well-positioned to contribute to advancements in oncology, rare diseases, and other therapeutic areas.

17. Aliri Bioanalysis

• Website: aliribio.com
• Ownership type: Private
• Headquarters: Colorado Springs, Colorado, United States (USA)
• Employee distribution: United States (USA) 77%, France 19%, Other 5%
• Latest funding: July 2008
• Founded year: 1991
• Headcount: 51-200
• LinkedIn: imabiotech

Aliri Bioanalysis, based in Colorado Springs, Colorado, is a bioanalytical contract research organization (CRO) that has been operational since 1991. The company specializes in drug development and spatial solutions, offering a comprehensive range of services that include bioanalysis, method development, and spatial biology. Aliri assists pharmaceutical and biotech clients in navigating the complexities of drug development, ensuring that projects are completed with speed and in compliance with regulatory standards. With a workforce of approximately 132 employees, Aliri has established itself as a reliable partner in the biotechnology industry. Their expertise spans various therapeutic areas, and they are committed to providing high-quality data that supports the development of life-saving therapies. Aliri's operational excellence is underscored by their experience with over 1,500 drugs and metabolites, showcasing their capability in handling a wide array of bioanalytical projects.

18. Pyxant Labs

• Website: pyxant.com
• Ownership type: Venture Capital
• Headquarters: Colorado Springs, Colorado, United States (USA)
• Latest funding: $530,000, August 2016
• Founded year: 2000
• Headcount: 51-200
• LinkedIn: pyxant-labs-inc.

Pyxant Labs, now known as Aliri, is a biotechnology company based in Colorado Springs, Colorado. Founded in 2000, the company specializes in bioanalytical and spatial solutions that are crucial for drug development. Aliri serves pharmaceutical and biotech clients by providing essential data and expertise to help navigate the complexities of bringing life-saving therapies to market. Their services include bioanalysis, method development, and spatial biology, ensuring that clients meet regulatory compliance and advance their projects in a timely manner. Aliri has a workforce of approximately 122 employees and has received funding, with the last reported amount being $530,000 in 2016. The company is committed to innovation and operational excellence, focusing on delivering high-quality data that supports drug development from discovery through clinical phases.

19. RefinedScience

• Website: refinedscience.com
• Ownership type: Private
• Headquarters: Aurora, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: refinedscience

RefinedScience, founded in 2019 and based in Aurora, Colorado, is a biotechnology company that specializes in precision drug development. The firm leverages high-fidelity patient data, clinical trial design, and advanced analytics powered by artificial intelligence and machine learning. Their mission is to improve the success rates of drug development and optimize clinical trials for pharmaceutical companies and healthcare organizations. RefinedScience has built a comprehensive platform that curates clinical data from various real-world sources, including a live-stream feed from a regional hospital system. They have also developed an extensive single-cell omics dataset in Acute Myeloid Leukemia, which is crucial for identifying novel drug targets. Their innovative approach has led to partnerships with industry leaders, such as the joint venture with Argenx, demonstrating their active role in the biotechnology landscape. RefinedScience's focus on high unmet medical needs and their commitment to integrating expert knowledge with data-driven insights further solidify their position in the industry.

20. Kromatid

• Website: kromatid.com
• Ownership type: Venture Capital
• Headquarters: Longmont, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series C, $4.9M, November 2023
• Founded year: 2007
• Headcount: 11-50
• LinkedIn: kromatid

Kromatid, founded in 2007 and based in Longmont, Colorado, is a biotechnology company that specializes in genomic integrity analysis. They provide essential services that support the development of cell and gene therapies, including genomic stability assays and custom karyotyping. Kromatid's innovative dGH™ platform allows for high-resolution detection of chromosomal changes, which is critical for ensuring the safety and efficacy of therapeutic products. The company primarily serves biotechnology and pharmaceutical firms that require detailed genomic insights to navigate the complexities of therapeutic development. Recently, Kromatid secured $4.8 million in Series C funding in November 2023, reflecting their active role in advancing genomic analysis technologies and their commitment to supporting the evolving needs of the industry.

21. Darwin Biosciences

• Website: darwin.bio
• Ownership type: Private
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2020
• Headcount: 11-50
• LinkedIn: darwin-biosciences

Darwin Biosciences, based in Boulder, Colorado, is a private biotechnology firm founded in March 2020. The company specializes in developing innovative diagnostic solutions aimed at infectious diseases, with a particular emphasis on saliva-based diagnostics. This approach allows for early detection of infections, which is crucial for effective public health responses. Darwin's technology leverages signals from human saliva to identify infections before symptoms appear, thus enabling timely interventions. The company has established partnerships with various healthcare organizations and government entities, underscoring its commitment to enhancing public health safety. With a team of experts in infectious disease, immunology, and molecular biology, Darwin is positioned to make significant contributions to the field of diagnostics, especially as it continues to evolve its platform to address emerging pathogen threats.

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