Biomedical engineering companies in Indiana operate at the intersection of medicine and technology, developing devices and systems that enhance healthcare. This industry spans various specializations, including surgical instruments, orthopedic implants, and advanced imaging technologies. With a strong focus on innovation, companies are increasingly exploring nanotechnology and data-driven solutions to address healthcare challenges. Indiana's biomedical sector benefits from close ties to research institutions, fostering collaboration that propels growth and advances patient care. The industry is poised for expansion, driven by a rising demand for minimally invasive procedures and personalized medical solutions.


This list highlights 21 notable biomedical engineering companies based in Indiana, ranging from well-established giants to innovative startups. Key players vary in size, with some employing over 1,000 staff and others maintained by small teams. Founded between 1950 and 2023, these companies specialize in medical devices, surgical technologies, and engineering services. Headquarters are predominantly situated in cities like Indianapolis and Bloomington, reflecting Indiana's robust ecosystem for biomedical innovation and manufacturing. Founder backgrounds range from corporate to family-owned, enriching the state's industrial fabric.


Continue reading to discover the top biomedical engineering companies in Indiana.


Top 21 Biomedical Engineering Companies in Indiana


1. Paragon Medical

  • Website: paragonmedical.com
  • Ownership type: Corporate
  • Headquarters: Pierceton, Indiana, United States (USA)
  • Employee distribution: United States (USA) 83%, Poland 13%, China 3%, Other 1%
  • Latest funding: $1.9B, October 2023
  • Founded year: 1991
  • Headcount: 1001-5000
  • LinkedIn: mwlifesciences

Paragon Medical, founded in 1991 and based in Pierceton, Indiana, is a prominent medical manufacturer focused on high-precision components and products tailored for the healthcare industry. The company offers a wide array of services, including product design, development, regulatory support, and manufacturing, catering primarily to medical device manufacturers. Paragon Medical's expertise spans various healthcare applications, including orthopaedics, cardiovascular devices, surgical robotics, and drug delivery systems. With a workforce of over 800 employees and multiple facilities across the globe, they are well-positioned to accelerate product development and ensure compliance with industry standards. Their recent funding of $1.9 billion in October 2023 underscores their financial strength and commitment to innovation in medical manufacturing.


2. Cook Advanced Technologies


Cook Advanced Technologies, based in West Lafayette, Indiana, is a family-owned medical device manufacturer that specializes in the research, development, and delivery of innovative medical solutions. Established in 2012, the company operates as a division of Cook Medical and is dedicated to addressing unmet clinical needs through collaboration with healthcare professionals. Their work spans various aspects of product development, including concept generation, detailed design, and early clinical feasibility studies. Cook Advanced Technologies is involved in pilot production and small-scale manufacturing, ensuring that new medical devices are effectively transitioned from concept to commercialization. The company emphasizes high standards of quality, ethics, and service, striving to enhance patient care worldwide. Their team of skilled professionals is committed to finding better, simpler, and more efficient ways to treat patients, making them a relevant player in the biomedical engineering industry.


3. NICO Corporation

  • Website: niconeuro.com
  • Ownership type: Venture Capital
  • Headquarters: Indianapolis, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: $12.6M, October 2022
  • Founded year: 2007
  • Headcount: 11-50
  • LinkedIn: nico-neuro-and-spine

NICO Corporation, founded in 2007 and based in Indianapolis, Indiana, is a medical technology company that specializes in minimally invasive neurosurgery. The firm is dedicated to developing innovative surgical instruments and systems aimed at improving surgical outcomes and operational efficiency for healthcare providers. Their primary clientele includes neurosurgeons and medical facilities that utilize their advanced technologies in various surgical procedures. NICO's flagship products, such as the NICO Myriad and BrainPath systems, are designed to facilitate safer and more effective surgical interventions. The company has also engaged in pre-clinical research and clinical trials, further solidifying its role in advancing neurosurgical techniques. In 2022, NICO Corporation secured approximately $12.6 million in funding, reflecting investor confidence in their technology and growth trajectory.


4. Cook Medical

  • Website: cookmedical.com
  • Ownership type: Private Equity
  • Headquarters: Bloomington, Indiana, United States (USA)
  • Employee distribution: United States (USA) 58%, Ireland 13%, Denmark 8%, Other 21%
  • Latest funding: July 2024
  • Founded year: 1963
  • Headcount: 10001+
  • LinkedIn: cookmedical

Cook Medical, founded in 1963 and based in Bloomington, Indiana, is a prominent medical device manufacturer. The company specializes in creating products for minimally invasive procedures, catering to healthcare professionals and institutions worldwide. Their product range includes devices for vascular interventions, critical care, endoscopy, and urology, among others. Cook Medical emphasizes innovation and quality, striving to provide effective treatment options that enhance patient care. With a workforce exceeding 7,600 employees and operations in multiple countries, including Ireland, Denmark, and Australia, Cook Medical plays a significant role in the medical device industry. The company is privately held and has not reported any recent funding, indicating stability and self-sufficiency in its operations.


5. Nexxt Spine

  • Website: nexxtspine.com
  • Ownership type: Private
  • Headquarters: Noblesville, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 2009
  • Headcount: 51-200
  • LinkedIn: nexxt-spine-llc

Nexxt Spine, LLC, based in Noblesville, Indiana, is a private medical device manufacturer founded in 2009. The company specializes in the design and production of spinal implants and surgical instruments, focusing on innovative solutions that enhance surgical efficiency and improve patient outcomes. Nexxt Spine prides itself on its in-house manufacturing capabilities, which allow for high-quality products tailored to the specific needs of healthcare providers. Their product portfolio includes the NEXXT MATRIXX® system, which features 3D printed porous titanium implants, and various cervical and lumbar plating systems. The company has received recognition for its workplace culture, being named one of Indiana's Best Places to Work in Manufacturing in 2022. Additionally, Nexxt Spine has achieved significant milestones, such as receiving FDA clearance for its navigation-compatible instrumentation system and obtaining patents for its innovative designs. This commitment to technological advancement and quality positions Nexxt Spine as a notable player in the biomedical engineering sector.


6. CTE, Mediliant Group

  • Website: culvertool.com
  • Ownership type: Private
  • Headquarters: Plymouth, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 1950
  • Headcount: 51-200
  • LinkedIn: culver-tool-%26-engineering

CTE, Mediliant Group, based in Plymouth, Indiana, is a private company specializing in the manufacturing of orthopedic implants. Founded in 1950, the company has evolved significantly over the decades, particularly since it began focusing on the medical sector in 1989. CTE is recognized for its expertise in producing spinal implants and has established itself as a reliable contract manufacturer for various medical device companies. Their services include co-designing, engineering, machining, and additive manufacturing, which are critical in developing high-quality medical devices. CTE is committed to maintaining rigorous quality standards and compliance with industry regulations, ensuring that their products enhance patient care. The company operates entirely within the United States and has a workforce of approximately 56 employees, reflecting a focused and specialized approach to their operations.


7. Nanovis

  • Website: nanovistechnology.com
  • Ownership type: Venture Capital
  • Headquarters: Columbia City, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: $5.5M, August 2018
  • Founded year: 2006
  • Headcount: 11-50
  • LinkedIn: nanovis

Nanovis is a medical technology company based in Columbia City, Indiana, specializing in advanced implant solutions through the application of nanotechnology. Founded in 2006, the company focuses on enhancing the biological response of dental and orthopedic implants, tackling critical issues such as infection and osseointegration. Their flagship product, nanoVIS Ti Surface Technology, is designed to improve the integration of implants with bone and reduce bacterial colonization. Nanovis has established strong relationships with healthcare providers and device manufacturers, positioning itself as a key player in the market. The company has successfully implanted over 20,000 devices, showcasing its impact on patient outcomes. In 2018, Nanovis secured $5.5 million in funding, further supporting its growth and innovation in the biomedical field.


8. Evergen (Formerly Cook Biotech)

  • Website: cookbiotech.com
  • Ownership type: Corporate
  • Headquarters: West Lafayette, Indiana, United States (USA)
  • Employee distribution: United States (USA) 93%, China 4%, Denmark 3%
  • Latest funding: January 2024
  • Founded year: 1995
  • Headcount: 201-500
  • LinkedIn: cook-biotech

Evergen, formerly known as Cook Biotech, is a medical device manufacturer based in West Lafayette, Indiana. Founded in 1995, the company specializes in advanced tissue-repair products that utilize extracellular matrices, particularly porcine small intestinal submucosa (SIS). Their product line includes various tissue grafts and matrices designed for surgical applications across multiple areas, including head and neck, chest and abdomen, pelvis, and extremities. Evergen's innovative approach to tissue management aims to enhance patient recovery and outcomes. The company has produced over six million advanced tissue-repair products for global distribution, reflecting its significant role in the medical device industry. Recently, Evergen became part of RTI Surgical, further solidifying its position in the market and expanding its reach in the biomedical field.


9. MED Institute

  • Website: medinstitute.com
  • Ownership type: Private
  • Headquarters: West Lafayette, Indiana, United States (USA)
  • Employee distribution: United States (USA) 94%, Iran 3%, India 3%
  • Founded year: 1983
  • Headcount: 11-50
  • LinkedIn: med-institute

MED Institute, founded in 1983 and based in West Lafayette, Indiana, is a private consulting and engineering services company that specializes in medical device development. With a team of experts, they provide a wide array of services that include medical device engineering, testing, regulatory support, and clinical trial management. Their clientele primarily consists of businesses in the medical device sector, and they have successfully assisted devices across 42 medical specialties in reaching markets worldwide. MED Institute is ISO 13485 certified and has a history of ISO/IEC 17025:2017 accreditation, ensuring that their quality systems are robust and their testing methods are reliable. They have also collaborated with the FDA on research projects, demonstrating their active involvement in advancing medical device safety and efficacy. Their commitment to high-quality service is reflected in their client satisfaction ratings, which average 4.98 out of 5.


10. Cook Research Incorporated

  • Website: cookresearchinc.com
  • Ownership type: Private
  • Headquarters: West Lafayette, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 1983
  • Headcount: 201-500
  • LinkedIn: cook-research-incorporated

Cook Research Incorporated, based in West Lafayette, Indiana, has been a key player in the medical research field since its founding in 1983. Originally known as MED Institute, the company was established to support Cook Medical in the development and regulatory approval of innovative medical products. With a dedicated team of engineers, scientists, and regulatory professionals, Cook Research provides essential services such as clinical research, pre-clinical testing, and medical writing. Their expertise is particularly valuable in navigating the complexities of product development, ensuring that medical devices meet stringent regulatory standards. The company is certified to ISO 13485 and accredited under the FDA ASCA Program, highlighting their commitment to quality and compliance. Cook Research also emphasizes collaboration with academic institutions, notably Purdue University, to foster innovation in medical solutions. Their operational focus on improving patient care through scientific advancements underscores their relevance in the biomedical engineering industry.


11. Avalign Cutting Instruments Division, NGInstruments

  • Website: avaligntech.com
  • Ownership type: Private Equity
  • Headquarters: Warsaw, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: December 2018
  • Founded year: 1995
  • Headcount: 51-200
  • LinkedIn: nginstruments-inc.

Avalign Cutting Instruments Division, NGInstruments is a private equity-owned medical device manufacturer based in Warsaw, Indiana. Founded in 1995, the company specializes in producing high-quality surgical instruments and orthopedic implants. Avalign serves healthcare professionals by providing precision-engineered products designed for various surgical applications, including joint replacement, spine, and trauma surgeries. Their operations are characterized by integrated product planning and advanced manufacturing processes, ensuring reliability and efficiency in the medical device supply chain. Avalign's offerings include a range of platforms such as precision machined instruments, delivery systems, and innovative implant technologies. The company is dedicated to maintaining high performance and quality standards, making it a trusted partner in the medical device industry.


12. Trimedx

  • Website: trimedx.com
  • Ownership type: Private
  • Headquarters: Indianapolis, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: Other (Debt), $200,000, January 2014
  • Founded year: 1998
  • Headcount: 1001-5000
  • LinkedIn: trimedx

Trimedx, founded in 1998 and based in Indianapolis, Indiana, is a clinical engineering services company that specializes in managing and optimizing clinical assets for healthcare organizations. With a workforce of over 2,400 employees, Trimedx offers a comprehensive range of services, including clinical engineering, asset management, and cybersecurity solutions. Their expertise is particularly valuable to healthcare providers navigating the complexities of medical device management and regulatory compliance. Trimedx's innovative solutions, such as their GeoSense real-time location system, enhance the efficiency of medical equipment utilization, thereby improving patient care. The company has been recognized for its contributions to the industry, including being named a top provider in medical equipment maintenance services. Their focus on patient safety and operational efficiency positions them as a key player in the biomedical engineering sector.


13. Qualitex

  • Website: qualitexinc.net
  • Ownership type: Private
  • Headquarters: Columbia City, Indiana, United States (USA)
  • Employee distribution: United States (USA) 85%, Colombia 15%
  • Founded year: 1993
  • Headcount: 11-50
  • LinkedIn: qualitex-inc-

Qualitex, Inc. is a private medical device manufacturer based in Columbia City, Indiana, founded in 1993. With a workforce of around 27 employees, the company operates primarily in the medical, automotive, aerospace, and agricultural sectors. Qualitex specializes in contract manufacturing, focusing on the production of medical devices such as implants and surgical instruments, particularly for spine and orthopedic applications. They offer a comprehensive suite of services, including machining, inspection, and product development, catering to both established companies and startups. Qualitex is recognized for its commitment to quality, holding multiple certifications such as ISO 9001, ISO 13485, and ISO 17025, along with being FDA registered. Their experience in manufacturing and inspection processes positions them as a valuable partner in the medical device supply chain.


14. On Target Laboratories

  • Website: ontargetlabs.com
  • Ownership type: Venture Capital
  • Headquarters: West Lafayette, Indiana, United States (USA)
  • Employee distribution: United States (USA) 91%, Morocco 4%, South Africa 4%
  • Latest funding: Series C, $30.0M, November 2023
  • Founded year: 2010
  • Headcount: 11-50
  • LinkedIn: on-target-laboratories-llc

On Target Laboratories, founded in 2010 and based in West Lafayette, Indiana, is a medical technology company dedicated to enhancing cancer surgery through innovative imaging solutions. The company specializes in the development of intraoperative imaging agents that help surgeons identify and remove cancerous tissues more effectively. Their flagship product, Cytalux, has received FDA approval and is designed to illuminate cancerous lesions during surgery, thereby improving surgical outcomes. On Target Laboratories operates primarily within the oncology field, focusing on technologies that empower healthcare providers to achieve better results for patients. The company has recently raised $30 million in Series C funding, which will support the commercialization of their products and further research initiatives. With a team of scientists and researchers, On Target Laboratories is committed to advancing real-time cancer imaging and improving the overall quality of surgical care.


15. Engineered Medical Systems, Inc.

  • Website: engmedsys.com
  • Ownership type: Private
  • Headquarters: Indianapolis, Indiana, United States (USA)
  • Employee distribution: United States (USA) 81%, Malaysia 19%
  • Founded year: 1985
  • Headcount: 51-200
  • LinkedIn: engineered-medical-systems-inc.

Engineered Medical Systems, Inc. (EMS) is a medical device manufacturer based in Indianapolis, Indiana, with a secondary facility in Penang, Malaysia. Founded in 1985, the company specializes in producing disposable air management and electronic medical devices. EMS serves healthcare providers and medical device distributors, ensuring that their products meet stringent regulatory standards. The company boasts a robust quality program, underscoring its commitment to delivering high-quality products. With over 100,000 square feet of manufacturing space, EMS offers comprehensive services from product design to prototype development, injection molding, and assembly. Their engineering team is dedicated to innovation, creating unique designs while adhering to quality and regulatory requirements. EMS is ISO 13485 certified, reflecting their dedication to quality management in the medical device industry. The company has established a distribution pipeline that spans more than 70 countries, highlighting its global reach and operational capabilities.


16. MW Life Sciences

  • Website: mwlifesciences.com
  • Ownership type: Private
  • Headquarters: Pierceton, Indiana, United States (USA)
  • Founded year: 1991
  • Headcount: 1001-5000
  • LinkedIn: mwlifesciences

MW Life Sciences, founded in 1991 and based in Pierceton, Indiana, is a prominent player in the medical device manufacturing sector. The company specializes in the production of surgical instruments, implantable components, and drug delivery systems, catering to the needs of healthcare providers and medical device manufacturers. With a workforce of approximately 461 employees, MW Life Sciences operates multiple facilities across the United States and internationally, ensuring a broad reach in the medical market. Their manufacturing capabilities are supported by rigorous certifications, including ISO 13485:2016 and FDA registration, which underscore their commitment to quality and safety in medical products. The company’s extensive product offerings include surgical staples, catheter guide wires, and diagnostic equipment components, reflecting their integral role in enhancing surgical procedures and patient care.


17. Recovery Force Health

  • Website: rfhealth.com
  • Ownership type: Venture Capital
  • Headquarters: Fishers, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: $1.2M, March 2023
  • Founded year: 2019
  • Headcount: 11-50
  • LinkedIn: recovery-force-health

Recovery Force Health, founded in 2019 and based in Fishers, Indiana, specializes in medical devices aimed at improving patient mobility and reducing complications during recovery. The company has developed innovative solutions such as the MAC System, the first wearable therapeutic compression device that provides real-time mobility data, and the ELEVATE Patient Positioners, which enhance patient comfort and compliance. Recovery Force Health collaborates with healthcare providers to integrate these technologies into patient care, demonstrating a commitment to improving healthcare outcomes. In March 2023, the company secured $1.25 million in funding, reflecting strong investor interest in their approach to addressing critical challenges in patient recovery. Their focus on data-driven solutions and partnerships with institutions like the Mayo Clinic highlights their role in advancing healthcare technology.


18. Complexus Medical

  • Website: complexusmedical.com
  • Ownership type: Private
  • Headquarters: Mishawaka, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 1990
  • Headcount: 51-200
  • LinkedIn: complexus-medical

Complexus Medical, based in Mishawaka, Indiana, is a private medical device manufacturer that has been operational since 1990. The company specializes in the production of high-quality orthopedic and spine instruments and implants. With a workforce of approximately 52 employees, Complexus Medical has evolved from its origins as a small tool and die shop into a significant player in the orthopedic device and implant industry. Their state-of-the-art facilities are equipped to handle complex manufacturing processes, ensuring that each product meets stringent regulatory standards. Complexus Medical is dedicated to quality assurance, employing advanced inspection techniques and maintaining compliance with international standards. Their product offerings include a range of surgical instruments and implantable components, showcasing their expertise in precision engineering. The company has also been recognized for its operational excellence, receiving accolades such as the National Top Shop Award and being named a Company to Watch by the Indiana Economic Development Corporation.


19. Micropulse

  • Website: micropulseinc.com
  • Ownership type: Private
  • Headquarters: Columbia City, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 1988
  • Headcount: 201-500
  • LinkedIn: micropulse-inc-

Micropulse Incorporated, based in Columbia City, Indiana, is a private medical device manufacturer that has been operational since 1988. The company specializes in orthopedic instruments and implants, catering to a variety of clients within the orthopedic industry. Micropulse is dedicated to producing high-quality products that meet stringent regulatory standards. Their offerings include a range of orthopedic instruments, implants, custom-made cases and trays, and sterile packaging solutions. The company prides itself on its commitment to quality, integrity, and customer service, which has allowed it to build strong partnerships with major, mid-tier, and start-up companies in the orthopedic market. With a workforce of approximately 182 employees, Micropulse continues to grow and adapt to the evolving needs of the industry, focusing on continuous improvement and innovation in manufacturing processes.


20. SITES Medical

  • Website: sitesmedical.com
  • Ownership type: Private
  • Headquarters: Columbia City, Indiana, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 2008
  • Headcount: 51-200
  • LinkedIn: sites-medical

SITES Medical, founded in 2008 and based in Columbia City, Indiana, is a private medical device manufacturer that specializes in orthopedic technologies. The company provides a range of products and services, including innovative implant materials and comprehensive research and development (R&D) and manufacturing services specifically designed for orthopedic OEMs. SITES Medical emphasizes a rapid product concept-to-launch process, which is crucial for helping clients navigate the complexities of the orthopedic market. Their notable platform technology, OsteoSync Ti, is recognized for its effectiveness in promoting bone ingrowth and has been successfully implanted in over 200,000 devices. The company also offers contract R&D services, regulatory support, and full-service manufacturing capabilities, ensuring high-quality outcomes for their partners. SITES Medical's focus on collaboration and innovation positions it as a valuable player in the orthopedic medical device industry.


21. Instrumedical Technologies, Inc.


Instrumedical Technologies, Inc., based in Warsaw, Indiana, is a family-owned medical device manufacturer that has been in operation since 1982. The company specializes in the production of orthopedic instruments and implants, catering primarily to orthopedic companies worldwide. With a strong emphasis on quality and precision, Instru-med has built a reputation for manufacturing high-quality, close-tolerance instruments and implants. Their services include prototyping, repair, and manufacturing of surgical instruments and implants, which are critical in the medical field. The company operates from a modern 60,000 square foot facility and is recognized for its commitment to quality, evidenced by its ISO 13485 certification and FDA registration. Instru-med's focus on lean manufacturing principles further enhances its operational efficiency, allowing for timely delivery and cost-effective production. Their expertise in CNC precision machining and a variety of special processes positions them as a reliable partner in the orthopedic medical device industry.



Biomedical Engineering Insights: Key Companies in Indiana


CompanyHeadquarterSizeFoundedOwnership
Paragon MedicalPierceton, Indiana, United States (USA)1001-50001991Corporate
Cook Advanced TechnologiesWest Lafayette, Indiana, United States (USA)11-502012Family Owned
NICO CorporationIndianapolis, Indiana, United States (USA)11-502007Venture Capital
Cook MedicalBloomington, Indiana, United States (USA)10001+1963Private Equity
Nexxt SpineNoblesville, Indiana, United States (USA)51-2002009Private
CTE, Mediliant GroupPlymouth, Indiana, United States (USA)51-2001950Private
NanovisColumbia City, Indiana, United States (USA)11-502006Venture Capital
Evergen (Formerly Cook Biotech)West Lafayette, Indiana, United States (USA)201-5001995Corporate
MED InstituteWest Lafayette, Indiana, United States (USA)11-501983Private
Cook Research IncorporatedWest Lafayette, Indiana, United States (USA)201-5001983Private
Avalign Cutting Instruments Division, NGInstrumentsWarsaw, Indiana, United States (USA)51-2001995Private Equity
TrimedxIndianapolis, Indiana, United States (USA)1001-50001998Private
QualitexColumbia City, Indiana, United States (USA)11-501993Private
On Target LaboratoriesWest Lafayette, Indiana, United States (USA)11-502010Venture Capital
Engineered Medical Systems, Inc.Indianapolis, Indiana, United States (USA)51-2001985Private
MW Life SciencesPierceton, Indiana, United States (USA)1001-50001991Private
Recovery Force HealthFishers, Indiana, United States (USA)11-502019Venture Capital
Complexus MedicalMishawaka, Indiana, United States (USA)51-2001990Private
MicropulseColumbia City, Indiana, United States (USA)201-5001988Private
SITES MedicalColumbia City, Indiana, United States (USA)51-2002008Private
Instrumedical Technologies, Inc.Warsaw, Indiana, United States (USA)51-2001982Family Owned


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