Population health management companies in the US are dedicated to improving health outcomes across various demographics. These companies employ data analytics, technology, and care coordination solutions to manage chronic diseases, reduce healthcare costs, and enhance patient experiences. As the healthcare landscape evolves, these firms increasingly focus on value-based care, driven by the need for cost containment and improved patient satisfaction. With advancements in artificial intelligence and machine learning, the ability to analyze social determinants of health is becoming critical. This sector is poised for growth, adapting to new models of care delivery and expanding partnerships with healthcare stakeholders.

The list features 20 notable population health management companies founded between 1988 and 2017, headquartered mainly in Texas and Massachusetts. They range from small firms with under 50 employees to massive enterprises like Optum with over 10,000 staff. These companies specialize in varying aspects of population health, such as analytics, patient engagement, disease management, and care coordinating solutions. Their exclusive focus is directed towards optimizing healthcare services and improving outcomes within communities across the United States.

Continue reading to learn about the top population health management companies in the US.

Top 20 Population Health Management Companies in the US

1. ZeOmega

• Website: zeomega.com
• Ownership type: Private Equity
• Headquarters: Plano, Texas, United States (USA)
• Employee distribution: India 84%, United States (USA) 16%
• Latest funding: October 2020
• Founded year: 2001
• Headcount: 501-1000
• LinkedIn: zeomega

ZeOmega, founded in 2001 and based in Plano, Texas, is a healthcare technology company that specializes in population health management and care management solutions. The company offers the Jiva platform, which provides a comprehensive suite of services aimed at improving care delivery and managing chronic conditions for healthcare plans and systems. ZeOmega serves a variety of clients, including health care plans, health systems, and government programs, with a focus on enhancing patient outcomes and operational efficiency. The company has been recognized for its performance, having received accolades such as the Best in KLAS award for Payer Care Management Solutions in 2022, 2023, and 2024. With a workforce of approximately 680 employees, the company has a significant presence in the healthcare technology sector, emphasizing the importance of data integration and AI-powered insights to drive better health outcomes. ZeOmega's commitment to addressing social determinants of health and improving care access further solidifies its role in the population health management industry.

2. Lightbeam Health Solutions

• Website: lightbeamhealth.com
• Ownership type: Venture Capital
• Headquarters: Dallas, Texas, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: February 2016
• Founded year: 2013
• Headcount: 201-500
• LinkedIn: lightbeamhealth

Lightbeam Health Solutions, based in Dallas, Texas, is a healthcare technology firm that specializes in population health management and value-based care services. Established in 2013, the company provides a comprehensive suite of solutions designed to enhance healthcare analytics, care management, and advisory services for healthcare organizations. Lightbeam's platform is tailored to help clients improve patient outcomes while effectively managing costs. The company has made a notable impact in the industry, generating over $2.5 billion in savings through the Medicare Shared Savings Program and more than $4 billion across various value-based contracts since its inception. Their innovative approach includes the use of artificial intelligence and remote patient monitoring, which are critical in today's healthcare environment. Lightbeam has also received accolades, such as being recognized as a finalist for the Microsoft Partner of the Year in 2024, underscoring their commitment to excellence in healthcare technology.

3. HealthEC, LLC

• Website: healthec.com
• Ownership type: Venture Capital
• Headquarters: Edison, New Jersey, United States (USA)
• Employee distribution: India 83%, United States (USA) 17%
• Latest funding: October 2023
• Founded year: 2010
• Headcount: 51-200
• LinkedIn: healthec

HealthEC, LLC, founded in 2010 and based in Edison, New Jersey, is a healthcare technology company that specializes in population health management. The firm provides a robust platform designed to enhance patient outcomes and streamline care delivery for hospitals, clinics, and payers. Their offerings include data analytics, care management, and advisory services, all aimed at helping healthcare organizations transition to value-based care models. HealthEC's platform is notable for its ability to aggregate and analyze both structured and unstructured data, enabling healthcare providers to identify high-risk patients and close care gaps effectively. The company has been recognized for its contributions to the industry, receiving accolades such as Best in KLAS, which underscores its commitment to quality and performance in population health management. With a workforce that includes a significant percentage of employees based in India, HealthEC leverages global talent to enhance its service offerings and maintain a competitive edge in the healthcare technology sector.

4. Zyter|TruCare

• Website: zyter.com
• Ownership type: Private
• Headquarters: Rockville, Maryland, United States (USA)
• Employee distribution: United States (USA) 76%, Czech Republic 20%, India 2%, Other 2%
• Founded year: 2002
• Headcount: 201-500
• LinkedIn: casenet-llc

Zyter|TruCare, based in Rockville, Maryland, is a healthcare technology company founded in 2002. The firm focuses on delivering innovative software and services aimed at managing value-based care. Their solutions cater to health plans, health systems, and public health organizations, emphasizing the importance of improving patient outcomes and optimizing healthcare delivery. Zyter|TruCare's product suite includes tools for population health management, virtual health, and connected health, all designed to facilitate better care coordination and patient engagement. The company has made significant strides in the healthcare technology sector, particularly with its TruCare platform, which integrates various health management functions into a single, user-friendly interface. This integration is crucial for organizations looking to enhance their operational efficiency and patient care capabilities.

5. Optum

• Website: optum.com
• Ownership type: Private
• Headquarters: Eden Prairie, Minnesota, United States (USA)
• Employee distribution: United States (USA) 49%, India 41%, Philippines 5%, Other 5%
• Founded year: 2011
• Headcount: 10001+
• LinkedIn: optum

Optum, Inc., founded in 2011 and based in Eden Prairie, Minnesota, is a healthcare services provider that offers a wide range of solutions aimed at enhancing health outcomes and managing costs. With over 93,000 employees, Optum operates on a global scale, serving employers, health plans, and government agencies. The company provides technology services, pharmacy care, and consulting, focusing on innovative healthcare solutions. Notably, Optum is involved in population health management, offering services that include behavioral health, patient access, and prevention and well-being initiatives. Their analytics capabilities allow for improved decision-making and outcomes, making them a key player in the healthcare industry. Optum's commitment to improving healthcare access and outcomes is evident in their partnerships with various stakeholders, including state and federal governments, to streamline healthcare delivery and enhance public health initiatives.

6. Casenet, LLC

• Website: casenetllc.com
• Ownership type: Corporate
• Headquarters: Bedford, Massachusetts, United States (USA)
• Latest funding: February 2021
• Founded year: 2002
• Headcount: 201-500
• LinkedIn: casenet-llc

Casenet, LLC, now branded as Zyter|TruCare, is a healthcare technology company based in Bedford, Massachusetts. Founded in 2002, the company specializes in providing innovative solutions for managing value-based care. Their platform offers a wide range of services tailored to population health, virtual health, and connected health, catering to healthcare plans, systems, and public health organizations. Casenet's focus is on enhancing health outcomes while simultaneously reducing costs through advanced technology and managed services. The company has made significant strides in the healthcare technology space, particularly in the realm of care management, and has been recognized for its contributions to improving healthcare delivery. As of February 2021, there has been no reported funding, indicating a stable operational model without recent external financial backing.

7. Persivia Inc.

• Website: persivia.com
• Ownership type: Venture Capital
• Headquarters: Marlborough, Massachusetts, United States (USA)
• Employee distribution: Pakistan 52%, United States (USA) 46%, Canada 2%
• Latest funding: $107.0M, April 2025
• Founded year: 2005
• Headcount: 51-200
• LinkedIn: persiviainc

Persivia Inc., founded in 2005 and based in Marlborough, Massachusetts, is a healthcare technology company that specializes in population health management and analytics. The firm offers a suite of solutions, including CareSpace® and Data Cloud, aimed at helping healthcare providers and payers enhance care delivery and operational efficiency. Their platform leverages artificial intelligence to integrate multiple data sources, providing actionable insights that improve patient outcomes and reduce healthcare costs. Persivia has received significant venture capital funding, totaling $107 million as of April 2025, which underscores investor confidence in their innovative approach. The company serves a variety of clients, including hospitals, physician groups, and public health organizations, positioning itself as a key player in the healthcare technology sector.

8. Twistle by Health Catalyst

• Website: twistle.com
• Ownership type: Corporate
• Headquarters: Albuquerque, New Mexico, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $104.5M, June 2021
• Founded year: 2011
• Headcount: 51-200
• LinkedIn: twistle-inc

Twistle by Health Catalyst, based in Albuquerque, New Mexico, is a healthcare technology company that specializes in enhancing patient engagement and care coordination. Founded in 2011, Twistle operates under the umbrella of Health Catalyst, a provider of data and analytics solutions aimed at improving healthcare delivery. The company offers a platform that automates communication between care teams and patients, which is essential for driving better health outcomes. Their services are designed to reduce hospital readmissions, decrease the length of patient stays, and improve overall patient satisfaction. With a focus on evidence-based protocols and data integration, Twistle supports healthcare organizations in optimizing their population health management strategies. The company has received significant funding, amounting to $104.5 million as of June 2021, which underscores its potential for growth and innovation in the healthcare sector.

9. AssureCare LLC

• Website: assurecare.com
• Ownership type: Venture Capital
• Headquarters: Cincinnati, Ohio, United States (USA)
• Employee distribution: India 59%, United States (USA) 41%
• Latest funding: Other (Debt), $377,000, February 2014
• Founded year: 1993
• Headcount: 51-200
• LinkedIn: assurecare-software

AssureCare LLC, based in Cincinnati, Ohio, is a healthcare technology firm founded in 1993. The company focuses on providing innovative solutions for population health management and care management. Their offerings are designed to support payors, providers, and pharmacies in enhancing care coordination and patient engagement. AssureCare operates through a software-as-a-service (SaaS) model, delivering a suite of solutions that include population health management, care management, utilization management, quality management, and medication management. With a workforce of approximately 412 employees, the company has a significant presence in both the United States and India. AssureCare has received funding, with the last reported amount being $377,000 in 2014, indicating ongoing investment in their technology and services. Their platform aims to improve healthcare delivery by connecting various stakeholders, ultimately leading to better health outcomes for patients.

10. Navvis (healthcare)

• Website: navvishealthcare.com
• Ownership type: Corporate
• Headquarters: St. Louis, Missouri, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: October 2022
• Founded year: 2007
• Headcount: 201-500
• LinkedIn: navvishealthcare

Navvis Healthcare, based in St. Louis, Missouri, is a healthcare consulting firm that specializes in population health management and value-based care solutions. Founded in 2007, the company has grown to employ around 230 professionals. Navvis partners with health systems, physician enterprises, and health plans across the United States to enhance patient care and optimize healthcare delivery. Their services include training for healthcare providers, data management, and strategies for improving patient throughput. By focusing on value-based care, Navvis aims to improve health outcomes while reducing costs for their clients. They have managed millions of patients and supported thousands of physicians, showcasing their extensive involvement in the healthcare sector. Their innovative approach and commitment to transforming healthcare delivery make them a significant player in the population health management space.

11. Tandigm Health

• Website: tandigmhealth.com
• Ownership type: Private
• Headquarters: West Conshohocken, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $1.9M, April 2022
• Founded year: 2014
• Headcount: 51-200
• LinkedIn: tandigm-health

Tandigm Health, founded in 2014 and based in West Conshohocken, Pennsylvania, is a private healthcare management company dedicated to population health management and clinical services. With a workforce of approximately 223 employees, Tandigm Health supports primary care and specialty practices by providing innovative health management tools and administrative services. Their mission is to improve individual and collective health outcomes through a strong regional network of independent practices and delivery systems. The company serves a significant patient base, with around 170,000 patients across the Greater Philadelphia region. Tandigm Health has also received funding, with a reported amount of $1,881,536 in April 2022, which underscores their ongoing growth and investment in enhancing healthcare delivery. Their focus on value-based care, along with their clinical services such as Complex Care Management and Comprehensive Medication Management, positions them as a key player in the population health management space.

12. Medecision

• Website: medecision.com
• Ownership type: Corporate
• Headquarters: King Of Prussia, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: June 2008
• Founded year: 1988
• Headcount: 201-500
• LinkedIn: medecision

Medecision, founded in 1988 and based in King of Prussia, Pennsylvania, is a healthcare technology company that focuses on innovative solutions for care management, data analytics, and consumer engagement. The company serves health plans, health systems, and third-party administrators, providing tools that enhance care coordination and improve health outcomes. Their flagship offering, the Aerial Data Platform, allows organizations to manage and analyze health data effectively, facilitating timely interventions and personalized care strategies. Medecision also offers consulting services through its Aveus division, helping organizations navigate the complexities of healthcare delivery and improve operational efficiency. With a workforce of approximately 242 employees, Medecision has established itself as a significant player in the healthcare technology sector, focusing on solutions that drive value-based care and enhance patient engagement.

13. Vitalware

• Website: vitalware.com
• Ownership type: Corporate
• Headquarters: Yakima, Washington, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $120.0M, August 2020
• Founded year: 2011
• Headcount: 51-200
• LinkedIn: vitalware

Vitalware, based in Yakima, Washington, is a healthcare technology firm founded in 2011. The company specializes in providing data and analytics solutions that enhance patient outcomes and operational efficiency for healthcare organizations. Vitalware's services include population health management, patient engagement, and clinical quality improvement. They cater to a variety of clients, including health systems and insurers, leveraging data to facilitate healthcare transformation. In 2020, Vitalware secured $120 million in funding, which underscores their growth and commitment to advancing healthcare technology. Their focus on patient stratification and care coordination positions them as a significant player in the population health management sector.

14. Optum 360

• Website: optum360.com
• Ownership type: Private
• Headquarters: Eden Prairie, Minnesota, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1997
• Headcount: 51-200
• LinkedIn: optum-360

Optum 360, based in Eden Prairie, Minnesota, is a healthcare services provider that has been operational since 1997. The company specializes in a wide array of solutions, including healthcare, financial services, and pharmacy management. Optum 360 serves a variety of clients, including employers, health plans, and government agencies, with a focus on improving health outcomes and managing costs. Their services are designed to enhance patient care through innovative approaches, particularly in population health management. The company leverages data analytics and technology to provide insights that help organizations make informed decisions about health management. This capability is crucial for addressing the complexities of population health, as it allows for targeted interventions and improved health outcomes across different demographics. With a workforce of around 105 employees, Optum 360 operates entirely within the United States, emphasizing its commitment to the local healthcare market.

15. MedeAnalytics

• Website: medeanalytics.com
• Ownership type: Private Equity
• Headquarters: Richardson, Texas, United States (USA)
• Employee distribution: United States (USA) 63%, Ukraine 34%, Other 3%
• Latest funding: October 2020
• Founded year: 1993
• Headcount: 201-500
• LinkedIn: medeanalytics-inc

MedeAnalytics, founded in 1993 and based in Richardson, Texas, is a healthcare analytics provider that focuses on improving operational efficiency and patient outcomes for healthcare organizations. The company offers a variety of solutions, including analytics for value-based care, revenue cycle management, and consulting services. Their primary clientele includes healthcare providers, payers, and government programs. With a workforce of approximately 383 employees, MedeAnalytics has developed a robust platform that supports over 65 million lives and serves more than 2,000 healthcare providers and health plans. Their innovative approach integrates advanced analytics with a focus on social determinants of health, enabling organizations to make informed decisions that enhance population health management. MedeAnalytics has not reported any recent funding, indicating a stable operational status since its last funding round in 2020.

16. DataQ Health

• Website: dataqhealth.com
• Ownership type: Private
• Headquarters: United States (USA)
• Employee distribution: Pakistan 99%, Other 1%
• Founded year: 2017
• Headcount: 201-500
• LinkedIn: wisemaninnovations

DataQ Health is a healthcare technology provider based in the United States, specializing in data-driven solutions that enhance patient care and outcomes. Founded in 2017, the company has quickly established itself in the healthcare industry by offering services such as population health management and care coordination. Their innovative technology and analytics empower healthcare organizations and providers to improve operational efficiency and patient health. DataQ Health's flagship offerings include the 360 Platform, which integrates data analytics and clinical expertise to deliver actionable insights for targeted interventions. The company has successfully partnered with thousands of healthcare providers and practices, demonstrating its impact on improving care quality and closing care gaps. With a dedicated team of professionals, DataQ Health is committed to transforming healthcare delivery through advanced technology and compassionate service.

17. Applied Health Analytics, LLC

• Website: appliedhealth.net
• Ownership type: Private
• Headquarters: Nashville, Tennessee, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2009
• Headcount: 11-50
• LinkedIn: applied-health-analytics

Applied Health Analytics, LLC, founded in 2009, is a Nashville-based healthcare technology provider that focuses on population health management and employer-centric strategies. The company offers proprietary technology and consulting services designed to assist health systems and employers in managing health benefit expenses while improving health outcomes. Their solutions include advanced data aggregation services and sales management tools, which enhance the efficiency of healthcare delivery. Applied Health Analytics has formed strategic partnerships with prominent organizations, including Vanderbilt University Medical Center and Atrium Health, to develop and implement innovative population health initiatives. Their technology platforms, such as bIQ and bSMART, are designed to facilitate risk stratification and member engagement, helping clients identify health risks and align them with appropriate services. The company’s commitment to evidence-based practices and its focus on enhancing the commercial market share for health systems underscore its relevance in the population health management sector.

18. i2i Population Health

• Website: i2ipophealth.com
• Ownership type: Venture Capital
• Headquarters: Franklin, Tennessee, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series A, May 2016
• Founded year: 2000
• Headcount: 51-200
• LinkedIn: i2i-systems-inc-

i2i Population Health, based in Franklin, Tennessee, is a healthcare technology company that specializes in population health management solutions. Founded in 2000, the company has developed a suite of services that includes data activation, care management, and interactive analytics. Their primary clientele consists of provider organizations and health plans, which utilize i2i's technology to enhance care coordination and improve patient outcomes. The company operates through a Software as a Service (SaaS) model, providing both software solutions and consulting services. i2i has made significant strides in the industry, managing health records for over 36 million individuals and integrating data from more than 3105 facilities. Their commitment to improving healthcare delivery is evident in their focus on interoperability and analytics, which empower healthcare providers to make informed decisions and optimize care delivery.

19. Carenet Health

• Website: carenethealthcare.com
• Ownership type: Private
• Headquarters: San Antonio, Texas, United States (USA)
• Employee distribution: United States (USA) 79%, Philippines 18%, Other 3%
• Founded year: 1988
• Headcount: 1001-5000
• LinkedIn: carenet-health

Carenet Health, founded in 1988 and based in San Antonio, Texas, is a private healthcare service provider with a workforce of over 2,000 employees. The company specializes in consumer engagement and support solutions, offering a variety of services such as telehealth, clinical support, and advocacy. Carenet Health partners with healthcare companies, hospital systems, and government programs to enhance care delivery and improve patient experiences. Their innovative approach includes utilizing technology and data to create personalized healthcare experiences. The company has established itself as a significant player in the healthcare engagement space, supporting over 500 health plans and providers. Carenet Health's commitment to improving healthcare outcomes is evident in their focus on chronic care management and shared decision-making, which are critical elements in managing population health effectively.

20. Arcadia

• Website: arcadia.io
• Ownership type: Venture Capital
• Headquarters: Boston, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 97%, Other 3%
• Latest funding: Other (Debt), $125.0M, April 2023
• Founded year: 2002
• Headcount: 201-500
• LinkedIn: arcadia-io

Arcadia is a healthcare data analytics company based in Boston, Massachusetts, founded in 2002. With a workforce of over 500 employees, the company has developed a comprehensive data platform aimed at enhancing patient outcomes and operational efficiency for healthcare providers, payers, and government entities. Arcadia's offerings include analytics dashboards, care management solutions, and healthcare reporting services, which empower clients to make informed decisions based on data. The company has recently secured $125 million in funding, reflecting strong investor interest in its innovative approach to healthcare analytics. Arcadia collaborates with healthcare providers to implement population health management strategies, particularly in risk-based contracts, and partners with payers to improve performance metrics. Their focus on social determinants of health (SDoH) and health equity further demonstrates their commitment to addressing the broader factors influencing health outcomes.

Population Health Management Insights: Key Companies in the US

Company	Headquarter	Size	Founded	Ownership
ZeOmega	Plano, Texas, United States (USA)	501-1000	2001	Private Equity
Lightbeam Health Solutions	Dallas, Texas, United States (USA)	201-500	2013	Venture Capital
HealthEC, LLC	Edison, New Jersey, United States (USA)	51-200	2010	Venture Capital
Zyter|TruCare	Rockville, Maryland, United States (USA)	201-500	2002	Private
Optum	Eden Prairie, Minnesota, United States (USA)	10001+	2011	Private
Casenet, LLC	Bedford, Massachusetts, United States (USA)	201-500	2002	Corporate
Persivia Inc.	Marlborough, Massachusetts, United States (USA)	51-200	2005	Venture Capital
Twistle by Health Catalyst	Albuquerque, New Mexico, United States (USA)	51-200	2011	Corporate
AssureCare LLC	Cincinnati, Ohio, United States (USA)	51-200	1993	Venture Capital
Navvis (healthcare)	St. Louis, Missouri, United States (USA)	201-500	2007	Corporate
Tandigm Health	West Conshohocken, Pennsylvania, United States (USA)	51-200	2014	Private
Medecision	King Of Prussia, Pennsylvania, United States (USA)	201-500	1988	Corporate
Vitalware	Yakima, Washington, United States (USA)	51-200	2011	Corporate
Optum 360	Eden Prairie, Minnesota, United States (USA)	51-200	1997	Private
MedeAnalytics	Richardson, Texas, United States (USA)	201-500	1993	Private Equity
DataQ Health	United States (USA)	201-500	2017	Private
Applied Health Analytics, LLC	Nashville, Tennessee, United States (USA)	11-50	2009	Private
i2i Population Health	Franklin, Tennessee, United States (USA)	51-200	2000	Venture Capital
Carenet Health	San Antonio, Texas, United States (USA)	1001-5000	1988	Private
Arcadia	Boston, Massachusetts, United States (USA)	201-500	2002	Venture Capital

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