The pharmaceutical manufacturing industry in the US is pivotal for producing essential medications and treatments. Companies vary from large multinationals to small biotech firms, all focused on developing drugs that meet medical needs. This sector is evolving rapidly, driven by advances in technology and a growing emphasis on personalized medicine. Increasingly, organizations are investing in research to innovate therapies, especially in areas such as immunology, oncology, and gene therapy. As public health demands continue to rise, the industry is poised for significant growth, adapting to global challenges such as pandemics and emerging health crises.

The companies featured in this list range from large multinationals to smaller biotech firms, with employee sizes varying from under 100 to nearly 10,000. Headquartered in various locations across the United States, these organizations were founded between 1964 and 2022, each with its focus on specific therapeutic areas. From plasma-derived therapies at Kedrion Biopharma to cancer treatments from Seattle Genetics, they innovate and deliver critical health solutions for patients and healthcare providers.

Continue reading to explore the top pharmaceutical manufacturing companies in the US.

Top 20 Pharmaceutical Manufacturing Companies in the US

1. Kedrion Biopharma

• Website: kedrion.com
• Ownership type: Private Equity
• Headquarters: Fort Lee, New Jersey, United States (USA)
• Employee distribution: Italy 49%, United States (USA) 27%, United Kingdom (UK) 14%, Other 11%
• Latest funding: September 2022
• Founded year: 2001
• Headcount: 1001-5000
• LinkedIn: kedrion-biopharma

Kedrion Biopharma is a biopharmaceutical company founded in 2001, headquartered in Fort Lee, New Jersey. The company specializes in the production and distribution of plasma-derived therapies aimed at treating rare and debilitating conditions, such as coagulation disorders and immunodeficiencies. With a workforce of over 2,200 employees, Kedrion operates multiple production plants across Europe and North America, and it has established plasma collection centers in the United States and the Czech Republic. The company has expanded its capabilities through strategic acquisitions, including the purchase of Bio Products Laboratory in 2022, which has enhanced its portfolio of plasma-derived medicines. Kedrion is dedicated to ensuring access to essential medical products and maintaining high standards of quality and safety in its operations. They distribute their products in over 100 countries, reflecting their global reach and commitment to addressing the needs of patients with rare diseases.

2. Seattle Genetics

• Website: seattlegenetics.com
• Ownership type: Private
• Headquarters: Bothell, Washington, United States (USA)
• Founded year: 1998
• Headcount: 1001-5000
• LinkedIn: seattle-genetics

Seattle Genetics, founded in 1998 and based in Bothell, Washington, is a biopharmaceutical company dedicated to developing and manufacturing innovative therapies for cancer treatment. The company is particularly known for its pioneering work in antibody-drug conjugates, which combine targeted therapies with potent cytotoxic agents to improve treatment outcomes for patients with various types of cancer. Seattle Genetics has a robust pipeline of products and is actively involved in clinical trials aimed at addressing unmet medical needs in oncology. Their commitment to research and development is evident in their collaborations with other organizations and their focus on advancing precision medicine. With a workforce of over 2,000 employees, Seattle Genetics continues to play a crucial role in the pharmaceutical industry, striving to improve the lives of patients through innovative therapies.

3. Medifarma

• Website: medifarma.com.pe
• Ownership type: Private
• Headquarters: United States (USA)
• Employee distribution: Peru 81%, Colombia 10%, Ecuador 5%, Other 4%
• Founded year: 1964
• Headcount: 1001-5000
• LinkedIn: medifarmalab

Medifarma S.A. is a private pharmaceutical company based in Peru, founded in 1964. It specializes in the production of high-quality health products aimed at both healthcare professionals and consumers. The company emphasizes adherence to Good Manufacturing Practices, which underscores its commitment to safety and efficacy in its product offerings. Medifarma operates primarily in Peru, with a workforce that is predominantly located there, but it also has a presence in Colombia and Ecuador. The company is recognized as one of the top three pharmaceutical laboratories in Peru and holds the position of the leading national capital laboratory in terms of sales. Medifarma is dedicated to continuous innovation and improvement, investing in advanced technology and infrastructure to enhance its manufacturing capabilities. Its focus on quality and responsibility extends to its environmental practices and employee training initiatives, further solidifying its role in the pharmaceutical industry.

4. Laboratorios AC FARMA

• Website: acfarma.com
• Ownership type: Private
• Headquarters: United States (USA)
• Employee distribution: Peru 98%, Other 2%
• Founded year: 1993
• Headcount: 501-1000
• LinkedIn: laboratorios-ac-farma

Laboratorios AC FARMA S.A. is a private pharmaceutical manufacturer based in Peru, established in 1993. The company specializes in the production of high-quality pharmaceutical products aimed at supporting health restoration and maintenance. With a workforce of approximately 482 employees, AC FARMA operates with a commitment to quality and safety, utilizing advanced technology and modern infrastructure designed to meet rigorous international standards. The company has a strong focus on research and development, continuously evolving its product lines based on scientific and ethical principles. AC FARMA is dedicated to serving healthcare professionals and institutions, ensuring that their medications are effective and reliable. They have received certifications for Good Manufacturing Practices, which underscores their commitment to maintaining high standards in their production processes. Their operational model includes manufacturing for third parties, allowing them to cater to both national and international markets, thus enhancing their presence in the pharmaceutical industry.

5. Pfizer 21

• Website: pfizer.dk
• Ownership type: Private
• Headquarters: Manchester Township, New Jersey, United States (USA)
• Employee distribution: India 74%, Saudi Arabia 26%
• Founded year: 1998
• Headcount: 5001-10000
• LinkedIn: pfizer-21

Pfizer 21, based in Manchester Township, New Jersey, is a private biopharmaceutical company founded in 1998. It specializes in the research, development, and manufacturing of innovative medications and treatments. Pfizer 21 serves healthcare providers, patients, and organizations by offering a broad spectrum of prescription medications. The company is dedicated to enhancing health outcomes through clinical research and collaboration with healthcare professionals. With a workforce that is primarily located in India and Saudi Arabia, Pfizer 21 is involved in various therapeutic areas, conducting clinical studies to advance treatment options. Their commitment to innovation and patient care is evident in their ongoing efforts to develop new therapies and improve existing ones, making them a notable entity in the pharmaceutical sector.

6. Pfizer UK

• Website: pfizer.co.uk
• Ownership type: Corporate
• Headquarters: United States (USA)
• Employee distribution: United Kingdom (UK) 80%, Ireland 20%
• Latest funding: May 2024
• Founded year: 1952
• Headcount: 51-200
• LinkedIn: pfizer-uk

Pfizer UK, a subsidiary of Pfizer Inc., operates primarily in the pharmaceutical sector, focusing on the development and manufacturing of prescription medicines and vaccines. Established in 1952, the company has a strong presence in the UK, with a workforce that is predominantly based there. Pfizer UK is dedicated to advancing healthcare through innovative therapies that target a range of health conditions. The company emphasizes research and development, with numerous clinical trials underway to bring new medicines to market. Their portfolio includes a wide array of therapeutic areas, showcasing their commitment to addressing significant health challenges. Pfizer UK also engages in collaborations with healthcare professionals and organizations to enhance patient care and improve health outcomes. Their contributions extend beyond medicine, as they actively participate in initiatives aimed at reducing health inequalities and supporting science education.

7. NPS Pharma

• Website: shire.com
• Ownership type: Corporate
• Headquarters: Bedminster, New Jersey, United States (USA)
• Employee distribution: United States (USA) 51%, Algeria 12%, Ireland 12%, Other 25%
• Latest funding: $86.4B, April 2018
• Founded year: 1986
• Headcount: 201-500
• LinkedIn: nps-pharmaceuticals

NPS Pharma, part of Takeda Pharmaceutical Company Limited, is based in Bedminster, New Jersey. Founded in 1986, the company specializes in the research, development, manufacturing, and marketing of innovative medicines. NPS Pharma focuses on therapeutic areas such as gastrointestinal diseases, rare diseases, oncology, and vaccines, aiming to provide effective treatments for patients with limited options. With a workforce of approximately 148 employees, the company operates globally, with a notable presence in the United States and several other countries. Takeda's commitment to transforming lives through its pharmaceutical products is evident in its extensive research and development efforts, which are geared towards addressing unmet medical needs. The company has received substantial funding, indicating strong investor confidence in its potential for growth and innovation.

8. Agensys, Inc.

• Website: astellas.us
• Ownership type: Private
• Headquarters: Santa Monica, California, United States (USA)
• Founded year: 1997
• Headcount: 201-500
• LinkedIn: agensys

Agensys, Inc., based in Santa Monica, California, operates as a private entity under the umbrella of Astellas Pharma US, Inc. Founded in 1997, the company is dedicated to the development and marketing of pharmaceutical products that address critical health issues. Its primary focus areas include oncology, cardiology, and immunology, where it strives to enhance patient outcomes through innovative therapies. Agensys is involved in various stages of drug development, from research to clinical trials, and actively collaborates with healthcare providers to ensure that its products meet the needs of patients. The company emphasizes patient-centric approaches, providing resources and support to both patients and healthcare professionals. While there is no reported funding, Agensys continues to operate within a robust pharmaceutical framework, contributing to the broader goals of Astellas Pharma.

9. Affinivax Inc.

• Website: affinivax.com
• Ownership type: Corporate
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $2.1B, May 2022
• Founded year: 2014
• Headcount: 51-200
• LinkedIn: affinivax-inc.

Affinivax Inc. is a biotechnology firm based in Cambridge, Massachusetts, founded in 2014. The company specializes in the development and manufacturing of vaccines, leveraging its innovative technology platform to create advanced vaccine candidates. Affinivax is dedicated to addressing significant public health challenges through its research and development efforts. The company has received substantial funding, totaling $210 million as of May 2022, which underscores its active role in the pharmaceutical industry and its commitment to advancing vaccine technology. Affinivax's focus on vaccine development positions it as a relevant player in the pharmaceutical manufacturing sector, contributing to the ongoing efforts to combat infectious diseases and improve global health outcomes.

10. Prometheus Biosciences, Inc.

• Website: prometheusbiosciences.com
• Ownership type: Corporate
• Headquarters: San Diego, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $10.8B, April 2023
• Founded year: 1995
• Headcount: 51-200
• LinkedIn: prometheusbiosciences

Prometheus Biosciences, Inc. is a biotechnology firm based in San Diego, California, founded in 1995. The company specializes in developing targeted therapies for autoimmune diseases, particularly through the use of monoclonal antibodies. Their innovative approach aims to address significant unmet medical needs in this area. Prometheus has been involved in various stages of drug development, including research, clinical trials, and regulatory processes. Recently, they secured $108 million in funding, which underscores investor confidence in their pipeline and potential to bring new treatments to market. Prometheus is committed to advancing healthcare solutions that improve patient outcomes in autoimmune conditions.

11. Sanofi Genzyme

• Website: sanofigenzyme.com
• Ownership type: Private
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Founded year: 1981
• Headcount: 5001-10000
• LinkedIn: sanofigenzyme

Sanofi Genzyme, based in Cambridge, Massachusetts, is a prominent healthcare and pharmaceutical company founded in 1981. It operates under the larger umbrella of Sanofi, focusing on improving lives through innovative medicines and vaccines. The company serves a wide range of health conditions, with a strong emphasis on research and development. Sanofi Genzyme is particularly noted for its work in immunology, neurology, oncology, and rare diseases, showcasing a commitment to addressing unmet medical needs. Their vaccine production capabilities are noteworthy, as they are recognized as a top producer of poliomyelitis and influenza vaccines. Sanofi Genzyme also emphasizes sustainability and social impact, aiming to enhance access to healthcare and support vulnerable communities. With nearly 10,000 employees, the company is well-positioned to continue its contributions to the pharmaceutical industry.

12. TESARO, Inc.

• Website: tesarobio.com
• Ownership type: Corporate
• Headquarters: Waltham, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 74%, France 12%, Puerto Rico 3%, Other 10%
• Latest funding: $5.1B, December 2018
• Founded year: 2010
• Headcount: 501-1000
• LinkedIn: tesaro

TESARO, Inc. is a pharmaceutical company based in Waltham, Massachusetts, established in 2010. The company specializes in the development and manufacturing of innovative therapies for cancer treatment, with a strong focus on oncology. TESARO is known for its product Zejula (niraparib), a medication approved for the treatment of ovarian cancer. The company has garnered significant attention in the pharmaceutical industry, particularly for its commitment to addressing unmet medical needs in oncology. In December 2018, TESARO was acquired by GSK, a global healthcare company, which has further integrated its operations into GSK's extensive portfolio of vaccines and medicines. This acquisition has positioned TESARO's innovations within a larger framework, allowing for broader distribution and development capabilities under GSK's umbrella.

13. USpharma Ltd

• Website: uspharmaltd.com
• Ownership type: Corporate
• Headquarters: Miami Lakes, Florida, United States (USA)
• Employee distribution: United States (USA) 97%, India 3%
• Latest funding: July 2016
• Founded year: 2016
• Headcount: 51-200
• LinkedIn: uspharmaltd

USpharma Ltd, founded in 2016 and based in Miami Lakes, Florida, is a pharmaceutical company dedicated to the development and commercialization of brand and pharmaceutically-equivalent products. The company serves both consumer health and prescription markets, ensuring that its offerings meet the needs of patients and healthcare providers alike. USpharma operates a modern facility that spans over 100,000 square feet, equipped with advanced manufacturing capabilities and compliant with FDA regulations. This facility underscores their commitment to producing high-quality healthcare products. With a workforce primarily located in the United States, USpharma Ltd is positioned to respond effectively to market demands and maintain rigorous quality standards in its operations.

14. Prati-Donaduzzi

• Website: pratidonaduzzi.com.br
• Ownership type: Private
• Headquarters: Toledo, Ohio, United States (USA)
• Employee distribution: Brazil 98%, Other 2%
• Founded year: 1993
• Headcount: 5001-10000
• LinkedIn: pratidonaduzzi

Prati-Donaduzzi is a Brazilian pharmaceutical company established in 1993, headquartered in Toledo, Paraná. The company focuses on manufacturing a wide array of pharmaceutical products, including generics, dietary supplements, and phytotherapy medicines. With a workforce of approximately 4,000 employees, Prati-Donaduzzi has positioned itself as a key supplier in the Brazilian market, notably being the largest provider of pharmaceuticals to the government. The company emphasizes innovation and quality, supported by modern research facilities and a proprietary logistics system. Their production capacity reaches 12 billion therapeutic doses annually, reflecting their significant role in ensuring the availability of essential medications. Prati-Donaduzzi also engages in various social responsibility projects, demonstrating a commitment to community well-being alongside their business objectives.

15. VelosBio Inc.

• Website: velosbio.com
• Ownership type: Corporate
• Headquarters: San Diego, California, United States (USA)
• Latest funding: $2.8B, November 2020
• Founded year: 2017
• Headcount: 11-50
• LinkedIn: velosbioinc

VelosBio Inc. is a biotechnology firm established in 2017, located in San Diego, California. The company specializes in the development of innovative cancer therapies, utilizing cutting-edge technology to create targeted treatments. VelosBio's commitment to addressing significant health challenges is evident in their research initiatives and clinical trials aimed at improving patient outcomes in oncology. In November 2020, the company secured $275 million in funding, which underscores the confidence investors have in their potential to advance drug development and bring new therapies to market. VelosBio's focus on research and its active role in the pharmaceutical sector make it a noteworthy entity in the industry.

16. Poly Pharmaceuticals

• Website: polypharm.net
• Ownership type: Private
• Headquarters: Quitman, Mississippi, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1980
• Headcount: 51-200
• LinkedIn: poly-pharmaceuticals

Poly Pharmaceuticals, Inc. is a privately held pharmaceutical company based in Quitman, Mississippi, founded in 1980 by a group of pharmacists. The company specializes in the development and marketing of branded, generic, and over-the-counter pharmaceutical products. Poly Pharmaceuticals offers a variety of therapeutic products aimed at addressing common health issues such as cough, cold, allergy, sinusitis, pain relief, and urological health. They distribute their products to healthcare professionals, pharmacies, and wholesalers across the United States. The company is dedicated to bringing new products to market each year through strategic business alliances, acquisitions, and licensing, ensuring a steady flow of innovative and cost-effective medications for patients and caregivers.

17. Bamboo Therapeutics, Inc. a wholly owned subsidiary of Pfizer Inc.

• Website: bambootherapeutics.com
• Ownership type: Corporate
• Headquarters: Chapel Hill, North Carolina, United States (USA)
• Latest funding: $654.0M, August 2016
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: bamboo-therapeutics

Bamboo Therapeutics, Inc., a wholly owned subsidiary of Pfizer Inc., is based in Chapel Hill, North Carolina. Founded in 2014, the company is dedicated to the development and manufacturing of innovative therapies, particularly focusing on gene therapy for rare diseases. This specialization allows Bamboo Therapeutics to address unmet medical needs through advanced research and development. As part of Pfizer, Bamboo Therapeutics benefits from the larger company's extensive resources and expertise in the pharmaceutical sector. The company has received substantial funding, amounting to $654 million, which underscores its potential and the confidence investors have in its mission to create impactful treatments. Bamboo Therapeutics is actively involved in the pharmaceutical industry, contributing to the advancement of therapies that can significantly improve patient outcomes.

18. FUJIFILM Diosynth Biotechnologies

• Website: fujifilmdiosynth.com
• Ownership type: Corporate
• Headquarters: Morrisville, North Carolina, United States (USA)
• Employee distribution: Denmark 43%, United States (USA) 40%, United Kingdom (UK) 17%
• Latest funding: $890.0M, August 2019
• Founded year: 2011
• Headcount: 1001-5000
• LinkedIn: fujifilm-diosynth-biotechnologies

FUJIFILM Diosynth Biotechnologies is a biotechnology company based in Morrisville, North Carolina, specializing in contract development and manufacturing services for biologics, vaccines, and advanced therapies. Founded in 2011, the company has quickly established itself as a key player in the pharmaceutical manufacturing sector. They partner with pharmaceutical and biotechnology firms, providing essential expertise in cGMP processes to ensure the safe and effective delivery of products. With a workforce of over 5,000 employees distributed across facilities in the United States, Denmark, the United Kingdom, and Japan, FUJIFILM Diosynth Biotechnologies supports clients through all phases of drug development, from pre-clinical studies to commercialization. Their commitment to quality and innovation is evident in their extensive capabilities, which include mammalian cell culture, microbial fermentation, and advanced therapies such as gene and cell therapy. The company has also made significant investments to expand its manufacturing capacity, reflecting its strategic focus on meeting the growing demands of the pharmaceutical industry.

19. i3 Pharmaceuticals, LLC

• Website: i3pharmaceuticals.com
• Ownership type: Private
• Headquarters: Warminster, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2015
• Headcount: 51-200
• LinkedIn: i3-pharmaceuticals-llc

i3 Pharmaceuticals, LLC is a private pharmaceutical company based in Warminster, Pennsylvania, established in September 2015. The company specializes in the development and manufacturing of complex solid oral specialty pharmaceutical products. With a workforce of approximately 38 employees, i3 Pharmaceuticals operates from a modern 150,000 square foot facility that includes research and analytical laboratories, pilot and commercial manufacturing plants, and warehousing. Their product portfolio includes several FDA-approved medications, such as Selegiline HCl and Ranolazine extended-release tablets, showcasing their ability to bring challenging formulations to market. i3 Pharmaceuticals is committed to innovation and quality, focusing on high technological barrier products that meet the needs of healthcare providers and pharmacies. Their mission emphasizes insight, ingenuity, and integrity, reflecting their dedication to excellence in the pharmaceutical industry.

20. Laboratorios Induquimica SA

• Website: induquimica.com
• Ownership type: Private
• Headquarters: United States (USA)
• Employee distribution: Peru 100%
• Founded year: 1991
• Headcount: 51-200
• LinkedIn: laboratorios-induquimica

Laboratorios Induquimica SA is a pharmaceutical company founded in 1991, located in Peru. The company specializes in the production of a wide range of medications, including antibiotics, antineoplastics, and cardiovascular drugs. They cater to healthcare providers, hospitals, and pharmacies, ensuring access to high-quality pharmaceutical products essential for effective patient treatment. In addition to their manufacturing capabilities, Laboratorios Induquimica offers contract manufacturing and quality control services, showcasing their involvement in the broader pharmaceutical supply chain. The company adheres to stringent quality standards, as evidenced by their certifications in Good Manufacturing Practices (BPM) and ISO 9001. Their focus on research and development, along with a commitment to innovation, positions them as a significant player in the pharmaceutical industry.

Pharmaceutical Manufacturing Insights: Key Companies in the US

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