Pennsylvania's pharmaceutical manufacturing sector is a dynamic industry focused on the development and production of medication and therapeutic solutions. Companies range from large corporations to small startups, each specializing in unique products such as generics, biologics, and specialty drugs. This vibrant industry aligns with significant healthcare needs, driving innovation in drug delivery, efficacy, and safety. An increasing emphasis on personalized medicine and biologics points to a future where advanced therapies cater to specific patient profiles, enhancing treatment outcomes. The state's rich research environment fosters collaboration between manufacturers and academic institutions, positioning it well for growth and transformation.

This list features 20 prominent pharmaceutical manufacturing companies in Pennsylvania, characterized by varied sizes and specialties. With headquarter locations across the state—from Langhorne to Bethlehem—these companies were founded primarily in the early 2000s to date. Their offerings span a broad spectrum, including generics, specialized therapies, and innovative manufacturing processes. Each company contributes to an industry trend focused on improving patient care and drug effectiveness, ensuring that Pennsylvania remains a key player in the pharmaceutical sector.

Continue reading to explore the top pharmaceutical manufacturing companies in Pennsylvania.

Top 20 Pharmaceutical Manufacturing Companies in Pennsylvania

1. Jubilant Pharma

• Website: jubilantpharma.com
• Ownership type: Private
• Headquarters: Yardley, Pennsylvania, United States (USA)
• Latest funding: Other (Debt), $400.0M, July 2022
• Founded year: 2014
• Headcount: 1001-5000
• LinkedIn: jubilant-pharma

Jubilant Pharma, founded in 2014 and based in Yardley, Pennsylvania, is a private pharmaceutical company that specializes in allergy therapy products, radiopharmaceuticals, and contract manufacturing. The company serves healthcare providers, including allergists and hospitals, by offering a range of products essential for treating allergies and other medical conditions. With a product portfolio that includes over 200 allergenic extracts and specialized skin test devices, Jubilant Pharma is recognized as a significant player in the allergy therapy market. They are also the sole producer of venom products for allergy treatment in the United States. Their operations are supported by a robust research and development framework, which focuses on innovation and the development of new products. The company has manufacturing facilities in North America and India, allowing them to cater to a global market. In July 2022, Jubilant Pharma secured $400 million in funding, underscoring their active role in the pharmaceutical sector and their potential for future growth.

2. i3 Pharmaceuticals, LLC

• Website: i3pharmaceuticals.com
• Ownership type: Private
• Headquarters: Warminster, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2015
• Headcount: 51-200
• LinkedIn: i3-pharmaceuticals-llc

i3 Pharmaceuticals, LLC is a private pharmaceutical company based in Warminster, Pennsylvania, established in September 2015. The company specializes in the development and manufacturing of complex solid oral specialty pharmaceutical products. With a workforce of approximately 38 employees, i3 Pharmaceuticals operates from a modern 150,000 square foot facility that includes advanced research and analytical laboratories, as well as pilot and commercial manufacturing plants. Their product portfolio includes medications that address difficult formulation challenges, such as poorly soluble drugs and unstable molecules. i3 Pharmaceuticals has successfully filed multiple Abbreviated New Drug Applications (ANDAs) with the FDA, gaining approval for products like Selegiline HCl and Ranolazine extended-release tablets. Their mission emphasizes quality and innovation, aiming to improve patient outcomes through their specialized offerings. The company is committed to maintaining high standards in product development and manufacturing processes, ensuring they meet the rigorous demands of the pharmaceutical industry.

3. Sigmapharm Laboratories, LLC

• Website: sigmapharm.com
• Ownership type: Private
• Headquarters: Bensalem, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 94%, Morocco 6%
• Founded year: 2005
• Headcount: 51-200
• LinkedIn: sigmapharm-laboratories

Sigmapharm Laboratories, LLC, based in Bensalem, Pennsylvania, is a private pharmaceutical company that specializes in the development, manufacturing, and marketing of unique generic and branded drug products. Founded in 2005, Sigmapharm has carved out a niche in the pharmaceutical industry by focusing on innovative technologies that address complex drug formulation challenges. The company operates state-of-the-art facilities equipped for research and development, analytical chemistry, and manufacturing. Sigmapharm's product portfolio includes a range of generic medications, often with minimal competition, and they have successfully navigated the regulatory landscape to achieve FDA approvals for their products. Their proprietary technologies enhance drug solubility, bioavailability, and stability, allowing them to create formulations that are often unmatched by competitors. With a dedicated team of professionals and a commitment to quality, Sigmapharm continues to serve healthcare providers and patients with effective treatment options.

4. KVK Tech, Inc.

• Website: kvktech.com
• Ownership type: Private
• Headquarters: Newtown, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2004
• Headcount: 501-1000
• LinkedIn: kvk-tech-inc-

KVK Tech, Inc., founded in 2004 and based in Newtown, Pennsylvania, is a pharmaceutical manufacturer that focuses on the development and production of FDA-approved generic and specialty brand medications. The company is dedicated to providing affordable alternatives to high-cost brand medicines, serving pharmacies, healthcare providers, and patients. KVK Tech operates its manufacturing facilities in the United States, ensuring compliance with FDA, DEA, and DEP guidelines. The company prides itself on its commitment to quality and customer service, which is reflected in its operations and product offerings. KVK Tech is also expanding its capabilities, with plans for a new sterile injectable plant and ongoing investments in research and development to enhance its product portfolio. This strategic focus positions KVK Tech as a relevant player in the pharmaceutical manufacturing sector, addressing the challenges of today's healthcare system.

5. Particle Sciences, A Lubrizol Life Science Company

• Website: particlesciences.com
• Ownership type: Corporate
• Headquarters: Bethlehem, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: December 2023
• Founded year: 1991
• Headcount: 51-200
• LinkedIn: particlesciencesinc

Particle Sciences, A Lubrizol Life Science Company, is a pharmaceutical contract development and manufacturing organization (CDMO) based in Bethlehem, Pennsylvania. Founded in 1991, the company has built a reputation for its expertise in various aspects of drug development, including active pharmaceutical ingredient (API) development, drug product formulation, and cGMP manufacturing. They provide services that support both clinical trials and commercial production, ensuring compliance with regulatory standards. Particle Sciences focuses on delivering tailored solutions to pharmaceutical clients, helping them navigate the complexities of drug development from preclinical stages to market readiness. Their capabilities include handling high-potency APIs, sterile products, and complex formulations, making them a valuable partner in the pharmaceutical industry.

6. M8 Pharmaceuticals, Inc

• Website: m8pharmaceuticals.com
• Ownership type: Private
• Headquarters: Berwyn, Pennsylvania, United States (USA)
• Employee distribution: Mexico 59%, Brazil 39%, Other 1%
• Latest funding: $125.0M, February 2019
• Founded year: 2007
• Headcount: 201-500
• LinkedIn: moksha8

M8 Pharmaceuticals, Inc., based in Berwyn, Pennsylvania, is a biopharmaceutical company established in 2007. The company specializes in licensing, marketing, and distributing innovative therapeutics across Latin America, with a strong focus on addressing critical health needs in the region. M8 collaborates with global pharmaceutical firms to ensure that healthcare providers and patients have access to essential medications. Their portfolio includes therapeutic areas such as central nervous system disorders, cardiometabolism, respiratory issues, gastroenterology, oncology, and rare diseases. M8 has a significant presence in Mexico and Brazil, where they have established a robust network to facilitate the commercialization of their products. In 2019, M8 Pharmaceuticals secured $125 million in funding, which underscores investor confidence in their business model and growth potential. The company continues to expand its reach and capabilities, particularly following its acquisition by Acino, which enhances its operational strength in the Latin American market.

7. Virtus Pharmaceuticals

• Website: virtusrx.com
• Ownership type: Private Equity
• Headquarters: Langhorne, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Debt), December 2019
• Founded year: 2011
• Headcount: 11-50
• LinkedIn: virtus-pharmaceuticals

Virtus Pharmaceuticals, based in Langhorne, Pennsylvania, is a healthcare company that specializes in delivering innovative pharmaceutical products aimed at improving patient health. Founded in 2011, the company operates with a small team of 11-50 employees, focusing on serving independent pharmacies and drug chains. This strategic focus ensures that unique medicines are accessible to patients who need them. Virtus emphasizes quality and safety in its operations, collaborating with various partners to enhance the healthcare market. Their commitment to pharmacovigilance ensures that only the highest quality products reach customers, reflecting their dedication to patient safety. The company is actively involved in the pharmaceutical sector, translating scientific advancements into accessible treatments that help patients lead healthier lives. Virtus Pharmaceuticals operates under the umbrella of Acertis Pharmaceuticals, which further strengthens its market presence and operational capabilities.

8. Genus Lifesciences Inc.

• Website: genuslifesciences.com
• Ownership type: Private
• Headquarters: Allentown, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1999
• Headcount: 51-200
• LinkedIn: genus-lifesciences-inc

Genus Lifesciences Inc., founded in 1999 and based in Allentown, Pennsylvania, is a pharmaceutical manufacturer that specializes in both branded and generic drugs. The company is dedicated to obtaining FDA approvals for drugs that were previously marketed without the necessary regulatory oversight. This commitment not only addresses safety and efficacy concerns but also aligns with the industry's push for compliance with modern standards. Genus Lifesciences employs a team of over 150 professionals who are involved in various phases of pharmaceutical operations, from research and development to manufacturing and quality assurance. Their product offerings include a range of oral solutions, tablets, and creams, which are distributed to pharmacies, hospitals, and other healthcare providers throughout the United States. The company also emphasizes Good Manufacturing Practices (GMPs) to ensure high-quality production processes. With ongoing research efforts and a pipeline of new products, Genus Lifesciences is positioned to contribute to the pharmaceutical landscape effectively.

9. Tavotek Biotherapeutics

• Website: tavotek.com
• Ownership type: Corporate
• Headquarters: Lower Gwynedd Township, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 68%, China 32%
• Latest funding: Series B, $35.0M, November 2021
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: tavotek

Tavotek Biotherapeutics, founded in 2019 and based in Lower Gwynedd Township, Pennsylvania, is a biopharmaceutical company dedicated to discovering, developing, and commercializing therapeutic medicines for patients with serious diseases. The company focuses on conditions with significant unmet medical needs, including various cancers and autoimmune disorders. Tavotek operates through advanced research and development platforms, including TavoSelect™, TavoPrecise™, and TavoELITE™, which are designed to enhance drug discovery and development processes. With a team comprised of experienced professionals from major pharmaceutical companies, Tavotek is well-positioned to leverage its expertise in biologics. The company has received substantial funding, totaling $35 million in its Series B round in November 2021, which supports its ongoing research initiatives and clinical trials. Tavotek's active engagement in clinical trials, such as the recent Phase 1 trial for TAVO412, underscores its commitment to advancing new treatment options in the pharmaceutical industry.

10. Penn Life Sciences

• Website: pennlifesciences.com
• Ownership type: Private
• Headquarters: Langhorne, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2004
• Headcount: 51-200
• LinkedIn: pennlifesciences

Penn Life Sciences, founded in 2004 and based in Langhorne, Pennsylvania, is a private pharmaceutical manufacturer dedicated to addressing significant drug shortages in the United States. The company specializes in the development and production of FDA-approved medicines, focusing on high-quality and affordable alternatives to meet the needs of healthcare providers and organizations. Their operations include a robust CDMO partnership, which allows them to collaborate effectively in pharmaceutical manufacturing. With a facility designed to exceed industry standards, Penn Life Sciences is equipped to produce a substantial volume of sterile drug products, thereby contributing to alleviating domestic drug shortages. The company prides itself on its commitment to quality, affordability, and integrity, ensuring that all products are manufactured in compliance with stringent regulatory guidelines. Their mission reflects a proactive stance in advancing medical care while maintaining a focus on ethical business practices.

11. Colorcon

• Website: colorcon.com
• Ownership type: Private
• Headquarters: Harleysville, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 30%, United Kingdom (UK) 18%, India 17%, Other 36%
• Founded year: 1961
• Headcount: 1001-5000
• LinkedIn: colorcon

Colorcon, established in 1961 and based in Harleysville, Pennsylvania, is a private company that specializes in the design and development of specialty excipients and functional packaging for the pharmaceutical and nutritional industries. With a workforce of over 1,150 employees, Colorcon operates globally, with a notable presence in the United States, United Kingdom, India, Brazil, and France. The company provides a wide array of products, including film coatings and formulation development assistance, aimed at enhancing patient compliance and product stability. Their solutions are tailored to meet the unique challenges faced by pharmaceutical manufacturers, helping to streamline processes and improve overall efficiency. Colorcon's commitment to innovation is evident in their technical service teams, which support clients from product concept through to commercialization, ensuring that their offerings remain relevant and effective in a competitive market.

12. Venatorx Pharmaceuticals, Inc.

• Website: venatorx.com
• Ownership type: Venture Capital
• Headquarters: Malvern, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $24.7M, September 2022
• Founded year: 2010
• Headcount: 51-200
• LinkedIn: venatorx-pharmaceuticals-inc.

Venatorx Pharmaceuticals, Inc. is a pharmaceutical company based in Malvern, Pennsylvania, founded in 2010. The company specializes in the discovery and development of novel anti-infectives aimed at treating multi-drug-resistant bacterial infections and hard-to-treat viral infections. Venatorx operates through a dedicated research and development framework, which has led to the filing of over 120 patents. Their lead product, cefepime-taniborbactam, is currently under FDA review following successful Phase 3 trials for complicated urinary tract infections. The company has also secured significant funding, including a $24.7 million round in 2022, and has been awarded contracts from BARDA to support the development of its therapies. Venatorx's commitment to combating antibiotic resistance and its innovative approach to drug development position it as a noteworthy entity in the pharmaceutical industry.

13. Spark Therapeutics, Inc.

• Website: sparktx.com
• Ownership type: Corporate
• Headquarters: Philadelphia, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $4.3B, February 2019
• Founded year: 2013
• Headcount: 501-1000
• LinkedIn: spark-therapeutics-inc

Spark Therapeutics, Inc., founded in 2013 and headquartered in Philadelphia, Pennsylvania, is a biotechnology company dedicated to advancing gene therapy for genetic diseases. The company emerged from two decades of research at the Children's Hospital of Philadelphia, aiming to transform patient care through innovative therapies. Spark Therapeutics is particularly known for its work on hemophilia and inherited retinal diseases, where traditional treatment options have been limited. Their flagship product, Luxturna, represents a significant milestone as the first approved gene therapy for a genetic disease in both the U.S. and Europe. With a workforce of approximately 847 employees, Spark is committed to developing therapies that offer long-lasting effects for patients. The company has also secured substantial funding, amounting to $4.3 billion, which underscores investor confidence in their mission and capabilities. Their upcoming Gene Therapy Innovation Center will further enhance their manufacturing capabilities, positioning them as a key player in the gene therapy space.

14. ARx, LLC

• Website: arxpharma.com
• Ownership type: Private
• Headquarters: Glen Rock, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2005
• Headcount: 51-200
• LinkedIn: arx_llc

ARx, LLC, based in Glen Rock, Pennsylvania, is a pharmaceutical manufacturer that specializes in drug delivery systems. Founded in 2005 as a subsidiary of Adhesives Research Inc., the company has carved out a niche in the development and production of oral thin films and transdermal patches. These products are designed to improve patient compliance and therapeutic effectiveness, addressing a critical need in the pharmaceutical market. ARx partners with both generic and branded drug companies, facilitating the creation of FDA-approved products that meet specific therapeutic needs. With a workforce of around 53 employees, ARx has built a reputation for its expertise in drug product development, quality support, and commercial manufacturing. The company has been operational for over 15 years and has successfully launched multiple products, demonstrating its capability and commitment to the pharmaceutical industry.

15. BlueWhale Bio

• Website: bluewhale.bio
• Ownership type: Venture Capital
• Headquarters: Philadelphia, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $18.0M, September 2023
• Founded year: 2022
• Headcount: 11-50
• LinkedIn: bluewhale-bio

BlueWhale Bio, Inc. is a biotechnology firm based in Philadelphia, Pennsylvania, founded in 2022. The company specializes in the development of cell-based and gene therapies, aiming to enhance the manufacturing processes associated with these innovative treatments. With a team led by renowned immunotherapy experts Carl June and James Riley from the University of Pennsylvania, BlueWhale Bio is focused on overcoming key bottlenecks in the production of cell therapies. Their goal is to make these therapies more accessible and effective for patients. Recently, the company secured $18 million in seed funding, which will support their efforts to innovate and improve the manufacturing landscape for cell and gene therapies. BlueWhale Bio's commitment to addressing critical shortcomings in the current treatment paradigm positions them as a relevant player in the pharmaceutical manufacturing industry.

16. Nordic Pharma, Inc.

• Website: nordicpharmausa.com
• Ownership type: Private
• Headquarters: Berwyn, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 85%, Canada 8%, Romania 8%
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: amring-pharmaceuticals-inc-

Nordic Pharma, Inc., based in Berwyn, Pennsylvania, is a pharmaceutical company that specializes in the development and distribution of generic medications. Founded in 2014, the company aims to provide safe, reliable, and affordable drugs to healthcare providers, pharmacies, and hospitals. Their operations include manufacturing and supplying a range of generic pharmaceuticals, with a focus on filling niche markets where few generics are available. Nordic Pharma is committed to promoting health across communities by enhancing the quality of life through accessible medications. The company operates with a vertically integrated supply chain, allowing for oversight of manufacturing and sourcing. Their product portfolio includes various generics, such as Lamotrigine Orally Disintegrating Tablets and Timolol Maleate Ophthalmic Solution, which are designed to meet specific market demands. Nordic Pharma's approach emphasizes partnerships with development and supply chain partners who share their commitment to quality and value.

17. Braeburn

• Website: braeburnrx.com
• Ownership type: Private
• Headquarters: Plymouth Meeting, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 98%, Other 2%
• Latest funding: Other (Debt), $110.0M, January 2018
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: braeburn

Braeburn is a private pharmaceutical company based in Plymouth Meeting, Pennsylvania, founded in 2012. The company is dedicated to transforming the management of opioid use disorder (OUD), focusing on innovative solutions that improve access to treatment and reduce stigma associated with the condition. Braeburn collaborates closely with healthcare providers and community organizations to support individuals affected by OUD. Their flagship product, BRIXADI, is designed to assist in the treatment of this chronic condition. With a workforce of approximately 227 employees, Braeburn has also secured significant funding, totaling $110 million as of January 2018, to support its initiatives. The company actively engages in research and development, seeking partnerships to address unmet needs in the market, particularly in the area of opioid addiction treatment.

18. Duchesnay USA

• Website: duchesnayusa.com
• Ownership type: Family Owned
• Headquarters: Rosemont, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: info-duchesnayusa-com

Duchesnay USA is a family-owned pharmaceutical company based in Princeton, New Jersey, dedicated to improving women's health. Founded in 2012, the company is a member of the Duchesnay Pharmaceutical Group, which has a history dating back to 1970 in Canada. Duchesnay USA focuses on providing safe and effective therapeutic options for women, particularly during pregnancy and menopause. Their product portfolio includes Bonjesta®, Osphena®, and Diclegis®, which address specific health needs related to obstetrics and gynecology. The company emphasizes high standards of product quality and has a commitment to reshoring and nearshoring to ensure the accessibility of their medications. With a strong focus on innovation and collaboration, Duchesnay USA aims to enhance the quality of life for women at every stage of their lives.

19. Adare Pharma Solutions

• Website: adarepharmasolutions.com
• Ownership type: Private Equity
• Headquarters: Philadelphia, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 59%, Italy 36%, Other 6%
• Latest funding: September 2020
• Founded year: 2015
• Headcount: 501-1000
• LinkedIn: adare-pharmaceuticals

Adare Pharma Solutions is a private equity-backed Contract Development and Manufacturing Organization (CDMO) based in Philadelphia, Pennsylvania. Founded in 2015, the company has quickly established itself as a key player in the pharmaceutical industry, focusing on the development and manufacturing of oral dosage forms. Adare offers a wide range of services, including formulation development, specialized drug delivery technologies, and analytical services. Their expertise extends to areas such as taste masking, controlled release, and solubility enhancement, which are critical for improving patient adherence and therapeutic outcomes. With a global footprint that includes facilities in the United States and Italy, Adare is equipped to support pharmaceutical companies through all stages of product development, from early-stage research to commercial-scale manufacturing. The company has a proven track record, having successfully launched numerous products that are now available in international markets.

20. Aqua Pharmaceuticals, an Almirall Company

• Website: aquapharm.com
• Ownership type: Corporate
• Headquarters: Exton, Pennsylvania, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: December 2013
• Founded year: 2004
• Headcount: 51-200
• LinkedIn: aqua-pharmaceuticals

Aqua Pharmaceuticals, an Almirall Company, is a pharmaceutical firm based in Exton, Pennsylvania, established in 2004. The company specializes in dermatology, focusing on the development and manufacturing of innovative prescription medicines aimed at treating various skin conditions. Their product portfolio includes treatments for acne, actinic keratosis, dermatitis, and impetigo, which are trusted by healthcare professionals and patients alike. Aqua Pharmaceuticals operates under the broader umbrella of Almirall, a global dermatology company headquartered in Barcelona, Spain, which enhances its reach and resources. The company is dedicated to improving skin health and quality of life through effective treatments, and it serves healthcare professionals and patients across multiple countries. Aqua Pharmaceuticals has not reported any recent funding, indicating a stable operational model within its niche market.

Pharmaceutical Manufacturing Insights: Key Companies in Pennsylvania

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