Pharmaceutical manufacturing in Indiana focuses on the creation and distribution of medications and therapeutics aimed at improving health outcomes. Companies in this sector range from large established firms to nimble startups, engaging in everything from drug development to contract manufacturing. A commitment to quality compliance and innovation drives the sector forward, with advances in biologics and biotechnology shaping new therapies. Indiana's proximity to academic institutions and research facilities further fosters a robust ecosystem for pharmaceutical advancements, paving the way for significant growth and investment opportunities in the coming years.

The companies featured in this list vary in size—from small startups with fewer than 50 employees to larger firms employing thousands. Operating in key markets like Carmel, Bloomington, and Indianapolis, they were founded between 1931 and 2020. Specializations include contract manufacturing, drug formulation, and biopharmaceutical development. Each company brings unique innovations to the table, contributing to Indiana's reputation as a vital hub for pharmaceutical manufacturing.

Continue reading to learn more about Indiana's pharmaceutical manufacturing companies.

Top 20 Pharmaceutical Manufacturing Companies in Indiana

1. Waterstone Pharmaceuticals, Inc.

• Website: waterstonepharma.com
• Ownership type: Venture Capital
• Headquarters: Carmel, Indiana, United States (USA)
• Employee distribution: China 100%
• Latest funding: Other (Debt), $19.0M, September 2012
• Founded year: 2008
• Headcount: 501-1000
• LinkedIn: waterstone-pharmaceuticals-inc.

Waterstone Pharmaceuticals, Inc., founded in 2008 and based in Carmel, Indiana, is a pharmaceutical company dedicated to the research and production of medications targeting metabolic diseases, including diabetes and kidney disease. The company serves healthcare providers and pharmaceutical businesses by providing innovative drug solutions and high-quality pharmaceutical products. Waterstone's operations include drug development and manufacturing, with a particular emphasis on high molecular polymer drug intermediates. The company has established a robust production platform, including facilities that meet GMP standards, and has received significant funding, including $19 million in 2012, to support its growth and development initiatives. Waterstone's commitment to addressing critical health issues through its specialized focus on metabolic diseases underscores its relevance in the pharmaceutical manufacturing sector.

2. Baxter Pharmaceutical Solutions LLC.

• Website: baxterbiopharmasolutions.com
• Ownership type: Private
• Headquarters: Bloomington, Indiana, United States (USA)
• Founded year: 1931
• Headcount: 1001-5000
• LinkedIn: indiana-metal-craft

Baxter Pharmaceutical Solutions LLC, also known as Simtra BioPharma Solutions, is a contract development and manufacturing organization based in Bloomington, Indiana. Founded in 1931, the company has built a reputation for its expertise in the pharmaceutical and biopharmaceutical sectors. Simtra specializes in the development and manufacturing of sterile injectable products, offering a comprehensive range of services that include formulation development, lyophilization cycle optimization, and fill/finish operations. Their facilities in Bloomington and Halle/Westfalen, Germany, are compliant with current Good Manufacturing Practices (cGMP) and ISO 14001-certified, ensuring high-quality production standards. The company serves a global clientele, providing critical support to pharmaceutical companies in meeting regulatory requirements and delivering life-saving medications to patients. Simtra's commitment to quality and innovation is evident in their ongoing investments in facility expansion and technological advancements, which enhance their manufacturing capabilities.

3. Applied Laboratories, Inc.

• Website: appliedlabs.com
• Ownership type: Private
• Headquarters: Columbus, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1984
• Headcount: 51-200
• LinkedIn: applied-laboratories-inc.

Applied Laboratories, Inc., based in Columbus, Indiana, is a private contract manufacturer that has been serving the pharmaceutical and healthcare industries since its inception in 1984. Initially established as a regulatory consulting firm specializing in FDA submissions, the company has expanded its capabilities to include comprehensive contract manufacturing and packaging services. With a workforce of approximately 53 employees, Applied Laboratories operates a 200,000 square foot facility designed to meet Good Manufacturing Practices (cGMP) standards. Their services range from product formulation and quality control to innovative packaging solutions for liquids, creams, gels, and ointments. The company is registered with the FDA as both a drug and medical device manufacturing site, ensuring compliance with stringent regulatory requirements. Their commitment to quality and customer service is evident in their approach to continuous improvement and customer satisfaction, making them a reliable partner for pharmaceutical companies looking to bring products to market.

4. Sudo Biosciences

• Website: sudobio.com
• Ownership type: Private Equity
• Headquarters: Carmel, Indiana, United States (USA)
• Employee distribution: United States (USA) 50%, United Kingdom (UK) 50%
• Latest funding: Series B, $30.0M, February 2024
• Founded year: 2020
• Headcount: 11-50
• LinkedIn: sudo-biosciences

Sudo Biosciences is a biopharmaceutical company based in Carmel, Indiana, established in 2020. The company is dedicated to designing and developing novel medicines, specifically targeting the tyrosine kinase 2 (TYK2) pseudokinase domain. This focus is particularly relevant for treating a range of immune-mediated inflammatory conditions, including multiple sclerosis and various dermatologic diseases. Sudo's pipeline includes promising candidates that are expected to enter clinical trials in 2024. The company has successfully raised $147 million in Series B financing, which will support the advancement of their TYK2 inhibitors into clinical settings. With a team of experienced professionals from notable pharmaceutical backgrounds, Sudo aims to transform patient care through innovative therapeutics.

5. Exelead

• Website: exeleadbiopharma.com
• Ownership type: Corporate
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $780.0M, January 2022
• Founded year: 2017
• Headcount: 201-500
• LinkedIn: exelead

Exelead, founded in 2017 and based in Indianapolis, Indiana, is a contract pharmaceutical manufacturer that specializes in lipid nanoparticles, liposomes, and pegylation formulations. The company supports pharmaceutical and biotech firms by offering a range of services that span from preclinical development to commercial manufacturing. Exelead's facilities are equipped to handle both small and large batch sizes, catering to the needs of clients at various stages of drug development. Their expertise in complex formulations positions them as a valuable partner for companies focused on innovative therapies. In January 2022, Exelead secured $780 million in funding, reflecting strong market confidence in their capabilities and growth potential. This financial backing enables them to enhance their manufacturing processes and expand their service offerings, further solidifying their role in the pharmaceutical industry.

6. Singota Solutions

• Website: singota.com
• Ownership type: Private
• Headquarters: Bloomington, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2006
• Headcount: 51-200
• LinkedIn: singota-solutions

Singota Solutions, based in Bloomington, Indiana, is a contract development and manufacturing organization (CDMO) that provides a range of services tailored to the pharmaceutical and biotechnology sectors. Founded in 2006, the company has evolved from its original identity as BioConvergence LLC to focus on expediting the drug development process. Singota specializes in drug formulation development, testing, aseptic filling, and supply chain management. Their state-of-the-art facilities support small batch aseptic filling and cold chain pharmaceutical storage, ensuring compliance with stringent regulatory standards. Singota's commitment to transparency and collaboration is evident in their E-Transparency system, which allows clients to access project data securely. The company has built a reputation for reliability and innovation, making it a valuable partner for clients navigating the complexities of drug development.

7. Toralgen

• Website: toralgen.com
• Ownership type: Venture Capital
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $8.3M, December 2020
• Founded year: 2017
• Headcount: 1-10
• LinkedIn: toralgen

Toralgen, based in Indianapolis, Indiana, is a biotechnology company that specializes in the development of advanced drug delivery systems. Founded in 2017, the company is in the preclinical stage and is focused on creating oral therapeutics for diabetes and autoimmune disorders. Their proprietary poly-bile nanoparticle platform is designed to improve the oral delivery and absorption of biologics, which traditionally face challenges in oral administration. Toralgen collaborates with pharmaceutical partners to enhance patient compliance and experience, aiming to replace painful injections with easy-to-swallow pills. The company has successfully raised $8.3 million in seed funding, reflecting strong investor interest in their innovative approach. Additionally, they have been recognized as one of the top five emerging drug delivery startups, highlighting their potential impact in the pharmaceutical industry.

8. INCOG BioPharma Services

• Website: incogbiopharma.com
• Ownership type: Venture Capital
• Headquarters: Fishers, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series B, $42.9M, May 2024
• Founded year: 2020
• Headcount: 201-500
• LinkedIn: incog-biopharma

INCOG BioPharma Services, based in Fishers, Indiana, is a contract development and manufacturing organization (CDMO) that specializes in the biopharmaceutical industry. Founded in 2020, the company offers a range of services including formulation, filling, and quality control for injectable drug products. With a focus on providing reliable partnerships for biopharmaceutical companies, INCOG aims to navigate the complexities of drug development and ensure timely market delivery. The company has made significant investments in state-of-the-art facilities and equipment, enhancing its capabilities in sterile injectable manufacturing. Recently, INCOG secured over $42 million in Series B funding, which underscores its growth trajectory and commitment to expanding its operational capacity. Their leadership team boasts extensive experience in the industry, having supported numerous successful drug launches and regulatory approvals. INCOG BioPharma Services is dedicated to improving patient outcomes by delivering high-quality manufacturing solutions tailored to the needs of its clients.

9. Eradivir

• Website: eradivir.com
• Ownership type: Venture Capital
• Headquarters: West Lafayette, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $1.0M, September 2024
• Founded year: 2020
• Headcount: 11-50
• LinkedIn: eradivir

Eradivir is a biotechnology firm based in West Lafayette, Indiana, established in 2020. The company specializes in developing antiviral therapeutics, with a primary focus on influenza and other respiratory infections. Utilizing a unique platform of small molecule immunotherapies, Eradivir aims to enhance the immune system's ability to combat diseases. Their lead molecule, EV25, has shown promise in preclinical studies, outperforming existing treatments for influenza. The company is actively engaged in clinical trials to validate its products and advance its research initiatives. Eradivir has recently completed a $10.25 million Series A funding round, which will support its Phase 2a study of the EV25 treatment. With a dedicated team of industry experts and a commitment to innovation, Eradivir is positioned to make significant contributions to the field of antiviral therapeutics.

10. ParaPRO, LLC

• Website: parapro.com
• Ownership type: Private
• Headquarters: Carmel, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2002
• Headcount: 51-200
• LinkedIn: parapro-llc

ParaPRO, LLC, founded in 2002 and based in Carmel, Indiana, is a specialty pharmaceutical company dedicated to developing and commercializing anti-parasitic therapies. The company has carved out a niche in the treatment of infestations such as head lice and scabies, which affect millions of people annually. Their flagship product, Natroba™ (spinosad) Topical Suspension, received FDA approval in 2011 and has become the most frequently prescribed medication for head lice. ParaPRO's commitment to innovation is evident in their focus on creating effective treatments that tackle the growing issue of resistance to conventional therapies. They collaborate with healthcare providers and organizations to enhance patient outcomes and support families dealing with these infestations. ParaPRO's approach combines scientific rigor with a patient-centered philosophy, aiming to improve the quality of care for those affected by these conditions.

11. BioConvergence LLC

• Website: bioc.us
• Ownership type: Private
• Headquarters: Bloomington, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2005
• Headcount: 51-200
• LinkedIn: bioconvergence-llc

BioConvergence LLC, known as Singota Solutions, is a private company based in Bloomington, Indiana, founded in 2005. It operates as a Contract Development and Manufacturing Organization (CDMO) with a strong emphasis on the pharmaceutical and biotechnology sectors. Singota Solutions provides a comprehensive suite of services that includes aseptic filling, analytical testing, formulation development, and supply chain management. Their expertise lies in supporting small pharmaceutical companies, particularly in the preclinical and clinical phases of drug development. The company is recognized for its advanced aseptic manufacturing capabilities, utilizing state-of-the-art technology to ensure high standards of safety and efficacy. Singota Solutions has built a reputation for its agile and customer-centric approach, allowing clients to navigate the complexities of drug development more effectively. They maintain a GMP-compliant facility and are committed to delivering quality services tailored to the specific needs of their clients.

12. SpectronRx

• Website: spectronrx.com
• Ownership type: Private
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2004
• Headcount: 51-200
• LinkedIn: spectronrx

SpectronRx, founded in 2004 and based in Indianapolis, Indiana, is a private pharmaceutical company that specializes in radiopharmaceuticals and contract development services. The company offers a comprehensive suite of solutions for drug development, including regulatory assistance and isotope procurement. Their services cater to pharmaceutical companies and research organizations, ensuring compliance with regulatory standards and facilitating the timely delivery of critical medical products. With a team of experts, including multiple PhDs in radiochemistry, SpectronRx is well-equipped to handle complex projects in the field of nuclear medicine. They have established a strong reputation for their capabilities in monoclonal antibody, nanobody, and peptide labeling, as well as their logistics expertise in managing the cold chain for drug delivery. SpectronRx operates multiple facilities and is actively expanding its operations to meet the growing demand for radiopharmaceuticals and theranostics.

13. Sentry BioPharma Services, Inc.

• Website: sentrybps.com
• Ownership type: Private
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2006
• Headcount: 51-200
• LinkedIn: sentry-biopharma-services-inc-

Sentry BioPharma Services, Inc., founded in 2006 and based in Indianapolis, Indiana, operates as a biopharmaceutical service provider. The company specializes in pharmaceutical storage, distribution, and packaging solutions tailored for biotech and pharmaceutical firms. Sentry offers a range of services, including controlled temperature management, quality assurance, and clinical trial support. Their expertise in handling temperature-sensitive products ensures compliance with stringent regulatory requirements, safeguarding the integrity of pharmaceuticals throughout the supply chain. Sentry's facility is recognized for its adherence to Good Manufacturing Practices (cGMP) and is accredited by the National Association of Boards of Pharmacy (NABP). With a global footprint, Sentry has successfully managed over 40,000 shipments across more than 40 countries, demonstrating their capability in international drug distribution. Their commitment to quality and customer service positions them as a reliable partner for life science organizations.

14. Genezen

• Website: genezen.com
• Ownership type: Private Equity
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $18.5M, November 2023
• Founded year: 2014
• Headcount: 51-200
• LinkedIn: genezen-laboratories

Genezen, founded in 2014 and based in Indianapolis, Indiana, is a biotechnology company that specializes in contract development and manufacturing organization (CDMO) services for gene and cell therapies. The company focuses on the production of viral vectors, including lentivirus, retrovirus, and adeno-associated virus, which are critical components in the development of advanced therapies. Genezen's state-of-the-art facility is designed to meet stringent quality standards, ensuring compliance with both FDA and EMA regulations. Their commitment to quality is reflected in their robust quality management system and dedicated quality assurance team. In November 2023, Genezen secured $18.5 million in funding, which underscores their growth trajectory and the increasing demand for their services in the biotechnology and pharmaceutical sectors. By providing comprehensive support from pre-clinical research to commercial manufacturing, Genezen plays a vital role in accelerating the development of innovative therapies that aim to improve patient outcomes.

15. IntegriMedical

• Website: integrimedical.com
• Ownership type: Private
• Headquarters: Bainbridge, Indiana, United States (USA)
• Employee distribution: India 100%
• Latest funding: May 2024
• Founded year: 2020
• Headcount: 51-200
• LinkedIn: integrimedical-llc

IntegriMedical is a private medical technology company based in Bainbridge, Indiana, founded in 2020. The company focuses on developing innovative drug delivery solutions, with a particular emphasis on its Needle Free Injection System (NFIS). This system aims to enhance patient comfort and compliance while minimizing the risks associated with traditional needle injections. IntegriMedical's primary customers include healthcare professionals and institutions that seek effective and safe methods for medication administration. The company operates globally, with manufacturing and research facilities in the USA, India, Hong Kong, and Hungary. IntegriMedical is committed to quality and regulatory compliance, holding certifications such as CE, MDSAP, CDSCO, and ISO 13485. Their NFIS has undergone clinical trials, demonstrating its effectiveness in reducing pain and improving the injection experience for patients, particularly children and those with needle phobia.

16. Efp, LLC.

• Website: efppackaging.com
• Ownership type: Private
• Headquarters: Elkhart, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1954
• Headcount: 201-500
• LinkedIn: efp-corporation

Efp, LLC. is a manufacturing company based in Elkhart, Indiana, established in 1954. The company specializes in protective packaging and cold chain solutions, providing a range of products that include temperature-controlled shipping solutions and molded packaging materials. Efp primarily serves the pharmaceutical, medical device, and food industries, ensuring that temperature-sensitive products are delivered safely and efficiently. With multiple facilities across the United States, Efp is well-positioned to meet the logistical demands of its clients. The company has developed a strong reputation for its innovative approach to packaging design and its commitment to sustainability, making it a key player in the packaging sector for pharmaceuticals. Efp's services include consultation, design, and testing, which are essential for maintaining compliance with industry regulations. Their focus on quality and customer service has allowed them to build lasting relationships with businesses that rely on their expertise in cold chain logistics.

17. Efp, LLC.

• Website: efpcorp.com
• Ownership type: Private
• Headquarters: Elkhart, Indiana, United States (USA)
• Founded year: 1954
• Headcount: 201-500
• LinkedIn: efp-corporation

Efp, LLC., based in Elkhart, Indiana, has been operational since 1954. The company specializes in protective packaging and cold chain solutions, catering to various industries, including pharmaceuticals and food. Efp is committed to ensuring that products maintain their integrity during transit, which is particularly vital for temperature-sensitive pharmaceuticals. They offer a range of innovative packaging products and services, including consultation and design, to meet the specific needs of their clients. Efp operates multiple manufacturing facilities across the United States, emphasizing sustainability and quality in their operations. Their cold chain solutions, such as the PharmaTuff line, are designed to meet the stringent requirements of pharmaceutical shipping, ensuring compliance with industry standards. Efp's involvement in the pharmaceutical sector is significant, as they provide the necessary packaging solutions that support the safe delivery of pharmaceutical products.

18. B2S Life Sciences

• Website: b2slifesciences.com
• Ownership type: Private
• Headquarters: Franklin, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: b2slifesciences

B2S Life Sciences, based in Franklin, Indiana, is a biotechnology firm founded in 2014. The company focuses on biotherapeutic enablement, providing custom reagent products and services tailored to the needs of clients in the pharmaceutical and biotechnology sectors. Their offerings include assay development, life cycle management, and data analytics, which are essential for ensuring compliance and efficiency in the drug development process. B2S Life Sciences operates as a contract research organization (CRO), emphasizing the generation and management of critical reagents that support regulated bioanalysis and drug development. Their team comprises experienced professionals with extensive backgrounds in drug development and bioanalytical methods, allowing them to assist clients from late-phase discovery through to regulatory submissions. B2S Life Sciences has not reported any funding, indicating a self-sustained operational model.

19. Schaefer Technologies, INC

• Website: schaefer-technologies.net
• Ownership type: Private
• Headquarters: Indianapolis, Indiana, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1932
• Headcount: 51-200
• LinkedIn: schaefer-technologies-inc

Schaefer Technologies, INC, based in Indianapolis, Indiana, has been a prominent machinery manufacturer since its founding in 1932. The company specializes in capsule filling equipment tailored for the pharmaceutical, nutraceutical, and cannabis industries. With a workforce of 51-200 employees, Schaefer Technologies offers a range of products including softgel equipment, capsule filling machines for both powder and liquid, and capsule banding solutions. Their services extend beyond manufacturing, providing engineering support, equipment validation, and maintenance plans to ensure operational efficiency and compliance with good manufacturing practices. Schaefer Technologies has built a reputation for quality and reliability, serving clients with a commitment to customer support and technical expertise. Their machinery is designed to meet the specific needs of pharmaceutical production, making them a valuable partner in the industry.

20. Inotiv

• Website: inotiv.com
• Ownership type: Private
• Headquarters: West Lafayette, Indiana, United States (USA)
• Employee distribution: United States (USA) 96%, United Kingdom (UK) 2%, Other 2%
• Founded year: 1974
• Headcount: 1001-5000
• LinkedIn: inotiv

Inotiv, based in West Lafayette, Indiana, is a contract research organization founded in 1974. The company employs approximately 1,757 individuals and operates primarily in the United States, with a small presence in the UK and other regions. Inotiv specializes in life sciences, offering a comprehensive suite of services that includes drug metabolism, pharmacokinetics, toxicology assessments, and research models. Their expertise is crucial for pharmaceutical and biotech companies, as well as government agencies and academic institutions, in navigating the complexities of drug discovery and development. Inotiv's services support clients through various phases of research, from discovery to preclinical and clinical development, ensuring that safety and efficacy are thoroughly evaluated. Their commitment to high-quality data and regulatory compliance underpins their reputation in the industry.

Pharmaceutical Manufacturing Insights: Key Companies in Indiana

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