The biomedical engineering industry in California thrives on innovation, integrating engineering principles with biological sciences to create solutions that enhance healthcare. Companies span from large diagnostics firms to nimble startups, each aiming to address unique medical challenges through cutting-edge products. Today, the focus is on developing tools that provide faster diagnostics, improved treatment options, and enhanced patient monitoring systems. As the demand for smarter healthcare solutions grows, the industry is expected to accelerate, with a push toward integrating artificial intelligence and machine learning to revolutionize medical device applications. Education and startup incubators are also propelling growth within this space.

The companies listed here illustrate California's biomedical engineering sector, representing various stages of growth from startups to mature enterprises. With headquarters in cities such as Brea, Alameda, and San Francisco, these firms were founded between 1935 and 2019, showcasing a mixture of stability and new thinking. Specializations include diagnostics, medical devices, and therapeutic solutions, with sizes varying from small teams to those boasting over 10,000 employees. This spectrum reflects a collaborative ecosystem, rich in technological advancements and innovative medical solutions, tailored for evolving healthcare needs.

Read on to discover the top biomedical engineering companies in California.

Top 20 Biomedical Engineering Companies in California

1. Beckman Coulter Diagnostics

• Website: beckmancoulter.com
• Ownership type: Corporate
• Headquarters: Brea, California, United States (USA)
• Employee distribution: United States (USA) 45%, India 12%, China 5%, Other 39%
• Latest funding: $6.8B, February 2011
• Founded year: 1935
• Headcount: 10001+
• LinkedIn: beckman-coulter

Beckman Coulter Diagnostics, based in Brea, California, is a prominent player in the diagnostic solutions sector. Founded in 1935, the company has built a reputation for developing and manufacturing biomedical testing products that serve clinical laboratories and healthcare organizations. Their product portfolio includes a wide array of diagnostic instruments and automation systems designed to improve laboratory efficiency and enhance patient care. Beckman Coulter is dedicated to innovation, striving to connect clinical research with practical care delivery. Their focus on areas such as chemistry, immunoassay, hematology, and microbiology reflects their commitment to addressing critical healthcare needs. The company employs over 11,000 individuals globally, with a significant presence in the United States, India, and China, indicating their operational scale and international reach. Beckman Coulter's ongoing efforts to provide comprehensive diagnostic solutions position them as a vital entity in the biomedical engineering landscape.

2. iota Biosciences, Inc. powered by Astellas

• Website: iota.bio
• Ownership type: Corporate
• Headquarters: Alameda, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $127.5M, October 2020
• Founded year: 2017
• Headcount: 51-200
• LinkedIn: iota-biosciences

iota Biosciences, Inc. powered by Astellas is a bioelectronics company based in Alameda, California, founded in 2017. The company is dedicated to developing innovative diagnostic and therapeutic devices that aim to enhance patient care and transform disease management. iota Biosciences builds on award-winning ultrasound technology from the University of California, Berkeley, and is committed to creating state-of-the-art bioelectronic devices that are both safe and effective. Their technology focuses on wireless communication with custom implantable medical devices, which could revolutionize treatment options for conditions that are currently difficult to manage. iota is exploring applications in various medical fields, including bladder disorders, autoimmune diseases, cancer, and neural disorders. The company has received significant funding, amounting to $127.5 million in 2020, which underscores its potential for growth and innovation in the biomedical engineering sector.

3. Theranova, LLC

• Website: theranova.com
• Ownership type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: July 2016
• Founded year: 2006
• Headcount: 11-50
• LinkedIn: theranova-llc

Theranova, LLC, based in San Francisco, California, is a medical device development firm that specializes in guiding medical devices from initial concept through clinical trials and into commercialization. Founded in 2006, the company operates as a venture studio and incubator, focusing on innovative solutions that aim to enhance patient outcomes, expand healthcare access, and lower costs for patients and payers. Theranova has successfully spun out 20 companies and has raised over $35 million from government grants, alongside securing more than $400 million for its portfolio companies. The firm has achieved 12 regulatory clearances and approvals from the FDA, filed over 120 patents, and conducted more than 30 clinical trials, showcasing its active involvement in the biomedical engineering field.

4. NOVO Engineering, Inc.

• Website: novoengineering.com
• Ownership type: Private
• Headquarters: Vista, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2004
• Headcount: 51-200
• LinkedIn: novo-engineering

NOVO Engineering, Inc., based in Vista, California, is a private company founded in 2004 that specializes in engineering services and product development. With a workforce of approximately 51-200 employees, NOVO focuses on medical device development, biotech instruments, and custom automation solutions. Their clientele primarily consists of businesses in the medical and biotech sectors, seeking expert assistance to bring innovative products to market. The company operates under an ISO-certified quality system, ensuring high standards in project deliverables. NOVO's engineering team has a proven track record of developing a wide range of medical devices, including on-body injectors, insulin pumps, and continuous glucose monitoring systems. Their capabilities extend to hardware and software development, systems engineering, and pre-production manufacturing, making them a valuable partner for companies looking to navigate the complexities of product development in the biomedical field.

5. gener8

• Website: gener8.net
• Ownership type: Private Equity
• Headquarters: San Jose, California, United States (USA)
• Employee distribution: United States (USA) 84%, Costa Rica 16%
• Latest funding: August 2018
• Founded year: 2002
• Headcount: 201-500
• LinkedIn: gener8-inc-

Gener8 is an engineering and product design firm based in San Jose, California, founded in 2002. The company specializes in providing comprehensive engineering services, including product development, prototyping, and manufacturing, specifically for clients in the biotechnology, life sciences, and medical device sectors. Gener8 has completed thousands of projects, focusing on the commercialization of complex instruments and consumables. Their expertise spans various areas, including instrument design, software development, and quality and regulatory services. Gener8 has worked with a range of clients, from startups to established medical device manufacturers, helping them navigate the challenges of bringing innovative products from concept to market. The firm prides itself on delivering tailored solutions that meet the unique needs of each client, ensuring high-quality results that align with industry standards.

6. Paramit

• Website: paramit.com
• Ownership type: Corporate
• Headquarters: Morgan Hill, California, United States (USA)
• Latest funding: $1.0B, June 2021
• Founded year: 1990
• Headcount: 201-500
• LinkedIn: paramit-corporation

Paramit, based in Morgan Hill, California, is a medical device manufacturer that specializes in electronics-based medical devices and life science instruments. Founded in 1990, the company has built a reputation for providing comprehensive services that span the entire product lifecycle, from initial product development to high-quality manufacturing. With facilities in Silicon Valley and Malaysia, Paramit is well-equipped to meet the demands of both U.S. and global markets. The company is ISO 13485 certified, ensuring adherence to strict regulatory standards essential for medical device production. Paramit collaborates closely with clients to navigate the complexities of the medical device industry, offering expertise in areas such as mechatronics, optics, and robotics. Their innovative manufacturing processes, including the vPoke mechanical assembly, highlight their commitment to precision and quality. As part of the Tecan Group, Paramit benefits from enhanced resources and a broader engineering talent pool, further solidifying its position in the biomedical engineering field.

7. Flex Partners INC.

• Website: flex-partners.com
• Ownership type: Private
• Headquarters: Solana Beach, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1995
• Headcount: 1-10
• LinkedIn: flex-partners-inc.

Flex Partners INC., based in Solana Beach, California, is a private medical device development firm established in 1995. The company specializes in the design and engineering of medical instruments, offering a comprehensive suite of services that includes prototyping, product testing, and business development. With a team that collectively holds over 150 years of experience in the medical device industry, Flex Partners assists both established companies and startups in navigating the complexities of product commercialization. They have developed a wide range of medical devices, from intravenous infusion systems to cardiovascular implants, and have been awarded numerous patents, reflecting their innovative approach. Flex Partners positions itself as a trusted outsourcing partner or a virtual engineering department, providing essential support to clients in achieving their product development goals.

8. Stellartech Research Corporation

• Website: stellartec.com
• Ownership type: Private
• Headquarters: Milpitas, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1988
• Headcount: 51-200
• LinkedIn: stellartech-research

Stellartech Research Corporation, founded in 1988 and based in Milpitas, California, is a private medical device manufacturer. The company specializes in the design, development, and contract manufacturing of advanced medical systems that utilize radiofrequency, ultrasound, and other energy sources. Stellartech serves healthcare professionals and medical device companies by providing innovative solutions for energy-based therapies. Their product portfolio includes a range of devices for various medical applications, such as cardiac ablation, uterine lining ablation, and nerve stimulation. With a state-of-the-art facility and a team of experts, Stellartech collaborates with partners to bring new medical technologies to market. The company has a strong reputation for its expertise in energy delivery systems and has been involved in the development of numerous firsts in the medical device industry. Stellartech operates under a rigorous quality management system, ensuring compliance with industry standards for Class II and Class III medical devices.

9. Shifamed

• Website: shifamed.com
• Ownership type: Private
• Headquarters: Campbell, California, United States (USA)
• Employee distribution: United States (USA) 85%, Pakistan 5%, Ukraine 3%, Other 6%
• Founded year: 2008
• Headcount: 201-500
• LinkedIn: shifamed

Shifamed is a private medical technology company based in Campbell, California, founded in 2008. It operates as an innovation hub, dedicated to developing next-generation medical products that enhance clinical standards and improve patient lives. The company collaborates with a network of healthcare providers, investors, and manufacturers to tackle pressing clinical challenges through innovative technology. Shifamed's operations include extensive research and development, prototype creation, and comprehensive clinical and regulatory support. They have a structured process that begins with identifying unmet clinical needs and progresses through rigorous evaluation, internal seed funding, prototype development, and market preparation. Shifamed has successfully nurtured several portfolio companies, which have achieved notable milestones in the medical device industry, showcasing their commitment to advancing healthcare solutions.

10. MicroCube

• Website: microcube.org
• Ownership type: Private
• Headquarters: Fremont, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2005
• Headcount: 11-50
• LinkedIn: microcube

MicroCube is a private medical device company based in Fremont, California, founded in 2005. The company specializes in identifying clinical needs and developing innovative technologies to address them. With a team of 11 to 50 employees, MicroCube operates as a self-sufficient entity, managing projects from concept through to regulatory approval. Their in-house capabilities include clinical practice knowledge, design, rapid prototyping, and market mapping, which allows them to efficiently navigate the complexities of medical device development. MicroCube's culture promotes mentorship and growth among its team members, aiming to cultivate the next generation of innovators in the medical device industry. They serve healthcare providers and medical professionals, focusing on delivering turnkey products and procedures for clinical use.

11. InCube Labs

• Website: incubelabs.com
• Ownership type: Private
• Headquarters: San Jose, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: November 2018
• Founded year: 1995
• Headcount: 51-200
• LinkedIn: incube-labs

InCube Labs, founded in 1995 and based in San Jose, California, is a private medical technology company dedicated to developing and commercializing innovative solutions in the life sciences sector. The company focuses on addressing chronic diseases through advanced therapies and medical devices, targeting both healthcare providers and patients. With a multi-disciplinary approach, InCube Labs has successfully created effective treatment options across various therapeutic areas, including urology, gastroenterology, women's health, central nervous system disorders, orthopedics, metabolic diseases, and oncology. The company has established a strong network of resources in clinical, regulatory, and manufacturing disciplines, which supports its portfolio of companies. Notably, InCube Labs has filed over 900 patent applications, showcasing its commitment to innovation and intellectual property development. Their work has led to the formation of several successful companies, such as Rani Therapeutics and SacraMed, which are focused on delivering breakthrough medical solutions. InCube Labs continues to strive for advancements that can significantly enhance patient care and reduce healthcare costs.

12. Synaptic

• Website: synapticmed.com
• Ownership type: Venture Capital
• Headquarters: Carlsbad, California, United States (USA)
• Employee distribution: United States (USA) 73%, China 27%
• Latest funding: Other (Debt), $40.0M, November 2024
• Founded year: 2005
• Headcount: 201-500
• LinkedIn: synaptic-medical-llc

Synaptic Medical, founded in 2005 and based in Carlsbad, California, is a medical device manufacturer that specializes in cardiac electrophysiology products. The company is dedicated to developing innovative solutions aimed at improving treatment outcomes for patients with arrhythmias. Their product line includes advanced cryoablation devices and catheters, which are essential tools for healthcare providers in the management of cardiac conditions. Synaptic's mission emphasizes a holistic approach to healthcare, aiming to positively impact individuals and communities. With a workforce of around 84 employees and a significant portion of their operations in China, Synaptic is positioned to serve a global market. The company recently secured $40 million in funding, indicating strong investor confidence in their growth trajectory and product development.

13. ACI Medical, LLC

• Website: acimedical.com
• Ownership type: Private
• Headquarters: San Marcos, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1984
• Headcount: 11-50
• LinkedIn: aci-medical-llc

ACI Medical, LLC, based in San Marcos, California, is a private medical device manufacturer founded in 1984. The company specializes in non-invasive vascular technologies, developing and selling therapeutic products aimed at patients with various vascular conditions. Their notable product, the ArtAssist® device, is designed to enhance blood flow for individuals suffering from peripheral arterial disease and other related ailments. ACI Medical's offerings also include the FlowDyn™ device for athletes, the APG® Air Plethysmograph for diagnosing chronic venous disease, and the VenaPulse® device for hands-free venous exams. The company prides itself on its commitment to quality and innovation, with a focus on improving patient outcomes through effective treatment options. ACI Medical also provides contract manufacturing services, showcasing their engineering capabilities in producing miniature pumps and custom molding solutions for medical applications.

14. Nventric, Inc.

• Website: nventric.com
• Ownership type: Venture Capital
• Headquarters: Arcadia, California, United States (USA)
• Employee distribution: United States (USA) 88%, South Korea 12%
• Latest funding: Series B, $10.5M, February 2024
• Founded year: 2019
• Headcount: 51-200
• LinkedIn: nventric-inc

Nventric, Inc., founded in 2019 and based in Arcadia, California, is a medical device manufacturer that specializes in creating advanced solutions for vascular diseases. The company is dedicated to developing proprietary products, including catheters, stents, and electrophysiology devices, aimed at improving patient care and treatment methodologies. Nventric collaborates closely with healthcare professionals to ensure that their innovations meet the needs of both patients and physicians. With a strong focus on research and development, the company has secured significant funding, including a recent Series B round totaling over $10 million in February 2024. This financial backing supports their mission to transform the medical device industry and enhance patient outcomes. Nventric operates globally, with a presence in both the United States and South Korea, allowing them to leverage local expertise while addressing international market needs. Their commitment to quality is underscored by their ISO 13485 certification, ensuring that their products adhere to stringent safety and efficacy standards.

15. Datrend Systems Inc.

• Website: datrend.com
• Ownership type: Private
• Headquarters: Richmond, California, United States (USA)
• Founded year: 1991
• Headcount: 11-50
• LinkedIn: datrend-systems-inc.

Datrend Systems Inc., based in Richmond, California, is a private company founded in 1991. It specializes in the development and production of advanced biomedical testing instruments. The company’s product line includes electrical safety analyzers, infusion device analyzers, and various other testing equipment designed for healthcare providers. Datrend's instruments are crucial for hospitals and medical device manufacturers, helping them meet stringent safety standards and improve patient care. The company is known for its innovative Vision-Pad Technology, which integrates with existing systems to enhance functionality and ease of use. Datrend also offers custom app development and integrated solutions, showcasing its adaptability to the evolving needs of the healthcare sector. With a dedicated team and a focus on quality, Datrend Systems Inc. continues to play a significant role in the biomedical equipment manufacturing industry.

16. Technical Manufacturing West LLC

• Website: tmwmedical.com
• Ownership type: Private
• Headquarters: Santa Clarita, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2010
• Headcount: 51-200
• LinkedIn: technical-manufacturing-west-llc

Technical Manufacturing West LLC, based in Santa Clarita, California, is a private medical device manufacturer that has been operational since 2010. The company specializes in creating innovative surgical instrumentation and custom-built medical devices. With a workforce of approximately 29 employees, TMW collaborates closely with medical device companies and surgical professionals to improve patient outcomes through advanced manufacturing techniques. Their services cover the entire spectrum of medical device development, from initial prototyping to full-scale production. TMW has completed thousands of projects and has a history of working with a variety of surgical specialties, including cardiovascular, orthopedics, and neurosurgery. The company prides itself on its ISO 13485 certification, which underscores its commitment to quality management in the medical device industry. TMW's focus on innovation and customer collaboration positions it as a relevant entity in the biomedical engineering field.

17. SMP Tech, Inc.

• Website: smptech.com
• Ownership type: Corporate
• Headquarters: Elk Grove, California, United States (USA)
• Employee distribution: Indonesia 50%, United States (USA) 50%
• Latest funding: June 2023
• Founded year: 1990
• Headcount: 1-10
• LinkedIn: smp-technology

SMP Tech, Inc., founded in 1990 and based in Elk Grove, California, is an engineering firm that specializes in product design and manufacturing services tailored for the medical technology sector. The company offers a comprehensive suite of services, including turnkey medical device development, automation solutions, and engineering analysis. SMP Tech has a notable track record in developing medical systems, ranging from low-cost disposable drug delivery components to intricate surgical instruments. Their approach emphasizes risk reduction and efficiency in product development, making them a reliable partner for businesses in the medical and high-tech industries. SMP Tech also markets its proprietary product, the SaniAssist™ Hands-Free Door Pull, which addresses hygiene concerns in public spaces. Their engineering expertise is complemented by a commitment to quality and customer satisfaction, as evidenced by their collaborations with various clients in the medical field.

18. Leonhardt Ventures | Cal-X Stars Business Accelerator Inc

• Website: leonhardtventures.com
• Ownership type: Private
• Headquarters: Los Angeles, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1982
• Headcount: 201-500
• LinkedIn: leonhardt-ventures---cal-x-stars-business-accelerator-inc

Leonhardt Ventures | Cal-X Stars Business Accelerator Inc, founded in 1982, operates as a venture creation lab and innovation accelerator based in Los Angeles, California. The company specializes in regenerative medicine and medical technology, developing bioelectric products that aim to enhance healthspan and tackle various medical challenges. Their portfolio includes a range of startups that are involved in clinical trials and innovative therapies, catering to healthcare providers and researchers. Leonhardt Ventures is also known for its accelerator programs, which support the growth of startups in the biomedical field. The firm has a strong emphasis on the convergence of bioelectrics and biologics, positioning itself at the forefront of advancements in longevity and healing. With a dedicated team and a clear focus on innovation, Leonhardt Ventures continues to contribute to the biomedical engineering sector.

19. New Deantronics

• Website: newdean.com
• Ownership type: Private
• Headquarters: Walnut Creek, California, United States (USA)
• Employee distribution: Taiwan 78%, United States (USA) 22%
• Founded year: 1985
• Headcount: 501-1000
• LinkedIn: new-deantronics

New Deantronics, founded in 1985 in San Francisco, California, is a medical device manufacturer specializing in surgical and medical devices. The company operates primarily from its facility in Sparks, Nevada, and has a significant engineering and manufacturing presence in Taiwan. New Deantronics focuses on providing innovative solutions that enhance surgical procedures and improve patient care. Their product offerings include advanced medical devices used in various fields such as general surgery, neurosurgery, cardiology, orthopedics, and aesthetics. The company emphasizes quality, timely delivery, and collaboration with healthcare professionals to ensure that their devices meet the evolving needs of the medical community. Recently, New Deantronics has made headlines for establishing a new 200,000 square foot production facility, which will also serve as a hub for medical device start-ups, further solidifying its role in the biomedical engineering sector.

20. Apical Instruments

• Website: apicalinstruments.com
• Ownership type: Private
• Headquarters: Redwood City, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1995
• Headcount: 11-50
• LinkedIn: apical-instruments

Apical Instruments, based in Redwood City, California, is a medical device company founded in 1995. The firm specializes in the design, development, and manufacturing of medical devices, catering to clients in the medical device and biotechnology sectors. With a team of experienced professionals, Apical Instruments offers a full suite of services that streamline the development process, ensuring compliance with regulatory standards such as FDA and ISO 13485. Their capabilities include proof of concept, prototyping, product development, validation, and production. The company prides itself on its ability to deliver quality products with low failure rates, and it maintains its own manufacturing facility to oversee the entire production lifecycle. Apical Instruments has been a partner to various companies since its inception, helping them bring innovative medical solutions to market efficiently and effectively.

Biomedical Engineering Insights: Key Companies in California

Company	Headquarter	Size	Founded	Ownership
Beckman Coulter Diagnostics	Brea, California, United States (USA)	10001+	1935	Corporate
iota Biosciences, Inc. powered by Astellas	Alameda, California, United States (USA)	51-200	2017	Corporate
Theranova, LLC	San Francisco, California, United States (USA)	11-50	2006	Venture Capital
NOVO Engineering, Inc.	Vista, California, United States (USA)	51-200	2004	Private
gener8	San Jose, California, United States (USA)	201-500	2002	Private Equity
Paramit	Morgan Hill, California, United States (USA)	201-500	1990	Corporate
Flex Partners INC.	Solana Beach, California, United States (USA)	1-10	1995	Private
Stellartech Research Corporation	Milpitas, California, United States (USA)	51-200	1988	Private
Shifamed	Campbell, California, United States (USA)	201-500	2008	Private
MicroCube	Fremont, California, United States (USA)	11-50	2005	Private
InCube Labs	San Jose, California, United States (USA)	51-200	1995	Private
Synaptic	Carlsbad, California, United States (USA)	201-500	2005	Venture Capital
ACI Medical, LLC	San Marcos, California, United States (USA)	11-50	1984	Private
Nventric, Inc.	Arcadia, California, United States (USA)	51-200	2019	Venture Capital
Datrend Systems Inc.	Richmond, California, United States (USA)	11-50	1991	Private
Technical Manufacturing West LLC	Santa Clarita, California, United States (USA)	51-200	2010	Private
SMP Tech, Inc.	Elk Grove, California, United States (USA)	1-10	1990	Corporate
Leonhardt Ventures | Cal-X Stars Business Accelerator Inc	Los Angeles, California, United States (USA)	201-500	1982	Private
New Deantronics	Walnut Creek, California, United States (USA)	501-1000	1985	Private
Apical Instruments	Redwood City, California, United States (USA)	11-50	1995	Private

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