Pharmaceutical manufacturing in Colorado focuses on the production of drugs and treatments, with companies spanning from biotechnology to generics. Industry players include both large manufacturers and nimble startups engaged in complex drug innovations and pediatric medications. This sector is rapidly evolving, particularly with advancements in biologics and personalized medicine. There is a growing trend towards collaborative efforts between pharmaceutical firms and research institutions to enhance product efficacy and streamline distribution. As public health needs change, the industry is increasingly looking toward vaccines and therapies that target specific diseases, leveraging technological innovations to address urgent health issues.

The companies listed here represent a cross-section of Colorado's pharmaceutical manufacturing scene. They range from large scale operations like Tolmar, sized over 1,000 employees, to small visionary firms like BioLoomics with fewer than 50 staff. Founded between 1926 and 2022, these companies focus on areas such as oncology, allergy treatments, and pediatric drug delivery. With a combination of private, venture capital, and corporate ownership types, they illustrate a blend of established expertise and fresh innovation aimed at diverse therapeutic needs.

Continue reading to learn about Colorado’s top pharmaceutical manufacturing companies.

Top 19 Pharmaceutical Manufacturing Companies in Colorado

1. Tolmar

• Website: tolmar.com
• Ownership type: Private
• Headquarters: Fort Collins, Colorado, United States (USA)
• Employee distribution: United States (USA) 95%, Canada 3%, Other 2%
• Founded year: 2007
• Headcount: 1001-5000
• LinkedIn: tolmar.

Tolmar is a private pharmaceutical company based in Fort Collins, Colorado, founded in 2007. The company focuses on creating innovative treatments primarily in the fields of urology, oncology, and endocrinology. Tolmar is known for its long-acting injectable medications, including Fensolvi®, a treatment for Central Precocious Puberty, Eligard®, which is used in managing advanced prostate cancer, and Jatenzo®, a testosterone replacement therapy. With a workforce of approximately 906 employees, Tolmar operates its own manufacturing facilities, ensuring a reliable supply of its products. The company emphasizes a patient-centered approach, aiming to improve treatment experiences and outcomes. Tolmar's commitment to research and development, along with its robust manufacturing capabilities, positions it as a significant player in the pharmaceutical sector.

2. Clovis Oncology

• Website: allos.com
• Ownership type: Corporate
• Headquarters: Westminster, Colorado, United States (USA)
• Latest funding: September 2012
• Founded year: 1992
• Headcount: 51-200
• LinkedIn: allos-therapeutics

Clovis Oncology, known as Allos, is a pharmaceutical company based in Westminster, Colorado. Founded in 1992, the company specializes in drug development, leveraging Causal AI technology to enhance clinical development pathways. Allos aims to address unmet patient needs by making innovative generics accessible, particularly in light of the growing aging population and the rise in chronic health conditions. Their approach is data-driven, focusing on optimizing the lifecycle of complex drugs. The team at Allos comprises scientists, technologists, and pharmaceutical experts who have collectively worked on over 50 complex drugs. They actively seek collaborations with researchers and pharmaceutical companies to co-develop drugs or license their innovative formulations, showcasing their commitment to advancing healthcare solutions.

3. Silvergate Pharmaceuticals, Inc.

• Website: silvergatepharma.com
• Ownership type: Corporate
• Headquarters: Greenwood, Colorado, United States (USA)
• Latest funding: June 2019
• Founded year: 2010
• Headcount: 11-50
• LinkedIn: silvergate-pharmaceuticals

Silvergate Pharmaceuticals, Inc., based in Greenwood, Colorado, is a pharmaceutical company established in 2010. The firm is dedicated to developing and commercializing innovative medications tailored for pediatric patients. Their product lineup includes FDA-approved solutions such as Qbrelis, the first oral solution of lisinopril for children, and Xatmep, a ready-to-use oral solution of methotrexate. These products address significant health challenges faced by children, such as hypertension and acute lymphoblastic leukemia. Silvergate's focus on pediatric drug delivery innovation highlights their commitment to improving the quality and accessibility of medications for young patients. The company operates with a small team, emphasizing agility and specialized expertise in their field.

4. VitriVax

• Website: vitrivaxbio.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Grant), $3.6M, December 2024
• Founded year: 2017
• Headcount: 11-50
• LinkedIn: vitrivax

VitriVax is a biotechnology firm based in Boulder, Colorado, established in 2017. The company specializes in vaccine development and formulation technology, aiming to enhance global vaccination efforts. Their innovative Atomic Layering Thermostable Antigen and Adjuvant (ALTA™) technology addresses critical challenges in vaccine distribution, such as maintaining stability during transport and reducing the need for multiple doses. This technology allows for the creation of vaccines that can withstand high temperatures and be administered in a single shot, making them suitable for use in remote areas with limited cold chain capabilities. VitriVax collaborates with healthcare organizations and vaccine manufacturers to improve public health outcomes. The company has received significant funding, including a $3.6 million grant and a $29 million contract from the Department of Defense, which underscores their active involvement in the vaccine development sector.

5. Millipore Corporation

• Website: emdmillipore.com
• Ownership type: Corporate
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $7.2B, March 2010
• Founded year: 1954
• Headcount: 51-200
• LinkedIn: millipore-corporation

Millipore Corporation, also known as Merck Millipore, is a prominent life science supplier based in Boulder, Colorado. Founded in 1954, the company has established itself as a key provider of products and services tailored for the biotechnology and pharmaceutical industries. Their extensive portfolio includes analytical tools, biopharmaceutical manufacturing solutions, and advanced water purification systems. These offerings are designed to meet the rigorous demands of research, development, and production processes in drug therapies. Millipore's commitment to quality and compliance with industry standards positions it as a reliable partner for organizations in need of high-quality materials and services. The company operates with a workforce of approximately 222 employees, all based in the United States, and is part of the larger Merck KGaA group, which enhances its capabilities and reach in the life sciences sector.

6. Reven Pharmaceuticals

• Website: reven.com
• Ownership type: Venture Capital
• Headquarters: Golden, Colorado, United States (USA)
• Latest funding: Series D, $23.0M, January 2019
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: reven-pharmaceuticals

Reven Pharmaceuticals, founded in 1999 and based in Golden, Colorado, is a pharmaceutical company dedicated to innovative drug development and therapeutic solutions. The company specializes in addressing unmet medical needs through its proprietary RJX technology, which targets various health conditions, including cancer and cardiovascular diseases. Reven engages in clinical trials and collaborates with research organizations to enhance its offerings. The company has received significant funding, with a Series D round amounting to $23 million in 2019, reflecting strong investor interest. Reven's mission is to improve patient outcomes and quality of life by developing advanced treatment options, making it a notable player in the pharmaceutical industry.

7. SCN BestCo

• Website: scnbestco.com
• Ownership type: Private Equity
• Headquarters: Golden, Colorado, United States (USA)
• Employee distribution: United States (USA) 96%, Canada 4%
• Latest funding: July 2013
• Founded year: 1960
• Headcount: 1001-5000
• LinkedIn: scnbestco

SCN BestCo, founded in 1960 and based in Golden, Colorado, is a pharmaceutical manufacturer that specializes in creating innovative dosage forms for dietary supplements and over-the-counter drugs. The company has a strong focus on products such as gummies, lozenges, soft chews, and their proprietary SuperGel™. With manufacturing facilities in California, North Carolina, and Canada, SCN BestCo is registered with the FDA and adheres to stringent quality standards, ensuring that their products meet federal regulations for safety and efficacy. They serve a variety of clients, including national retailers and consumer brands, by offering contract manufacturing and private label services. Their expertise in formulation and manufacturing has allowed them to transform the consumer healthcare experience, making health and wellness more enjoyable for consumers. SCN BestCo's commitment to innovation is reflected in their extensive portfolio of products and their ability to create custom formulations tailored to client specifications.

8. BioLoomics

• Website: bioloomics.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $8.7M, September 2023
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: bioloomics-llc

BioLoomics, founded in 2019 and based in Boulder, Colorado, is a biotechnology firm dedicated to revolutionizing cancer treatment through the development of advanced antibody-drug conjugates (ADCs). The company emerged from years of DARPA-funded research at the University of Colorado, Boulder, where co-founders Jeremy Jacobsen and Dr. Douglas Chapnick recognized the potential of single-cell testing in antibody evolution. BioLoomics employs cutting-edge techniques in synthetic biology, artificial intelligence, and robotics to enhance the efficacy of cancer therapies. Recently, they secured $8.7 million in seed funding to further their mission of creating safer and more effective cancer therapeutics. Their team comprises experts in various scientific fields, all driven by a shared goal of addressing critical gaps in cancer care.

9. STAQ Pharma

• Website: staqpharma.com
• Ownership type: Venture Capital
• Headquarters: Denver, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series E-K, $30.0M, December 2024
• Founded year: 2017
• Headcount: 51-200
• LinkedIn: staq-pharma

STAQ Pharma, founded in 2017 and based in Denver, Colorado, is a pharmaceutical outsourcing facility that specializes in compounded medications. The company addresses critical drug shortages by providing safe and effective treatments to healthcare providers across the United States. With state-of-the-art facilities in Denver and Columbus, STAQ Pharma adheres to current Good Manufacturing Practices (cGMP) and is an FDA-registered 503B outsourcing partner. Their operations include the production of sterile medications, with a focus on innovative development to meet the evolving needs of healthcare professionals. Recently, STAQ Pharma has launched an oncology portfolio and has been involved in supporting the production of an intranasal spray targeting COVID-19. The company has also secured significant funding, with a Series E-K round raising $30 million in December 2024, indicating strong investor confidence in their mission and capabilities.

10. Greffex, Inc.

• Website: greffex.com
• Ownership type: Private
• Headquarters: Aurora, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: greffex-inc-

Greffex, Inc. is a biotechnology firm based in Aurora, Colorado, founded in 1999. The company specializes in genetic engineering and vaccine development, utilizing its proprietary GreVac technology to create innovative vaccines aimed at infectious diseases. Greffex has been particularly active in developing vaccines for COVID-19 and avian flu, demonstrating a commitment to rapid production and distribution to meet urgent public health needs. Their technology allows for the quick creation of vaccines, with the ability to produce millions of doses efficiently and cost-effectively. Greffex has received a contract from the National Institute of Health, valued at up to $18.9 million, to advance its vaccine candidates through clinical trials. This contract highlights their involvement in biodefense and the development of vaccines for emerging infectious diseases. Greffex's approach to vaccine development, which includes a focus on safety and stability, positions them as a notable entity in the pharmaceutical manufacturing industry.

11. AJNA BioSciences

• Website: ajnabiosciences.com
• Ownership type: Private
• Headquarters: Littleton, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $2.1M, June 2024
• Founded year: 2021
• Headcount: 11-50
• LinkedIn: ajna-biosciences

AJNA BioSciences, founded in 2021 and based in Littleton, Colorado, is a private pharmaceutical company dedicated to pioneering botanical drug development. The firm specializes in transforming medicinal plants and fungi into FDA-approved drugs, addressing the increasing demand for safer and more effective therapeutic options. Their primary focus is on conditions such as Autism Spectrum Disorder and depression, where traditional treatments may fall short. AJNA's unique approach involves a rigorous drug development platform that includes sourcing plant species with established therapeutic use, applying modern scientific methods to standardize raw materials, and conducting FDA clinical trials to ensure safety and efficacy. The company has received funding amounting to over $2 million as of June 2024, indicating investor confidence in their innovative strategies. With a specialized team that includes veterans from the FDA and experts in botanical pharmacology, AJNA is well-positioned to make significant contributions to the pharmaceutical industry.

12. PharmaJet

• Website: pharmajet.com
• Ownership type: Venture Capital
• Headquarters: Golden, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: October 2023
• Founded year: 2005
• Headcount: 11-50
• LinkedIn: pharmajet-inc

PharmaJet, founded in 2005 and based in Golden, Colorado, is a MedTech company that specializes in needle-free injection systems designed for vaccines and therapeutics. The company offers innovative solutions that enhance vaccine delivery, aiming to improve patient experiences and increase vaccination coverage. Its flagship products, Tropis and Stratis, are engineered to deliver medications intradermally, intramuscularly, and subcutaneously without the use of needles. PharmaJet's systems have received significant regulatory approvals, including the CE Mark and WHO PQS certification, which validate their safety and efficacy. The company collaborates with various pharmaceutical firms and healthcare organizations to facilitate the global distribution of vaccines, particularly in response to infectious diseases. PharmaJet's technology not only addresses the challenges associated with traditional needle injections but also aims to reduce the risks of needlestick injuries and improve overall vaccination rates.

13. Steriline

• Website: steriline.it
• Ownership type: Family Owned
• Headquarters: Como, Colorado, United States (USA)
• Employee distribution: Italy 89%, India 9%, United States (USA) 2%
• Founded year: 1989
• Headcount: 201-500
• LinkedIn: steriline-srl

Steriline S.r.l., founded in 1989 and based in Como, Italy, is a family-owned company that specializes in the manufacture of pharmaceutical equipment. The company focuses on aseptic processing solutions tailored for injectable drugs, offering a range of products that include closed RABS, rotary washing machines, and intelligent compounding systems. Steriline's equipment is designed to meet the rigorous demands of sterile production environments, ensuring compliance with current Good Manufacturing Practices (cGMP) and other regulatory requirements. With a workforce of approximately 199 employees, the company has a strong presence in Italy, India, and the United States. Steriline is also involved in robotics and artificial vision through its Steriline Robotics division, which enhances its product offerings for the preparation of injectable drugs in hospitals and compounding centers. Their commitment to innovation and quality positions them as a relevant player in the pharmaceutical manufacturing industry.

14. Leiters Health

• Website: leiters.com
• Ownership type: Private Equity
• Headquarters: Englewood, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: November 2021
• Founded year: 1926
• Headcount: 201-500
• LinkedIn: leiters

Leiters Health, founded in 1926 and based in Englewood, Colorado, is a private equity-owned company specializing in pharmaceutical compounding services. They provide a range of high-quality compounded sterile preparations and pharmacy services tailored for hospitals, surgery centers, and clinics. By outsourcing their compounding needs to Leiters, healthcare organizations can enhance compliance with regulatory standards while improving patient care. The company is recognized as an FDA-registered 503B outsourcing provider, which underscores its commitment to quality and safety in pharmaceutical manufacturing. Leiters Health has also made strategic moves to expand its capabilities, including the acquisition of a new manufacturing facility in Buena, New Jersey, aimed at increasing production capacity and broadening its product offerings. Their services include pain management solutions and ophthalmic preparations, reflecting their focus on addressing specific healthcare needs.

15. InDevR, Inc.

• Website: indevr.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series B, $9.0M, January 2023
• Founded year: 2003
• Headcount: 11-50
• LinkedIn: indevr-inc-

InDevR, Inc., founded in 2003 and based in Boulder, Colorado, is a biotechnology firm that specializes in advanced analytical technologies aimed at enhancing vaccine development and manufacturing. The company offers a range of products, including the VaxArray Portfolio and the CypherOne System, which are designed to improve testing efficiency and data quality for vaccine manufacturers. InDevR's clientele primarily consists of biopharmaceutical companies that seek to optimize their vaccine testing processes. The company has recently secured $9 million in Series B funding as of January 2023, indicating ongoing investment in their innovative solutions. InDevR's commitment to providing expert services and custom solutions addresses the unique challenges faced in vaccine development, making them a notable entity in the pharmaceutical manufacturing sector.

16. Corgenix Medical Corporation

• Website: corgenix.com
• Ownership type: Corporate
• Headquarters: Broomfield, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $16.0M, August 2014
• Founded year: 1990
• Headcount: 11-50
• LinkedIn: corgenix-medical-corporation

Corgenix Medical Corporation, founded in 1990 and based in Broomfield, Colorado, is a medical diagnostics company that specializes in clinical laboratory services, clinical trial management, and contract development and manufacturing for diagnostic tests. With a workforce of around 32 employees, Corgenix operates as a full-service partner to the diagnostics and pharmaceutical industries. They provide a unique array of products and capabilities, focusing on the development, tech transfer, registration, manufacturing, and commercialization of specialty diagnostic tests. Corgenix is recognized for its CAP/CLIA accredited laboratory and is an experienced Contract Development and Manufacturing Organization (CDMO). Their client base includes biotech companies, pharmaceutical firms, cancer centers, and academic laboratories, highlighting their integral role in the development and commercialization of diagnostic solutions. Corgenix is also part of the Sebia Group, which enhances their capabilities in the field of in vitro diagnostics. Their commitment to quality is underscored by their ISO-13485 certification and FDA registration, ensuring compliance with stringent regulatory standards.

17. Think Bioscience

• Website: thinkbioscience.com
• Ownership type: Venture Capital
• Headquarters: Boulder, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $6.0M, May 2024
• Founded year: 2019
• Headcount: 1-10
• LinkedIn: think-bioscience

Think Bioscience, founded in 2019 and based in Boulder, Colorado, is a biotechnology firm dedicated to the development of small-molecule therapeutics. The company leverages synthetic biology to tackle the intricate challenges of drug discovery, particularly for diseases that have few or no effective treatments available. Their innovative approach involves programming living systems to create new medicines, utilizing a unique platform that combines microbiology, enzymology, and data science. Think Bioscience collaborates with pharmaceutical companies and research institutions, providing them with cutting-edge solutions for drug development. The company has recently raised $6 million in seed funding, reflecting its commitment to advancing its technology and expanding its impact in the pharmaceutical industry.

18. Picocyl

• Website: picocyl.com
• Ownership type: Private
• Headquarters: Golden, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2016
• Headcount: 11-50
• LinkedIn: picocyl

Picocyl, founded in 2016 and based in Golden, Colorado, is a private company that specializes in the manufacturing of medical devices, particularly innovative drug delivery systems. The company is known for its advanced solutions, including gas-powered Pico-Cylinders, which are designed for various medical applications. Their clientele includes medical device manufacturers and healthcare providers who seek reliable and efficient drug delivery technologies. Picocyl operates under stringent quality standards, with an ISO 13485 certified manufacturing facility that emphasizes rapid development and cleanroom practices. Their product offerings include components such as the Breakaway Septum, Valve Release, Pico-Pin, and Actuator, which are integral to applications like autoinjectors, implantables, and needle-free injectors. Picocyl's focus on innovation and quality has established it as a notable entity in the medical device industry, particularly in the context of drug delivery solutions.

19. Aleksia Therapeutics

• Website: aleksiatx.com
• Ownership type: Private
• Headquarters: Golden, Colorado, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2022
• Headcount: 11-50
• LinkedIn: aleksia-therapeutics

Aleksia Therapeutics is a biotechnology firm based in Golden, Colorado, dedicated to developing innovative therapies for cancer patients whose conditions are driven by genetic alterations. Founded in 2022, the company is composed of a team of scientists and experts who leverage advanced chemistry to create therapeutic options that address significant gaps in current cancer treatments. Their primary focus is on oncology, where they aim to provide solutions that conventional therapies cannot reach. Aleksia Therapeutics operates with a clear mission to improve patient outcomes through targeted drug development, emphasizing the importance of selectivity and engagement in drug action. The company is privately owned and has not reported any funding to date, indicating that they may still be in the early stages of their growth trajectory. Their commitment to addressing unmet medical needs in oncology positions them as a relevant entity within the pharmaceutical manufacturing sector.

Pharmaceutical Manufacturing Insights: Key Companies in Colorado

Company	Headquarter	Size	Founded	Ownership
Tolmar	Fort Collins, Colorado, United States (USA)	1001-5000	2007	Private
Clovis Oncology	Westminster, Colorado, United States (USA)	51-200	1992	Corporate
Silvergate Pharmaceuticals, Inc.	Greenwood, Colorado, United States (USA)	11-50	2010	Corporate
VitriVax	Boulder, Colorado, United States (USA)	11-50	2017	Venture Capital
Millipore Corporation	Boulder, Colorado, United States (USA)	51-200	1954	Corporate
Reven Pharmaceuticals	Golden, Colorado, United States (USA)	11-50	1999	Venture Capital
SCN BestCo	Golden, Colorado, United States (USA)	1001-5000	1960	Private Equity
BioLoomics	Boulder, Colorado, United States (USA)	11-50	2019	Venture Capital
STAQ Pharma	Denver, Colorado, United States (USA)	51-200	2017	Venture Capital
Greffex, Inc.	Aurora, Colorado, United States (USA)	11-50	1999	Private
AJNA BioSciences	Littleton, Colorado, United States (USA)	11-50	2021	Private
PharmaJet	Golden, Colorado, United States (USA)	11-50	2005	Venture Capital
Steriline	Como, Colorado, United States (USA)	201-500	1989	Family Owned
Leiters Health	Englewood, Colorado, United States (USA)	201-500	1926	Private Equity
InDevR, Inc.	Boulder, Colorado, United States (USA)	11-50	2003	Venture Capital
Corgenix Medical Corporation	Broomfield, Colorado, United States (USA)	11-50	1990	Corporate
Think Bioscience	Boulder, Colorado, United States (USA)	1-10	2019	Venture Capital
Picocyl	Golden, Colorado, United States (USA)	11-50	2016	Private
Aleksia Therapeutics	Golden, Colorado, United States (USA)	11-50	2022	Private

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