Biopharmaceutical companies in Ohio are at the forefront of innovation, focusing on the development of drugs and therapies to address various health challenges. This dynamic industry features a mix of organizations, from startups to established firms, specializing in areas like gene therapy, infectious diseases, oncology, and drug delivery systems. As healthcare needs grow increasingly complex, Ohio's biopharmaceutical sector is positioning itself to meet these demands through the adoption of advanced technologies and novel research methodologies. The collaborative spirit among local universities and research institutions further fuels the growth, promoting a cycle of continuous improvement and breakthroughs in patient care.

The listed companies represent a vibrant cross-section of Ohio's biopharmaceutical industry, featuring a range of sizes from small startups to larger corporations. Many were founded in the past decade, demonstrating the region's growing appeal for biopharma innovation. Headquartered primarily in Columbus and Cincinnati, these firms specialize in various fields, including drug development, clinical trials, and biomanufacturing. With substantial investments propelling them forward, these organizations are focused on producing effective solutions to improve health outcomes.

Continue reading to discover Ohio’s top biopharmaceutical companies.

Top 19 Biopharmaceutical Companies Companies in Ohio

1. Orange Grove Bio

• Website: orangegrovebio.com
• Ownership type: Venture Capital
• Headquarters: Cincinnati, Ohio, United States (USA)
• Latest funding: $5.1M, April 2024
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: orange-grove-bio

Orange Grove Bio is a biotechnology firm based in Cincinnati, Ohio, founded in 2019. The company is dedicated to advancing drug development specifically targeting cancer, autoimmune, and inflammatory diseases. By collaborating with research institutions and universities, Orange Grove Bio aims to streamline the technology licensing process and accelerate the development of promising therapies. Their operations are supported by a team of experts, including PhDs and venture partners, who conduct thorough analyses of therapeutic efficacy and clinical design. Recently, the company secured nearly $5.08 million in funding, reflecting confidence from investors in their innovative approach and potential impact on patient care. Orange Grove Bio's focus on regions outside traditional venture capital hubs allows them to tap into valuable biomedical innovations that may otherwise be overlooked, further enhancing their role in the biopharmaceutical industry.

2. Clarametyx Biosciences

• Website: clarametyx.com
• Ownership type: Corporate
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series A, January 2025
• Founded year: 2020
• Headcount: 1-10
• LinkedIn: clarametyx-biosciences

Clarametyx Biosciences, founded in 2020 and based in Columbus, Ohio, is a biotechnology firm dedicated to developing innovative therapies and vaccines aimed at serious bacterial infections linked to biofilms. The company is actively working on two primary products: CMTX-101, an immune-enabling antibody therapy, and CMTX-301, a vaccine designed to prevent biofilm formation. Clarametyx's technology platform is built around the understanding that biofilms can shield bacteria from both immune responses and antibiotics, making infections harder to treat. Their research is particularly focused on chronic infections, such as those associated with cystic fibrosis, and they are currently conducting clinical trials to evaluate the safety and efficacy of their therapies. Clarametyx has also secured funding, including a notable $33 million Series A financing round, to advance its anti-biofilm biologics. This financial backing supports their mission to improve treatment outcomes and tackle the growing issue of antibiotic resistance.

3. AmplifyBio

• Website: amplify-bio.com
• Ownership type: Venture Capital
• Headquarters: West Jefferson, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $49.8M, November 2023
• Founded year: 2021
• Headcount: 201-500
• LinkedIn: amplifybio

AmplifyBio, founded in 2021 and based in West Jefferson, Ohio, is a contract research organization (CRO) that specializes in preclinical services and drug development. The company offers a comprehensive suite of services, including toxicology studies, pharmacokinetics, and advanced therapy manufacturing. AmplifyBio primarily serves clients in the pharmaceutical and biotechnology sectors, providing expertise to navigate the complexities of drug discovery and regulatory compliance. With a workforce of approximately 178 employees, the company has quickly established itself as a significant player in the industry. AmplifyBio has also secured substantial funding, with a recent investment of $49.75 million in November 2023, which underscores its growth potential and commitment to enhancing its service offerings. The company operates a state-of-the-art facility that supports a wide range of drug modalities, including small molecules, cell and gene therapies, and mRNA therapeutics, making it a valuable partner for organizations looking to advance their drug development programs.

4. Forge Biologics

• Website: forgebiologics.com
• Ownership type: Corporate
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 99%, Other 1%
• Latest funding: $620.0M, November 2023
• Founded year: 2020
• Headcount: 201-500
• LinkedIn: forge-biologics

Forge Biologics is a biotechnology firm based in Columbus, Ohio, that focuses on the development and manufacturing of gene therapies. Established in 2020, the company specializes in providing comprehensive manufacturing solutions for adeno-associated virus (AAV) gene therapies and plasmid DNA. Their state-of-the-art facility, known as the Hearth, spans over 200,000 square feet and adheres to cGMP standards, ensuring that their production processes meet the rigorous quality requirements of the biopharmaceutical industry. Forge Biologics is committed to accelerating the development of innovative treatments for rare diseases, exemplified by their pipeline project, FBX-101, aimed at addressing Krabbe Disease. The company has recently secured $620 million in funding, reflecting strong market interest and positioning them for future growth in the competitive gene therapy landscape.

5. CinRx Pharma

• Website: cinrx.com
• Ownership type: Venture Capital
• Headquarters: Cincinnati, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series B, $73.0M, May 2024
• Founded year: 2015
• Headcount: 11-50
• LinkedIn: cinrx-pharma

CinRx Pharma, based in Cincinnati, Ohio, is a pharmaceutical company dedicated to advancing a portfolio of high-impact medicines. Founded in 2015, the company specializes in drug development targeting significant health issues such as obesity, diabetes, and hypertension. CinRx Pharma employs a strategic approach to selecting drug candidates, leveraging extensive operational, scientific, and clinical expertise. Their pipeline includes various therapeutic areas, with active projects like CIN-110 for obesity currently in Phase 1 clinical trials. The company has recently secured $73 million in funding, reflecting investor confidence and a commitment to advancing their innovative therapies. CinRx Pharma serves healthcare providers and patients, aiming to transform treatment options and enhance quality of life.

6. Sermonix Pharmaceuticals

• Website: sermonixpharma.com
• Ownership type: Venture Capital
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Series A, $40.0M, November 2021
• Founded year: 2014
• Headcount: 11-50
• LinkedIn: sermonix-pharmaceuticals

Sermonix Pharmaceuticals is a biotechnology firm based in Columbus, Ohio, founded in 2014 by Dr. David Portman, a recognized expert in women's health. The company is dedicated to developing targeted oncology therapies for women, with a particular emphasis on addressing the needs of patients with estrogen receptor-positive breast cancer. Their primary investigational product, lasofoxifene, is an oral therapy currently undergoing clinical trials, including the ELAINE studies, which aim to assess its efficacy in patients who have shown resistance to standard hormonal treatments. Sermonix's approach is rooted in precision medicine, focusing on the unique challenges faced by women in oncology. The company has successfully secured $40 million in Series A funding as of November 2021, indicating strong investor confidence in their mission and pipeline.

7. Aprecia Pharmaceuticals

• Website: aprecia.com
• Ownership type: Private Equity
• Headquarters: Mason, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Other (Debt), $30.0M, July 2016
• Founded year: 2004
• Headcount: 51-200
• LinkedIn: aprecia-pharmaceuticals

Aprecia Pharmaceuticals, founded in 2004 and based in Mason, Ohio, is a private equity-backed pharmaceutical manufacturer that specializes in advanced additive manufacturing and 3D printing technologies for drug delivery. The company has carved out a niche in the pharmaceutical industry by offering innovative solutions that focus on precision formulation and comprehensive support throughout the drug development process. Aprecia's expertise allows clients to enhance their product offerings and streamline manufacturing operations. With a robust portfolio of 126 granted patents and 52 pending, Aprecia is recognized for its pioneering work in 3D printing for pharmaceuticals. The company has successfully brought products like Spiritam® to market, showcasing its ability to utilize 3D printing as a viable manufacturing platform. Aprecia's facility is cGMP compliant and FDA inspected, reflecting its commitment to quality and regulatory standards. The company has also secured $30 million in funding, which underscores its potential for growth and innovation in the biopharmaceutical space.

8. Oakwood Labs

• Website: oakwoodlabs.com
• Ownership type: Private
• Headquarters: Oakwood, Ohio, United States (USA)
• Employee distribution: United States (USA) 98%, Canada 2%
• Founded year: 1997
• Headcount: 51-200
• LinkedIn: oakwood-laboratories

Oakwood Labs, founded in 1997 and based in Oakwood, Ohio, is a pharmaceutical development company that specializes in the creation and manufacturing of sustained release injectable products. Utilizing their proprietary Chroniject™ technology, Oakwood Labs offers a full suite of services that support all phases of long-acting injectable (LAI) development. Their capabilities range from initial feasibility assessments to GMP manufacturing, making them a comprehensive partner for pharmaceutical companies. With over 25 years of experience in drug encapsulation, Oakwood has developed a strong reputation for their ability to customize drug delivery solutions across various therapeutic areas, including oncology, cardiovascular, and central nervous system disorders. The company operates an FDA-approved aseptic manufacturing facility, ensuring that they meet rigorous quality standards for both clinical and commercial supplies. Oakwood Labs has successfully partnered with numerous global pharmaceutical firms, demonstrating their commitment to quality and timely project execution.

9. Andelyn Biosciences

• Website: andelynbio.com
• Ownership type: Private
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 99%
• Latest funding: Other (Grant), $5.0M, February 2022
• Founded year: 2020
• Headcount: 201-500
• LinkedIn: andelyn-biosciences

Andelyn Biosciences, based in Columbus, Ohio, is a private biotechnology firm founded in 2020. The company specializes in gene therapy and viral vector manufacturing, offering a comprehensive suite of services that includes process development, analytical testing, and quality control. With a workforce of approximately 232 employees, Andelyn plays a crucial role in helping biotechnology and pharmaceutical companies transition from research to scalable manufacturing. They have been involved in the production of over 450 cGMP clinical batches and have supported more than 75 IND applications, showcasing their expertise in the field. Their facilities are designed to meet the rigorous demands of gene therapy development, and they utilize advanced technologies to ensure compliance with regulatory standards. In February 2022, Andelyn received a grant of $5 million, further underscoring their commitment to innovation and growth in the biopharmaceutical sector.

10. InfinixBio

• Website: infinixbio.com
• Ownership type: Private
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2012
• Headcount: 11-50
• LinkedIn: jeffcheck

InfinixBio, founded in 2012 and based in Columbus, Ohio, is a biotechnology services company that operates as a contract research organization (CRO). The firm specializes in a range of services that include early drug development, pre-clinical and clinical services, bioProduction, and diagnostics. InfinixBio partners with biotech and pharmaceutical companies, offering expertise that helps clients navigate complex regulatory pathways and streamline their product development processes. The company prides itself on its collaborative approach, employing a cross-functional team of scientists, many of whom hold advanced degrees and have extensive experience in their fields. With a focus on innovation, InfinixBio has contributed to numerous successful projects, helping clients achieve significant milestones in drug development. Their commitment to providing tailored solutions and maintaining a strong client relationship underscores their relevance in the biopharmaceutical industry.

11. North Cliff Consultants, Inc.

• Website: northclifftesting.com
• Ownership type: Corporate
• Headquarters: Cincinnati, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: July 2022
• Founded year: 1986
• Headcount: 11-50
• LinkedIn: north-cliff-consultants

North Cliff Consultants, Inc., also known as Velocity Clinical Research, is a clinical research organization based in Cincinnati, Ohio. Founded in 1986, the company specializes in conducting clinical trials for new pharmaceuticals, medical devices, and diagnostics. They collaborate with pharmaceutical and biotechnology firms to facilitate the research and development of innovative medical solutions. Velocity Clinical Research operates a network of fully integrated research sites across the United States and Europe, providing essential services that connect patients with clinical trials. Their commitment to advancing medical research is evident in their efforts to ensure diverse participation in studies, which is vital for the development of effective treatments. Participants in their trials often receive medical exams and may be compensated for their involvement, highlighting their focus on participant engagement and welfare.

12. Camargo, A Division of Premier Consulting

• Website: camargopharma.com
• Ownership type: Corporate
• Headquarters: Cincinnati, Ohio, United States (USA)
• Employee distribution: United States (USA) 66%, Canada 34%
• Latest funding: May 2021
• Founded year: 2003
• Headcount: 51-200
• LinkedIn: camargo-pharmaceutical-services

Camargo, A Division of Premier Consulting, is a consulting firm based in Cincinnati, Ohio, founded in 2003. The company specializes in pharmaceutical and biotechnology services, offering a comprehensive range of consulting solutions that include drug development strategy, regulatory support, clinical pharmacology, and commercial strategy. Their expertise is particularly valuable for biotech and pharmaceutical companies seeking guidance through the intricate processes of drug development and regulatory approval. With a team of scientists, researchers, and strategists, Camargo aims to help innovators transform their ideas into viable medical treatments. They have a strong focus on regulatory interactions, often engaging with the FDA to facilitate the approval process for their clients' products. Their services also extend to nonclinical and clinical development, quality assurance, and statistical consulting, making them a multifaceted partner in the biopharmaceutical sector.

13. PumasAI

• Website: pumasai.com
• Ownership type: Private
• Headquarters: Delaware, Ohio, United States (USA)
• Employee distribution: United States (USA) 45%, India 23%, France 12%, Other 20%
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: pumas-ai

PumasAI, founded in 2019 and based in Delaware, Ohio, is a private consulting firm that specializes in healthcare technology. The company focuses on providing data analytics tools and consulting services tailored for pharmaceutical and biotechnology companies, healthcare providers, and regulatory agencies. Their offerings include model-informed drug development services and clinical decision support systems, which aim to streamline the drug development process and enhance patient care. PumasAI has developed a suite of products, including the Pumas software for scientific modeling and the Lyv clinical decision support system, which are designed to optimize drug development and dosing strategies. The firm has successfully supported numerous regulatory submissions and has a growing client base, indicating its active role in the biopharmaceutical industry. PumasAI's team comprises experts in pharmacology, pharmacometrics, and data science, reflecting their commitment to advancing healthcare through innovative technology and consulting solutions.

14. QTest Labs

• Website: qtestlabs.com
• Ownership type: Private
• Headquarters: Columbus, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: qtest-labs

QTest Labs, based in Columbus, Ohio, is a contract research organization that has been operational since 1999. The company specializes in cardiovascular research and development, offering a range of services tailored to the needs of pharmaceutical and biotechnology firms. Their offerings include ex vivo and in vivo assays, disease models, and expert consultation aimed at enhancing the understanding of drug safety and efficacy. With a team of experienced scientists, including board-certified veterinary cardiologists and a biomedical engineer, QTest Labs is equipped to conduct comprehensive studies that address the complexities of cardiovascular physiology. Their facilities are designed to support rigorous research practices, ensuring high-quality results that meet the demands of their clients in the biopharmaceutical industry.

15. Prati-Donaduzzi

• Website: pratidonaduzzi.com.br
• Ownership type: Private
• Headquarters: Toledo, Ohio, United States (USA)
• Employee distribution: Brazil 98%, Other 2%
• Founded year: 1993
• Headcount: 5001-10000
• LinkedIn: pratidonaduzzi

Prati-Donaduzzi is a private pharmaceutical company based in Toledo, Paraná, Brazil, founded in 1993. The company specializes in manufacturing a wide array of pharmaceutical products, including generics, phytotherapy medicines, dietary supplements, and active pharmaceutical ingredients. With a workforce of approximately 3,880 employees, Prati-Donaduzzi has established itself as a key supplier in the Brazilian market, particularly noted for producing the most-consumed generic pharmaceutical product in the country. The company operates modern research facilities and has a strong focus on innovation, quality control, and sustainable practices. They also engage in various projects aimed at social responsibility and education, further solidifying their role in the healthcare sector. Prati-Donaduzzi has received recognition in several industry rankings, highlighting their growth and commitment to excellence in the pharmaceutical field.

16. Sterling Research Group, a Meridian Clinical Research Company | Cincinnati, OH

• Website: sterlingresearch.org
• Ownership type: Private
• Headquarters: Cincinnati, Ohio, United States (USA)
• Founded year: 1999
• Headcount: 11-50
• LinkedIn: sterling-research

Sterling Research Group, a Meridian Clinical Research Company based in Cincinnati, Ohio, is a clinical research organization founded in 1999. The company specializes in conducting clinical trials for new drugs, medical devices, and diagnostics. They collaborate with pharmaceutical and biotechnology companies to facilitate the research and development process, ensuring that trials are conducted efficiently and effectively. Sterling Research Group's services include participant recruitment and study-related medical exams, primarily serving businesses in the healthcare sector. Their commitment to advancing medical science is evident in their focus on providing the right patients and investigators for clinical trials, which are critical for the approval of new treatments and therapies.

17. Cell X Technologies

• Website: cellxtechnologies.com
• Ownership type: Venture Capital
• Headquarters: Cleveland, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: Seed, $6.0M, August 2024
• Founded year: 2019
• Headcount: 11-50
• LinkedIn: cell-x-technologies

Cell X Technologies, founded in 2019 and based in Cleveland, Ohio, is a biotechnology firm specializing in advanced cell processing solutions. The company has developed the Celligent™ platform, which integrates robotics, imaging, and artificial intelligence to enhance the development of cellular therapies. This platform is designed to automate and optimize processes, ensuring that therapies are consistent, reproducible, and compliant with Good Manufacturing Practices (GMP). Cell X Technologies addresses critical needs in the life sciences sector, particularly in the commercialization of autologous and allogeneic cell therapies, as well as applications in tissue engineering and artificial organs. With a team of industry veterans and a focus on innovation, the company is positioned to make significant contributions to the field of cellular therapies. Recently, they secured $6 million in seed funding, reflecting investor confidence in their technology and potential impact.

18. Smithfield BioScience

• Website: smithfieldbioscience.com
• Ownership type: Corporate
• Headquarters: Cincinnati, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: February 2008
• Founded year: 2017
• Headcount: 51-200
• LinkedIn: smithfield-bioscience

Smithfield BioScience, founded in 2017 and based in Cincinnati, Ohio, is a biopharmaceutical company that focuses on the production of porcine-derived bioproducts for medical applications. The company supplies pharmaceutical ingredients and components for medical devices, ensuring high quality and traceability throughout its supply chain. Smithfield BioScience is part of a vertically integrated platform that allows for comprehensive oversight of the production process, from hog farming to the final product. They are particularly known for manufacturing Heparin Sodium, a critical ingredient used in various medical procedures, including cardiac surgery and dialysis. The company is committed to sustainability and minimizing waste by utilizing parts of the hog that are not typically consumed as food. Their operations are USDA-approved and FDA-registered, which underscores their adherence to regulatory standards in the biopharmaceutical industry. Smithfield BioScience also engages in research and development to explore new applications for their products, further solidifying their role in advancing medical solutions.

19. Peri

• Website: periedu.com
• Ownership type: Private
• Headquarters: Blue Ash, Ohio, United States (USA)
• Employee distribution: United States (USA) 100%
• Founded year: 2005
• Headcount: 11-50
• LinkedIn: professional-education-and-research-institution-llc

The Professional Education and Research Institute (PERI), founded in 2005 and based in Blue Ash, Ohio, operates as a Clinical Research Organization (CRO). Specializing in the management of clinical trials for pharmaceuticals, biotechnology, and medical devices, PERI offers a comprehensive suite of services including clinical trial management, data management, medical writing, and scientific development. Their expertise spans various therapeutic areas, with a notable focus on conditions such as diabetic foot ulcers, venous leg disease, and gene therapy. PERI has established a reputation for quality and efficiency, working closely with clients to ensure successful trial outcomes. Their international reach includes partnerships with sponsors from North America, Europe, Asia, and Australia, highlighting their capability to manage complex clinical trials across different regulatory environments. PERI's commitment to high-quality research and their collaborative approach with clinical research sites and key opinion leaders further solidifies their role in advancing medical science.

Biopharmaceutical Companies Insights: Key Companies in Ohio

Company	Headquarter	Size	Founded	Ownership
Orange Grove Bio	Cincinnati, Ohio, United States (USA)	11-50	2019	Venture Capital
Clarametyx Biosciences	Columbus, Ohio, United States (USA)	1-10	2020	Corporate
AmplifyBio	West Jefferson, Ohio, United States (USA)	201-500	2021	Venture Capital
Forge Biologics	Columbus, Ohio, United States (USA)	201-500	2020	Corporate
CinRx Pharma	Cincinnati, Ohio, United States (USA)	11-50	2015	Venture Capital
Sermonix Pharmaceuticals	Columbus, Ohio, United States (USA)	11-50	2014	Venture Capital
Aprecia Pharmaceuticals	Mason, Ohio, United States (USA)	51-200	2004	Private Equity
Oakwood Labs	Oakwood, Ohio, United States (USA)	51-200	1997	Private
Andelyn Biosciences	Columbus, Ohio, United States (USA)	201-500	2020	Private
InfinixBio	Columbus, Ohio, United States (USA)	11-50	2012	Private
North Cliff Consultants, Inc.	Cincinnati, Ohio, United States (USA)	11-50	1986	Corporate
Camargo, A Division of Premier Consulting	Cincinnati, Ohio, United States (USA)	51-200	2003	Corporate
PumasAI	Delaware, Ohio, United States (USA)	11-50	2019	Private
QTest Labs	Columbus, Ohio, United States (USA)	11-50	1999	Private
Prati-Donaduzzi	Toledo, Ohio, United States (USA)	5001-10000	1993	Private
Sterling Research Group, a Meridian Clinical Research Company | Cincinnati, OH	Cincinnati, Ohio, United States (USA)	11-50	1999	Private
Cell X Technologies	Cleveland, Ohio, United States (USA)	11-50	2019	Venture Capital
Smithfield BioScience	Cincinnati, Ohio, United States (USA)	51-200	2017	Corporate
Peri	Blue Ash, Ohio, United States (USA)	11-50	2005	Private

Want to Find More Biopharmaceutical Companies Companies?

If you want to find more companies that provide innovative drugs, therapies, and clinical trial services you can do so with Inven. This list was built with Inven and there are hundreds of companies like these globally.

With Inven you'll also get to know the company's:

• Detailed Ownership: Who owns the company? Is it a public or private company? What is the ownership structure?
• Contact data: Who are the founders and CEO's? What are their emails and phone numbers?
• Financials: How do these companies perform financially? What are their revenues and profit margins?

...and a lot more!