Minnesota's biopharmaceutical sector thrives on innovation, driven by companies exploring new medicines and therapies. This industry focuses on the development and expansion of treatments for a range of health challenges, leveraging advanced technologies and scientific research. With a notable emphasis on regenerative medicine and oncology, companies work closely with medical institutions to bring solutions from lab to life. The state's collaborative environment between academic institutions and industry contributes to a robust pipeline of new therapies, positioning Minnesota as an important player in the biopharmaceutical sphere. As research advances, the future is promising for novel treatment options and improved healthcare outcomes.


The companies featured here showcase a mix of sizes and histories, ranging from small startups to larger established firms. With founding years spanning from 1981 to 2023, they reflect a blend of innovation and experience. Headquartered mainly in cities like Minneapolis and Rochester, these organizations specialize in areas such as microbiome therapies, drug delivery, and regenerative solutions. The presence of significant funding and partnerships highlights a growing trend in the biopharmaceutical market, emphasizing both growth potential and collaborative efforts driving research and development.


Read on for insights into Minnesota's top biopharmaceutical companies.


Top 19 Biopharmaceutical Companies Companies in Minnesota


1. Rebiotix Inc (a Ferring Company)

  • Website: rebiotix.com
  • Ownership type: Corporate
  • Headquarters: Roseville, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: April 2018
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: rebiotix

Rebiotix Inc., a Ferring Company, is a biotechnology firm based in Roseville, Minnesota, founded in 2011. The company is dedicated to developing microbiome-based therapeutics, with a primary focus on innovative treatments for recurrent Clostridioides difficile infections. Through its pioneering work in fecal transplant therapies, Rebiotix aims to restore gut health and prevent the recurrence of infections, addressing a significant healthcare challenge. As part of Ferring Pharmaceuticals, Rebiotix benefits from enhanced capabilities and resources, allowing it to advance its research and development efforts in the biopharmaceutical sector. The company is committed to improving patient outcomes and is actively involved in clinical studies to validate its therapeutic approaches.


2. Humanetics Corporation

  • Website: humaneticscorp.com
  • Ownership type: Private
  • Headquarters: Minneapolis, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: Other (Grant), $5.0M, December 2024
  • Founded year: 1988
  • Headcount: 11-50
  • LinkedIn: humanetics-corporation

Humanetics Corporation, based in Minneapolis, Minnesota, is a private pharmaceutical company founded in 1988. The company is dedicated to developing and commercializing innovative treatments aimed at enhancing human health, particularly in the areas of oncology and radiation exposure. Humanetics has made significant strides with its lead product, BIO 300, which is designed to improve outcomes for cancer patients undergoing radiation therapy and to serve as a medical countermeasure against radiation injuries. The company has established a strong presence in the biopharmaceutical industry through its collaborations with federal agencies, including the Department of Defense and the National Cancer Institute, securing over $60 million in funding to support its research initiatives. Humanetics is currently engaged in multiple clinical trials, focusing on various applications of BIO 300, including its use in treating non-small cell lung cancer and mitigating the effects of radiation exposure. Their commitment to addressing urgent health needs positions them as a relevant player in the biopharmaceutical sector.


3. Be The Match BioTherapies


Be The Match BioTherapies, founded in 2016 and based in Minneapolis, Minnesota, operates as a private consulting company focused on the biopharmaceutical and biotechnology sectors. With a workforce of between 1,001 and 5,000 employees, the firm specializes in offering educational webinars and consulting services tailored to the needs of biopharma companies, transplant centers, and regulatory bodies. Their expertise lies in helping these entities navigate the complexities associated with cell therapies, which are critical for improving patient outcomes in various medical conditions. By providing insights and guidance, Be The Match BioTherapies plays a vital role in enhancing the understanding and implementation of cell therapy practices within the industry.


4. R&D Systems

  • Website: rndsystems.com
  • Ownership type: Private
  • Headquarters: Minneapolis, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 78%, India 9%, China 7%, Other 7%
  • Founded year: 1985
  • Headcount: 1001-5000
  • LinkedIn: r%26d-systems

R&D Systems, founded in 1985 and based in Minneapolis, Minnesota, is a biotechnology company dedicated to the development and manufacturing of high-quality research reagents and tools for the life sciences sector. With a workforce of over 600 employees, the company provides a wide array of products, including recombinant proteins, antibodies, and custom services tailored for researchers in biotechnology, pharmaceuticals, and academic institutions. Their extensive product catalog supports various research areas, such as cancer, immunology, and neuroscience. R&D Systems emphasizes quality and consistency in their offerings, which is crucial for advancing scientific research. They also provide custom services, including protein development and bioactivity testing, further enhancing their role in the biopharmaceutical landscape. The company operates under the Bio-Techne brand, which broadens its reach and capabilities in the industry.


5. Cytotheryx, Inc.

  • Website: cytotheryx.com
  • Ownership type: Private
  • Headquarters: Rochester, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 2019
  • Headcount: 11-50
  • LinkedIn: cytotheryx

Cytotheryx, Inc., founded in 2019 and based in Rochester, Minnesota, is a biotechnology firm dedicated to the development of primary human hepatocytes for the treatment and research of liver diseases. The company specializes in creating bioartificial livers and hepatocyte transplantation therapies, addressing the critical shortage of high-quality liver cells for medical applications. With a small team of 11-50 employees, Cytotheryx is positioned to make significant contributions to the biopharmaceutical industry by providing reliable and consistent sources of hepatocytes. Their platform technology allows for the scalable production of these cells, which can enhance drug development, toxicology studies, and regenerative medicine. Collaborations with notable institutions like Mayo Clinic further underscore their commitment to advancing liver disease treatments and research.


6. Imanis Life Sciences

  • Website: imanislife.com
  • Ownership type: Private
  • Headquarters: Rochester, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: $1.0M, March 2014
  • Founded year: 2012
  • Headcount: 11-50
  • LinkedIn: imanis-life-sciences-llc

Imanis Life Sciences, founded in 2012 and based in Rochester, Minnesota, is a private biotechnology company that specializes in life sciences research. The company offers a range of products, including cell lines, lentiviral vectors, and oncolytic viruses, as well as services such as custom product development and assay validation. Their clientele includes researchers and organizations within the biotechnology and pharmaceutical sectors, who depend on Imanis for high-quality research tools and support. Imanis is particularly focused on advancing research in regenerative medicine, gene therapy, and oncology drug discovery, making significant contributions to the development of therapies and technologies in these critical areas. The company operates with a team of skilled scientists and utilizes state-of-the-art laboratories to ensure the quality and effectiveness of their offerings.


7. Recombinetics

  • Website: recombinetics.com
  • Ownership type: Venture Capital
  • Headquarters: Eagan, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: Series A, $34.0M, August 2018
  • Founded year: 2008
  • Headcount: 11-50
  • LinkedIn: recombinetics-inc.

Recombinetics, founded in 2008 and based in Eagan, Minnesota, is a biotechnology firm that specializes in gene editing technologies for both biomedical research and agricultural applications. The company offers a range of services, including the development of gene-edited animal models and preclinical research, aimed at enhancing health outcomes and improving food production sustainability. Recombinetics has established itself as a player in the gene editing space, particularly in livestock, and is recognized for its innovative approaches to solving complex challenges in health and agriculture. Their recent funding of $34 million in a Series A round in 2018 underscores their potential for growth and development in the biopharmaceutical sector. The company is also involved in creating advanced animal models for studying human diseases, which is crucial for the development of new therapies. Through its subsidiaries, such as Sarxion Biologics and Therillume, Recombinetics is actively engaged in regenerative medicine and precision medicine, further solidifying its relevance in the biopharmaceutical industry.


8. Nanocopoeia

  • Website: nanocopoeia.com
  • Ownership type: Private
  • Headquarters: Saint Paul, Minnesota, United States (USA)
  • Latest funding: Other (Grant), $500,000, September 2006
  • Founded year: 2001
  • Headcount: 11-50
  • LinkedIn: nanocopoeia

Nanocopoeia, founded in 2001 and based in Saint Paul, Minnesota, is a privately held specialty research company dedicated to pharmaceutical development. The company emerged from a technology license with the University of Minnesota and has since focused on solving complex drug formulation challenges. Their expertise lies in enhancing drug solubility and bioavailability, which are critical factors in the effectiveness of pharmaceutical products. Nanocopoeia employs proprietary atomization technology to create macro-scale drug formulation particles, ensuring high surface area and uniformity. This innovative approach has led to significant advancements in patient safety and drug performance. The company has also demonstrated a commitment to collaboration, successfully partnering with other organizations to co-develop and out-license their technologies. With a small but technically skilled team, Nanocopoeia continues to make strides in the biopharmaceutical field, addressing high-value drug product issues.


9. Rion

  • Website: riontx.com
  • Ownership type: Venture Capital
  • Headquarters: Rochester, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: Seed, $1,000, June 2017
  • Founded year: 2017
  • Headcount: 11-50
  • LinkedIn: rion-health

Rion, based in Rochester, Minnesota, is a regenerative medicine company that specializes in exosome technology aimed at tissue regeneration. Founded in 2017, Rion emerged from the Mayo Clinic Employee Entrepreneurial Program, leveraging cutting-edge research to develop its flagship product, Purified Exosome Product (PEP™). This innovative product is derived from platelets and is designed to promote healing and recovery in patients. Rion's proprietary manufacturing process allows for the mass production of PEP™, addressing a critical challenge in the scalability of exosome-based therapies. The company is actively involved in advancing the understanding and application of exosomes in regenerative medicine, with a focus on various therapeutic applications. Rion's commitment to research and development is evident in its ongoing efforts to explore the potential of exosomes in drug delivery and tissue repair.


10. Douglas Scientific

  • Website: douglasscientific.com
  • Ownership type: Corporate
  • Headquarters: Alexandria, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: April 2016
  • Founded year: 2009
  • Headcount: 51-200
  • LinkedIn: douglas-scientific

Douglas Scientific, based in Alexandria, Minnesota, is a biotechnology service provider founded in 2009. The company specializes in the discovery, development, and manufacture of nucleic acid-based therapeutics. Their offerings include a range of services such as analytics, gene editing, and bioinformatics. Douglas Scientific primarily serves pharmaceutical and biotechnology companies that require advanced solutions for drug development. With a commitment to high-quality service delivery and scientific excellence, they play a significant role in the evolving landscape of nucleic acid medicines, which are becoming increasingly important in modern therapeutics.


11. Kindeva Drug Delivery

  • Website: kindevadd.com
  • Ownership type: Corporate
  • Headquarters: Woodbury, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 66%, United Kingdom (UK) 34%
  • Latest funding: Other (Grant), $42.0M, August 2023
  • Founded year: 2020
  • Headcount: 1001-5000
  • LinkedIn: kindeva

Kindeva Drug Delivery, founded in 2020 and based in Woodbury, Minnesota, is a contract development and manufacturing organization (CDMO) that specializes in drug-device combination products. The company offers a wide range of services, including aseptic injectable fill-finish, regulatory support, and analytical services. Kindeva is known for its innovative approaches to drug delivery, particularly in pulmonary, nasal, injectable, and transdermal therapies. With a workforce of over 1,200 employees and facilities in the United States and the United Kingdom, Kindeva is well-equipped to support pharmaceutical and biotechnology companies in accelerating product development and ensuring compliance with regulatory standards. The company has also received significant funding, with a recent grant of over $41 million in August 2023, which underscores its commitment to advancing drug delivery technologies and sustainability initiatives.


12. Engage Health, Inc.

  • Website: engagehealth.com
  • Ownership type: Private
  • Headquarters: Eagan, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 2001
  • Headcount: 11-50
  • LinkedIn: engage-health

Engage Health, Inc., founded in 2001 and based in Eagan, Minnesota, is a private health research firm that specializes in the market development of rare diseases. With a dedicated team of professionals, the company offers comprehensive services that include clinical trial support, consulting, and patient-researcher connections. Their proprietary database, EnCompass®, is a critical resource that characterizes over 1.4 million healthcare providers and patients, facilitating the development of therapies for more than 100 rare disease areas. Engage Health has built a reputation for its commitment to improving patient access to therapies and advancing research in the rare disease space. Their extensive experience and focus on rare diseases make them a notable entity within the biopharmaceutical industry.


13. MD Biosciences Minnesota (MLM Medical Labs)

  • Website: mdbiosciences.com
  • Ownership type: Corporate
  • Headquarters: Oakdale, Minnesota, United States (USA)
  • Latest funding: October 2020
  • Founded year: 1991
  • Headcount: 51-200
  • LinkedIn: md-biosciences

MD Biosciences Minnesota, also known as MLM Medical Labs, is a corporate entity based in Oakdale, Minnesota, established in 1991. The company operates as a biomedical laboratory, providing a variety of laboratory services that include preclinical and clinical laboratory services, biomarker studies, and immunology models. They cater primarily to clients in the biomedical and pharmaceutical sectors, assisting in drug development and research through high-quality laboratory services. Their expertise spans several areas, including cancer, arthritis, and metabolic diseases, which are critical in advancing therapeutic solutions. MD Biosciences is recognized for its commitment to quality, having achieved CLIA certification, which ensures that their laboratory testing meets stringent federal standards. This certification enhances their credibility in the clinical diagnostics arena, allowing them to support a wide range of research initiatives and clinical trials.


14. Laboratoire XO

  • Website: laboratoirexo.com
  • Ownership type: Private Equity
  • Headquarters: St. Cloud, Minnesota, United States (USA)
  • Latest funding: October 2022
  • Founded year: 2015
  • Headcount: 11-50
  • LinkedIn: laboratoire-x.o

Laboratoire XO, also known as LXO Group, is a pharmaceutical and medical device manufacturer based in St. Cloud, Minnesota. Established in 2015, the company has carved out a niche in providing essential medications and medical devices, focusing on therapeutic areas such as cardiology, central nervous system disorders, and internal medicine. With a commitment to quality, ethics, and transparency, LXO has successfully executed 20 acquisitions since its inception, significantly enhancing its product offerings and market presence. The company operates in over 80 countries, ensuring access to high-quality treatments for healthcare providers and patients alike. LXO's recent acquisition of Nimotop®, a medication used for treating vasospasms, underscores its strategy to expand its portfolio and maintain a strong international presence. The company prides itself on producing a majority of its products in Europe, with a focus on sustainability and corporate social responsibility.


15. DaVita Clinical Research

  • Website: davitaclinicalresearch.com
  • Ownership type: Corporate
  • Headquarters: Edina, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Latest funding: November 2012
  • Founded year: 2000
  • Headcount: 51-200
  • LinkedIn: davita-clinical-research

DaVita Clinical Research, founded in 2000 and based in Edina, Minnesota, operates as a clinical research organization with a strong emphasis on renal health. The company provides a comprehensive suite of services that includes late-phase clinical trials, health economics, and outcomes research. Their primary clientele consists of pharmaceutical and biotech companies, as well as healthcare providers, who depend on DaVita's expertise to facilitate drug development and enhance patient care. With a history rooted in nephrology, DaVita Clinical Research has expanded its capabilities to address various specialty populations and primary care needs. The organization has been instrumental in advancing knowledge and practice in clinical research, particularly in the context of chronic kidney disease and end-stage renal disease. Their commitment to improving patient outcomes through research is evident in their extensive network of research sites and partnerships with healthcare professionals.


16. Nu-Tek BioSciences

  • Website: nu-tekbiosciences.com
  • Ownership type: Private
  • Headquarters: Minnetonka, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 2009
  • Headcount: 11-50
  • LinkedIn: nutek-bioscience

Nu-Tek BioSciences, founded in 2009 and based in Minnetonka, Minnesota, is a biotechnology firm dedicated to the production of animal-free peptones and cell culture media tailored for pharmaceutical applications. The company operates the only completely animal-free peptone manufacturing facility in the United States, which allows them to provide solutions that significantly reduce contamination risks associated with animal products. Their product line includes soy, pea, wheat, and rice peptones, as well as yeast extracts, all designed to support drug development and industrial fermentation processes. Nu-Tek's commitment to sustainability and regulatory compliance positions them as a valuable partner for pharmaceutical manufacturers seeking reliable and safe media supplements. They actively engage with clients to customize solutions that meet specific project needs, showcasing their adaptability and customer-centric approach.


17. IDD Research Solutions INC (former I5 Clinical Research ) A Unit of Medlix Group

  • Website: iddresearch.com
  • Ownership type: Private
  • Headquarters: Minnetonka, Minnesota, United States (USA)
  • Employee distribution: India 98%, Other 2%
  • Founded year: 2009
  • Headcount: 51-200
  • LinkedIn: idd-research-solutions-inc

IDD Research Solutions INC, formerly known as I5 Clinical Research, is a clinical research organization based in Minnetonka, Minnesota. Founded in 2009, the company specializes in providing comprehensive services for drug development and clinical trials. With a workforce of approximately 118 employees, the organization has developed innovative solutions like iSMART and iPET, which aim to streamline trial processes for pharmaceutical and biotechnology clients. These products focus on digitalizing and automating various aspects of clinical trial conduct, thereby enhancing efficiency and reducing costs. IDD Research Solutions has completed numerous Phase II and III studies and has a strong track record of client retention, indicating a solid reputation in the industry. Their services include site management, regulatory affairs, clinical monitoring, and data management, making them a strategic partner for companies in need of clinical research support. The company operates primarily in India, with a small presence in the United States, reflecting a global approach to clinical research.


18. Veterinary Pharmaceutical Solutions


Veterinary Pharmaceutical Solutions (VPS), based in Saint Peter, Minnesota, has been a dedicated provider of compounded medications for livestock since its inception in 1995. The company specializes in creating tailored pharmaceutical solutions that address specific health needs in the livestock industry. With a team comprising pharmacists, technicians, and veterinarians, VPS emphasizes innovation and quality in its offerings. Their product range includes water-soluble amoxicillin, meloxicam, and various injectable products, all designed to meet the unique requirements of veterinarians and livestock producers. VPS has established itself as a trusted partner in livestock care, having treated over 2 billion pigs, showcasing their impact in the veterinary pharmaceutical space. The company operates without reported external funding, indicating a self-sustaining business model that has evolved through years of industry experience.


19. Biovest International

  • Website: hollow-fiber.com
  • Ownership type: Private
  • Headquarters: Minneapolis, Minnesota, United States (USA)
  • Employee distribution: United States (USA) 100%
  • Founded year: 1981
  • Headcount: 51-200
  • LinkedIn: biovest-international

Biovest International, also known as Cell Culture Company, is a biotechnology firm based in Minneapolis, Minnesota. Founded in 1981, the company specializes in the development and manufacturing of hollow fiber bioreactors, which are essential for cell culture and bioprocessing applications. Their products are utilized across various sectors, including diagnostics, therapeutics, and research, providing efficient solutions for protein production. Biovest's technology is particularly significant in the production of monoclonal antibodies and recombinant proteins, which are vital for modern therapeutics. The company operates with a commitment to quality and continuous improvement, ensuring that their bioreactors meet the rigorous demands of the biopharmaceutical industry. With a dedicated team and a focus on innovation, Biovest International plays a crucial role in enhancing productivity and efficiency in biotechnological processes.



Biopharmaceutical Companies Insights: Key Companies in Minnesota


CompanyHeadquarterSizeFoundedOwnership
Rebiotix Inc (a Ferring Company)Roseville, Minnesota, United States (USA)11-502011Corporate
Humanetics CorporationMinneapolis, Minnesota, United States (USA)11-501988Private
Be The Match BioTherapiesMinneapolis, Minnesota, United States (USA)1001-50002016Private
R&D SystemsMinneapolis, Minnesota, United States (USA)1001-50001985Private
Cytotheryx, Inc.Rochester, Minnesota, United States (USA)11-502019Private
Imanis Life SciencesRochester, Minnesota, United States (USA)11-502012Private
RecombineticsEagan, Minnesota, United States (USA)11-502008Venture Capital
NanocopoeiaSaint Paul, Minnesota, United States (USA)11-502001Private
RionRochester, Minnesota, United States (USA)11-502017Venture Capital
Douglas ScientificAlexandria, Minnesota, United States (USA)51-2002009Corporate
Kindeva Drug DeliveryWoodbury, Minnesota, United States (USA)1001-50002020Corporate
Engage Health, Inc.Eagan, Minnesota, United States (USA)11-502001Private
MD Biosciences Minnesota (MLM Medical Labs)Oakdale, Minnesota, United States (USA)51-2001991Corporate
Laboratoire XOSt. Cloud, Minnesota, United States (USA)11-502015Private Equity
DaVita Clinical ResearchEdina, Minnesota, United States (USA)51-2002000Corporate
Nu-Tek BioSciencesMinnetonka, Minnesota, United States (USA)11-502009Private
IDD Research Solutions INC (former I5 Clinical Research ) A Unit of Medlix GroupMinnetonka, Minnesota, United States (USA)51-2002009Private
Veterinary Pharmaceutical SolutionsSaint Peter, Minnesota, United States (USA)11-501995Private
Biovest InternationalMinneapolis, Minnesota, United States (USA)51-2001981Private


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