The pharmaceuticals industry in the U.S. is pivotal, focusing on the research, development, and production of medications and vaccines. Companies range from large multinationals to specialized biotech firms, with a shift towards personalized medicine and advanced treatments. Health challenges such as aging populations and the rise of chronic diseases drive continuous innovation. Notably, biotechnology companies like Seattle Genetics are at the forefront of drug development, developing targeted therapies that improve patient outcomes. As the sector embraces digital advancements, the landscape is evolving rapidly, impacting everything from production processes to patient engagement strategies.

This list highlights 18 pharmaceuticals companies in the U.S., reflecting various company sizes and specializations. From established giants like Pfizer to innovative biotech firms such as Alzheon, these organizations represent different foundational years and headquarters across the nation. They collectively address health issues through medications for cancer, autoimmune diseases, and rare disorders, showcasing the breadth of research and development efforts within the industry. Many of these companies are also investing in advanced technologies and sustainable practices, reinforcing their commitment to improving health outcomes.

Read on to discover more about top pharmaceuticals companies in the U.S.

Top 18 Pharmaceuticals Companies in the US

1. Seattle Genetics

• Website: seattlegenetics.com
• Ownership type: Private
• Headquarters: Bothell, Washington, United States (USA)
• Founded year: 1998
• Headcount: 1001-5000
• LinkedIn: seattle-genetics

Seattle Genetics, founded in 1998 and based in Bothell, Washington, is a biopharmaceutical company dedicated to the development and commercialization of innovative therapies for cancer. The company is particularly recognized for its pioneering work in antibody-drug conjugates (ADCs), which combine targeted therapies with potent cytotoxic agents to improve treatment outcomes for patients with various types of cancer. Seattle Genetics has successfully brought several products to market, including Adcetris, which is used to treat certain lymphomas. The company is committed to extensive research and development, focusing on advancing its pipeline of therapies aimed at addressing significant unmet medical needs in oncology. With a workforce of over 2,000 employees, Seattle Genetics continues to push the boundaries of cancer treatment through scientific innovation and collaboration with healthcare providers.

2. Acceleron Pharma

• Website: acceleronpharma.com
• Ownership type: Corporate
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 94%, Canada 6%
• Latest funding: $11.5B, September 2021
• Founded year: 2003
• Headcount: 201-500
• LinkedIn: acceleron-pharma

Acceleron Pharma, based in Cambridge, Massachusetts, is a biotechnology company founded in 2003. The company is dedicated to developing therapies for serious diseases, with a particular emphasis on hematology and pulmonary medicine. Acceleron is known for its innovative approach to drug development, focusing on the underlying biology of diseases to create targeted therapies. Their pipeline includes several promising candidates aimed at treating conditions such as pulmonary arterial hypertension and other rare diseases. The company has received significant funding, with a reported last funding amount of $115 million in September 2021, which underscores investor confidence in their research and development efforts. Acceleron Pharma's commitment to advancing medical science positions it as a relevant player in the pharmaceutical sector.

3. Pfizer 21

• Website: pfizer.dk
• Ownership type: Private
• Headquarters: Manchester Township, New Jersey, United States (USA)
• Employee distribution: India 74%, Saudi Arabia 26%
• Founded year: 1998
• Headcount: 5001-10000
• LinkedIn: pfizer-21

Pfizer 21, based in Manchester Township, New Jersey, is a private biopharmaceutical company that specializes in the research, development, and manufacturing of innovative medications. Founded in 1998, Pfizer has a long-standing history in the pharmaceutical industry, with roots tracing back to 1849. The company is dedicated to serving healthcare providers, patients, and organizations by offering a wide range of prescription medications. Pfizer actively conducts clinical research aimed at enhancing health outcomes and collaborates closely with healthcare professionals to improve patient care. With a workforce that includes a significant presence in India and Saudi Arabia, Pfizer is committed to addressing global health challenges. Their ongoing investment in research and development underscores their role in advancing medical science and providing effective treatments for various health conditions.

4. NPS Pharma

• Website: shire.com
• Ownership type: Corporate
• Headquarters: Bedminster, New Jersey, United States (USA)
• Employee distribution: United States (USA) 51%, Algeria 12%, Ireland 12%, Other 25%
• Latest funding: $86.4B, April 2018
• Founded year: 1986
• Headcount: 201-500
• LinkedIn: nps-pharmaceuticals

NPS Pharma, a subsidiary of Takeda Pharmaceutical Company Limited, is based in Bedminster, New Jersey. Founded in 1986, the company has carved out a niche in the pharmaceutical industry by concentrating on the research, development, manufacturing, and marketing of innovative medicines. Their therapeutic focus includes gastrointestinal diseases, rare diseases, oncology, and vaccines, which are critical areas in healthcare. NPS Pharma is dedicated to transforming the lives of patients, particularly those with limited treatment options. The company operates globally, with a workforce that spans several countries, including the United States, Algeria, Ireland, India, and Ghana. Their commitment to advancing medical science is evident in their robust pipeline and ongoing clinical trials aimed at delivering effective treatments to patients in need.

5. Pfizer UK

• Website: pfizer.co.uk
• Ownership type: Corporate
• Headquarters: United States (USA)
• Employee distribution: United Kingdom (UK) 80%, Ireland 20%
• Latest funding: May 2024
• Founded year: 1952
• Headcount: 51-200
• LinkedIn: pfizer-uk

Pfizer UK, established in 1952, is a pharmaceutical company that specializes in developing and manufacturing prescription medicines and vaccines. With a workforce of approximately 163 employees, the company operates primarily in the United Kingdom, with a smaller presence in Ireland. Pfizer UK is dedicated to providing innovative therapies that address a wide range of health conditions, ensuring that healthcare professionals and patients have access to effective treatments. The company emphasizes research and development, which is vital for maintaining a steady pipeline of new medicines. Pfizer UK also engages in various initiatives aimed at improving healthcare standards, such as supporting education and collaborating with healthcare organizations. Their commitment to addressing health inequalities and enhancing patient information reflects their broader responsibility to society. Pfizer UK is part of a global network that collaborates with academic institutions and other organizations to advance medical science and improve health outcomes.

6. Eisai US

• Website: us.eisai.com
• Ownership type: Private
• Headquarters: Nutley, New Jersey, United States (USA)
• Employee distribution: United States (USA) 89%, Other 11%
• Founded year: 1995
• Headcount: 1001-5000
• LinkedIn: eisai

Eisai US, based in Nutley, New Jersey, is a pharmaceutical company that specializes in creating innovative treatments primarily in the fields of oncology and neurology. Founded in 1995, the company operates with a workforce of approximately 2,955 employees. Eisai US is dedicated to addressing the unmet needs of patients and healthcare providers through its extensive product offerings and active participation in clinical trials. Their product portfolio includes notable medications such as Leqembi for Alzheimer's disease and Lenvima for cancer treatment. Eisai US is also committed to human health care, which is reflected in their community involvement initiatives and patient support programs. They actively engage in corporate responsibility efforts, aiming to make a positive impact on the lives of patients and their families. This focus on patient-centric solutions and their ongoing research efforts solidify their position in the pharmaceutical sector.

7. Amplyx, now a subsidiary of Pfizer Inc.

• Website: amplyx.com
• Ownership type: Corporate
• Headquarters: San Diego, California, United States (USA)
• Latest funding: April 2021
• Founded year: 2006
• Headcount: 11-50
• LinkedIn: amplyx-pharmaceuticals-inc

Amplyx, now a subsidiary of Pfizer Inc., is based in San Diego, California, and was founded in 2006. The company specializes in the development of innovative therapies for serious fungal infections, particularly targeting patients with weakened immune systems. Amplyx's lead product candidate, APX001, is designed to treat invasive fungal infections, which are a significant concern in healthcare settings. As part of Pfizer, Amplyx benefits from the extensive resources and research capabilities of a global pharmaceutical leader, allowing it to advance its clinical programs and contribute to the broader mission of improving patient outcomes in infectious disease management.

8. Agensys, Inc.

• Website: astellas.us
• Ownership type: Private
• Headquarters: Santa Monica, California, United States (USA)
• Founded year: 1997
• Headcount: 201-500
• LinkedIn: agensys

Agensys, Inc., based in Santa Monica, California, operates as a subsidiary of Astellas Pharma US, Inc. Founded in 1997, the company is dedicated to the development and marketing of pharmaceutical products that address critical health issues. Its primary focus areas include oncology, cardiology, and immunology, where it aims to enhance patient outcomes through innovative therapies. Agensys is involved in various stages of drug development, from research to clinical trials, and emphasizes collaboration with healthcare providers to ensure that its products meet the needs of patients. The company also provides resources and support for patients and caregivers, reflecting its commitment to patient-centric care. While there is no reported funding, Agensys continues to operate within a robust corporate structure that supports its mission in the pharmaceutical industry.

9. Neopharmed Gentili S.P.A.

• Website: neogen.it
• Ownership type: Private
• Headquarters: Milan, Michigan, United States (USA)
• Employee distribution: Italy 100%
• Founded year: 2018
• Headcount: 201-500
• LinkedIn: neopharmed-gentili-s.p.a.

Neopharmed Gentili S.P.A. is an Italian pharmaceutical company based in Milan, founded in 2018. The company is dedicated to the commercialization of high therapeutic value solutions, targeting multiple therapeutic areas including cardio-metabolic, neuro-psychiatric, vascular, osteo-articular, pneumological, gastrointestinal, and antibiotic treatments. Neopharmed Gentili provides a range of products such as medications, medical devices, dietary supplements, and cosmetics, aiming to enhance health outcomes and improve the quality of life for patients. The company prides itself on its commitment to innovation and research, which are integral to its operations. Neopharmed Gentili collaborates with notable multinational partners, enhancing its capabilities and market reach. Their focus on social responsibility and sustainability further underscores their commitment to the healthcare sector and the communities they serve.

10. Alzheon, Inc. | Preserving Future Memories

• Website: alzheon.com
• Ownership type: Venture Capital
• Headquarters: Framingham, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 93%, Czech Republic 7%
• Latest funding: Series E-K, $100.0M, June 2024
• Founded year: 2013
• Headcount: 11-50
• LinkedIn: alzheon

Alzheon, Inc. is a biotechnology firm based in Framingham, Massachusetts, established in 2013. The company is dedicated to developing innovative treatments for Alzheimer's disease, a condition that poses significant challenges to patients and healthcare systems alike. Their flagship product, valiltramiprosate (ALZ-801), is currently undergoing Phase 3 clinical trials, specifically targeting patients with the APOE4/4 genotype, who are at a higher risk for disease progression. Alzheon has engaged in extensive research and development, aiming to address unmet medical needs in Alzheimer's care. The company has also secured substantial funding, including a recent $100 million investment, which reflects strong backing from venture capital sources. This financial support is crucial for advancing their clinical trials and bringing their treatment closer to market. Alzheon’s commitment to precision medicine and their focus on a genetically targeted approach position them as a noteworthy player in the pharmaceutical industry, particularly in the field of neurodegenerative disorders.

11. Laboratorios AC FARMA

• Website: acfarma.com
• Ownership type: Private
• Headquarters: United States (USA)
• Employee distribution: Peru 98%, Other 2%
• Founded year: 1993
• Headcount: 501-1000
• LinkedIn: laboratorios-ac-farma

Laboratorios AC FARMA S.A. is a pharmaceutical manufacturer established in 1993, primarily focused on producing high-quality pharmaceutical products. The company serves healthcare professionals and institutions, providing effective medications aimed at health restoration and maintenance. With a workforce of approximately 482 employees, the company operates with advanced technology and adheres to rigorous quality standards. AC FARMA is committed to continuous improvement and innovation, developing new product lines based on scientific and ethical principles. Their manufacturing capabilities include a range of solid, semi-solid, and liquid formulations, including specialized products such as hormonal and oncological medications. The company has achieved certifications in Good Manufacturing Practices, ensuring compliance with international quality standards. Although there is no reported funding, their operational model and commitment to quality position them as a significant entity in the pharmaceutical industry, particularly in the Latin American market.

12. MedImmune

• Website: medimmune.com
• Ownership type: Venture Capital
• Headquarters: Gaithersburg, Maryland, United States (USA)
• Employee distribution: United States (USA) 78%, United Kingdom (UK) 18%, Other 4%
• Latest funding: $15.6B, April 2007
• Founded year: 1987
• Headcount: 1001-5000
• LinkedIn: medimmune

MedImmune, founded in 1987 and based in Gaithersburg, Maryland, is a biopharmaceutical company that operates as a subsidiary of AstraZeneca. The company specializes in the research and development of innovative medicines across various therapeutic areas, including oncology, cardiovascular, and respiratory diseases. MedImmune is dedicated to improving health outcomes through its extensive pipeline of products, which reflects its commitment to addressing unmet medical needs. The company employs approximately 960 people, with a significant portion of its workforce located in the United States. MedImmune's focus on sustainability and ethical practices further underscores its role in the healthcare sector, as it seeks to enhance patient care and access to treatments.

13. Sanofi Genzyme

• Website: sanofigenzyme.com
• Ownership type: Private
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Founded year: 1981
• Headcount: 5001-10000
• LinkedIn: sanofigenzyme

Sanofi Genzyme, based in Cambridge, Massachusetts, is a prominent healthcare and pharmaceutical company founded in 1981. As a subsidiary of Sanofi, it focuses on developing innovative medicines and vaccines aimed at improving patient outcomes across various health conditions. The company operates globally, emphasizing research and development to deliver effective healthcare solutions. Sanofi Genzyme's portfolio includes treatments for immunology, neurology, oncology, rare blood disorders, and other rare diseases. Their commitment to social impact is evident through initiatives aimed at enhancing healthcare access and supporting vulnerable communities. With nearly 10,000 employees, Sanofi Genzyme plays a crucial role in the pharmaceutical industry, driving advancements in science and technology to meet the needs of patients worldwide.

14. Prometheus Biosciences, Inc.

• Website: prometheusbiosciences.com
• Ownership type: Corporate
• Headquarters: San Diego, California, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $10.8B, April 2023
• Founded year: 1995
• Headcount: 51-200
• LinkedIn: prometheusbiosciences

Prometheus Biosciences, Inc. is a biotechnology firm based in San Diego, California, founded in 1995. The company is dedicated to developing precision medicine for patients suffering from autoimmune diseases, with a strong emphasis on inflammatory bowel disease (IBD). Their innovative approach leverages advanced science to create targeted therapies that address the underlying causes of these conditions. Prometheus is actively involved in clinical trials, showcasing their commitment to research and development in the pharmaceutical sector. Recently, they secured substantial funding, which underscores investor confidence in their potential to deliver effective treatments and expand their pipeline of drug candidates. This funding will likely support their ongoing research efforts and clinical programs, further solidifying their position in the pharmaceutical industry.

15. Portola Pharmaceuticals

• Website: portola.com
• Ownership type: Corporate
• Headquarters: South San Francisco, California, United States (USA)
• Employee distribution: United States (USA) 93%, United Kingdom (UK) 7%
• Latest funding: $1.4B, May 2020
• Founded year: 2003
• Headcount: 201-500
• LinkedIn: portola-pharmaceuticals

Portola Pharmaceuticals, founded in 2003 and based in South San Francisco, California, is a biopharmaceutical company dedicated to developing innovative therapies for patients with serious medical conditions. The company has made significant strides in the field of hematology, particularly with its focus on anticoagulation therapies. Portola's notable products include Andexxa, which is designed to reverse the effects of certain anticoagulants, and Bevyxxa, an oral anticoagulant. The company has received substantial funding, with a reported last funding amount of $1.4 billion in May 2020, which underscores investor confidence in its potential. Despite facing challenges, including a restructuring after its acquisition by Alexion Pharmaceuticals, Portola remains committed to addressing critical health needs and improving patient outcomes in the rare disease community.

16. Salix Pharmaceuticals

• Website: salix.com
• Ownership type: Corporate
• Headquarters: Bridgewater, New Jersey, United States (USA)
• Employee distribution: United States (USA) 99%
• Latest funding: February 2015
• Founded year: 1988
• Headcount: 501-1000
• LinkedIn: salix-pharmaceuticals

Salix Pharmaceuticals, founded in 1988 and based in Bridgewater, New Jersey, is a specialty pharmaceutical company dedicated to developing and marketing innovative treatments for gastrointestinal disorders. The company serves healthcare professionals and patients, focusing on chronic GI conditions such as overt hepatic encephalopathy, irritable bowel syndrome, and ulcerative colitis. Salix has a strong commitment to research and development, aiming to improve patient outcomes and enhance quality of life. With a workforce of approximately 761 employees, Salix operates primarily in the United States and has a history of significant product approvals, including XIFAXAN® and RELISTOR®. The company is a subsidiary of Bausch Health Companies Inc., which further supports its operational capabilities and market reach.

17. TESARO, Inc.

• Website: tesarobio.com
• Ownership type: Corporate
• Headquarters: Waltham, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 74%, France 12%, Puerto Rico 3%, Other 10%
• Latest funding: $5.1B, December 2018
• Founded year: 2010
• Headcount: 501-1000
• LinkedIn: tesaro

TESARO, Inc. is a pharmaceutical company based in Waltham, Massachusetts, established in 2010. The company specializes in the development and commercialization of innovative medicines for cancer treatment. Its flagship product, Zejula (niraparib), is a treatment for ovarian cancer and has been approved in multiple markets. TESARO is dedicated to addressing unmet medical needs in oncology, focusing on improving patient outcomes through its research and development initiatives. The company has garnered significant funding, with a total of $5.1 billion raised as of December 2018, reflecting its potential and the confidence investors have in its mission to advance cancer therapies.

18. Affinivax Inc.

• Website: affinivax.com
• Ownership type: Corporate
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Employee distribution: United States (USA) 100%
• Latest funding: $2.1B, May 2022
• Founded year: 2014
• Headcount: 51-200
• LinkedIn: affinivax-inc.

Affinivax Inc. is a biotechnology firm based in Cambridge, Massachusetts, founded in 2014. The company specializes in the development of vaccines, particularly focusing on innovative multivalent vaccine technologies. Their research aims to address significant public health challenges by creating vaccines that can provide broader protection against infectious diseases. Affinivax is actively engaged in advancing its pipeline of vaccine candidates, which are designed to enhance immune responses and improve efficacy. The company has attracted substantial funding, with a notable investment of $210 million in May 2022, underscoring its potential and relevance in the pharmaceutical landscape.

Pharmaceuticals Insights: Key Companies in the US

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