The US healthcare industry is a vast network focused on improving patient health through a mix of services and products. It includes pharmaceutical firms, medical technology companies, healthcare providers, and insurance organizations. With a growing emphasis on technology, telemedicine, and personalized care, the sector is evolving rapidly to meet the increasing demand for innovative solutions. Interesting trends show that investments in digital health and biotechnology are driving a transformation, as companies develop advanced treatments and enhance accessibility. As healthcare expenses rise, addressing these challenges will require more efficient models and collaboration across various stakeholders.


This list highlights 19 prominent healthcare investors from various backgrounds, including venture capital firms and corporate investment groups. Hailing from key locations like New York, San Francisco, and Chicago, these investors range in size, funding both established ventures and innovative startups. Founded in years from 1946 to 2023, they collectively reported 1,073 investments in 2024, demonstrating a strong commitment to growth within the healthcare sector. Investors such as StartUp Health and Y Combinator are fostering the next generation of healthcare solutions by supporting visionary entrepreneurs and cutting-edge companies.


Top 19 Healthcare Investors in the US


1. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that helps entrepreneurs launch and grow their businesses. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Among its diverse portfolio, Y Combinator has made significant investments in the healthcare sector, including Reliance Health, which raised $6 million in Series A funding in 2020, and RelianceHMO, which also raised $6 million in Series A funding the same year. Additionally, they have invested in Akido Labs, further showcasing their engagement in healthcare innovation. These transactions highlight Y Combinator's role in supporting healthcare startups alongside its broader investment strategy.


2. OrbiMed

  • Website: orbimed.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1989
  • Headcount: 51-200
  • Number of deals in 2024: 52
  • LinkedIn: orbimed-advisors

OrbiMed is an investment firm founded in 1989, based in New York, specializing in healthcare investments. With approximately $17 billion in assets under management, OrbiMed focuses on providing capital to companies engaged in various aspects of healthcare, including biopharmaceuticals, medical devices, and healthcare services. Notable transactions include leading a $100 million Series F funding round for Health Catalyst, a provider of data analytics for healthcare transformation, and participating in a $168 million Series D financing for Crossover Health, a tech-enabled national healthcare organization. Additionally, OrbiMed provided a $50 million non-dilutive credit facility to DarioHealth, further showcasing their active role in supporting healthcare innovation. Their clients include medical institutions and investment funds, emphasizing their influence in the healthcare investment landscape.


3. MedTech Innovator

  • Website: medtechinnovator.org
  • Type: Corporate
  • Headquarters: Los Angeles, California, United States (USA)
  • Founded year: 2013
  • Headcount: 11-50
  • Number of deals in 2024: 85
  • LinkedIn: medtech-innovator

MedTech Innovator is the largest accelerator for medical technology companies, founded in 2013 and based in Los Angeles, California. As a not-for-profit organization, it provides accelerator programs, mentorship, and competitions aimed at helping startups in the medical device, digital health, and diagnostics sectors. In 2024 alone, MedTech Innovator has been involved in 85 investments, showcasing their active role in the healthcare innovation landscape. Notable transactions include supporting Patientory, which raised funds through a grant in 2017, and several companies like Dopl Technologies and INIA Biosciences that received non-equity assistance in 2024. These activities highlight their commitment to nurturing healthcare startups and driving advancements in medical technology.


4. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm founded in 1977, based in Menlo Park, California. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Notably, NEA has been involved in several significant healthcare transactions, including a $80 million Series A investment in Bright Healthcare in 2016, a $4.7 million Series A investment in Omada Health in 2013, and a $165 million growth equity funding round for Paladina Health in 2018. These investments highlight NEA's active role in supporting innovative healthcare solutions and companies.


5. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, founded in 2011, that is dedicated to health innovation. They support health entrepreneurs and startups through their Health Moonshot Communities, providing essential resources, networking opportunities, and media content aimed at addressing significant health challenges. StartUp Health has been involved in notable transactions within the healthcare sector, including a $65 million Series B investment in Cityblock Health, which focuses on providing healthcare services to underserved communities. They also participated in the Series B funding of Devoted Health, a company that serves seniors, raising $300 million, and Human Longevity, which raised $220 million to develop health technology solutions. Additionally, they have invested in early-stage companies like CliniVantage Healthcare and Hurdle, both of which are focused on healthcare solutions. Their diverse portfolio and commitment to health innovation make them a significant player in the healthcare investment landscape.


6. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

The Deep Tech Fund, part of Alumni Ventures, is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios. With a network of over 10,000 investors, the firm focuses on connecting them with high-quality investment opportunities in the startup ecosystem. Notably, the fund has been involved in several significant transactions in the healthcare sector, including investments in Centivo, a digital health plan company, and Accolade, a healthcare tech company. Additionally, they participated in the Series B funding for Sami, a Brazilian health plan operator, and have also invested in Taro Health, indicating a strong interest in healthcare innovation and technology.


7. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024, they have made 253 investments across multiple sectors, including healthcare. Notably, they have invested in companies like Heal, which raised funds through a convertible note, and Ciba Health, a virtual healthcare platform that raised significant funding in both Seed and Series A rounds. Their investment in Gaja Health further demonstrates their engagement in the healthcare space, highlighting their role in supporting startups that aim to improve health outcomes and address chronic conditions.


8. Perceptive Advisors


Perceptive Advisors is a New York-based venture capital firm founded in 1999, specializing in the life sciences sector. The firm provides capital solutions and investment management services to both private and public healthcare companies, focusing on areas such as biotechnology, pharmaceuticals, and medical devices. Their expertise is instrumental in helping clients secure funding for innovation and growth in the healthcare industry. Notable transactions include participation in Crossover Health's $168M Series D financing, Omada Health's $192M Series E funding round, and significant post-IPO equity investments in Clover Health and DarioHealth. These transactions highlight Perceptive Advisors' active role in advancing healthcare solutions and their commitment to the sector.


9. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

Sosv is a venture capital firm founded in 1995, based in the United States, that specializes in funding and supporting deep tech startups through its development programs. With a focus on sectors like health and climate technology, Sosv provides venture capital investment and resources to help startups grow and succeed. In the healthcare context, Sosv has been involved in several significant transactions, including investments in The CareVoice, a Shanghai-based health insurtech platform, where they participated in multiple funding rounds from Seed to Series B, supporting the company's R&D and expansion efforts. Additionally, Sosv invested in medIQ, further showcasing their commitment to healthcare innovation. Operating globally, Sosv connects innovative companies with investors, making them a key player in the healthcare investment landscape.


10. GV (Google Ventures)

  • Website: gv.com
  • Type: Venture Capital
  • Headquarters: San Francisco Bay Area, California, United States (USA)
  • Founded year: 2009
  • Headcount: 51-200
  • Number of deals in 2024: 74
  • LinkedIn: gv

GV (Google Ventures) is a venture capital firm founded in 2009, based in the San Francisco Bay Area, California. With over $10 billion in assets under management, GV focuses on funding and supporting innovative technology startups across various sectors, including life sciences and artificial intelligence. Notably, GV has invested in several healthcare-related companies, such as Oscar Health, which raised $32.5 million in a venture round in 2015, and One Medical, a concierge medical group that received $30 million in funding in 2013, led by GV. Additionally, GV participated in Aledade's funding rounds, contributing to their Series C round of $64 million in 2020 and a Series B round in 2017. These investments highlight GV's active role in the healthcare industry, particularly in companies that leverage technology to improve healthcare delivery and access.


11. Silicon Valley Bank

  • Website: svb.com
  • Type: Venture Capital
  • Headquarters: Santa Clara, California, United States (USA)
  • Founded year: 1983
  • Headcount: 5001-10000
  • Number of deals in 2024: 31
  • LinkedIn: silicon-valley-bank

Silicon Valley Bank is a commercial bank founded in 1983, specializing in providing financial services to the innovation economy, particularly tech startups and venture capital firms. They offer a range of products including business banking, global payments, and asset management, helping clients navigate financial challenges and support their growth. Notably, Silicon Valley Bank has been involved in significant transactions within the healthcare sector, such as providing a $50 million capital raise for Teladoc Health, the largest telemedicine company in the US, through a combination of a term loan and a revolving line of credit. They also supported Oak Street Health with a $300 million credit facility aimed at operational and strategic capital. Additionally, they participated in financing DispatchHealth, a company focused on providing in-home healthcare services, through both debt financing and a Series E round. These transactions highlight their active role in the healthcare industry, particularly in supporting innovative healthcare solutions.


12. Polaris Partners

  • Website: polarispartners.com
  • Type: Venture Capital
  • Headquarters: Boston, Massachusetts, United States (USA)
  • Founded year: 1996
  • Headcount: 11-50
  • Number of deals in 2024: 19
  • LinkedIn: polaris-partners

Polaris Partners is a venture capital firm based in Boston, Massachusetts, founded in 1996. The firm specializes in healthcare and biotechnology investments, partnering with entrepreneurs to provide funding and strategic guidance to help them innovate and grow their businesses. Polaris has a diverse portfolio that includes companies focused on transformative healthcare solutions. Notable transactions include funding for Best Doctors, which raised an undisclosed amount in a venture round in October 2023, and Africa Healthcare Network, which has received multiple rounds of funding to expand care centers for kidney patients. Additionally, they have invested in Life Line Screening and Aspect Medical Systems, further solidifying their commitment to the healthcare sector. Polaris operates primarily in the investment management space, supporting early-stage companies in bringing their products to market.


13. F-Prime


F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts, founded in 1946. The firm specializes in creating and investing in healthcare and technology companies, providing both venture capital investments and advisory services to entrepreneurs. F-Prime has a global presence and expertise that enables them to effectively support startups in developing innovative solutions. Notably, F-Prime has been involved in significant transactions within the healthcare sector, including multiple funding rounds for Centivo, a digital health plan company, where they participated in Series A, B, and a recent venture round, raising substantial amounts such as $75 million in 2024 and $51 million in 2021. Additionally, they have also invested in Devoted Health, which closed a $175 million Series E funding round, further demonstrating their active role in the healthcare investment landscape.


14. General Catalyst


General Catalyst is a venture capital firm founded in 2000, based in San Francisco, California. The firm specializes in early-stage and growth investments across various industries, including technology and healthcare. General Catalyst provides capital and strategic guidance to help startups and growth-stage companies scale their operations effectively. Notably, General Catalyst has been actively involved in the healthcare sector, particularly through its investments in Oscar Health. The firm participated in several funding rounds for Oscar, including a $225 million round in June 2020, a $165 million round in March 2018, and a $400 million investment in February 2016, which valued the company at $2.7 billion. These transactions highlight General Catalyst's commitment to the healthcare industry and its role in supporting innovative health insurance solutions.


15. HUB International

  • Website: hubinternational.com
  • Type: Corporate
  • Headquarters: Chicago, Illinois, United States (USA)
  • Founded year: 1998
  • Headcount: 10001+
  • Number of deals in 2024: 37
  • LinkedIn: hub-international

HUB International Limited is a corporate insurance brokerage based in Chicago, Illinois, founded in 1998. The firm provides a comprehensive range of insurance and risk management services to businesses, organizations, and individuals. Their offerings include business insurance, employee benefits, retirement services, and personal insurance, aimed at helping clients manage risks and protect their assets across various industries. Notably, HUB International has made significant strides in the healthcare sector through strategic acquisitions. In June 2023, they acquired the employee benefits assets of HORAN Health, which serves over 650 small and mid-size companies across 48 states, establishing a new regional hub called Hub Heartland. Additionally, in June 2021, they acquired EnterMedicare, a Medicare tech platform, further solidifying their presence in the healthcare market. These transactions highlight HUB International's commitment to expanding its services in the healthcare domain, making it a relevant player in this industry.


16. Government of Canada

  • Website: canada.ca
  • Type: Corporate
  • Headquarters: Canada, Kentucky, United States (USA)
  • Founded year: 1999
  • Headcount: 10001+
  • Number of deals in 2024: 137
  • LinkedIn: government-of-canada

The Government of Canada is a public entity that provides a wide range of services and information to Canadian citizens and residents, addressing various needs including employment, immigration, health care, and taxation. It operates through multiple departments and agencies to ensure access to essential services and support for individuals and businesses across the country. In the healthcare context, the Government of Canada has been involved in significant funding initiatives, such as the MNCY SCN Health Outcomes Improvement Fund (HOIF) which supports Alberta Health Services with grants for health improvement projects. Additionally, it has provided grants to Fraser Health, Shared Health, Saskatchewan Health Authority, and Women’s College Hospital, demonstrating its active role in financing healthcare projects that aim to enhance health services and outcomes in Canada.


17. 500 Global

  • Website: 500.co
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2010
  • Headcount: 201-500
  • Number of deals in 2024: 98
  • LinkedIn: 500-startups

500 Global is a venture capital firm and startup accelerator based in San Francisco, California, founded in 2010. The firm focuses on early-stage technology companies, providing funding, mentorship, and resources to help founders scale their businesses. Notably, 500 Global has made significant investments in the healthcare sector, particularly in Carbon Health, which raised $350 million in Series D funding in July 2021, and $28 million in Series B funding in May 2020. These investments highlight 500 Global's commitment to supporting innovative healthcare solutions and expanding access to healthcare services through technology.


18. Frazier Healthcare Partners


Frazier Healthcare Partners is a venture capital firm based in Seattle, Washington, founded in 1991. The firm specializes in healthcare and life sciences investments, focusing on growth buyout investments in profitable healthcare businesses and innovative biopharmaceuticals. With a robust portfolio, Frazier Healthcare has been involved in notable transactions such as Sierra Oncology, which raised $59.5 million in a Series D round in 2014, and multiple funding rounds for Portola Pharmaceuticals, including a Series C round that raised $70 million in 2007 and another Series C round that raised approximately $60.1 million in 2008. Their clients primarily consist of healthcare companies seeking capital to scale operations and enhance service offerings, further solidifying their commitment to the healthcare sector.


19. Pfizer

  • Website: pfizer.com
  • Type: Corporate
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1849
  • Headcount: 10001+
  • Number of deals in 2024: 10
  • LinkedIn: pfizer

Pfizer Inc. is a prominent pharmaceutical and biotechnology company founded in 1849, headquartered in New York, New York. With over 10,000 employees, Pfizer develops and produces a diverse range of medicines and vaccines aimed at improving patient health outcomes. The company operates globally, addressing urgent health needs through its innovative products. In recent years, Pfizer has made significant investments in the healthcare sector, including the acquisition of Arena Pharmaceuticals for $6.7 billion in December 2021, which bolstered its therapeutic offerings. Additionally, Pfizer has engaged in grant funding, such as a $250,000 grant to Urban Health Plan in August 2023 and an undisclosed amount to PATH in November 2021, showcasing its commitment to enhancing healthcare access and outcomes. These transactions highlight Pfizer's active role in the healthcare industry, making it a key player in advancing medical solutions.



Healthcare Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
OrbiMedNew York, New York, United States (USA)51-200198952
MedTech InnovatorLos Angeles, California, United States (USA)11-50201385
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
StartUp HealthNew York, New York, United States (USA)11-5020110
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
Perceptive AdvisorsNew York, New York, United States (USA)11-50199945
SosvUnited States (USA)51-2001995170
GV (Google Ventures)San Francisco Bay Area, California, United States (USA)51-200200974
Silicon Valley BankSanta Clara, California, United States (USA)5001-10000198331
Polaris PartnersBoston, Massachusetts, United States (USA)11-50199619
F-PrimeCambridge, Massachusetts, United States (USA)11-50194639
General CatalystSan Francisco, California, United States (USA)51-2002000144
HUB InternationalChicago, Illinois, United States (USA)10001+199837
Government of CanadaCanada, Kentucky, United States (USA)10001+1999137
500 GlobalSan Francisco, California, United States (USA)201-500201098
Frazier Healthcare PartnersSeattle, Washington, United States (USA)51-200199127
PfizerNew York, New York, United States (USA)10001+184910


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