The medical devices industry in the US is crucial for enhancing healthcare. It includes companies developing products such as diagnostic tools, surgical equipment, and sensors. This innovative sector is continuously growing, driven by technological advancements in telehealth, AI, and biotechnology. Manufacturers are now focusing more on wearables and point-of-care testing to meet rising demands for personalized medicine. Interestingly, the market is projected to reach $650 billion by 2027, fueled by the increasing prevalence of chronic diseases and an aging population. This evolution highlights the importance of investment in the development of effective and efficient medical devices.


The investors featured in this article range from venture capital firms to corporate backers. Headquartered primarily in major US cities like New York and San Francisco, these firms vary in size, with team sizes ranging from small to large organizations. Founded between the mid-20th century and the 2000s, they have collectively completed 1,017 investments in 2024 alone, showcasing a robust activity in advancing medical technology. Investors include ARCH Venture Partners, Plug and Play Tech Center, and Pfizer, all of which play pivotal roles in pushing the industry forward.


Top 16 Medical Devices Investors in the US


1. MedTech Innovator

  • Website: medtechinnovator.org
  • Type: Corporate
  • Headquarters: Los Angeles, California, United States (USA)
  • Founded year: 2013
  • Headcount: 11-50
  • Number of deals in 2024: 85
  • LinkedIn: medtech-innovator

MedTech Innovator is a not-for-profit organization based in Los Angeles, California, founded in 2013. It serves as the largest accelerator for medical technology companies, providing accelerator programs, mentorship, and competitions to support startups in the medical device, digital health, and diagnostics sectors. In 2024 alone, MedTech Innovator was involved in 85 investments, showcasing its active role in the industry. Notable transactions include funding for Tasso, which raised a seed round, and various grants for companies like Surgisense Corporation and PeriCor, indicating a commitment to advancing medical technology and supporting innovative solutions in healthcare.


2. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that includes resources like the Startup School and co-founder matching services. Y Combinator has successfully launched over 4,000 startups, establishing itself as a key player in the technology startup ecosystem. Notably, Y Combinator has invested in medical device companies such as Corveus Medical, which raised funds in both pre-seed and non-equity assistance rounds, and Vena Medical, which secured funding in a seed round. These transactions highlight Y Combinator's engagement in the medical devices sector, showcasing their capability to support innovative healthcare solutions.


3. OrbiMed

  • Website: orbimed.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1989
  • Headcount: 51-200
  • Number of deals in 2024: 52
  • LinkedIn: orbimed-advisors

OrbiMed is an investment firm specializing in healthcare investments, founded in 1989 and based in New York, New York. With approximately $17 billion in assets under management, OrbiMed focuses on providing capital to companies engaged in biopharmaceuticals, medical devices, and healthcare services. Notable transactions in the medical devices sector include a $50 million investment in Insulet in 2006, which is known for its innovative insulin delivery systems, and a $37.3 million equity round for CardiAQ Valve Technologies in 2012, aimed at developing transcatheter mitral valve implants. Additionally, OrbiMed has been involved in multiple funding rounds for SuperDimension, a company specializing in advanced imaging technologies for minimally invasive procedures. These investments highlight OrbiMed's active role in supporting innovation within the medical devices industry.


4. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Notably, NEA has been involved in several significant transactions within the medical devices space, including investments in VertiFlex, a developer of minimally invasive interventions for spinal stenosis, and Spine Wave, which focuses on spinal surgery solutions. These investments highlight NEA's active role in supporting innovative medical device companies, reinforcing their relevance in this sector.


5. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

SOSV is a venture capital firm founded in 1995, specializing in funding and supporting deep tech startups through its development programs. With a global reach, SOSV connects innovative companies with investors, providing not only venture capital investment but also resources to help startups grow and succeed. In the medical devices sector, SOSV has been involved in significant transactions, particularly with the Irish medtech startup CroíValve. They participated in multiple funding rounds for CroíValve, including a $16 million Series B round in August 2024, an undisclosed Series A round in July 2023, and earlier seed rounds in 2019. These investments are aimed at supporting CroíValve's development of a minimally invasive treatment for tricuspid regurgitation, showcasing SOSV's active role in the medical devices industry.


6. Perceptive Advisors


Perceptive Advisors is a New York-based venture capital firm founded in 1999, specializing in the life sciences sector. The firm provides capital solutions and investment management services to both private and public healthcare companies, with a strong focus on biotechnology, pharmaceuticals, and medical devices. Notably, Perceptive Advisors has been involved in several significant transactions in the medical devices arena, including multiple funding rounds for Vapotherm, a company known for its advanced respiratory care technologies. They participated in Vapotherm's Series C and Series D funding rounds, raising substantial amounts of capital to support the company's growth. In 2024, they also facilitated an acquisition involving Vapotherm, further emphasizing their active role in the medical devices market. Additionally, their investment in Orchestra BioMed, which focuses on innovative medical solutions, highlights their commitment to advancing healthcare technologies.


7. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios, leveraging a network of over 10,000 investors to connect them with high-quality investment opportunities in the startup ecosystem. The fund has been actively involved in the medical devices sector, with notable transactions including a $50 million Series C investment in Cala Health, which specializes in neuromodulation therapies, and multiple investments in NeuSpera Medical, which focuses on implantable neuromodulation technology. Additionally, they have invested in Innoblative Designs, further showcasing their engagement in the medical devices space.


8. Silicon Valley Bank

  • Website: svb.com
  • Type: Venture Capital
  • Headquarters: Santa Clara, California, United States (USA)
  • Founded year: 1983
  • Headcount: 5001-10000
  • Number of deals in 2024: 31
  • LinkedIn: silicon-valley-bank

Silicon Valley Bank is a commercial bank founded in 1983, located in Santa Clara, California, specializing in providing financial services to the innovation economy, particularly tech startups and venture capital firms. They offer a range of products including business banking, global payments, and asset management, helping clients navigate financial challenges and support their growth. Notably, Silicon Valley Bank has been involved in several significant transactions within the medical devices sector, including debt financing for CardioFocus, which raised $11 million in 2013 and $5 million in 2011, as well as Cardiovascular Systems, which raised $29 million in post-IPO debt in 2010. Additionally, they supported Spectranetics with $110 million in post-IPO debt in 2015 and provided $1.5 million in debt financing to Cartiva in 2014. These transactions highlight their active role in financing medical device companies, reinforcing their relevance in this industry.


9. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, founded in 2011, that focuses on health innovation. They support health entrepreneurs and startups through their Health Moonshot Communities, providing resources, networking opportunities, and media content aimed at addressing significant health challenges. StartUp Health has been involved in various funding rounds for health technology companies, including notable transactions in the medical devices space. For instance, they participated in Cala Health's Series C funding round, which raised $50 million, and they have also invested in Lazurite, a company that is developing innovative medical devices. Other investments include Difinity Solutions and Tahmo, Inc., which, while not exclusively medical devices, contribute to the broader health technology landscape. Their offerings include newsletters, podcasts, and a journal that highlight progress in health technology and innovation, further emphasizing their commitment to advancing the medical devices sector.


10. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024 alone, they made 253 investments across different sectors. Notably, they have invested in medical device companies such as MintNeuro, which raised $1,273,670 in a seed round in November 2024, and S4 Medical, which focuses on developing a device to protect the esophagus during catheter ablation procedures. Their involvement in these medical device transactions highlights their engagement in this sector, alongside their broader technology investment strategy.


11. Polaris Partners

  • Website: polarispartners.com
  • Type: Venture Capital
  • Headquarters: Boston, Massachusetts, United States (USA)
  • Founded year: 1996
  • Headcount: 11-50
  • Number of deals in 2024: 19
  • LinkedIn: polaris-partners

Polaris Partners is a venture capital firm based in Boston, Massachusetts, founded in 1996. The firm specializes in healthcare and biotechnology investments, partnering with entrepreneurs to provide funding and strategic guidance to help them innovate and grow their businesses. Polaris has a diverse portfolio that includes transformative healthcare solutions, with notable investments in medical device companies such as Aspect Medical Systems, which raised $17.5 million in 1997, and GI Dynamics, which received multiple rounds of funding totaling over $30 million from 2003 to 2009 to advance its EndoBarrier device for treating type 2 diabetes and obesity. Additionally, they invested $9.1 million in BridgePoint Medical in 2010, further emphasizing their focus on the medical devices sector. Polaris operates primarily in the investment management space, supporting early-stage companies in bringing their products to market, particularly in the medical devices arena.


12. GV (Google Ventures)

  • Website: gv.com
  • Type: Venture Capital
  • Headquarters: San Francisco Bay Area, California, United States (USA)
  • Founded year: 2009
  • Headcount: 51-200
  • Number of deals in 2024: 74
  • LinkedIn: gv

GV (Google Ventures) is a venture capital firm based in the San Francisco Bay Area, founded in 2009. With over $10 billion in assets under management, GV focuses on various sectors, including life sciences and artificial intelligence. The firm partners with innovative technology startups, providing funding and support to help them navigate the challenges of building successful companies. Notably, GV has invested in Cala Health, which raised $50 million in Series C funding in 2019 and an additional $50 million in December 2024, showcasing its ongoing support for health technology. Furthermore, GV participated in the Series C funding round for Neuralink, a company focused on neurotechnology, and was involved in Element Science's Series C financing, which raised $145.6 million for the development of wearable medical devices. These investments underline GV's active engagement in the medical devices sector.


13. Frazier Healthcare Partners


Frazier Healthcare Partners is a venture capital firm based in Seattle, Washington, specializing in healthcare and life sciences investments. Founded in 1991, the firm focuses on growth buyout investments in profitable healthcare businesses and innovative biopharmaceuticals. Notably, Frazier has been involved in significant transactions within the medical devices sector, including BARRX Medical, which raised $15 million in Series D funding in 2010 and $27.8 million in Series C funding in 2006. Additionally, they invested in Pivot Medical, contributing $8 million in Series B funding in 2007 and $2 million in Series A funding earlier that same year. These transactions highlight Frazier's commitment to supporting innovative medical device companies, making them a relevant player in this industry.


14. ARCH Venture Partners

  • Website: archventure.com
  • Type: Venture Capital
  • Headquarters: Chicago, Illinois, United States (USA)
  • Founded year: 1986
  • Headcount: 11-50
  • Number of deals in 2024: 32
  • LinkedIn: arch-venture-partners

ARCH Venture Partners is a venture capital firm based in Chicago, Illinois, founded in 1986. The firm specializes in biotechnology investments, providing funding and strategic support to innovative companies in the life sciences sector. They primarily target early-stage biotech firms that are developing groundbreaking medical solutions. Notably, ARCH has been involved in significant transactions within the medical devices context, such as their investments in Cytrellis Biosystems, which raised funds to conclude clinical studies and obtain regulatory clearances for medical technologies. Additionally, their lead investment in SonoThera, which focuses on ultrasound-guided gene therapy, further highlights their commitment to advancing medical technologies. With 32 investments in 2024 alone, ARCH Venture Partners continues to play a pivotal role in supporting the development of innovative medical solutions.


15. Vivo Capital

  • Website: vivocapital.com
  • Type: Venture Capital
  • Headquarters: Palo Alto, California, United States (USA)
  • Founded year: 1996
  • Headcount: 51-200
  • Number of deals in 2024: 19
  • LinkedIn: vivo-capital

Vivo Capital is a venture capital firm based in Palo Alto, California, specializing in healthcare investments. Founded in 1996, the firm focuses on providing venture capital, private equity, and public equity investments to healthcare companies, facilitating innovation and growth in the sector. Vivo Capital has been actively involved in the medical devices industry, with notable transactions including a $26 million Series C financing for SentreHEART, which develops a suture delivery device, and a $137 million Series B round for Preventice Solutions, which is involved in medical technology. Additionally, they invested $50 million in Scientia Vascular to support advancements in the neurovascular stroke market. Their recent participation in funding rounds for Evaheart, a medical device manufacturer, further underscores their commitment to the medical devices sector. Overall, Vivo Capital's investment strategy is aligned with fostering innovation in healthcare technologies, making them a significant player in the medical devices landscape.


16. Pfizer

  • Website: pfizer.com
  • Type: Corporate
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1849
  • Headcount: 10001+
  • Number of deals in 2024: 10
  • LinkedIn: pfizer

Pfizer Inc. is a leading pharmaceutical and biotechnology company founded in 1849, headquartered in New York, New York, USA. The company develops and produces a wide range of medicines and vaccines aimed at improving patient health outcomes. Pfizer serves healthcare providers, hospitals, and patients globally. In addition to its core pharmaceutical business, Pfizer has made significant investments in the medical devices sector. For instance, it participated in funding rounds for Neuronetics, Inc., which develops the NeuroStar® Advanced Therapy, a TMS device for treating major depression. Pfizer's involvement in Neuronetics includes a $30 million Series E financing round in 2011 and additional investments in subsequent rounds. Furthermore, Pfizer invested in NovoCure Ltd., which is known for its innovative Novo-TTF device used in cancer treatment, highlighting its commitment to advancing medical technology alongside its pharmaceutical endeavors.



Medical Devices Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
MedTech InnovatorLos Angeles, California, United States (USA)11-50201385
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
OrbiMedNew York, New York, United States (USA)51-200198952
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
SosvUnited States (USA)51-2001995170
Perceptive AdvisorsNew York, New York, United States (USA)11-50199945
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
Silicon Valley BankSanta Clara, California, United States (USA)5001-10000198331
StartUp HealthNew York, New York, United States (USA)11-5020110
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
Polaris PartnersBoston, Massachusetts, United States (USA)11-50199619
GV (Google Ventures)San Francisco Bay Area, California, United States (USA)51-200200974
Frazier Healthcare PartnersSeattle, Washington, United States (USA)51-200199127
ARCH Venture PartnersChicago, Illinois, United States (USA)11-50198632
Vivo CapitalPalo Alto, California, United States (USA)51-200199619
PfizerNew York, New York, United States (USA)10001+184910


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