The respiratory device industry in the US focuses on medical technologies designed to assist patients with breathing issues. This booming sector includes companies that manufacture inhalers, nebulizers, and ventilators, showcasing both innovative technology and improved patient care. As the prevalence of respiratory conditions like asthma and COPD rises, demand for advanced solutions is increasing robustly. The industry is also leaning heavily into telemedicine and remote monitoring tools, aiming for enhanced accessibility and efficiency in patient management. This evolution is driven by technological advancements and a push for better healthcare outcomes, making the field ripe for investors and startups alike.


This roster showcases a spectrum of investors, including venture capital firms, corporate entities, and accelerator programs. Spread across major hubs like California and New York, these investors range from startups to well-established firms. Their 2024 deal counts highlight significant activity, with Plug and Play Tech Center and Y Combinator leading the way in engagement. Founded between the late 20th century and this decade, these firms vary in size, engaging in investments that advance innovations in respiratory health solutions, underscoring the market's dynamic nature.


Top 15 Respiratory Device Investors in the US


1. MedTech Innovator

  • Website: medtechinnovator.org
  • Type: Corporate
  • Headquarters: Los Angeles, California, United States (USA)
  • Founded year: 2013
  • Headcount: 11-50
  • Number of deals in 2024: 85
  • LinkedIn: medtech-innovator

MedTech Innovator is a not-for-profit organization based in Los Angeles, California, founded in 2013. It serves as the largest accelerator for medical technology companies, providing accelerator programs, mentorship, and competitions to support startups in the medical device, digital health, and diagnostics sectors. Among their notable transactions, they have supported Sonavi Labs, which focuses on respiratory health technology, and Spire Health, a company that develops respiratory monitoring solutions. These transactions highlight MedTech Innovator's commitment to fostering innovation in the respiratory device space, alongside their broader focus on medical technology.


2. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that helps entrepreneurs launch and grow their businesses. Y Combinator has successfully launched over 4,000 startups, establishing itself as a key player in the technology startup ecosystem. Among its notable investments, Y Combinator has backed companies in the respiratory device sector, including Spire Health, which raised funds in seed rounds in 2015 and 2019, focusing on health monitoring technologies. Additionally, they invested in Cambridge Mask Co, which specializes in respiratory protection solutions. These transactions highlight Y Combinator's engagement in the respiratory device industry, alongside its broader investment strategy.


3. OrbiMed

  • Website: orbimed.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1989
  • Headcount: 51-200
  • Number of deals in 2024: 52
  • LinkedIn: orbimed-advisors

OrbiMed is a prominent investment firm based in New York, specializing in healthcare investments. Founded in 1989, the firm manages approximately $17 billion in assets across various investment strategies, focusing on biopharmaceuticals, medical devices, and healthcare services. OrbiMed has been actively involved in the respiratory device sector, notably leading funding rounds for Inspire Medical Systems, which develops innovative therapies for sleep apnea, and participating in financing for Aerin Medical, a company focused on devices for nasal airway management. These transactions highlight OrbiMed's commitment to driving innovation in the respiratory device industry while maintaining a diverse investment portfolio in healthcare.


4. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

Sosv is a venture capital firm founded in 1995, specializing in funding and supporting deep tech startups through its development programs. With a focus on health and climate technology, Sosv provides venture capital investment and resources to help startups grow and succeed. In 2024 alone, they have made 170 investments, showcasing their active role in the startup ecosystem. Among their notable transactions, Sosv has invested in XN Health and Strados Labs. Strados Labs, in particular, raised significant funding through various rounds, including a $4.5 million seed round in 2021 and a convertible note in 2024, focusing on respiratory health monitoring solutions. This involvement highlights Sosv's commitment to advancing technologies in the respiratory device space.


5. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Among their notable transactions in the respiratory device context, NEA has invested in Lungpacer Medical, which focuses on developing innovative respiratory devices, and has been a significant investor in CVRx, a company that has raised substantial funding to advance clinical trials and expand its commercial activities in therapies that can impact respiratory health. These investments highlight NEA's commitment to supporting advancements in the respiratory device industry.


6. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios, leveraging a network of over 10,000 investors to connect them with high-quality investment opportunities in the startup ecosystem. Notably, the fund has been involved in various transactions, including Rensair, which raised an undisclosed amount in Series A funding on April 13, 2023, focusing on air purification technology that is relevant to respiratory health. Additionally, the fund has participated in investments in Leo Cancer Care, which is advancing radiation therapy, and Oura, a health tracking company, showcasing a diverse investment strategy that includes health-related technologies.


7. Perceptive Advisors


Perceptive Advisors is a New York-based venture capital firm founded in 1999, specializing in the life sciences sector. The firm provides capital solutions and investment management services to both private and public healthcare companies, with a focus on biotechnology, pharmaceuticals, and medical devices. Notably, Perceptive Advisors has been actively involved in the respiratory device market, particularly through their investments in Vapotherm, Inc. They have participated in multiple funding rounds for Vapotherm, including a Series C round of $30 million in November 2015, a Series D round of $45 million in May 2017, and another Series D round of $10 million in September 2018. Most recently, on June 17, 2024, they announced a definitive merger agreement with Vapotherm, further solidifying their commitment to the respiratory device sector. Additionally, they have invested in Verona Pharma, which also operates in the respiratory space, raising $200 million in post-IPO equity in July 2020. This track record highlights their expertise and active role in the respiratory device industry.


8. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, focused on health innovation. Founded in 2011, it supports health entrepreneurs and startups through its Health Moonshot Communities, providing resources, networking, and media content to tackle significant health challenges. StartUp Health has been involved in various funding transactions, including notable investments in eko.ai, which raised $4 million in a Seed Round in January 2020 and $1 million in a Pre-Seed Round in April 2018. They also supported Life Recovery Systems and Tahmo, Inc. in their Seed Rounds. While their primary focus is on health innovation broadly, their investments in companies that may contribute to respiratory health solutions make them a relevant player in the respiratory device sector.


9. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024, they have made 253 investments, showcasing their active role in the venture capital landscape. Among their notable transactions, they invested in Omniox, which raised funds in a Series D round, focusing on oxygen delivery solutions, and Visby Medical, which raised over $100 million in a Series C round, indicating their engagement in the healthcare sector. These investments highlight their commitment to supporting advancements in medical technology, including respiratory devices.


10. Silicon Valley Bank

  • Website: svb.com
  • Type: Venture Capital
  • Headquarters: Santa Clara, California, United States (USA)
  • Founded year: 1983
  • Headcount: 5001-10000
  • Number of deals in 2024: 31
  • LinkedIn: silicon-valley-bank

Silicon Valley Bank is a commercial bank founded in 1983, specializing in providing financial services to the innovation economy, particularly tech startups and venture capital firms. They offer a range of products including business banking, global payments, and asset management, helping clients navigate financial challenges and support their growth. In recent years, they have been involved in several significant transactions in the healthcare sector, including debt financing for companies like CVRx, which focuses on cardiovascular devices, and Verona Pharma and Savara Pharmaceuticals, both of which are engaged in developing therapeutics that may impact respiratory health. Their involvement in these transactions indicates a commitment to supporting innovation in the medical field, including areas related to respiratory devices.


11. GV (Google Ventures)

  • Website: gv.com
  • Type: Venture Capital
  • Headquarters: San Francisco Bay Area, California, United States (USA)
  • Founded year: 2009
  • Headcount: 51-200
  • Number of deals in 2024: 74
  • LinkedIn: gv

GV (Google Ventures) is a venture capital firm founded in 2009, based in the San Francisco Bay Area, California. With over $10 billion in assets under management, GV focuses on funding and supporting innovative technology startups across various sectors, including life sciences and artificial intelligence. Notably, GV has participated in significant funding rounds for companies like Element Science, which raised a total of $145.6 million in Series C financing to develop wearable medical devices, and Vitara Biomedical, which raised $50 million in Series B funding in 2024. These investments highlight GV's commitment to advancing medical technology, which can include respiratory devices and related health innovations.


12. Polaris Partners

  • Website: polarispartners.com
  • Type: Venture Capital
  • Headquarters: Boston, Massachusetts, United States (USA)
  • Founded year: 1996
  • Headcount: 11-50
  • Number of deals in 2024: 19
  • LinkedIn: polaris-partners

Polaris Partners is a venture capital firm based in Boston, Massachusetts, specializing in healthcare and biotechnology investments. Founded in 1996, the firm partners with entrepreneurs to provide funding and strategic guidance, helping them innovate and grow their businesses. Polaris has a diverse portfolio that includes companies focused on transformative healthcare solutions. Notably, they have invested in Respicardia, which raised $27 million in Series C funding in 2010 and $21 million in Series B funding in 2008, both aimed at developing solutions for sleep apnea. Additionally, they invested $10 million in PULMATRIX, INC. in 2015, a company dedicated to inhaled therapies for respiratory diseases. These investments highlight Polaris Partners' commitment to advancing technologies in the respiratory device space.


13. Vivo Capital

  • Website: vivocapital.com
  • Type: Venture Capital
  • Headquarters: Palo Alto, California, United States (USA)
  • Founded year: 1996
  • Headcount: 51-200
  • Number of deals in 2024: 19
  • LinkedIn: vivo-capital

Vivo Capital is a venture capital firm based in Palo Alto, California, specializing in healthcare investments. Founded in 1996, the firm provides venture capital, private equity, and public equity investments to healthcare companies, facilitating innovation and growth in the sector. Vivo Capital has been involved in several significant transactions, including investments in Synapse Biomedical, which focuses on neuromuscular stimulation technology that could have applications in respiratory care, and Preventice Solutions, which develops remote monitoring solutions that may include respiratory health monitoring. Additionally, their investments in Verona Pharma, a company focused on developing therapies for respiratory diseases, further highlight their engagement in the respiratory device and health technology space. Overall, Vivo Capital's portfolio reflects a commitment to advancing healthcare technologies, including those related to respiratory health.


14. Frazier Healthcare Partners


Frazier Healthcare Partners is a venture capital firm based in Seattle, Washington, specializing in healthcare and life sciences investments. Founded in 1991, the firm focuses on growth buyout investments in profitable healthcare businesses and innovative biopharmaceuticals. Frazier Healthcare Partners has been involved in significant transactions, including investments in CVRx, which raised substantial funding in Series D and E rounds, indicating a commitment to advancing medical technologies. Additionally, their investment in BARRX Medical, which also received multiple rounds of funding, showcases their interest in companies that develop medical devices. More recently, they invested in Savara Pharmaceuticals, which focuses on respiratory diseases, further solidifying their involvement in the respiratory device and healthcare sector.


15. F-Prime


F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts, founded in 1946. The firm specializes in creating and investing in healthcare and technology companies, providing both venture capital investments and advisory services to entrepreneurs. F-Prime has a global presence and expertise that enables them to effectively support start-ups in developing innovative solutions. Among their notable transactions, F-Prime has invested in Avalyn Pharma, which focuses on developing inhalation treatments for pulmonary conditions, including idiopathic pulmonary fibrosis. Their involvement in Avalyn's funding rounds (Series A, B, and C) highlights their commitment to advancing respiratory health solutions. Additionally, F-Prime's investment in Novaerus, a company that has developed air disinfection technology, further emphasizes their engagement in the respiratory device sector.



Respiratory Device Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
MedTech InnovatorLos Angeles, California, United States (USA)11-50201385
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
OrbiMedNew York, New York, United States (USA)51-200198952
SosvUnited States (USA)51-2001995170
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
Perceptive AdvisorsNew York, New York, United States (USA)11-50199945
StartUp HealthNew York, New York, United States (USA)11-5020110
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
Silicon Valley BankSanta Clara, California, United States (USA)5001-10000198331
GV (Google Ventures)San Francisco Bay Area, California, United States (USA)51-200200974
Polaris PartnersBoston, Massachusetts, United States (USA)11-50199619
Vivo CapitalPalo Alto, California, United States (USA)51-200199619
Frazier Healthcare PartnersSeattle, Washington, United States (USA)51-200199127
F-PrimeCambridge, Massachusetts, United States (USA)11-50194639


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