The nutritional supplement industry in the US has evolved into a robust sector driven by increasing consumer demand for health and wellness products. This industry includes a broad spectrum of businesses, from established brands producing vitamins and minerals to startups offering innovative solutions like sports nutrition and meal replacements. With an expanding focus on preventive health, companies are investing in research and development to create tailored nutrition options. Notably, the market is also seeing growth in plant-based and organic supplements, indicating a shift towards natural ingredients, appealing to health-conscious consumers looking for sustainable options.

The listed investors represent a mix of venture capital firms headquartered across major US cities, including San Francisco and New York. Established between 1977 and 2023, these firms vary in size and scope, with 2024 deal counts ranging from zero to over 800 investments. They play pivotal roles in supporting startups within the nutritional supplement field, showcasing their commitment to health innovation and technology. The collective energy behind these investors highlights a vibrant and competitive market ripe for growth and development.

Top 15 Nutritional Supplement Investors in the US

1. Y Combinator

• Website: ycombinator.com
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2005
• Headcount: 51-200
• Number of deals in 2024: 802
• LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. The firm provides funding and mentorship to early-stage technology companies through a structured program that includes resources like the Startup School and co-founder matching services. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Notably, Y Combinator has invested in several companies within the nutritional supplement sector, including Soylent, which raised $120,000 in a Pre-Seed round in 2012, and Nutrigene Inc., which also raised $120,000 in a Pre-Seed round in 2018. Additionally, they participated in the Seed round for Gainful, a company focused on personalized nutrition, further showcasing their engagement in the nutritional supplement industry. Their diverse portfolio reflects a willingness to explore various sectors, including health and nutrition.

2. Sosv

• Website: sosv.com
• Type: Venture Capital
• Headquarters: United States (USA)
• Founded year: 1995
• Headcount: 51-200
• Number of deals in 2024: 170
• LinkedIn: sosv

SOSV is a venture capital firm founded in 1995, specializing in funding and supporting deep tech startups through its development programs. With a global reach, SOSV connects innovative companies with investors, providing venture capital investment and resources to help startups grow and succeed. In the nutritional supplement context, SOSV has been involved in several relevant transactions, including Aminolabs, which raised $250,000 in a seed round in 2015, and Zotezo.com, which also raised an undisclosed amount in a seed round in 2019. More recently, they invested in Kresko RNAtech and Mimio Health, both of which focus on health-related innovations, further demonstrating their commitment to the health and nutrition sectors.

3. Deep Tech Fund (an Alumni Ventures Fund)

• Website: av.vc
• Type: Venture Capital
• Headquarters: Manchester, New Hampshire, United States (USA)
• Founded year: 2023
• Headcount: 51-200
• Number of deals in 2024: 258
• LinkedIn: deep-tech-fund-av-focused-fund

Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios, leveraging a network of over 10,000 investors to connect them with high-quality investment opportunities in the startup ecosystem. The fund has been involved in several notable transactions in the nutritional supplement sector, including a $15 million Series A investment in MEND, a company focused on nutritional products, and a $5 million Series A investment in Beam Organics, which also operates in the health and wellness space. These investments highlight the fund's engagement in the nutritional supplement industry, alongside its broader investment strategy.

4. 500 Global

• Website: 500.co
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2010
• Headcount: 201-500
• Number of deals in 2024: 98
• LinkedIn: 500-startups

500 Global is a venture capital firm and startup accelerator based in San Francisco, California, founded in 2010. The firm specializes in investing in early-stage technology companies, providing funding, mentorship, and resources to help founders scale their businesses. In addition to their broad focus on innovative startups, 500 Global has made notable investments in the nutritional supplement industry, including Ample Foods, which received $2 million in seed funding. This investment highlights their engagement with companies that are directly involved in nutrition and health. Furthermore, they have also invested in More Labs, which is known for its health-focused products, further demonstrating their interest in the nutritional supplement sector.

5. StartUp Health

• Website: startuphealth.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 2011
• Headcount: 11-50
• LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, focused on health innovation and supporting health entrepreneurs and startups through its Health Moonshot Communities. Founded in 2011, it provides resources, networking opportunities, and media content aimed at addressing significant health challenges. StartUp Health has been involved in various funding rounds, including investments in Vous Vitamin, which raised an undisclosed amount in a venture round in January 2022, indicating a focus on nutritional supplements. They also participated in funding for Gennev, a digital health company for women, which, while not strictly a nutritional supplement company, operates in the health and wellness space. Their investment in Resility Health and Greatist further demonstrates their commitment to health and wellness, making them a relevant player in the nutritional supplement industry.

6. Plug and Play Tech Center

• Website: plugandplaytechcenter.com
• Type: Venture Capital
• Headquarters: Sunnyvale, California, United States (USA)
• Founded year: 2006
• Headcount: 501-1000
• Number of deals in 2024: 253
• LinkedIn: plug-and-play-tech-center

Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024 alone, they have made 253 investments, showcasing their active role in the venture capital landscape. Notably, they have invested in companies like Sempera Organics, which focuses on organic nutritional products, and Natáur LLC, which is involved in the nutritional supplement sector. Additionally, they have supported Oobli, a company that has raised significant funding across multiple rounds, indicating their engagement with businesses that may intersect with health and nutrition. This diverse portfolio highlights their commitment to enhancing business development across various sectors, including nutritional supplements.

7. Goodwater Capital

• Website: goodwatercap.com
• Type: Venture Capital
• Headquarters: Burlingame, California, United States (USA)
• Founded year: 2014
• Headcount: 51-200
• Number of deals in 2024: 41
• LinkedIn: goodwater-capital

Goodwater Capital is a venture capital firm based in Burlingame, California, founded in 2014. The firm specializes in consumer technology and supports seed-stage entrepreneurs by providing investment, resources, and a community to help them grow. Goodwater Capital focuses on various sectors, including healthcare and financial services, aiming to improve access to technology solutions for underserved communities. Notably, Goodwater has participated in funding rounds for companies like Kindly Health, a sexual health wellness brand, and FitHub, which is likely related to fitness and health. These transactions highlight Goodwater's engagement in the health and wellness space, which is closely related to nutritional supplements, indicating their potential interest in this sector.

8. Khosla Ventures

• Website: khoslaventures.com
• Type: Venture Capital
• Headquarters: Menlo Park, California, United States (USA)
• Founded year: 2004
• Headcount: 51-200
• Number of deals in 2024: 97
• LinkedIn: khosla-ventures

Khosla Ventures is a venture capital firm founded in 2004 and based in Menlo Park, California. The firm specializes in providing funding and strategic guidance to startups across various sectors, including technology, healthcare, and sustainability. Notably, Khosla Ventures has been actively involved in the nutritional supplement space through its investments in Viome, a company that focuses on personalized health tests and nutritional insights. Khosla Ventures participated in several funding rounds for Viome, including a $25 million Series D round in September 2024 and multiple Series C rounds totaling over $170 million. These investments highlight Khosla Ventures' commitment to supporting innovations that enhance health and wellness, positioning them as a relevant player in the nutritional supplement industry.

9. Gaingels

• Website: gaingels.com
• Type: Venture Capital
• Headquarters: Burlington, Vermont, United States (USA)
• Founded year: 2015
• Headcount: 11-50
• Number of deals in 2024: 60
• LinkedIn: gaingels

Gaingels is a venture capital firm founded in 2015, based in Burlington, Vermont, dedicated to investing in companies with diverse leadership. The firm provides capital and support to startups, particularly those led by underrepresented groups, to foster diversity and inclusion in the innovation economy. Gaingels has been actively involved in various funding rounds, including significant investments in the nutritional supplement sector. For instance, they participated in a Series C funding round for ByHeart, which raised $95 million in May 2024, focusing on infant nutrition. They also invested in ByHeart's Series B round in July 2021, which raised $90 million. Additionally, Gaingels was part of the funding round for Drink Barcode, a performance-oriented beverage startup, indicating their interest in health-related products. Their commitment to enhancing board diversity and supporting innovative companies makes them a notable player in the venture capital landscape.

10. L Catterton

• Website: lcatterton.com
• Type: Private Equity
• Headquarters: United States (USA)
• Founded year: 1989
• Headcount: 201-500
• Number of deals in 2024: 23
• LinkedIn: l-catterton

L Catterton is a private equity firm founded in 1989, specializing in investment management with a focus on consumer brands across various sectors. The firm partners with middle market companies and high-growth enterprises, providing capital and strategic guidance to enhance brand equity and market presence. With a strong emphasis on consumer insights, L Catterton aims to drive growth and innovation within its portfolio companies. Notably, L Catterton has made significant investments in the nutritional supplement space, including a Series A funding round for Persona, a personalized vitamin program, and a Series B investment in Nutrafol, a company dedicated to hair wellness supplements. Additionally, L Catterton has invested in IAFSTORE, which operates in the online dietary supplement market in Italy. These transactions highlight L Catterton's active role in the nutritional supplement industry, reinforcing its commitment to supporting brands that align with consumer health and wellness trends.

11. New Enterprise Associates (NEA)

• Website: nea.com
• Type: Venture Capital
• Headquarters: Menlo Park, California, United States (USA)
• Founded year: 1977
• Headcount: 51-200
• Number of deals in 2024: 57
• LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Notably, NEA has invested in Ritual, a company focused on nutritional supplements, which raised $3.5 million in a seed round in 2016. They also participated in multiple funding rounds for Brandless, a company that offers health-related products, including nutritional supplements. Additionally, NEA's investment in Goop, a lifestyle brand that includes wellness products, further highlights their engagement in the health and wellness space. These transactions demonstrate NEA's active role in the nutritional supplement industry, making them a relevant investor in this category.

12. Pareto Holdings

• Website: pareto20.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 2020
• Headcount: 1-10
• Number of deals in 2024: 31
• LinkedIn: paretoholdings

Pareto Holdings is a venture capital firm and venture studio based in New York, New York, founded in 2020. The firm specializes in building and investing in early-stage companies, having made over 900 investments globally. Among their notable transactions in the nutritional supplement space, they invested in Health Via Modern Nutrition, which raised $5.62 million in a venture round in November 2020, and Belliwelli, which raised $1 million in a seed round in March 2021. These investments highlight Pareto Holdings' commitment to supporting exceptional entrepreneurs in the nutritional supplement industry, providing them with the necessary capital and operational support to grow their businesses.

13. IndieBio

• Website: indiebio.co
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2015
• Headcount: 1-10
• Number of deals in 2024: 76
• LinkedIn: indiebio

IndieBio is a venture capital firm founded in 2015 and based in San Francisco, California. It specializes in biotechnology and supports startups by providing investment, mentorship, and networking opportunities. IndieBio has been active in various sectors, including climate and food, which are crucial for developing innovative solutions in health and nutrition. Notably, they have invested in Aminolabs, which raised $250,000 in a seed round in 2015, indicating their involvement in the nutritional supplement space. They have also invested in Mimio Health and Kresko RNAtech, both of which are likely to be involved in health-related innovations, further showcasing their commitment to supporting companies that may contribute to the nutritional supplement industry.

14. CircleUp

• Website: circleup.com
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2012
• Headcount: 51-200
• LinkedIn: circleup

CircleUp is a financial services company based in San Francisco, California, founded in 2012. It empowers consumer brands through funding and support, offering business loans and equity financing. CircleUp leverages its Helio technology platform to provide data insights that help entrepreneurs make informed decisions. Notably, CircleUp has been involved in significant transactions within the nutritional supplement industry, including multiple rounds of funding for SmartyPants Vitamins, which raised over $12 million in total through various funding rounds facilitated by CircleUp. Additionally, CircleUp participated in HUM Nutrition's funding rounds, contributing to their growth in the beauty nutrition category with investments totaling $15 million in Series B and $5 million in Series A. These transactions highlight CircleUp's active role in supporting brands within the nutritional supplement sector.

15. FJ Labs

• Website: fjlabs.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 2015
• Headcount: 11-50
• Number of deals in 2024: 169
• LinkedIn: fj-labs

FJ Labs is a venture capital firm based in New York, founded in 2015, that specializes in investing in marketplace and network effect businesses. With a portfolio of over 1,000 companies, many of which have achieved unicorn status, FJ Labs provides capital and strategic guidance to entrepreneurs across various industries, including e-commerce and logistics. Notably, they have participated in funding rounds for companies in the nutritional supplement space, such as Verb Energy, which raised $3.5 million to develop green-tea powered energy bars, and Parsley Health, which focuses on health and wellness. Their investments reflect a commitment to supporting innovative startups that align with health and nutrition, making them a significant player in the nutritional supplement industry.

Nutritional Supplement Insights: Key Investors in the US

Investor	Headquarter	Size	Founded	Deals 2024
Y Combinator	San Francisco, California, United States (USA)	51-200	2005	802
Sosv	United States (USA)	51-200	1995	170
Deep Tech Fund (an Alumni Ventures Fund)	Manchester, New Hampshire, United States (USA)	51-200	2023	258
500 Global	San Francisco, California, United States (USA)	201-500	2010	98
StartUp Health	New York, New York, United States (USA)	11-50	2011	0
Plug and Play Tech Center	Sunnyvale, California, United States (USA)	501-1000	2006	253
Goodwater Capital	Burlingame, California, United States (USA)	51-200	2014	41
Khosla Ventures	Menlo Park, California, United States (USA)	51-200	2004	97
Gaingels	Burlington, Vermont, United States (USA)	11-50	2015	60
L Catterton	United States (USA)	201-500	1989	23
New Enterprise Associates (NEA)	Menlo Park, California, United States (USA)	51-200	1977	57
Pareto Holdings	New York, New York, United States (USA)	1-10	2020	31
IndieBio	San Francisco, California, United States (USA)	1-10	2015	76
CircleUp	San Francisco, California, United States (USA)	51-200	2012	0
FJ Labs	New York, New York, United States (USA)	11-50	2015	169

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