The population health management industry in the US focuses on improving health outcomes by addressing the needs of various communities. Companies in this sector include healthcare providers, data analytics firms, and health plan administrators, all collaborating to manage health risks, reduce costs, and enhance care quality. Innovations like telehealth solutions and patient engagement tools are changing the way health services are delivered. As the industry continues to grow, there's a strong emphasis on preventive care and utilizing technology to address chronic conditions, which can lead to improved overall population health and reduced healthcare spending.


The list of top investors in population health management showcases a mix of venture capital firms, corporate backers, and nonprofit organizations. With headquarters spread across the US, from San Francisco to New York, these investors vary in size and establish a notable presence with over 1,000 deals in 2024. Founded mostly between the late 20th century and early 21st century, these investors reflect a growing interest and commitment to health innovation, exemplified by their diverse funding strategies.


Top 13 Population Health Management Investors in the US


1. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies, helping entrepreneurs launch and grow their businesses through structured programs and resources like the Startup School. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Among its diverse portfolio, Y Combinator has invested in several companies relevant to population health management, including CareSkore, which focuses on patient engagement and care management; Able Health, which provides analytics for healthcare providers; and CareMessage, which enhances communication between healthcare providers and patients. Additionally, Y Combinator participated in a significant funding round for Helium Health, a company that aims to improve healthcare delivery in Nigeria and other African countries. These investments highlight Y Combinator's involvement in the healthcare sector, particularly in initiatives that align with population health management goals.


2. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, founded in 2011, that focuses on health innovation. It supports health entrepreneurs and startups through its Health Moonshot Communities, providing essential resources, networking opportunities, and media content aimed at addressing significant health challenges. StartUp Health has been involved in various transactions that highlight its commitment to health technology and innovation. Notable investments include Patientory, which focuses on blockchain technology for health data management, and OpenBeds, a platform designed to improve access to mental health services. These investments reflect StartUp Health's dedication to enhancing population health management through innovative solutions.


3. Government of Canada

  • Website: canada.ca
  • Type: Corporate
  • Headquarters: Canada, Kentucky, United States (USA)
  • Founded year: 1999
  • Headcount: 10001+
  • Number of deals in 2024: 137
  • LinkedIn: government-of-canada

The Government of Canada is a public entity that provides a wide range of services and information to Canadian citizens and residents, addressing needs such as employment, immigration, health care, and taxation. Founded in 1999, it operates through multiple departments and agencies to ensure access to essential services and support for individuals and businesses across the country. In recent years, the Government of Canada has been involved in several significant transactions aimed at enhancing population health management. For instance, it provided a grant of $4,000,000 to the Alliance For Healthier Communities in March 2023, which focuses on improving health services in communities. Additionally, it supported BlueDot with a $3,000,000 grant in January 2023, a company that uses data analytics to predict and manage health risks. The government also funds initiatives through Alberta Health Services, with grants aimed at improving health outcomes in the province. These transactions highlight the Government of Canada's active role in promoting health and well-being across the population, making it a key player in the field of population health management.


4. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. With a focus on technology, they have invested in a range of startups, including those in the healthcare sector. Notable transactions include investments in Helium Health, which focuses on health information systems, Health Gorilla, a health data exchange platform, and Redi.Health, which aims to improve healthcare access and delivery. These investments highlight their engagement in the population health management space, as they support technologies that enhance healthcare delivery and patient outcomes.


5. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

The Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios, leveraging a network of over 10,000 investors to connect them with high-quality investment opportunities in the startup ecosystem. The fund has been involved in several notable transactions in the healthcare technology sector, including investments in NeuroFlow, a digital behavioral health company that has raised significant funding to enhance its technology and team, and PulseData, which focuses on AI solutions for chronic kidney disease. These investments reflect the fund's interest in companies that contribute to population health management by addressing behavioral health and chronic disease management, thereby improving health outcomes for various populations.


6. 500 Global

  • Website: 500.co
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2010
  • Headcount: 201-500
  • Number of deals in 2024: 98
  • LinkedIn: 500-startups

500 Global is a venture capital firm and startup accelerator based in San Francisco, California, founded in 2010. The firm specializes in investing in early-stage technology companies, providing funding, mentorship, and resources to help founders scale their businesses. With a global focus, 500 Global has been involved in various transactions within the healthcare sector, including notable investments in Innovaccer, a company that offers data-driven solutions for healthcare providers, and CarePort Health, which focuses on care coordination and management. These investments highlight 500 Global's commitment to supporting innovative startups that aim to improve healthcare delivery and population health management. Other relevant transactions include investments in Reliv - Healthcare Made Simple and Automate Medical, further emphasizing their engagement in the healthcare technology landscape.


7. General Catalyst


General Catalyst is a venture capital firm founded in 2000, based in San Francisco, California. The firm specializes in early-stage and growth investments across various industries, including technology and healthcare. They provide capital and strategic guidance to help startups scale their operations effectively. Notably, General Catalyst has been involved in significant transactions within the population health management context, such as their investments in Maven Clinic, which raised $125 million in Series F funding in 2024 and focuses on telehealth services for women and families. Additionally, they participated in funding rounds for Homeward, a startup dedicated to improving healthcare access in rural areas, which raised $50 million in Series B funding in 2022. These investments highlight General Catalyst's commitment to supporting innovative healthcare solutions that aim to enhance population health management.


8. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Notably, NEA has invested in several companies that are pivotal in the population health management space. For instance, they led a $50 million Series D funding round for CareZone, a smartphone service designed to manage chronic health conditions, and participated in early funding rounds for Omada Health, which focuses on diabetes prevention. Furthermore, NEA's recent acquisition of NeueHealth, valued at approximately $1.3 billion, highlights their commitment to enhancing healthcare delivery and management, reinforcing their relevance in the population health management sector.


9. MedTech Innovator

  • Website: medtechinnovator.org
  • Type: Corporate
  • Headquarters: Los Angeles, California, United States (USA)
  • Founded year: 2013
  • Headcount: 11-50
  • Number of deals in 2024: 85
  • LinkedIn: medtech-innovator

MedTech Innovator is a not-for-profit organization based in Los Angeles, California, founded in 2013. It serves as the largest accelerator for medical technology companies, offering accelerator programs, mentorship, and competitions to support startups in the medical device, digital health, and diagnostics sectors. Notably, MedTech Innovator has been involved in transactions that are relevant to population health management, such as providing grants to Patientory, a company focused on health data management, and SilverCloud Health, which offers digital mental health solutions. Additionally, they have supported CloudMedx and Tricog Health through non-equity assistance, both of which are engaged in health analytics and remote monitoring, further emphasizing their commitment to enhancing population health outcomes through innovative technologies.


10. Gaingels

  • Website: gaingels.com
  • Type: Venture Capital
  • Headquarters: Burlington, Vermont, United States (USA)
  • Founded year: 2015
  • Headcount: 11-50
  • Number of deals in 2024: 60
  • LinkedIn: gaingels

Gaingels is a venture capital firm founded in 2015, based in Burlington, Vermont, dedicated to investing in companies with diverse leadership. The firm provides capital and support to startups, particularly those led by underrepresented groups, to foster diversity and inclusion in the innovation economy. Gaingels also offers scholarship programs and advisory services to enhance board diversity. Among their notable transactions, they invested in BrightInsight, which raised $101 million in Series C funding, indicating a focus on health technology solutions. Additionally, their investment in Pair Team, which raised $9 million in Series A funding, aims to expand access to healthcare services for Medicaid's most vulnerable patients, showcasing their commitment to population health management and improving healthcare access for underserved communities.


11. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

Sosv is a venture capital firm founded in 1995, based in the United States, that specializes in funding and supporting deep tech startups through its development programs. With a focus on sectors like health and climate technology, Sosv provides venture capital investment and resources to help startups grow and succeed. In 2024 alone, Sosv has made 170 investments, showcasing its active role in the venture capital landscape. Notably, Sosv has invested in Bloomlife, which raised $12.9 million in a Series B round in September 2024, and previously in a $4.5 million seed round in July 2018. Additionally, Sosv participated in funding rounds for Optimize Health, a digital healthcare platform that focuses on remote patient monitoring and chronic care management, including a $18.6 million Series B round in September 2023 and earlier funding rounds. These transactions highlight Sosv's engagement in the population health management sector, particularly in innovative health technology solutions.


12. GV (Google Ventures)

  • Website: gv.com
  • Type: Venture Capital
  • Headquarters: San Francisco Bay Area, California, United States (USA)
  • Founded year: 2009
  • Headcount: 51-200
  • Number of deals in 2024: 74
  • LinkedIn: gv

GV (Google Ventures) is a venture capital firm founded in 2009, based in the San Francisco Bay Area, California. With over $10 billion in assets under management, GV focuses on funding and supporting innovative technology startups across various sectors, including life sciences and artificial intelligence. Notably, GV has invested in companies like Aledade, which raised $64 million in Series C funding to enhance its healthcare provider network, and PatientPing, a care coordination company that secured $60 million in Series C funding to improve connections between healthcare providers and health plans. These investments highlight GV's commitment to advancing population health management through technology and innovation.


13. Liquid 2 Ventures

  • Website: liquid2.vc
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2015
  • Headcount: 1-10
  • Number of deals in 2024: 91
  • LinkedIn: liquid-2-ventures

Liquid 2 Ventures is a venture capital firm based in San Francisco, California, founded in 2015. The firm specializes in investing in technology startups at the pre-seed and seed stages, as well as growth-stage companies. They provide capital, mentorship, and access to a vast network of industry insiders to help founders navigate their entrepreneurial journeys. Notably, Liquid 2 Ventures has invested in several health-related startups, including CareSkore, which raised $4.3 million in a seed round in 2016, focusing on health analytics and patient engagement. They also invested in Bloomlife, which raised $4.5 million in a seed round in 2018, developing a pregnancy monitoring device that aligns with population health management by improving maternal health outcomes. Additionally, they invested in LucidAct Health, which raised $150,000 in 2019, further emphasizing their commitment to health technology solutions.



Population Health Management Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
StartUp HealthNew York, New York, United States (USA)11-5020110
Government of CanadaCanada, Kentucky, United States (USA)10001+1999137
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
500 GlobalSan Francisco, California, United States (USA)201-500201098
General CatalystSan Francisco, California, United States (USA)51-2002000144
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
MedTech InnovatorLos Angeles, California, United States (USA)11-50201385
GaingelsBurlington, Vermont, United States (USA)11-50201560
SosvUnited States (USA)51-2001995170
GV (Google Ventures)San Francisco Bay Area, California, United States (USA)51-200200974
Liquid 2 VenturesSan Francisco, California, United States (USA)1-10201591


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