The cardiovascular device industry in the US encompasses the design, manufacture, and sale of devices that support heart health. This sector includes pacemakers, stents, valves, and diagnostic tools. Companies range from established firms like Medtronic to innovative startups, all striving to meet the growing demand for cardiac solutions. With the rise in cardiovascular diseases, investment interest is surging, driving technological advancements such as minimally invasive procedures and AI integration. Trends point toward a future focused on personalized medicine and telehealth solutions, making this arena ripe for growth and innovation.

The list features a dynamic group of 19 investors engaged in the cardiovascular device space. Ranging from corporate entities to venture capital firms, they are headquartered in diverse locations across the US, such as California, Virginia, and New York. Sizes vary considerably, with firms having between 11 and over 10,000 employees. Established from 1946 to 2017, these investors recorded a collective 2024 deal count averaging multiple engagements, indicating robust activity and commitment to advancing cardiovascular technologies.

Top 19 Cardiovascular Device Investors in the US

1. MedTech Innovator

• Website: medtechinnovator.org
• Type: Corporate
• Headquarters: Los Angeles, California, United States (USA)
• Founded year: 2013
• Headcount: 11-50
• Number of deals in 2024: 85
• LinkedIn: medtech-innovator

MedTech Innovator is a not-for-profit organization based in Los Angeles, California, founded in 2013. It serves as the largest accelerator for medical technology companies, providing accelerator programs, mentorship, and competitions to support startups in the medical device, digital health, and diagnostics sectors. Among its notable transactions, MedTech Innovator has supported companies like Soundbite Medical Solutions, which raised $5.2 million in a Series A round, and Gradient Denervation Technologies, which received non-equity assistance. These transactions highlight MedTech Innovator's active role in fostering innovation within the cardiovascular device industry, alongside its broader focus on various medical technologies.

2. Y Combinator

• Website: ycombinator.com
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2005
• Headcount: 51-200
• Number of deals in 2024: 802
• LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that includes resources like the Startup School and co-founder matching services. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Among their investments, they have been involved in several transactions relevant to the cardiovascular device industry, including Corveus Medical, which raised $500,000 in both a Pre-Seed Round and Non-Equity Assistance in 2022, and Vena Medical, which raised $120,000 in a Seed Round in 2018. Additionally, Bodyport received $2,500,000 in a Seed Round in 2016. These investments highlight Y Combinator's engagement in the healthcare technology sector, particularly in innovations that could enhance cardiovascular health.

3. OrbiMed

• Website: orbimed.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 1989
• Headcount: 51-200
• Number of deals in 2024: 52
• LinkedIn: orbimed-advisors

OrbiMed is a prominent investment firm based in New York, specializing in healthcare investments across various sectors, including biopharmaceuticals, medical devices, and healthcare services. Founded in 1989, OrbiMed manages approximately $17 billion in assets and has a global reach. The firm has been actively involved in the cardiovascular device industry, leading significant funding rounds for companies such as CardiAQ Valve Technologies, which is developing a transcatheter mitral valve implant, and Acutus Medical, known for its high-resolution imaging and mapping systems for cardiac procedures. OrbiMed's investments in these companies highlight its strategic focus on innovative solutions in the cardiovascular space, supporting clinical trials, regulatory approvals, and commercialization efforts.

4. New Enterprise Associates (NEA)

• Website: nea.com
• Type: Venture Capital
• Headquarters: Menlo Park, California, United States (USA)
• Founded year: 1977
• Headcount: 51-200
• Number of deals in 2024: 57
• LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA has been actively involved in the cardiovascular device industry, notably through its investments in CVRx, a company dedicated to developing innovative therapies for heart disease. NEA co-led several funding rounds for CVRx, including a $93 million Series G round in 2019, a $50 million private equity round in 2020, and earlier rounds totaling over $200 million. This involvement highlights NEA's commitment to advancing healthcare technologies, particularly in the cardiovascular space.

5. Sosv

• Website: sosv.com
• Type: Venture Capital
• Headquarters: United States (USA)
• Founded year: 1995
• Headcount: 51-200
• Number of deals in 2024: 170
• LinkedIn: sosv

Sosv is a venture capital firm founded in 1995, based in the United States, that specializes in funding and supporting deep tech startups through its development programs. With a focus on health and climate technology, Sosv provides venture capital investment and resources to help startups grow and succeed. Notably, Sosv has been involved in several funding rounds for CroíValve, a medtech startup dedicated to developing minimally invasive treatments for tricuspid regurgitation. In 2024, they participated in a Series B round where CroíValve raised $16 million, and they were also involved in earlier funding rounds, including a Series A round in 2023 and 2022, which aimed to support feasibility studies for their innovative heart treatment solutions. This active engagement in the cardiovascular device sector highlights Sosv's commitment to advancing healthcare technologies.

6. Perceptive Advisors

• Website: perceptivelife.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 1999
• Headcount: 11-50
• Number of deals in 2024: 45
• LinkedIn: perceptive-advisors-llc

Perceptive Advisors is a New York-based investment firm founded in 1999, specializing in the life sciences sector. The firm provides capital solutions and investment management services to both private and public healthcare companies, with a focus on biotechnology, pharmaceuticals, and medical devices. Notably, Perceptive Advisors has been involved in significant transactions within the cardiovascular device space, including a $136 million financing round for Impulse Dynamics to support its heart failure therapy and a $60 million supplemental Series D financing for the same company aimed at U.S. commercialization of its Optimizer® Smart device. Additionally, they participated in funding rounds for Orchestra BioMed, which is known for developing innovative cardiovascular solutions. These transactions highlight Perceptive Advisors' commitment to advancing technologies in the cardiovascular device sector.

7. StartUp Health

• Website: startuphealth.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 2011
• Headcount: 11-50
• LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, focused on health innovation and supporting health entrepreneurs and startups through its Health Moonshot Communities. Founded in 2011, they provide resources, networking opportunities, and media content aimed at addressing significant health challenges. Their offerings include newsletters, podcasts, and a journal that highlight advancements in health technology and innovation. Among their notable transactions, they have invested in eko.ai, which raised funds in both seed and pre-seed rounds, focusing on digital health solutions for cardiovascular monitoring. Additionally, they have supported Cala Health and Flosonics, both of which are involved in health technology that can impact cardiovascular care. These investments demonstrate StartUp Health's commitment to fostering innovation in the health sector, including cardiovascular devices.

8. Plug and Play Tech Center

• Website: plugandplaytechcenter.com
• Type: Venture Capital
• Headquarters: Sunnyvale, California, United States (USA)
• Founded year: 2006
• Headcount: 501-1000
• Number of deals in 2024: 253
• LinkedIn: plug-and-play-tech-center

Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024 alone, they have made 253 investments, showcasing their active role in the venture capital landscape. Notably, they have invested in companies like S4 Medical, which is developing a device aimed at protecting the esophagus during catheter ablation procedures, and Coredio, which also raised funding in the medical device space. These transactions highlight their engagement in the cardiovascular device industry, making them a relevant player in this sector.

9. Silicon Valley Bank

• Website: svb.com
• Type: Venture Capital
• Headquarters: Santa Clara, California, United States (USA)
• Founded year: 1983
• Headcount: 5001-10000
• Number of deals in 2024: 31
• LinkedIn: silicon-valley-bank

Silicon Valley Bank is a commercial bank founded in 1983, located in Santa Clara, California, that specializes in providing financial services to the innovation economy, particularly tech startups and venture capital firms. They offer a range of products including business banking, global payments, and asset management, helping clients navigate financial challenges and support their growth. Notably, Silicon Valley Bank has been involved in several significant transactions within the cardiovascular device industry, including a $11 million debt financing for CardioFocus in 2013, a $15 million debt financing for CVRx in 2014, and a $29 million post-IPO debt for Cardiovascular Systems in 2010. These transactions highlight their active role in supporting companies that are innovating in the cardiovascular space.

10. GV (Google Ventures)

• Website: gv.com
• Type: Venture Capital
• Headquarters: San Francisco Bay Area, California, United States (USA)
• Founded year: 2009
• Headcount: 51-200
• Number of deals in 2024: 74
• LinkedIn: gv

GV (Google Ventures) is a venture capital firm based in the San Francisco Bay Area, founded in 2009, with over $10 billion in assets under management. The firm focuses on various sectors, including life sciences and artificial intelligence, and partners with innovative technology startups. Notably, GV has invested in Element Science, a medical device company that raised a total of $145.6 million in Series C financing to support the development of the Jewel Patch Wearable Cardioverter Defibrillator, a product aimed at addressing cardiovascular health. Additionally, GV has participated in funding rounds for Cala Health, which, while primarily focused on neuromodulation, may have applications relevant to cardiovascular health. These investments highlight GV's active role in the cardiovascular device industry.

11. Polaris Partners

• Website: polarispartners.com
• Type: Venture Capital
• Headquarters: Boston, Massachusetts, United States (USA)
• Founded year: 1996
• Headcount: 11-50
• Number of deals in 2024: 19
• LinkedIn: polaris-partners

Polaris Partners is a venture capital firm based in Boston, Massachusetts, founded in 1996. The firm specializes in healthcare and biotechnology investments, partnering with entrepreneurs to provide funding and strategic guidance to help them innovate and grow their businesses. Polaris has a diverse portfolio that includes companies focused on transformative healthcare solutions. Notably, they have made significant investments in the cardiovascular device sector, including multiple funding rounds for Cardiac Dimensions, which raised a total of $49 million across Series B, C, and D rounds. They also invested in BridgePoint Medical, contributing to its growth in the cardiovascular device market. Polaris operates primarily in the investment management space, supporting early-stage companies in bringing their products to market, particularly in the healthcare domain.

12. Frazier Healthcare Partners

• Website: frazierhealthcare.com
• Type: Venture Capital
• Headquarters: Seattle, Washington, United States (USA)
• Founded year: 1991
• Headcount: 51-200
• Number of deals in 2024: 27
• LinkedIn: frazier-healthcare-partners

Frazier Healthcare Partners is a venture capital firm based in Seattle, Washington, specializing in healthcare and life sciences investments. Founded in 1991, the firm focuses on growth buyout investments in profitable healthcare businesses and innovative biopharmaceuticals. Notably, Frazier has made substantial investments in cardiovascular device companies, including CVRx, which raised $84 million in Series E funding and $65 million in Series D funding, and EBR Systems, which secured $15 million in a venture round and $35 million in Series C funding. These transactions highlight Frazier's commitment to advancing technologies in the cardiovascular space, making them a significant player in this industry.

13. F-Prime

• Website: fprimecapital.com
• Type: Venture Capital
• Headquarters: Cambridge, Massachusetts, United States (USA)
• Founded year: 1946
• Headcount: 11-50
• Number of deals in 2024: 39
• LinkedIn: f-prime-capital-partners

F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts, founded in 1946. The firm specializes in creating and investing in healthcare and technology companies, providing both venture capital investments and advisory services to entrepreneurs. F-Prime has a global presence and expertise that enables them to effectively support start-ups in developing innovative solutions. Notably, F-Prime has participated in significant transactions within the cardiovascular device context, including investments in Farapulse, a company focused on cardiac arrhythmias, and Metcela, which is developing treatments for heart failure. Their involvement in these companies highlights their active role in advancing cardiovascular health technologies.

14. ARCH Venture Partners

• Website: archventure.com
• Type: Venture Capital
• Headquarters: Chicago, Illinois, United States (USA)
• Founded year: 1986
• Headcount: 11-50
• Number of deals in 2024: 32
• LinkedIn: arch-venture-partners

ARCH Venture Partners is a venture capital firm based in Chicago, Illinois, founded in 1986. The firm specializes in biotechnology investments, providing funding and strategic support to innovative companies in the life sciences sector. They primarily target early-stage biotech firms that are developing groundbreaking medical solutions. Notable transactions include investments in Bellerophon Therapeutics, which raised $80 million in a Series A round, and multiple funding rounds for Faraday Pharmaceuticals, a company focused on preventing muscle loss, which raised significant amounts in Series A and Series B rounds. Additionally, they participated in a Series A2 financing round for Verve Therapeutics, which is advancing programs related to cardiovascular health. While their investments span various areas of biotechnology, their involvement in companies related to cardiovascular health suggests a potential interest in this field, albeit not exclusively focused on cardiovascular devices.

15. Oxford Finance LLC

• Website: oxfordfinance.com
• Type: Corporate
• Headquarters: Alexandria, Virginia, United States (USA)
• Founded year: 2002
• Headcount: 51-200
• Number of deals in 2024: 2
• LinkedIn: oxford-finance-llc

Oxford Finance LLC is a corporate financial services company based in Alexandria, Virginia, founded in 2002. The firm specializes in providing flexible lending solutions to middle-market companies, particularly in the life sciences and healthcare sectors. They offer a variety of financial products, including enterprise lending, leveraged lending, and real estate financing, aimed at helping businesses secure the necessary capital for growth and innovation. Notably, Oxford Finance has been involved in several significant transactions within the cardiovascular device industry, including a $20 million debt financing for AliveCor in January 2019, an $11 million debt financing for CardioFocus in May 2013, a $20 million debt financing for CVRx in August 2016, and a $39 million Series B investment in Cardiac Dimensions in April 2018. These transactions highlight their active role in supporting the development and expansion of companies in the cardiovascular device market.

16. Vivo Capital

• Website: vivocapital.com
• Type: Venture Capital
• Headquarters: Palo Alto, California, United States (USA)
• Founded year: 1996
• Headcount: 51-200
• Number of deals in 2024: 19
• LinkedIn: vivo-capital

Vivo Capital is a venture capital firm based in Palo Alto, California, specializing in healthcare investments. Founded in 1996, the firm provides venture capital, private equity, and public equity investments to healthcare companies, facilitating innovation and growth in the sector. Vivo Capital has been involved in several significant transactions, including leading a $26 million Series C financing round for SentreHeart, which is developing the LARIAT suture delivery device aimed at cardiovascular applications. They also participated in a $137 million Series B financing for Preventice Solutions, which, while not exclusively cardiovascular, contributes to healthcare technology innovation. Their investment strategy focuses on companies that develop healthcare technologies and products, indicating a commitment to advancing medical devices, including those in the cardiovascular space.

17. Khosla Ventures

• Website: khoslaventures.com
• Type: Venture Capital
• Headquarters: Menlo Park, California, United States (USA)
• Founded year: 2004
• Headcount: 51-200
• Number of deals in 2024: 97
• LinkedIn: khosla-ventures

Khosla Ventures is a venture capital firm founded in 2004, based in Menlo Park, California. The firm specializes in providing funding and strategic guidance to startups across various sectors, including technology, healthcare, and sustainability. Khosla Ventures has been actively involved in the healthcare space, particularly in cardiovascular devices. They have made significant investments in companies like AliveCor, which raised multiple funding rounds with Khosla's participation, focusing on remote cardiology solutions and AI-powered ECG technology. Their investment in Aktiia, a company dedicated to managing hypertension, further emphasizes their commitment to innovations that improve cardiovascular health. Khosla Ventures supports entrepreneurs with resources and strategic insights, helping them navigate the challenges of building impactful health technologies.

18. Invus

• Website: invus.com
• Type: Venture Capital
• Headquarters: New York, New York, United States (USA)
• Founded year: 1985
• Headcount: 51-200
• Number of deals in 2024: 35
• LinkedIn: invus

Invus is a venture capital firm based in New York, specializing in equity investments and investment management since its founding in 1985. The firm partners with owner-managers across various industries to enhance business performance and create sustainable value. Invus has made significant investments in the cardiovascular device sector, including a Series A investment in Elixir Medical, which focuses on innovative cardiovascular solutions. They also participated in funding rounds for Vascular Dynamics, a medical device company, and CardiAQ Valve Technologies, which is developing transcatheter mitral valve implants. Additionally, Invus was involved in the Series C financing of Element Science, known for its wearable cardioverter defibrillator, and in the Series D financing of Ablative Solutions, which is conducting pivotal trials for its cardiovascular device. These transactions highlight Invus's commitment to advancing technologies in the cardiovascular space.

19. Redmile Group

• Website: redmilegroup.com
• Type: Venture Capital
• Headquarters: San Francisco, California, United States (USA)
• Founded year: 2007
• Headcount: 11-50
• Number of deals in 2024: 15
• LinkedIn: redmile-group

Redmile Group is an investment management firm based in San Francisco, California, founded in 2007. The firm specializes in providing asset management and investment strategies to high-net-worth individuals and institutional investors. Redmile Group has a diverse portfolio, but it has made notable investments in the cardiovascular device industry. For instance, they participated in a $136 million financing round for Impulse Dynamics, which focuses on heart failure therapy, and a $60 million supplemental Series D financing for the same company. Additionally, they were involved in funding rounds for TriVascular, which develops vascular devices, including a $40 million Series E and a $60 million Series D financing. These transactions highlight Redmile Group's active role in supporting innovations in cardiovascular devices and therapies.

Cardiovascular Device Insights: Key Investors in the US

Investor	Headquarter	Size	Founded	Deals 2024
MedTech Innovator	Los Angeles, California, United States (USA)	11-50	2013	85
Y Combinator	San Francisco, California, United States (USA)	51-200	2005	802
OrbiMed	New York, New York, United States (USA)	51-200	1989	52
New Enterprise Associates (NEA)	Menlo Park, California, United States (USA)	51-200	1977	57
Sosv	United States (USA)	51-200	1995	170
Perceptive Advisors	New York, New York, United States (USA)	11-50	1999	45
StartUp Health	New York, New York, United States (USA)	11-50	2011	0
Plug and Play Tech Center	Sunnyvale, California, United States (USA)	501-1000	2006	253
Silicon Valley Bank	Santa Clara, California, United States (USA)	5001-10000	1983	31
GV (Google Ventures)	San Francisco Bay Area, California, United States (USA)	51-200	2009	74
Polaris Partners	Boston, Massachusetts, United States (USA)	11-50	1996	19
Frazier Healthcare Partners	Seattle, Washington, United States (USA)	51-200	1991	27
F-Prime	Cambridge, Massachusetts, United States (USA)	11-50	1946	39
ARCH Venture Partners	Chicago, Illinois, United States (USA)	11-50	1986	32
Oxford Finance LLC	Alexandria, Virginia, United States (USA)	51-200	2002	2
Vivo Capital	Palo Alto, California, United States (USA)	51-200	1996	19
Khosla Ventures	Menlo Park, California, United States (USA)	51-200	2004	97
Invus	New York, New York, United States (USA)	51-200	1985	35
Redmile Group	San Francisco, California, United States (USA)	11-50	2007	15

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