The health information technology industry in the US focuses on improving healthcare delivery through technology. This includes companies that create software for electronic health records, telemedicine services, and health data analysis tools. With the growing emphasis on patient-centered care and data-driven decision-making, the industry is evolving rapidly. Innovations like artificial intelligence and cloud computing are transforming traditional practices, enhancing operational efficiency and patient engagement. The sector is on an upward trajectory, predicted to keep expanding as both healthcare providers and patients increasingly demand seamless access to digital healthcare solutions, boosting better health outcomes for all.


The array of investors featured here highlights the dynamic venture capital ecosystem within the US health information technology space. Predominantly venture capital firms, these investors are located in key tech hubs like Silicon Valley and New York. Many range in size from small offices with fewer than 10 employees up to large organizations managing thousands. Founded over several decades, their involvement in 2024 included a wide spectrum of deal counts, reflecting the sector's robust activity and interest. These firms are pivotal in shaping advancements in health technology companies, funding solutions destined to transform healthcare delivery.


Top 18 Health Information Technology Investors in the US


1. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that helps entrepreneurs launch and grow their businesses. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Among its notable investments in the health information technology sector are Helium Health, which raised multiple funding rounds including a $10 million Series A in 2020, and DrChrono, which received seed funding in 2011. Additionally, Y Combinator invested in CareMessage, a health tech startup that raised seed funding in 2014. These transactions highlight Y Combinator's active role in fostering innovation within the health information technology industry.


2. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They focus on connecting startups with corporations to foster growth and innovation across various sectors, including technology. In the health information technology space, Plug and Play has made significant investments in several startups. Notable transactions include Health Gorilla, which raised $100,000 in a Seed Round in 2016, and Helium Health, which secured an undisclosed amount in a Series A round in 2020. Additionally, they participated in the pre-Seed funding round for Bypa-ss, an Egyptian health-tech startup, which raised $1 million in 2021. Other investments include Periksa and Redi.Health, which raised funds in Seed Rounds. These transactions highlight Plug and Play's active role in supporting health information technology ventures.


3. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, founded in 2011, that focuses on health innovation. It supports health entrepreneurs and startups through its Health Moonshot Communities, providing essential resources, networking opportunities, and media content aimed at addressing significant health challenges. StartUp Health has been involved in several relevant transactions in the health information technology space, including seed investments in Patientory, a company focused on blockchain-based health data management, and Electronic Health Network, which aims to improve health data interoperability. Other notable investments include CliniVantage Healthcare, which provides healthcare solutions, and Curatio, a social health app designed to support patients. Their offerings, including newsletters, podcasts, and a journal, highlight progress in health technology and innovation, further emphasizing their role in the health information technology sector.


4. MedTech Innovator

  • Website: medtechinnovator.org
  • Type: Corporate
  • Headquarters: Los Angeles, California, United States (USA)
  • Founded year: 2013
  • Headcount: 11-50
  • Number of deals in 2024: 85
  • LinkedIn: medtech-innovator

MedTech Innovator is a not-for-profit organization based in Los Angeles, California, founded in 2013. It serves as the largest accelerator for medical technology companies, providing accelerator programs, mentorship, and competitions to support startups in the medical device, digital health, and diagnostics sectors. In 2024, they have made 85 investments, showcasing their active role in fostering innovation in healthcare. Notably, they have been involved in transactions such as Redox, which raised $1,000,000 in Series B funding, focusing on health data integration, and other companies like Patientory and MedAware, which are also relevant to health information technology. Their diverse portfolio highlights their commitment to advancing technologies that improve healthcare delivery and patient outcomes.


5. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios. With a network of over 10,000 investors, the firm focuses on connecting them with high-quality investment opportunities in the startup ecosystem. Notably, the fund has been involved in several transactions within the health information technology space, including a $130 million Series C funding for Luma Health, which enhances patient access and communication. Additionally, they participated in funding rounds for Accolade, a healthcare tech company that has raised over $200 million, indicating their active role in supporting health tech innovations. Other investments include Insiteflow, which is developing a cloud-based platform that could also have applications in health tech.


6. 500 Global

  • Website: 500.co
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2010
  • Headcount: 201-500
  • Number of deals in 2024: 98
  • LinkedIn: 500-startups

500 Global is a venture capital firm and startup accelerator based in San Francisco, California, founded in 2010. The firm specializes in investing in early-stage technology companies, providing funding, mentorship, and resources to help founders scale their businesses. With a global focus, 500 Global has made significant investments in various sectors, including health information technology. Notable transactions in this sector include a $2.5 million seed round for Innovaccer, which enhances healthcare data management; a $1.5 million seed round for Reliv - Healthcare Made Simple, aimed at streamlining healthcare services; and a $675,000 seed round for DrChrono, which offers electronic health record solutions. Additionally, they participated in a funding round for CarePort Health, which focuses on care coordination and management. These investments highlight 500 Global's active role in fostering innovation within the health IT landscape.


7. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

SOSV is a venture capital firm founded in 1995, specializing in funding and supporting deep tech startups through its development programs. With a global reach, SOSV connects innovative companies with investors and provides resources to help startups grow and succeed. Notably, SOSV has invested in Optimize Health, a Seattle-based digital healthcare platform that offers remote patient monitoring and chronic care management software, participating in multiple funding rounds including a $3.5 million seed round and an $18.6 million Series B round. Additionally, they have invested in RxAll, a startup focused on improving technology in the healthcare sector. These transactions highlight SOSV's commitment to the health information technology industry.


8. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm founded in 1977, based in Menlo Park, California. NEA specializes in investment management and advisory services for startups, particularly in the technology and healthcare sectors. The firm partners with entrepreneurs to provide funding and strategic guidance, helping them navigate the challenges of building successful businesses. NEA operates through a collaborative approach, emphasizing long-term relationships with founders. Notably, NEA has invested in health information technology companies such as Omada Health, which raised $4.7 million in Series A funding in 2013 and focuses on diabetes prevention, and Pager, which has received multiple rounds of funding, including $22 million in Series B in 2020. These transactions highlight NEA's commitment to advancing health technology solutions.


9. General Catalyst


General Catalyst is a venture capital firm founded in 2000, based in San Francisco, California. The firm specializes in early-stage and growth investments across various industries, including technology and healthcare. General Catalyst has been actively involved in the health information technology sector, leading significant funding rounds for startups that are innovating in this space. Notable transactions include a $20 million Series A investment in Osana, an Argentina-based healthcare startup, and a $66 million Series C funding for Aidoc, an Israeli company focused on AI-driven medical imaging solutions. They also participated in seed funding for DrChrono, a company that provides electronic health records on the iPad. These investments highlight General Catalyst's strategic focus on scaling health tech companies and enhancing healthcare delivery through technology.


10. Silicon Valley Bank

  • Website: svb.com
  • Type: Venture Capital
  • Headquarters: Santa Clara, California, United States (USA)
  • Founded year: 1983
  • Headcount: 5001-10000
  • Number of deals in 2024: 31
  • LinkedIn: silicon-valley-bank

Silicon Valley Bank is a commercial bank founded in 1983, located in Santa Clara, California, specializing in providing financial services to the innovation economy, particularly tech startups and venture capital firms. With a focus on business banking, global payments, and asset management, SVB helps clients navigate financial challenges and support their growth. In the health information technology sector, SVB has made notable investments, including a $2.6 million debt financing for DrChrono, a healthcare technology platform, and a $50 million capital raise for Teladoc Health, the largest telemedicine company in the US. Additionally, SVB participated in a $220 million Series E funding round for Komodo Health, a company that provides healthcare data analytics, and supported Sensely in its funding round aimed at platform development. These transactions highlight SVB's active role in fostering innovation within the health tech industry.


11. Gaingels

  • Website: gaingels.com
  • Type: Venture Capital
  • Headquarters: Burlington, Vermont, United States (USA)
  • Founded year: 2015
  • Headcount: 11-50
  • Number of deals in 2024: 60
  • LinkedIn: gaingels

Gaingels is a venture capital firm founded in 2015, based in Burlington, Vermont, dedicated to investing in companies with diverse leadership. The firm provides capital and support to startups, particularly those led by underrepresented groups, to foster diversity and inclusion in the innovation economy. Gaingels has been involved in notable transactions in the health information technology sector, including a $55 million Series C funding round for Suki, an AI-powered healthcare technology company, and a $101 million Series C funding for BrightInsight, which focuses on regulated digital health solutions. These investments highlight Gaingels' commitment to supporting innovation in healthcare technology while promoting diversity and inclusion within the industry.


12. Khosla Ventures

  • Website: khoslaventures.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 2004
  • Headcount: 51-200
  • Number of deals in 2024: 97
  • LinkedIn: khosla-ventures

Khosla Ventures is a venture capital firm founded in 2004, based in Menlo Park, California. The firm specializes in providing funding and strategic assistance to startups across various sectors, including technology, healthcare, and sustainability. Khosla Ventures has been particularly active in the health information technology sector, as evidenced by their significant investments in Sword Health, a virtual musculoskeletal care provider. They participated in multiple funding rounds for Sword Health, including Series A, B, C, and D, with total investments amounting to over $350 million. This consistent support for health tech startups illustrates Khosla Ventures' commitment to advancing healthcare solutions through technology.


13. Insight Partners

  • Website: insightpartners.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1995
  • Headcount: 201-500
  • Number of deals in 2024: 64
  • LinkedIn: insight--partners

Insight Partners is a venture capital firm based in New York, specializing in providing investment and advisory services to high-growth technology and software companies. Founded in 1995, the firm manages over $75 billion in assets and has a team of 201-500 professionals. Insight Partners supports its portfolio companies through capital investment and operational expertise, helping them scale effectively in competitive markets. Among their notable transactions in the health information technology sector are investments in Netsmart Technologies, which raised funds in 2007, and Kinnser Software, which secured significant Series A funding in both 2012 and 2014. They also led a $101 million Series C funding round for BrightInsight in 2021, a company focused on regulated digital health solutions. These investments highlight Insight Partners' commitment to advancing health information technology.


14. Liquid 2 Ventures

  • Website: liquid2.vc
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2015
  • Headcount: 1-10
  • Number of deals in 2024: 91
  • LinkedIn: liquid-2-ventures

Liquid 2 Ventures is a venture capital firm based in San Francisco, California, founded in 2015. The firm specializes in investing in technology startups at the pre-seed and seed stages, as well as growth-stage companies. They provide capital, mentorship, and access to a vast network of industry insiders to help founders navigate their entrepreneurial journeys. Notably, Liquid 2 Ventures has invested in several health information technology companies, including Akute Health, which raised a total of $497,500 in seed and pre-seed rounds in 2021, and CaptureProof, which raised funds in 2015. More recently, they invested in Lotus Health AI in 2024, further demonstrating their commitment to the health tech sector. Their focus on supporting exceptional founders to build lasting companies is evident in their diverse portfolio, which includes significant investments in health technology.


15. GV (Google Ventures)

  • Website: gv.com
  • Type: Venture Capital
  • Headquarters: San Francisco Bay Area, California, United States (USA)
  • Founded year: 2009
  • Headcount: 51-200
  • Number of deals in 2024: 74
  • LinkedIn: gv

GV (Google Ventures) is a venture capital firm founded in 2009, based in the San Francisco Bay Area, California. With over $10 billion in assets under management, GV focuses on funding and supporting innovative technology startups across various sectors, including life sciences and artificial intelligence. Notably, GV has invested in several health information technology companies, such as Aledade, which raised $64 million in Series C funding to expand its healthcare provider network, and PatientPing, a care coordination company that secured $60 million in Series C funding to enhance its services for healthcare providers and health plans. These investments reflect GV's commitment to advancing healthcare technology and improving patient care through innovative solutions.


16. OrbiMed

  • Website: orbimed.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1989
  • Headcount: 51-200
  • Number of deals in 2024: 52
  • LinkedIn: orbimed-advisors

OrbiMed is a prominent investment firm based in New York, specializing in healthcare investments since its founding in 1989. With approximately $17 billion in assets under management, OrbiMed focuses on various healthcare sectors, including biopharmaceuticals, medical devices, and healthcare services. The firm has made significant investments in health information technology, exemplified by their leadership in funding rounds for Health Catalyst, a company that provides data analytics solutions aimed at healthcare transformation. OrbiMed also invested in Practice Fusion, a provider of a free, web-based electronic health record system, which has expanded its offerings to include analytics and patient engagement tools. Additionally, their involvement with DarioHealth, which focuses on digital health solutions, and TigerConnect, a communication platform for healthcare providers, further underscores their commitment to advancing health IT. These transactions illustrate OrbiMed's strategic focus on driving innovation in the healthcare technology landscape.


17. SV Angel

  • Website: svangel.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2009
  • Headcount: 1-10
  • Number of deals in 2024: 44
  • LinkedIn: sv-angel

SV Angel is a venture capital firm based in San Francisco, California, founded in 2009. The firm specializes in investing in early-stage and growth-stage technology companies, providing not only financial backing but also strategic advice and access to a broad network of industry experts. SV Angel's mission is to foster innovation and assist startups in overcoming business development challenges. Among their notable investments in the health information technology sector are Practice Fusion, which raised significant funding for its electronic medical records platform, and PatientPing, a healthcare technology company that secured funding to expand its services. They also invested in Vital, a startup aiming to improve the EHR experience through AI-driven solutions. These investments highlight SV Angel's commitment to supporting advancements in health IT.


18. Intel Capital

  • Website: intelcapital.com
  • Type: Venture Capital
  • Headquarters: Santa Clara, California, United States (USA)
  • Founded year: 1991
  • Headcount: 11-50
  • Number of deals in 2024: 23
  • LinkedIn: intelcapital

Intel Capital is a venture capital firm based in Santa Clara, California, founded in 1991. The firm specializes in early-stage technology investments, focusing on areas such as AI, cloud computing, and semiconductor technologies. In addition to these sectors, Intel Capital has made significant investments in health information technology, notably in CareCloud, a provider of cloud-based practice management, electronic health records (EHR), and medical billing software. Intel Capital participated in multiple funding rounds for CareCloud, including Series A, B, and C rounds, which collectively raised substantial capital to enhance product innovation and customer success in the health IT space. They also invested in Pixeon, further showcasing their interest in health technology solutions. Through these investments, Intel Capital provides not only funding but also strategic support and access to Intel's extensive resources, helping startups in the health information technology sector to scale and innovate effectively.



Health Information Technology Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
StartUp HealthNew York, New York, United States (USA)11-5020110
MedTech InnovatorLos Angeles, California, United States (USA)11-50201385
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
500 GlobalSan Francisco, California, United States (USA)201-500201098
SosvUnited States (USA)51-2001995170
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
General CatalystSan Francisco, California, United States (USA)51-2002000144
Silicon Valley BankSanta Clara, California, United States (USA)5001-10000198331
GaingelsBurlington, Vermont, United States (USA)11-50201560
Khosla VenturesMenlo Park, California, United States (USA)51-200200497
Insight PartnersNew York, New York, United States (USA)201-500199564
Liquid 2 VenturesSan Francisco, California, United States (USA)1-10201591
GV (Google Ventures)San Francisco Bay Area, California, United States (USA)51-200200974
OrbiMedNew York, New York, United States (USA)51-200198952
SV AngelSan Francisco, California, United States (USA)1-10200944
Intel CapitalSanta Clara, California, United States (USA)11-50199123


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