The dietary supplement industry in the US is robust and evolving, catering to the growing consumer demand for health and wellness products. This sector includes companies producing vitamins, minerals, herbal products, and meal replacements, alongside functional foods designed to enhance wellbeing. As more consumers prioritize their health, the market continuously adapts, incorporating natural ingredients and innovative formulations. Trends such as personalized nutrition and clean labeling are winning consumer favor, indicating a shift toward transparency and customization. By 2026, the market is projected to surpass $70 billion, reflecting an increasing acceptance and reliance on dietary supplements in everyday life.


In the realm of investment, the top dietary supplement investors in the US represent a mixture of venture capital firms and private equity funds. Predominantly headquartered in California, New York, and Vermont, these firms vary in size but collectively participated in numerous deals in 2024. Established from 1977 to 2023, their investment strategies focus on startups innovating within health, nutrition, and technology sectors. Notably, they made substantial investments, with Y Combinator leading with 802 deals, underscoring an engaged commitment to fostering growth in dietary supplements and health-oriented ventures.


Top 16 Dietary Supplement Investors in the US


1. Y Combinator

  • Website: ycombinator.com
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2005
  • Headcount: 51-200
  • Number of deals in 2024: 802
  • LinkedIn: y-combinator

Y Combinator is a prominent startup accelerator and venture capital firm based in San Francisco, California, founded in 2005. It provides funding and mentorship to early-stage technology companies through a structured program that helps entrepreneurs launch and grow their businesses. Y Combinator has successfully launched over 4,000 startups, making it a key player in the technology startup ecosystem. Among its notable investments are companies in the dietary supplement space, such as Soylent, which raised $120,000 in a Pre-Seed round in 2012, and Nutrigene Inc., which also raised $120,000 in a Pre-Seed round in 2018. Additionally, Y Combinator has invested in Zenamins, a company focused on dietary supplements, further demonstrating its engagement in this industry. These transactions highlight Y Combinator's interest in supporting innovative companies within the dietary supplement sector, alongside its broader focus on technology and health-related startups.


2. Sosv

  • Website: sosv.com
  • Type: Venture Capital
  • Headquarters: United States (USA)
  • Founded year: 1995
  • Headcount: 51-200
  • Number of deals in 2024: 170
  • LinkedIn: sosv

SOSV is a venture capital firm founded in 1995, specializing in funding and supporting deep tech startups through its development programs. With a focus on health and climate technology, SOSV operates globally, connecting innovative companies with investors. Notably, they have invested in several companies relevant to the dietary supplement industry, including Aminolabs, which focuses on amino acid-based supplements, and Flore by Sun Genomics, which raised funds in both a Series B round and a convertible note, emphasizing their commitment to personalized health solutions. Their diverse portfolio and active engagement in health-related startups position them as a significant player in the dietary supplement sector.


3. 500 Global

  • Website: 500.co
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2010
  • Headcount: 201-500
  • Number of deals in 2024: 98
  • LinkedIn: 500-startups

500 Global is a venture capital firm and startup accelerator based in San Francisco, California, founded in 2010. The firm specializes in investing in early-stage technology companies, providing funding, mentorship, and resources to help founders scale their businesses. In recent years, 500 Global has made notable investments in the dietary supplement context, including Ample Foods, a nutrition start-up that focuses on providing convenient and healthy meal options. This investment highlights their interest in the nutrition and dietary supplement sector. Additionally, they have invested in More Labs, a company that develops products aimed at improving health and wellness, further demonstrating their engagement in the dietary supplement industry. With a total of 98 investments in 2024, 500 Global continues to actively seek innovative startups across various sectors, including those related to health and nutrition.


4. Deep Tech Fund (an Alumni Ventures Fund)

  • Website: av.vc
  • Type: Venture Capital
  • Headquarters: Manchester, New Hampshire, United States (USA)
  • Founded year: 2023
  • Headcount: 51-200
  • Number of deals in 2024: 258
  • LinkedIn: deep-tech-fund-av-focused-fund

Deep Tech Fund (an Alumni Ventures Fund) is a venture capital firm based in Manchester, New Hampshire, founded in 2023. It provides accredited investors and institutions with access to professionally-managed, diversified venture portfolios. With a network of over 10,000 investors, the firm focuses on connecting them with high-quality investment opportunities in the startup ecosystem. Among its notable transactions, the fund has invested in Vital Plan, which raised over $1.1 million in a venture round in 2018, and Womaness, a company focused on women's health and wellness, which raised $4 million in a seed round in 2021 and an undisclosed amount in a subsequent seed round in 2023. These investments highlight the fund's engagement in the dietary supplement industry, particularly in health-focused startups.


5. StartUp Health

  • Website: startuphealth.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2011
  • Headcount: 11-50
  • LinkedIn: startuphealth

StartUp Health is a not-for-profit organization based in New York, New York, founded in 2011, that focuses on health innovation. They support health entrepreneurs and startups through Health Moonshot Communities, providing resources, networking, and media content to address significant health challenges. Their offerings include newsletters, podcasts, and a journal that highlight progress in health technology and innovation. Notably, StartUp Health has participated in funding rounds for companies like Vous Vitamin, which raised an undisclosed amount in a venture round in January 2022, indicating their interest in dietary supplements. They also invested in Gennev, a digital health company for women, which raised $4M in seed funding in 2019, and Resility Health, which raised an undisclosed amount in a seed round in 2018. These transactions reflect their engagement in the health and wellness sector, which often includes dietary supplements.


6. Plug and Play Tech Center


Plug and Play Tech Center is an innovation hub and venture capital firm based in Sunnyvale, California, founded in 2006. They connect startups with corporations to foster growth and innovation, offering various programs including accelerator initiatives and investment opportunities. In 2024 alone, they have made 253 investments, showcasing their active role in the venture capital landscape. Notably, they have invested in Sempera Organics, which focuses on organic products, and Natáur LLC, which is involved in health-related initiatives. Additionally, their investment in Oobli, a company that has raised significant funding across multiple rounds, highlights their interest in innovative food solutions that may intersect with dietary supplements. This diverse portfolio indicates their willingness to engage with companies in the dietary supplement sector, alongside their broader technology focus.


7. Gaingels

  • Website: gaingels.com
  • Type: Venture Capital
  • Headquarters: Burlington, Vermont, United States (USA)
  • Founded year: 2015
  • Headcount: 11-50
  • Number of deals in 2024: 60
  • LinkedIn: gaingels

Gaingels is a venture capital firm founded in 2015, based in Burlington, Vermont, dedicated to investing in companies with diverse leadership. The firm provides capital and support to startups, particularly those led by underrepresented groups, to foster diversity and inclusion in the innovation economy. Gaingels has been involved in various transactions, including investments in health-related companies such as Parsley Health, which focuses on holistic health and wellness, and ByHeart, a company that specializes in infant nutrition. These investments highlight Gaingels' engagement in sectors that intersect with dietary supplements, showcasing their commitment to supporting innovative health solutions.


8. Goodwater Capital

  • Website: goodwatercap.com
  • Type: Venture Capital
  • Headquarters: Burlingame, California, United States (USA)
  • Founded year: 2014
  • Headcount: 51-200
  • Number of deals in 2024: 41
  • LinkedIn: goodwater-capital

Goodwater Capital is a venture capital firm based in Burlingame, California, founded in 2014. The firm specializes in consumer technology and supports seed-stage entrepreneurs by providing investment, resources, and a community to help them grow. Goodwater Capital focuses on various sectors, including healthcare and financial services, aiming to improve access to technology solutions for underserved communities. Notably, they have participated in funding rounds for companies like Kindly Health, a sexual health wellness brand, and Alfie Health, a virtual obesity management clinic, indicating their interest in health and wellness sectors that are closely related to dietary supplements. Additionally, their investment in FitHub, a fitness-related company, further demonstrates their engagement in the health and wellness space.


9. Khosla Ventures

  • Website: khoslaventures.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 2004
  • Headcount: 51-200
  • Number of deals in 2024: 97
  • LinkedIn: khosla-ventures

Khosla Ventures is a venture capital firm founded in 2004, based in Menlo Park, California. The firm specializes in providing funding and strategic guidance to startups, particularly in technology, healthcare, and sustainability sectors. Notably, Khosla Ventures has been actively involved in the health and wellness space, exemplified by their multiple investments in Viome, a company that focuses on personalized health tests and dietary supplements. In 2024, they participated in a Series D funding round for Viome, raising $25 million. Prior to that, they were involved in several Series C funding rounds, contributing to a total of $175 million raised by Viome. These transactions highlight Khosla Ventures' commitment to supporting innovations in health and dietary supplements, making them a relevant investor in this category.


10. L Catterton

  • Website: lcatterton.com
  • Type: Private Equity
  • Headquarters: United States (USA)
  • Founded year: 1989
  • Headcount: 201-500
  • Number of deals in 2024: 23
  • LinkedIn: l-catterton

L Catterton is a private equity firm founded in 1989, specializing in investment management with a focus on consumer brands across various sectors. The firm partners with middle market companies and high-growth enterprises, providing capital and strategic guidance to enhance brand equity and market presence. With a strong emphasis on consumer insights, L Catterton aims to drive growth and innovation within its portfolio companies. Notably, L Catterton has made significant investments in the dietary supplement sector, including a strategic investment in IAFSTORE, which supports its expansion in the Italian online dietary supplement market. They also led a Series A1 financing round for Persona, a personalized vitamin program, and participated in a Series B round for Nutrafol, a company focused on hair wellness supplements. These investments highlight L Catterton's commitment to the dietary supplement industry and its potential for growth.


11. New Enterprise Associates (NEA)

  • Website: nea.com
  • Type: Venture Capital
  • Headquarters: Menlo Park, California, United States (USA)
  • Founded year: 1977
  • Headcount: 51-200
  • Number of deals in 2024: 57
  • LinkedIn: new-enterprise-associates

New Enterprise Associates (NEA) is a prominent venture capital firm based in Menlo Park, California, founded in 1977. With a focus on investment management and advisory services, NEA specializes in supporting startups, particularly in the technology and healthcare sectors. The firm emphasizes long-term relationships with entrepreneurs, providing both funding and strategic guidance to help them navigate the challenges of building successful businesses. NEA has been involved in several notable transactions relevant to the dietary supplement industry, including a $3.5 million seed investment in Ritual, a company known for its dietary supplements, and a $15.5 million Series A investment in Green Chef, which delivers fresh, organic meal packages tailored to various dietary preferences. These investments highlight NEA's commitment to supporting health-oriented companies, making them a significant player in the dietary supplement space.


12. Government of Canada

  • Website: canada.ca
  • Type: Corporate
  • Headquarters: Canada, Kentucky, United States (USA)
  • Founded year: 1999
  • Headcount: 10001+
  • Number of deals in 2024: 137
  • LinkedIn: government-of-canada

The Government of Canada is a public entity that provides a wide range of services and information to Canadian citizens and residents, addressing various needs including employment, immigration, health care, and taxation. Founded in 1999, it operates through multiple departments and agencies to ensure access to essential services and support for individuals and businesses across the country. In recent years, the Government of Canada has engaged in several transactions relevant to the dietary supplement industry, including grants to companies like Big Mountain Foods, which raised $1,400,000 in July 2022, and Dose Juice, which secured debt financing in June 2020. These investments reflect the government's interest in supporting health-oriented businesses and promoting dietary supplements as part of its broader health initiatives.


13. General Catalyst


General Catalyst is a venture capital firm founded in 2000, based in San Francisco, California. The firm specializes in early-stage and growth investments across various industries, including technology and healthcare. They provide capital and strategic guidance to help startups and growth-stage companies scale their operations effectively. Notably, General Catalyst has invested in Elysium Health, a company focused on anti-aging supplements, participating in their Series C and Series B funding rounds. They also led a seed funding round for GetSupp, an AI-driven marketplace for nutrition and supplements. These transactions highlight General Catalyst's engagement in the dietary supplement sector, showcasing their commitment to supporting innovative companies in this space.


14. Pareto Holdings

  • Website: pareto20.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 2020
  • Headcount: 1-10
  • Number of deals in 2024: 31
  • LinkedIn: paretoholdings

Pareto Holdings is a venture capital firm and venture studio based in New York, New York, founded in 2020. The firm specializes in building and investing in early-stage companies, having made over 900 investments globally. Pareto Holdings focuses on exceptional entrepreneurs, providing them with the necessary capital and operational support to grow their businesses. Notably, they have invested in Health Via Modern Nutrition, which raised $5.62 million in a venture round, and Belliwelli, which raised $1 million in a seed round. These transactions highlight their involvement in the dietary supplement sector, showcasing their commitment to supporting innovative companies in this industry.


15. IndieBio

  • Website: indiebio.co
  • Type: Venture Capital
  • Headquarters: San Francisco, California, United States (USA)
  • Founded year: 2015
  • Headcount: 1-10
  • Number of deals in 2024: 76
  • LinkedIn: indiebio

IndieBio is a venture capital firm founded in 2015 and based in San Francisco, California. It specializes in biotechnology and supports startups by providing investment, mentorship, and networking opportunities to help them develop innovative solutions across various sectors, including climate and food. Notably, IndieBio has been involved in several transactions relevant to the dietary supplement industry, such as their investments in Flore by Sun Genomics, which has raised funds through multiple rounds (including Series B and Convertible Note) to develop personalized probiotic solutions. Additionally, they have invested in Aminolabs and Kresko RNAtech, further demonstrating their commitment to supporting biotech innovations that can impact health and wellness, including dietary supplements.


16. OrbiMed

  • Website: orbimed.com
  • Type: Venture Capital
  • Headquarters: New York, New York, United States (USA)
  • Founded year: 1989
  • Headcount: 51-200
  • Number of deals in 2024: 52
  • LinkedIn: orbimed-advisors

OrbiMed is a prominent investment firm based in New York, specializing in healthcare investments. Founded in 1989, the firm manages approximately $17 billion in assets across various investment strategies, focusing on biopharmaceuticals, medical devices, and healthcare services. Notably, OrbiMed has made significant investments in the dietary supplement space, including a Series C investment in Kapiva, an ayurvedic nutrition brand, which raised nearly $10 million in September 2024. This investment highlights OrbiMed's commitment to supporting companies that promote health and wellness through dietary supplements. Additionally, their previous investment in Kapiva in 2022 further emphasizes their ongoing interest in the sector. OrbiMed's diverse portfolio and strategic investments in health-related companies position them as a relevant player in the dietary supplement industry.



Dietary Supplement Insights: Key Investors in the US


InvestorHeadquarterSizeFoundedDeals 2024
Y CombinatorSan Francisco, California, United States (USA)51-2002005802
SosvUnited States (USA)51-2001995170
500 GlobalSan Francisco, California, United States (USA)201-500201098
Deep Tech Fund (an Alumni Ventures Fund)Manchester, New Hampshire, United States (USA)51-2002023258
StartUp HealthNew York, New York, United States (USA)11-5020110
Plug and Play Tech CenterSunnyvale, California, United States (USA)501-10002006253
GaingelsBurlington, Vermont, United States (USA)11-50201560
Goodwater CapitalBurlingame, California, United States (USA)51-200201441
Khosla VenturesMenlo Park, California, United States (USA)51-200200497
L CattertonUnited States (USA)201-500198923
New Enterprise Associates (NEA)Menlo Park, California, United States (USA)51-200197757
Government of CanadaCanada, Kentucky, United States (USA)10001+1999137
General CatalystSan Francisco, California, United States (USA)51-2002000144
Pareto HoldingsNew York, New York, United States (USA)1-10202031
IndieBioSan Francisco, California, United States (USA)1-10201576
OrbiMedNew York, New York, United States (USA)51-200198952


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